Search filters

List of works by James M Leiper

A Novel Pathway for Metabolism of the Cardiovascular Risk Factor Homoarginine by alanine:glyoxylate aminotransferase 2.

scientific article published on 18 October 2016

A novel DDAH-1 inhibitor improved cardiovascular function in a short-term anesthetized rat model of sepsis

scientific article

A novel DDAH-1 inhibitor improved sepsis-induced impairment in vasoreactivity to noradrenaline in a rat endotoxaemia model.

scientific article

Active site mutant dimethylarginine dimethylaminohydrolase 1 expression confers an intermediate tumour phenotype in C6 gliomas.

scientific article

Adenoviral-mediated overexpression of DDAH improves vascular tone regulation.

scientific article

Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure.

scientific article

Analysis of methylarginine metabolism in the cardiovascular system identifies the lung as a major source of ADMA

scientific article published in January 2007

Circulating methylarginine levels and the decline in renal function in patients with chronic kidney disease are modulated by DDAH1 polymorphisms

scientific article published on 9 December 2009

Dimethylarginine dimethylaminohydrolase 1 is involved in spinal nociceptive plasticity

scientific article published on 19 June 2015

Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in polymicrobial sepsis

scientific article

Dimethylarginine dimethylaminohydrolase-2 deficiency promotes vascular regeneration and attenuates pathological angiogenesis

scientific article published on 12 May 2016

Disruption of methylarginine metabolism impairs vascular homeostasis

scientific article

Effects of ADMA upon gene expression: an insight into the pathophysiological significance of raised plasma ADMA.

scientific article

Endothelial Dimethylarginine Dimethylaminohydrolase 1 Is an Important Regulator of Angiogenesis but Does Not Regulate Vascular Reactivity or Hemodynamic Homeostasis

scientific article published on 24 April 2015

Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study.

scientific article

Evidence for dysregulation of dimethylarginine dimethylaminohydrolase I in chronic hypoxia-induced pulmonary hypertension

scientific article

Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs

scientific article published on 9 December 2014

Expression of NG,NG-dimethylarginine dimethylaminohydrolase and protein arginine N-methyltransferase isoforms in diabetic rat kidney: effects of angiotensin II receptor blockers

scientific article published in October 2007

Genetic and pharmacological inhibition of dimethylarginine dimethylaminohydrolase 1 is protective in endotoxic shock.

scientific article

Hypoxia causes increased monocyte nitric oxide synthesis which is mediated by changes in dimethylarginine dimethylaminohydrolase 2 expression in animal and human models of normobaric hypoxia

scientific article published on 16 June 2016

Identification of microbial dimethylarginine dimethylaminohydrolase enzymes

scientific journal article

Isoform-specific regulation by N(G),N(G)-dimethylarginine dimethylaminohydrolase of rat serum asymmetric dimethylarginine and vascular endothelium-derived relaxing factor/NO

scientific article published on 02 August 2007

Metabolomic profiling of amines in sepsis predicts changes in NOS canonical pathways

scientific article published on 15 August 2017

Modulation of Rac1 activity by ADMA/DDAH regulates pulmonary endothelial barrier function.

scientific article published on 15 October 2008

NRF2 PREVENTS HYPERTENSION, INCREASED ADMA, MICROVASCULAR OXIDATIVE STRESS AND DYSFUNCTION IN MICE WITH TWO WEEKS OF ANGIOTENSIN II INFUSION.

scientific article

New tricks from an old dog: nitric oxide-independent effects of dimethylarginine dimethylaminohydrolase

scientific article published on 01 July 2006

Pharmacological inhibition of DDAH1 improves survival, haemodynamics and organ function in experimental septic shock.

scientific article published in June 2014

Rapid onset of severe septic shock in the pregnant mouse†

scientific article published on 01 February 2019

Reduced Renal Methylarginine Metabolism Protects against Progressive Kidney Damage

scientific article

Regulation of fluid reabsorption in rat or mouse proximal renal tubules by asymmetric dimethylarginine (ADMA) & dimethylarginine dimethylaminohydrolase (DDAH) 1.

scientific article published on 7 March 2018

Regulation of the ADMA-DDAH system in endothelial cells: a novel mechanism for the sterol response element binding proteins, SREBP1c and -2.

scientific article

Reply to letter regarding article, "evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs"

scientific article published on 01 October 2015

Response to letters regarding article, "unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine".

scientific article published on April 2014

Role of asymmetric methylarginine and connexin 43 in the regulation of pulmonary endothelial function

scientific article

Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase

scientific article

Symmetric dimethylarginine (SDMA) is raised in women with polycystic ovary syndrome: a pilot study.

scientific article published in July 2011

The ADMA/DDAH pathway is a critical regulator of endothelial cell motility

scientific article published on 27 February 2007

The ADMA/DDAH pathway regulates VEGF-mediated angiogenesis.

scientific article published on 24 September 2009

The biology and therapeutic potential of the DDAH/ADMA pathway.

scientific article published on January 2010

The response of the innate immune and cardiovascular systems to LPS in pregnant and nonpregnant mice

scientific article

The role of ATM in response to metformin treatment and activation of AMPK

scientific article published on 28 March 2012

The role of alanine glyoxylate transaminase-2 (agxt2) in β-alanine and carnosine metabolism of healthy mice and humans

scientific article published on 18 September 2020

The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis

scientific article published on June 2011

The therapeutic potential of targeting endogenous inhibitors of nitric oxide synthesis.

scientific article published on April 2011

Unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine.

scientific article published on 03 July 2013

cAMP phosphodiesterase inhibitors increases nitric oxide production by modulating dimethylarginine dimethylaminohydrolases.

scientific article

miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia.

scientific article

Paulina is supported by:

About Paulina

Help