List of works - Osheiza Abdulmalik

2'-O-methoxyethyl splice-switching oligos correct splicing from IVS2-745 β-thalassemia patient cells restoring HbA production and chain rebalance

scientific article published on 21 May 2020

5-hydroxymethyl-2-furfural modifies intracellular sickle haemoglobin and inhibits sickling of red blood cells

scientific article

A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells.

scientific article published on 10 April 2018

A hemoglobin variant associated with neonatal cyanosis and anemia

scientific article published on May 2011

A reverse time-course method for transcriptional chase analyses of mRNA half-lives in cultured cells.

scientific article

An Investigation of Structure-Activity Relationships of Azolylacryloyl Derivatives Yielded Potent and Long-Acting Hemoglobin Modulators for Reversing Erythrocyte Sickling

scientific article published on 02 November 2020

An erythroid chaperone that facilitates folding of alpha-globin subunits for hemoglobin synthesis

scientific article published in July 2007

Anti-sickling effect of MX-1520, a prodrug of vanillin: an in vivo study using rodents

scientific article

Aryloxyalkanoic Acids as Non-Covalent Modifiers of the Allosteric Properties of Hemoglobin

scientific article

Characterization of hemoglobin bassett (alpha94Asp-->Ala), a variant with very low oxygen affinity.

scientific article published in November 2004

Clinical Implications of the Association of Fetal Hemoglobin with Peripheral Oxygen Saturation in Sickle Cell Disease.

scientific article

Clinical, metabolic, and genetic characterization of hereditary methemoglobinemia caused by cytochrome b5 reductase deficiency in cats

scientific article published on 25 October 2019

Correction of murine hemoglobinopathies by prenatal tolerance induction and postnatal nonmyeloablative allogeneic BM transplants.

scientific article

Crystal structure of carbonmonoxy sickle hemoglobin in R-state conformation.

scientific article published on 13 April 2016

Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin

scientific article published on 19 October 2011

Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin. Corrigendum.

scientific article published on 5 November 2011

Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease.

scientific article published on 31 August 2017

Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Prodrugs as Drug Candidates for the Treatment of Ischemic Disorders: Insights into NO-Releasing Prodrug Biotransformation and Hemoglobin-NO Biochemistry

scientific article

Direct comparison of oligochaete erythrocruorins as potential blood substitutes.

scientific article

Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells

scientific article published on 01 July 2018

Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression

scientific article

Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression

Erythrocytic pyruvate kinase mutations causing hemolytic anemia, osteosclerosis, and seconday hemochromatosis in dogs

scientific article

Erythropoietin Prevents Anemia and Transfusions in Extremely Premature Lambs Supported by an EXTrauterine Environment for Neonatal Development (EXTEND)

scientific article published on 31 January 2019

Exploration of Structure-Activity Relationship of Aromatic Aldehydes Bearing Pyridinylmethoxy-Methyl Esters as Novel Antisickling Agents

scientific article published on 18 November 2020

Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers

scientific article published on 12 July 2016

Glutaraldehyde cross-linking increases the stability of Lumbricus terrestris erythrocruorin

scientific article published on 11 December 2017

HRI depletion cooperates with pharmacologic inducers to elevate fetal hemoglobin and reduce sickle cell formation

scientific article published on 01 September 2020

HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression

scientific article published on 16 April 2020

Hb Baden: structural and functional characterization.

scientific article published on November 2010

Hb Lake Tapawingo [α46(CE4)Phe→Ser; HBA2:c.140T>C]: a new unstable α chain hemoglobin variant associated with low systemic arterial saturation

scientific article published on January 2011

Hereditary methemoglobinemia in a cyanotic cat presented for ovariohysterectomy

scientific article published on 01 May 2019

Identification of a Small Molecule that Increases Hemoglobin Oxygen Affinity and Reduces SS Erythrocyte Sickling

scientific article

Identification of a novel class of covalent modifiers of hemoglobin as potential antisickling agents

scientific article published on June 2015

In vivo hematopoietic stem cell modification by mRNA delivery

scientific article published on 27 July 2023

Increasing the stability of Lumbricus terrestris erythrocruorin via poly(acrylic acid) conjugation

scientific article published on 19 June 2018

Investigating the magnetic susceptibility properties of fresh human blood for noninvasive oxygen saturation quantification

scientific article

MRI quantification of human fetal O2 delivery rate in the second and third trimesters of pregnancy

scientific article published on 22 January 2018

Mixed chimerism following in utero hematopoietic stem cell transplantation in murine models of hemoglobinopathy.

scientific article published in February 2003

New developments in anti-sickling agents: can drugs directly prevent the polymerization of sickle haemoglobin in vivo?

scientific article published on 8 September 2016

Prolonging the shelf life of Lumbricus terrestris erythrocruorin for use as a novel blood substitute

scientific article published on 20 February 2017

Purification of Lumbricus terrestris erythrocruorin (LtEc) with anion exchange chromatography

scientific article published on 16 May 2020

Purification of diverse hemoglobins by metal salt precipitation

scientific article published on 9 September 2015

Pyridyl derivatives of benzaldehyde as potential antisickling agents

scientific article

Rapid and reproducible characterization of sickling during automated deoxygenation in sickle cell disease patients

scientific article published on 08 March 2019

Rational design of pyridyl derivatives of vanillin for the treatment of sickle cell disease.

scientific article published on 6 April 2018

Rational modification of vanillin derivatives to stereospecifically destabilize sickle hemoglobin polymer formation

scientific article published on 02 October 2018

Short-term administration of JAK2 inhibitors reduces splenomegaly in mouse models of β-thalassemia intermedia and major

scientific article published on 2 November 2017

Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease

scientific article published on 10 November 2017

Structural basis for the potent antisickling effect of a novel class of five-membered heterocyclic aldehydic compounds.

scientific article published in September 2004

Structure of fully liganded Hb ζ2β2s trapped in a tense conformation

scientific article

Structures of R- and T-state hemoglobin Bassett: elucidating the structural basis for the low oxygen affinity of a mutant hemoglobin.

scientific article

T2 -prepared balanced steady-state free precession (bSSFP) for quantifying whole-blood oxygen saturation at 1.5T.

scientific article

The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells

scientific article published on 01 May 2019

Understanding Heterogeneity of Fetal Hemoglobin Induction through Comparative Analysis of F- and A-erythroblasts

scientific article published on 08 April 2020

VZHE-039, a novel antisickling agent that prevents erythrocyte sickling under both hypoxic and anoxic conditions

scientific article published on 20 November 2020

ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression

scientific article published on 01 December 2020

List of works by Osheiza Abdulmalik

2'-O-methoxyethyl splice-switching oligos correct splicing from IVS2-745 β-thalassemia patient cells restoring HbA production and chain rebalance

5-hydroxymethyl-2-furfural modifies intracellular sickle haemoglobin and inhibits sickling of red blood cells

A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells.

A hemoglobin variant associated with neonatal cyanosis and anemia

A reverse time-course method for transcriptional chase analyses of mRNA half-lives in cultured cells.

An Investigation of Structure-Activity Relationships of Azolylacryloyl Derivatives Yielded Potent and Long-Acting Hemoglobin Modulators for Reversing Erythrocyte Sickling

An erythroid chaperone that facilitates folding of alpha-globin subunits for hemoglobin synthesis

Anti-sickling effect of MX-1520, a prodrug of vanillin: an in vivo study using rodents

Aryloxyalkanoic Acids as Non-Covalent Modifiers of the Allosteric Properties of Hemoglobin

Characterization of hemoglobin bassett (alpha94Asp-->Ala), a variant with very low oxygen affinity.

Clinical Implications of the Association of Fetal Hemoglobin with Peripheral Oxygen Saturation in Sickle Cell Disease.

Clinical, metabolic, and genetic characterization of hereditary methemoglobinemia caused by cytochrome b5 reductase deficiency in cats

Correction of murine hemoglobinopathies by prenatal tolerance induction and postnatal nonmyeloablative allogeneic BM transplants.

Crystal structure of carbonmonoxy sickle hemoglobin in R-state conformation.

Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin

Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin. Corrigendum.

Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease.

Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Prodrugs as Drug Candidates for the Treatment of Ischemic Disorders: Insights into NO-Releasing Prodrug Biotransformation and Hemoglobin-NO Biochemistry

Direct comparison of oligochaete erythrocruorins as potential blood substitutes.

Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells

Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression

Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression

Erythrocytic pyruvate kinase mutations causing hemolytic anemia, osteosclerosis, and seconday hemochromatosis in dogs

Erythropoietin Prevents Anemia and Transfusions in Extremely Premature Lambs Supported by an EXTrauterine Environment for Neonatal Development (EXTEND)

Exploration of Structure-Activity Relationship of Aromatic Aldehydes Bearing Pyridinylmethoxy-Methyl Esters as Novel Antisickling Agents

Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers

Glutaraldehyde cross-linking increases the stability of Lumbricus terrestris erythrocruorin

HRI depletion cooperates with pharmacologic inducers to elevate fetal hemoglobin and reduce sickle cell formation

HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression

Hb Baden: structural and functional characterization.

Hb Lake Tapawingo [α46(CE4)Phe→Ser; HBA2:c.140T>C]: a new unstable α chain hemoglobin variant associated with low systemic arterial saturation

Hereditary methemoglobinemia in a cyanotic cat presented for ovariohysterectomy

Identification of a Small Molecule that Increases Hemoglobin Oxygen Affinity and Reduces SS Erythrocyte Sickling

Identification of a novel class of covalent modifiers of hemoglobin as potential antisickling agents

In vivo hematopoietic stem cell modification by mRNA delivery

Increasing the stability of Lumbricus terrestris erythrocruorin via poly(acrylic acid) conjugation

Investigating the magnetic susceptibility properties of fresh human blood for noninvasive oxygen saturation quantification

MRI quantification of human fetal O2 delivery rate in the second and third trimesters of pregnancy

Mixed chimerism following in utero hematopoietic stem cell transplantation in murine models of hemoglobinopathy.

New developments in anti-sickling agents: can drugs directly prevent the polymerization of sickle haemoglobin in vivo?

Prolonging the shelf life of Lumbricus terrestris erythrocruorin for use as a novel blood substitute

Purification of Lumbricus terrestris erythrocruorin (LtEc) with anion exchange chromatography

Purification of diverse hemoglobins by metal salt precipitation

Pyridyl derivatives of benzaldehyde as potential antisickling agents

Rapid and reproducible characterization of sickling during automated deoxygenation in sickle cell disease patients

Rational design of pyridyl derivatives of vanillin for the treatment of sickle cell disease.

Rational modification of vanillin derivatives to stereospecifically destabilize sickle hemoglobin polymer formation

Short-term administration of JAK2 inhibitors reduces splenomegaly in mouse models of β-thalassemia intermedia and major

Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease

Structural basis for the potent antisickling effect of a novel class of five-membered heterocyclic aldehydic compounds.

Structure of fully liganded Hb ζ2β2s trapped in a tense conformation

Structures of R- and T-state hemoglobin Bassett: elucidating the structural basis for the low oxygen affinity of a mutant hemoglobin.

T2 -prepared balanced steady-state free precession (bSSFP) for quantifying whole-blood oxygen saturation at 1.5T.

The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells

Understanding Heterogeneity of Fetal Hemoglobin Induction through Comparative Analysis of F- and A-erythroblasts

VZHE-039, a novel antisickling agent that prevents erythrocyte sickling under both hypoxic and anoxic conditions

ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression