List of works - Majid Hafezparast

A YAC contig encompassing the XRCC5 (Ku80) DNA repair gene and complementation of defective cells by YAC protoplast fusion

scientific article

A comprehensive assessment of the SOD1G93A low-copy transgenic mouse, which models human amyotrophic lateral sclerosis

scientific article published on 02 May 2011

A hamster-human subchromosomal hybrid cell panel for chromosome 2

scientific article published on 01 January 1993

A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice

scientific article

An extended panel of hamster-human hybrids for chromosome 2q.

scientific article published on November 1994

Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse

scientific article

Binding of dynein intermediate chain 2 to paxillin controls focal adhesion dynamics and migration.

scientific article published on 2 May 2012

Caspases and neurodegenerative diseases

scientific article published on 01 September 2000

Complementation analysis of testis tumor cells

scientific article published on 01 October 1997

Cytoplasmic dynein heavy chain: the servant of many masters

scientific article published on 10 September 2013

DYNC1H1 mutation alters transport kinetics and ERK1/2-cFos signalling in a mouse model of distal spinal muscular atrophy.

scientific article

Dynein-dynactin complex subunits are differentially localized in brain and spinal cord, with selective involvement in pathological features of neurodegenerative disease

scientific article published on 10 December 2007

Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing

scientific article

FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I-induced DNA breakage and transcriptional stress

scientific article published on 26 February 2019

From the cell membrane to the nucleus: unearthing transport mechanisms for dynein.

scientific article published on 12 July 2012

Genetic Insights into Mammalian Cytoplasmic Dynein Function Provided by Novel Mutations in the Mouse

Identification of a potential non-coding RNA biomarker signature for amyotrophic lateral sclerosis

scientific article published on 17 June 2020

Intermediate chain subunit as a probe for cytoplasmic dynein function: biochemical analyses and live cell imaging in PC12 cells

scientific article

Localization of a DNA repair gene (XRCC5) involved in double-strand-break rejoining to human chromosome 2 ⬇️

scientific article published on July 15, 1992

Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage.

scientific article

Mouse cytoplasmic dynein intermediate chains: identification of new isoforms, alternative splicing and tissue distribution of transcripts

scientific article

Mouse models for neurological disease

scientific article

Mutations in BICD2 cause dominant congenital spinal muscular atrophy and hereditary spastic paraplegia

scientific article

Mutations in cytoplasmic dynein lead to a Huntington's disease-like defect in energy metabolism of brown and white adipose tissues

scientific article published on 29 September 2010

Mutations in dynein link motor neuron degeneration to defects in retrograde transport

scientific article published in Science

Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?

scientific article published on 21 February 2017

No association with common Caucasian genotypes in exons 8, 13 and 14 of the human cytoplasmic dynein heavy chain gene (DNCHC1) and familial motor neuron disorders

article

Novel mutations expand the clinical spectrum of DYNC1H1-associated spinal muscular atrophy

scientific article

PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage.

scientific article

Potential of activated microglia as a source of dysregulated extracellular microRNAs contributing to neurodegeneration in amyotrophic lateral sclerosis

scientific article published on 28 April 2020

Prion disease incubation time is not affected in mice heterozygous for a dynein mutation

scientific article published on 01 January 2005

SHIRPA, a protocol for behavioral assessment: validation for longitudinal study of neurological dysfunction in mice.

scientific article published in June 2001

The SOD1 transgene in the G93A mouse model of amyotrophic lateral sclerosis lies on distal mouse chromosome 12

scientific article published on 01 June 2005

The kinesin light chain gene: its mapping and exclusion in mouse and human forms of inherited motor neuron degeneration

scientific article

The legs at odd angles (Loa) mutation in cytoplasmic dynein ameliorates mitochondrial function in SOD1G93A mouse model for motor neuron disease

scientific article

The phagocytic capacity of neurones

scientific article published on 01 May 2007

Wasted by an elongation factor ⬇️

scientific article published on June 1, 1998

List of works by Majid Hafezparast

A YAC contig encompassing the XRCC5 (Ku80) DNA repair gene and complementation of defective cells by YAC protoplast fusion

A comprehensive assessment of the SOD1G93A low-copy transgenic mouse, which models human amyotrophic lateral sclerosis

A hamster-human subchromosomal hybrid cell panel for chromosome 2

A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice

An extended panel of hamster-human hybrids for chromosome 2q.

Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse

Binding of dynein intermediate chain 2 to paxillin controls focal adhesion dynamics and migration.

Caspases and neurodegenerative diseases

Complementation analysis of testis tumor cells

Cytoplasmic dynein heavy chain: the servant of many masters

DYNC1H1 mutation alters transport kinetics and ERK1/2-cFos signalling in a mouse model of distal spinal muscular atrophy.

Dynein-dynactin complex subunits are differentially localized in brain and spinal cord, with selective involvement in pathological features of neurodegenerative disease

Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing

FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I-induced DNA breakage and transcriptional stress

From the cell membrane to the nucleus: unearthing transport mechanisms for dynein.

Genetic Insights into Mammalian Cytoplasmic Dynein Function Provided by Novel Mutations in the Mouse

Identification of a potential non-coding RNA biomarker signature for amyotrophic lateral sclerosis

Intermediate chain subunit as a probe for cytoplasmic dynein function: biochemical analyses and live cell imaging in PC12 cells

Localization of a DNA repair gene (XRCC5) involved in double-strand-break rejoining to human chromosome 2 ⬇️

Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage.

Mouse cytoplasmic dynein intermediate chains: identification of new isoforms, alternative splicing and tissue distribution of transcripts

Mouse models for neurological disease

Mutations in BICD2 cause dominant congenital spinal muscular atrophy and hereditary spastic paraplegia

Mutations in cytoplasmic dynein lead to a Huntington's disease-like defect in energy metabolism of brown and white adipose tissues

Mutations in dynein link motor neuron degeneration to defects in retrograde transport

Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?

No association with common Caucasian genotypes in exons 8, 13 and 14 of the human cytoplasmic dynein heavy chain gene (DNCHC1) and familial motor neuron disorders

Novel mutations expand the clinical spectrum of DYNC1H1-associated spinal muscular atrophy

PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage.

Potential of activated microglia as a source of dysregulated extracellular microRNAs contributing to neurodegeneration in amyotrophic lateral sclerosis

Prion disease incubation time is not affected in mice heterozygous for a dynein mutation

SHIRPA, a protocol for behavioral assessment: validation for longitudinal study of neurological dysfunction in mice.

The SOD1 transgene in the G93A mouse model of amyotrophic lateral sclerosis lies on distal mouse chromosome 12

The kinesin light chain gene: its mapping and exclusion in mouse and human forms of inherited motor neuron degeneration

The legs at odd angles (Loa) mutation in cytoplasmic dynein ameliorates mitochondrial function in SOD1G93A mouse model for motor neuron disease

The phagocytic capacity of neurones

Wasted by an elongation factor ⬇️