List of works - Cara J Gottardi

A Simple Method to Assess Abundance of the β-Catenin Signaling Pool in Cells

scientific article

A dileucine motif targets E-cadherin to the basolateral cell surface in Madin-Darby canine kidney and LLC-PK1 epithelial cells.

scientific article published on 18 April 2001

A single amino acid in E-cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes.

scientific article

A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages

scientific article published on 16 January 2020

Activity of the beta-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion

scientific article

Adiponectin inhibits Wnt co-receptor, Lrp6, phosphorylation and β-catenin signaling

scientific article published on 18 January 2016

Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: implications for signaling

scientific article

Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells

scientific article

Beyond epithelial-to-mesenchymal transition: Common suppression of differentiation programs underlies epithelial barrier dysfunction in mild, moderate, and severe asthma.

scientific article

Beyond β-catenin: prospects for a larger catenin network in the nucleus

scientific article published on 18 November 2015

Cadherins and cancer: how does cadherin dysfunction promote tumor progression?

scientific article

Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma? ⬇️

scientific article published on June 1, 2011

Cardiomyocytes of the Heart and Pulmonary Veins: Novel Contributors to Asthma?

scientific article published on 8 May 2017

Considerations for targeting β-catenin signaling in fibrosis.

scientific article

Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes

scientific article

E-Cadherin Suppresses Cellular Transformation by Inhibiting β-Catenin Signaling in an Adhesion-Independent Manner

scientific article (publication date: 28 May 2001)

E-cadherin phosphorylation occurs during its biosynthesis to promote its cell surface stability and adhesion.

scientific article

Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans

scientific article published on 03 December 2019

Fat in fibrosis

scientific article published on November 2013

Fibrosis in systemic sclerosis: common and unique pathobiology ⬇️

scientific article published on June 6, 2012

Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions

scientific article published in Nature Communications

ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours.

scientific article published in May 2013

Idiopathic Pulmonary Fibrosis and Lung Cancer: Finding Similarities within Differences

scientific article published on 01 December 2019

Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth

scientific article

Integrin Regulation of β-Catenin Signaling in Ovarian Carcinoma ⬇️

scientific article published on April 25, 2011

Issues associated with assessing nuclear localization of N-terminally unphosphorylated beta-catenin with monoclonal antibody 8E7

scientific article

Lrp5/β-Catenin Signaling Controls Lung Macrophage Differentiation and Inhibits Resolution of Fibrosis.

scientific article published on 26 September 2016

Macrophages as a Source and Recipient of Wnt Signals

scientific article published on 31 July 2019

Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development

scientific article

Molecular components of the adherens junction.

scientific article published on 14 January 2008

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.

scientific article published on 10 July 2017

Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin-β-catenin.

scientific article

Nesprin-2 interacts with {alpha}-catenin and regulates Wnt signaling at the nuclear envelope.

scientific article

Nuclear signaling from cadherin adhesion complexes

scientific article published on 12 February 2015

Nuclear α-catenin mediates the DNA damage response via β-catenin and nuclear actin

scientific article published on 27 March 2017

Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation

scientific article published on 31 March 2011

Persistent nuclear actin filaments inhibit transcription by RNA polymerase II.

scientific article published on 2 August 2016

Phospho-regulation of Beta-catenin adhesion and signaling functions.

scientific article published on October 2007

Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling

scientific article

Regenerative pathways and emphysema: a new paradigm?

scientific article published on 01 March 2011

Regulation of Wnt/beta-catenin signaling by protein kinases

scientific article

Resetting proteostasis with ISRIB promotes epithelial differentiation to attenuate pulmonary fibrosis

scientific article published in 2021

Signaling from the adherens junction.

scientific article

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

scientific article published on 01 June 2019

Sorting of ion pumps in polarized epithelial cells

scientific article published on 01 November 1997

Structural Determinants of the Mechanical Stability of α-Catenin

scientific article published on 12 June 2015

Terminal regions of beta-catenin come into view

scientific article

Terminating Wnt signals: a novel nuclear export mechanism targets activated (beta)-catenin.

scientific article published on 28 November 2005

The cardiac protein αT-catenin contributes to chemical-induced asthma

scientific article

The cardiomyocyte protein αT-catenin contributes to asthma through regulating pulmonary vein inflammation

scientific article

The increase in maternal expression of axin1 and axin2 contribute to the zebrafish mutant ichabod ventralized phenotype

scientific article published in March 2015

The junction-associated protein, zonula occludens-1, localizes to the nucleus before the maturation and during the remodeling of cell-cell contacts.

scientific article published on October 1996

The terminal region of beta-catenin promotes stability by shielding the Armadillo repeats from the axin-scaffold destruction complex.

scientific article published on 25 August 2009

Tyrosine-based membrane protein sorting signals are differentially interpreted by polarized Madin-Darby canine kidney and LLC-PK1 epithelial cells.

scientific article published on October 1998

UVB radiation‐induced β‐catenin signaling is enhanced by COX‐2 expression in keratinocytes ⬇️

scientific article published on August 18, 2011

When domestiques rebel: kinesins, cadherins and neuronal proliferation

scientific article published in May 2005

Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis

scientific article

Wnt-induced deubiquitination FoxM1 ensures nucleus β-catenin transactivation

scientific article published on 24 February 2016

Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells

scientific article published on August 2012

α-Catenin homodimers are recruited to phosphoinositide-activated membranes to promote adhesion.

scientific article

α-Catenin is an inhibitor of transcription

scientific article

α-Catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism.

scientific article

α-catenin cytomechanics--role in cadherin-dependent adhesion and mechanotransduction

scientific article published on 12 February 2014

αT-catenin in restricted brain cell types and its potential connection to autism.

scientific article published on 21 June 2016

αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family

scientific article published on 10 May 2018

β-catenin signaling: a novel mediator of fibrosis and potential therapeutic target

scientific article

List of works by Cara J Gottardi

A Simple Method to Assess Abundance of the β-Catenin Signaling Pool in Cells

A dileucine motif targets E-cadherin to the basolateral cell surface in Madin-Darby canine kidney and LLC-PK1 epithelial cells.

A single amino acid in E-cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes.

A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages

Activity of the beta-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion

Adiponectin inhibits Wnt co-receptor, Lrp6, phosphorylation and β-catenin signaling

Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: implications for signaling

Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells

Beyond epithelial-to-mesenchymal transition: Common suppression of differentiation programs underlies epithelial barrier dysfunction in mild, moderate, and severe asthma.

Beyond β-catenin: prospects for a larger catenin network in the nucleus

Cadherins and cancer: how does cadherin dysfunction promote tumor progression?

Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma? ⬇️

Cardiomyocytes of the Heart and Pulmonary Veins: Novel Contributors to Asthma?

Considerations for targeting β-catenin signaling in fibrosis.

Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes

E-Cadherin Suppresses Cellular Transformation by Inhibiting β-Catenin Signaling in an Adhesion-Independent Manner

E-cadherin phosphorylation occurs during its biosynthesis to promote its cell surface stability and adhesion.

Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans

Fat in fibrosis

Fibrosis in systemic sclerosis: common and unique pathobiology ⬇️

Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions

ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours.

Idiopathic Pulmonary Fibrosis and Lung Cancer: Finding Similarities within Differences

Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth

Integrin Regulation of β-Catenin Signaling in Ovarian Carcinoma ⬇️

Issues associated with assessing nuclear localization of N-terminally unphosphorylated beta-catenin with monoclonal antibody 8E7

Lrp5/β-Catenin Signaling Controls Lung Macrophage Differentiation and Inhibits Resolution of Fibrosis.

Macrophages as a Source and Recipient of Wnt Signals

Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development

Molecular components of the adherens junction.

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.

Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin-β-catenin.

Nesprin-2 interacts with {alpha}-catenin and regulates Wnt signaling at the nuclear envelope.

Nuclear signaling from cadherin adhesion complexes

Nuclear α-catenin mediates the DNA damage response via β-catenin and nuclear actin

Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation

Persistent nuclear actin filaments inhibit transcription by RNA polymerase II.

Phospho-regulation of Beta-catenin adhesion and signaling functions.

Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling

Regenerative pathways and emphysema: a new paradigm?

Regulation of Wnt/beta-catenin signaling by protein kinases

Resetting proteostasis with ISRIB promotes epithelial differentiation to attenuate pulmonary fibrosis

Signaling from the adherens junction.

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

Sorting of ion pumps in polarized epithelial cells

Structural Determinants of the Mechanical Stability of α-Catenin

Terminal regions of beta-catenin come into view

Terminating Wnt signals: a novel nuclear export mechanism targets activated (beta)-catenin.

The cardiac protein αT-catenin contributes to chemical-induced asthma

The cardiomyocyte protein αT-catenin contributes to asthma through regulating pulmonary vein inflammation

The increase in maternal expression of axin1 and axin2 contribute to the zebrafish mutant ichabod ventralized phenotype

The junction-associated protein, zonula occludens-1, localizes to the nucleus before the maturation and during the remodeling of cell-cell contacts.

The terminal region of beta-catenin promotes stability by shielding the Armadillo repeats from the axin-scaffold destruction complex.

Tyrosine-based membrane protein sorting signals are differentially interpreted by polarized Madin-Darby canine kidney and LLC-PK1 epithelial cells.

UVB radiation‐induced β‐catenin signaling is enhanced by COX‐2 expression in keratinocytes ⬇️

When domestiques rebel: kinesins, cadherins and neuronal proliferation

Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis

Wnt-induced deubiquitination FoxM1 ensures nucleus β-catenin transactivation

Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells

α-Catenin homodimers are recruited to phosphoinositide-activated membranes to promote adhesion.

α-Catenin is an inhibitor of transcription

α-Catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism.

α-catenin cytomechanics--role in cadherin-dependent adhesion and mechanotransduction

αT-catenin in restricted brain cell types and its potential connection to autism.

αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family

β-catenin signaling: a novel mediator of fibrosis and potential therapeutic target