List of works - Paul M Janssen

A Human-Specific Deletion in Mouse Cmah Increases Disease Severity in the mdx Model of Duchenne Muscular Dystrophy ⬇️

scientific article published on July 28, 2010

A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease

scientific article

A random cycle length approach for assessment of myocardial contraction in isolated rabbit myocardium.

scientific article published on 11 September 2009

AAV-mediated overexpression of human α7 integrin leads to histological and functional improvement in dystrophic mice

scientific article

Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT

scientific article

Abnormal frequency-dependent responses represent the pathophysiologic signature of contractile failure in human myocardium

scientific article published on 01 January 2004

Adenosine-Induced Atrial Fibrillation: Localized Reentrant Drivers in Lateral Right Atria due to Heterogeneous Expression of Adenosine A1 Receptors and GIRK4 Subunits in the Human Heart

scientific article published on 26 July 2016

Assessment of PKA and PKC inhibitors on force and kinetics of non-failing and failing human myocardium

scientific article published on 03 November 2018

Assessment of temporal functional changes and miRNA profiling of human iPSC-derived cardiomyocytes

scientific article published on 12 September 2019

Atrial fibrillation driven by micro-anatomic intramural re-entry revealed by simultaneous sub-epicardial and sub-endocardial optical mapping in explanted human hearts.

scientific article published on 8 June 2015

Atrial glutathione content, calcium current, and contractility

scientific article published on 25 July 2007

Cardiac troponin I tyrosine 26 phosphorylation decreases myofilament Ca2+ sensitivity and accelerates deactivation.

scientific article published on 22 September 2014

Cardiomyopathy in the dystrophin/utrophin-deficient mouse model of severe muscular dystrophy is characterized by dysregulation of matrix metalloproteinases ⬇️

scientific article published on June 29, 2012

Cardiovascular effects of gamma-MSH/ACTH-like peptides: structure-activity relationship

scientific article published on 01 December 1995

Challenges in cardiac muscle physiology ⬇️

scientific article published on April 13, 2010

Claudin-5 levels are reduced from multiple cell types in human failing hearts and are associated with mislocalization of ephrin-B1.

scientific article published on 7 November 2014

Claudin-5 levels are reduced in human end-stage cardiomyopathy

scientific article published on 25 April 2008

Comparison of telephone and face-to-face assessment of the modified Rankin Scale

scientific article published on 01 December 2009

Contractile Strength during Variable Heart Duration Is Species and Preload Dependent ⬇️

scientific article published on October 26, 2011

Contractile parameters and occurrence of alternans in isolated rat myocardium at supra-physiological stimulation frequency

scientific article published on 30 March 2012

Correction: Evaluation of Changes in Morphology and Function of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes (HiPSC-CMs) Cultured on an Aligned-Nanofiber Cardiac Patch.

scientific article published on 16 October 2015

Decrease in sarcoplasmic reticulum calcium content, not myofilament function, contributes to muscle twitch force decline in isolated cardiac trabeculae.

scientific article

Deletion of Galgt2 (B4Galnt2) reduces muscle growth in response to acute injury and increases muscle inflammation and pathology in dystrophin-deficient mice

scientific article

Designing proteins to combat disease: Cardiac troponin C as an example.

scientific article published on 18 February 2016

Determinants of frequency-dependent contraction and relaxation of mammalian myocardium.

scientific article published on 28 August 2007

Differential involvement of various sources of reactive oxygen species in thyroxin-induced hemodynamic changes and contractile dysfunction of the heart and diaphragm muscles.

scientific article published on 17 March 2015

Dissociation of Calcium Transients and Force Development following a Change in Stimulation Frequency in Isolated Rabbit Myocardium

scientific article published on 15 April 2015

Dissociation of force decline from calcium decline by preload in isolated rabbit myocardium

scientific article published on 04 December 2007

Dysfunction in the βII spectrin-dependent cytoskeleton underlies human arrhythmia

scientific article

Dysfunction of the β2-spectrin-based pathway in human heart failure

scientific article published on 22 April 2016

Early treatment with lisinopril and spironolactone preserves cardiac and skeletal muscle in Duchenne muscular dystrophy mice.

scientific article published on 18 July 2011

Effect of exercise training and myocardial infarction on force development and contractile kinetics in isolated canine myocardium

scientific article published on 28 January 2016

Effect of muscle dimensions on trabecular contractile performance under physiological conditions

scientific article published on 05 August 2005

Effect of muscle length on cross-bridge kinetics in intact cardiac trabeculae at body temperature ⬇️

scientific article published on January 1, 2013

Effect of twitch interval duration on the contractile function of subsequent twitches in isolated rat, rabbit, and dog myocardium under physiological conditions ⬇️

scientific article published on July 21, 2011

Effects of hydroxyl radical induced-injury in atrial versus ventricular myocardium of dog and rabbit

scientific article

Effects of increased preload on the force-frequency response and contractile kinetics in early stages of cardiac muscle hypertrophy ⬇️

scientific article published on March 30, 2012

Effects of increased systolic Ca²⁺ and phospholamban phosphorylation during β-adrenergic stimulation on Ca²⁺ transient kinetics in cardiac myocytes.

scientific article

Emerging role of oxidative stress in metabolic syndrome and cardiovascular diseases: important role of Rac/NADPH oxidase

scientific article

Evaluation of Changes in Morphology and Function of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes (HiPSC-CMs) Cultured on an Aligned-Nanofiber Cardiac Patch

scientific article

FK506 does not affect cardiac contractility and adrenergic response in vitro.

scientific article

Follistatin gene delivery enhances muscle growth and strength in nonhuman primates

scientific article

Frequency- and afterload-dependent cardiac modulation in vivo by troponin I with constitutively active protein kinase A phosphorylation sites.

scientific article published on 15 January 2004

Frequency-dependent acceleration of relaxation involves decreased myofilament calcium sensitivity

scientific article published on 05 January 2007

Frequency-dependent contractile strength in mice over- and underexpressing the sarco(endo)plasmic reticulum calcium-ATPase

scientific article published on 25 January 2007

Genetic disruption of Ano5 in mice does not recapitulate human ANO5-deficient muscular dystrophy.

scientific article

Homologous Recombination Mediates Functional Recovery of Dysferlin Deficiency following AAV5 Gene Transfer ⬇️

scientific article published on June 15, 2012

Human sinoatrial node structure: 3D microanatomy of sinoatrial conduction pathways.

scientific article published on 29 December 2015

IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism ⬇️

scientific article published on February 20, 2012

Impact of heart rate on cross-bridge cycling kinetics in failing and non-failing human myocardium

scientific article published on 26 July 2019

Impact of hydroxyl radical-induced injury on calcium handling and myofilament sensitivity in isolated myocardium.

scientific article

Improvement of cardiac contractile function by peptide-based inhibition of NF-κB in the utrophin/dystrophin-deficient murine model of muscular dystrophy ⬇️

scientific article published on May 17, 2011

In vivo assessment of contractile strength distinguishes differential gene function in skeletal muscle of zebrafish larvae

scientific article

Increased phosphorylation of tropomyosin, troponin I, and myosin light chain-2 after stretch in rabbit ventricular myocardium under physiological conditions.

scientific article

Induction of hypertrophy in vitro by mechanical loading in adult rabbit myocardium

scientific article published on 12 October 2007

Influence of metabolic dysfunction on cardiac mechanics in decompensated hypertrophy and heart failure

scientific article

Influence of pyruvate on economy of contraction in isolated rabbit myocardium.

scientific article published on 29 May 2007

Insights into length-dependent regulation of cardiac cross-bridge cycling kinetics in human myocardium.

scientific article published on 05 February 2016

Integration of High-Resolution Optical Mapping and 3-Dimensional Micro-Computed Tomographic Imaging to Resolve the Structural Basis of Atrial Conduction in the Human Heart.

scientific article

Isometric contraction induces rapid myocyte remodeling in cultured rat right ventricular papillary muscles

scientific article

Kinetics of cardiac muscle contraction and relaxation are linked and determined by properties of the cardiac sarcomere.

scientific article

Lengthening-contractions in isolated myocardium impact force development and worsen cardiac contractile function in the mdx mouse model of muscular dystrophy ⬇️

scientific article published on December 2, 2010

Levosimendan improves diastolic and systolic function in failing human myocardium.

scientific article published in September 2000

Load-induced cardiomyocyte apoptosis in cultured multicellular myocardial preparations is unaltered in presence of the beta-adrenoceptor antagonist nebivolol.

scientific article published on 20 December 2008

Low levels of Survival Motor Neuron protein are sufficient for normal muscle function in the SMNΔ7 mouse model of SMA.

scientific article

Measurement of myofilament calcium sensitivity at physiological temperature in intact cardiac trabeculae

scientific article published on 01 May 2006

Method-related effects of adenovirus-mediated LacZ and SERCA1 gene transfer on contractile behavior of cultured failing human cardiomyocytes.

scientific article published on 10 December 2004

Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart

scientific article

Molecular basis of diastolic dysfunction.

scientific article published on January 2008

Murine strain differences in contractile function are temperature- and frequency-dependent

scientific article published on 06 January 2006

Myocardial Rac1 exhibits partial involvement in thyroxin-induced cardiomyocyte hypertrophy and its inhibition is not sufficient to improve cardiac dysfunction or contractile abnormalities in mouse papillary muscles

scientific article published on 01 June 2013

Myocardial contraction-relaxation coupling ⬇️

scientific article published on September 17, 2010

N-Glycolylneuraminic acid deficiency worsens cardiac and skeletal muscle pathophysiology in α-sarcoglycan-deficient mice

scientific article published on 20 March 2013

Neuronal Na+ channel blockade suppresses arrhythmogenic diastolic Ca2+ release

scientific article

Neuronal nitric oxide synthase signaling within cardiac myocytes targets phospholamban.

scientific article published on 09 April 2008

Overexpression of sarcolipin decreases myocyte contractility and calcium transient

scientific article published on 01 January 2005

Peptide-based inhibition of NF-κB rescues diaphragm muscle contractile dysfunction in a murine model of Duchenne muscular dystrophy.

scientific article

Post-translational modifications of myofilament proteins involved in length-dependent prolongation of relaxation in rabbit right ventricular myocardium

scientific article published on 19 October 2012

Prednisolone attenuates improvement of cardiac and skeletal contractile function and histopathology by lisinopril and spironolactone in the mdx mouse model of Duchenne muscular dystrophy.

scientific article

Preservation of contractile characteristics of human myocardium in multi-day cell culture.

scientific article published in August 1999

Rac-Induced Left Ventricular Dilation in Thyroxin-Treated ZmRacD Transgenic Mice: Role of Cardiomyocyte Apoptosis and Myocardial Fibrosis ⬇️

scientific article published on August 24, 2012

Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease

scientific article

Recovery following Thyroxine Treatment Withdrawal, but Not Propylthiouracil, Averts In Vivo and Ex Vivo Thyroxine-Provoked Cardiac Complications in Adult FVB/N Mice.

scientific article published on 16 July 2017

Role of Endothelin in the Induction of Cardiac Hypertrophy In Vitro ⬇️

scientific article published on August 17, 2012

Role of Oxidative Stress in Thyroid Hormone-Induced Cardiomyocyte Hypertrophy and Associated Cardiac Dysfunction: An Undisclosed Story

scientific article

Role of cardiac myosin binding protein C in sustaining left ventricular systolic stiffening

scientific article

S100A1: a regulator of myocardial contractility

scientific article

SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia

scientific journal article

SERCA overexpression reduces hydroxyl radical injury in murine myocardium

scientific article published on 23 June 2006

Silencing miR-370-3p rescues funny current and sinus node function in heart failure

scientific article published on 09 July 2020

Small and large animal models in cardiac contraction research: advantages and disadvantages

scientific article (publication date: March 2014)

Staurosporine inhibits frequency-dependent myofilament desensitization in intact rabbit cardiac trabeculae.

scientific article

Sustaining cardiac claudin-5 levels prevents functional hallmarks of cardiomyopathy in a muscular dystrophy mouse model.

scientific article

Targeted overexpression of sarcolipin in the mouse heart decreases sarcoplasmic reticulum calcium transport and cardiac contractility.

scientific article published on 19 December 2005

Temporal changes in expression of connexin 43 after load-induced hypertrophy in vitro.

scientific article published on 09 January 2009

The Effect of Sorafenib, Tadalafil and Macitentan Treatments on Thyroxin-Induced Hemodynamic Changes and Cardiac Abnormalities

scientific article

The Frank-Starling mechanism involves deceleration of cross-bridge kinetics and is preserved in failing human right ventricular myocardium

scientific article

The Need for Speed: Mice, Men, and Myocardial Kinetic Reserve

scientific article published on July 2016

The effect of applied mechanical vibration on two different phases of rat papillary muscle relaxation

scientific article published on 01 November 1997

The effect of diastolic vibration on the relaxation of rat papillary muscle

scientific article published on 01 August 1996

The effect of myosin light chain 2 dephosphorylation on Ca2+ -sensitivity of force is enhanced in failing human hearts

scientific article (publication date: February 2003)

The force-temperature relationship in healthy and dystrophic mouse diaphragm; implications for translational study design.

scientific article

The positive inotropic effect of pyruvate involves an increase in myofilament calcium sensitivity.

scientific article

The rates of Ca2+ dissociation and cross-bridge detachment from ventricular myofibrils as reported by a fluorescent cardiac troponin C.

scientific article

Tissue triage and freezing for models of skeletal muscle disease.

scientific article

Transient and sustained impacts of hydroxyl radicals on sarcoplasmic reticulum function: protective effects of nebivolol

scientific article published on 01 February 1999

Tropomyosin Ser-283 pseudo-phosphorylation slows myofibril relaxation ⬇️

scientific article published on December 8, 2012

Truncated CASK does not alter skeletal muscle or protein interactors.

scientific article published in September 2008

UCHL1 protects against ischemic heart injury via activating HIF-1α signal pathway

Up-regulation of sarcoplasmic reticulum Ca(2+) uptake leads to cardiac hypertrophy, contractile dysfunction and early mortality in mice deficient in CASQ2.

scientific article published on 6 November 2012

Utrophin deficiency worsens cardiac contractile dysfunction present in dystrophin-deficient mdx mice

scientific article published on 15 July 2005

Vascular remodeling-associated hypertension leads to left ventricular hypertrophy and contractile dysfunction in profilin-1 transgenic mice

scientific article published on 01 December 2012

mdx Mice Manifest More Severe Muscle Dysfunction and Diaphragm Force Deficits than Do mdx Mice ⬇️

scientific article published on September 3, 2011

List of works by Paul M Janssen

A Human-Specific Deletion in Mouse Cmah Increases Disease Severity in the mdx Model of Duchenne Muscular Dystrophy ⬇️

A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease

A random cycle length approach for assessment of myocardial contraction in isolated rabbit myocardium.

AAV-mediated overexpression of human α7 integrin leads to histological and functional improvement in dystrophic mice

Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT

Abnormal frequency-dependent responses represent the pathophysiologic signature of contractile failure in human myocardium

Adenosine-Induced Atrial Fibrillation: Localized Reentrant Drivers in Lateral Right Atria due to Heterogeneous Expression of Adenosine A1 Receptors and GIRK4 Subunits in the Human Heart

Assessment of PKA and PKC inhibitors on force and kinetics of non-failing and failing human myocardium

Assessment of temporal functional changes and miRNA profiling of human iPSC-derived cardiomyocytes

Atrial fibrillation driven by micro-anatomic intramural re-entry revealed by simultaneous sub-epicardial and sub-endocardial optical mapping in explanted human hearts.

Atrial glutathione content, calcium current, and contractility

Cardiac troponin I tyrosine 26 phosphorylation decreases myofilament Ca2+ sensitivity and accelerates deactivation.

Cardiomyopathy in the dystrophin/utrophin-deficient mouse model of severe muscular dystrophy is characterized by dysregulation of matrix metalloproteinases ⬇️

Cardiovascular effects of gamma-MSH/ACTH-like peptides: structure-activity relationship

Challenges in cardiac muscle physiology ⬇️

Claudin-5 levels are reduced from multiple cell types in human failing hearts and are associated with mislocalization of ephrin-B1.

Claudin-5 levels are reduced in human end-stage cardiomyopathy

Comparison of telephone and face-to-face assessment of the modified Rankin Scale

Contractile Strength during Variable Heart Duration Is Species and Preload Dependent ⬇️

Contractile parameters and occurrence of alternans in isolated rat myocardium at supra-physiological stimulation frequency

Correction: Evaluation of Changes in Morphology and Function of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes (HiPSC-CMs) Cultured on an Aligned-Nanofiber Cardiac Patch.

Decrease in sarcoplasmic reticulum calcium content, not myofilament function, contributes to muscle twitch force decline in isolated cardiac trabeculae.

Deletion of Galgt2 (B4Galnt2) reduces muscle growth in response to acute injury and increases muscle inflammation and pathology in dystrophin-deficient mice

Designing proteins to combat disease: Cardiac troponin C as an example.

Determinants of frequency-dependent contraction and relaxation of mammalian myocardium.

Differential involvement of various sources of reactive oxygen species in thyroxin-induced hemodynamic changes and contractile dysfunction of the heart and diaphragm muscles.

Dissociation of Calcium Transients and Force Development following a Change in Stimulation Frequency in Isolated Rabbit Myocardium

Dissociation of force decline from calcium decline by preload in isolated rabbit myocardium

Dysfunction in the βII spectrin-dependent cytoskeleton underlies human arrhythmia

Dysfunction of the β2-spectrin-based pathway in human heart failure

Early treatment with lisinopril and spironolactone preserves cardiac and skeletal muscle in Duchenne muscular dystrophy mice.

Effect of exercise training and myocardial infarction on force development and contractile kinetics in isolated canine myocardium

Effect of muscle dimensions on trabecular contractile performance under physiological conditions

Effect of muscle length on cross-bridge kinetics in intact cardiac trabeculae at body temperature ⬇️

Effect of twitch interval duration on the contractile function of subsequent twitches in isolated rat, rabbit, and dog myocardium under physiological conditions ⬇️

Effects of hydroxyl radical induced-injury in atrial versus ventricular myocardium of dog and rabbit

Effects of increased preload on the force-frequency response and contractile kinetics in early stages of cardiac muscle hypertrophy ⬇️

Effects of increased systolic Ca²⁺ and phospholamban phosphorylation during β-adrenergic stimulation on Ca²⁺ transient kinetics in cardiac myocytes.

Emerging role of oxidative stress in metabolic syndrome and cardiovascular diseases: important role of Rac/NADPH oxidase

Evaluation of Changes in Morphology and Function of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes (HiPSC-CMs) Cultured on an Aligned-Nanofiber Cardiac Patch

FK506 does not affect cardiac contractility and adrenergic response in vitro.

Follistatin gene delivery enhances muscle growth and strength in nonhuman primates

Frequency- and afterload-dependent cardiac modulation in vivo by troponin I with constitutively active protein kinase A phosphorylation sites.

Frequency-dependent acceleration of relaxation involves decreased myofilament calcium sensitivity

Frequency-dependent contractile strength in mice over- and underexpressing the sarco(endo)plasmic reticulum calcium-ATPase

Genetic disruption of Ano5 in mice does not recapitulate human ANO5-deficient muscular dystrophy.

Homologous Recombination Mediates Functional Recovery of Dysferlin Deficiency following AAV5 Gene Transfer ⬇️

Human sinoatrial node structure: 3D microanatomy of sinoatrial conduction pathways.

IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism ⬇️

Impact of heart rate on cross-bridge cycling kinetics in failing and non-failing human myocardium

Impact of hydroxyl radical-induced injury on calcium handling and myofilament sensitivity in isolated myocardium.

Improvement of cardiac contractile function by peptide-based inhibition of NF-κB in the utrophin/dystrophin-deficient murine model of muscular dystrophy ⬇️

In vivo assessment of contractile strength distinguishes differential gene function in skeletal muscle of zebrafish larvae

Increased phosphorylation of tropomyosin, troponin I, and myosin light chain-2 after stretch in rabbit ventricular myocardium under physiological conditions.

Induction of hypertrophy in vitro by mechanical loading in adult rabbit myocardium

Influence of metabolic dysfunction on cardiac mechanics in decompensated hypertrophy and heart failure

Influence of pyruvate on economy of contraction in isolated rabbit myocardium.

Insights into length-dependent regulation of cardiac cross-bridge cycling kinetics in human myocardium.

Integration of High-Resolution Optical Mapping and 3-Dimensional Micro-Computed Tomographic Imaging to Resolve the Structural Basis of Atrial Conduction in the Human Heart.

Isometric contraction induces rapid myocyte remodeling in cultured rat right ventricular papillary muscles

Kinetics of cardiac muscle contraction and relaxation are linked and determined by properties of the cardiac sarcomere.

Lengthening-contractions in isolated myocardium impact force development and worsen cardiac contractile function in the mdx mouse model of muscular dystrophy ⬇️

Levosimendan improves diastolic and systolic function in failing human myocardium.

Load-induced cardiomyocyte apoptosis in cultured multicellular myocardial preparations is unaltered in presence of the beta-adrenoceptor antagonist nebivolol.

Low levels of Survival Motor Neuron protein are sufficient for normal muscle function in the SMNΔ7 mouse model of SMA.

Measurement of myofilament calcium sensitivity at physiological temperature in intact cardiac trabeculae

Method-related effects of adenovirus-mediated LacZ and SERCA1 gene transfer on contractile behavior of cultured failing human cardiomyocytes.

Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart

Molecular basis of diastolic dysfunction.

Murine strain differences in contractile function are temperature- and frequency-dependent

Myocardial Rac1 exhibits partial involvement in thyroxin-induced cardiomyocyte hypertrophy and its inhibition is not sufficient to improve cardiac dysfunction or contractile abnormalities in mouse papillary muscles

Myocardial contraction-relaxation coupling ⬇️

N-Glycolylneuraminic acid deficiency worsens cardiac and skeletal muscle pathophysiology in α-sarcoglycan-deficient mice

Neuronal Na+ channel blockade suppresses arrhythmogenic diastolic Ca2+ release

Neuronal nitric oxide synthase signaling within cardiac myocytes targets phospholamban.

Overexpression of sarcolipin decreases myocyte contractility and calcium transient

Peptide-based inhibition of NF-κB rescues diaphragm muscle contractile dysfunction in a murine model of Duchenne muscular dystrophy.

Post-translational modifications of myofilament proteins involved in length-dependent prolongation of relaxation in rabbit right ventricular myocardium

Prednisolone attenuates improvement of cardiac and skeletal contractile function and histopathology by lisinopril and spironolactone in the mdx mouse model of Duchenne muscular dystrophy.