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List of works by Giancarlo Aldini

A Combined High-Resolution Mass Spectrometric and in silico Approach for the Characterisation of Small Ligands of β2-Microglobulin

scientific article published on 01 July 2010

A method to measure the oxidizability of both the aqueous and lipid compartments of plasma ⬇️

scientific article published on November 1, 2001

A novel high resolution MS approach for the screening of 4-hydroxy-trans-2-nonenal sequestering agents

scientific article published in January 2014

A rapid and sensitive LC-ESI-MS/MS method for detection and quantitation of methylprednisolone and methylprednisolone acetate in rat plasma after intra-articular administration.

scientific article published on 2 October 2009

A sensitive and specific precursor ion scanning approach in liquid chromatography/electrospray ionization tandem mass spectrometry to detect methylprednisolone acetate and its metabolites in rat urine

scientific article published in June 2010

Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents

scientific article published on 18 August 2010

Acrolein‐sequestering ability of endogenous dipeptides: characterization of carnosine and homocarnosine/acrolein adducts by electrospray ionization tandem mass spectrometry ⬇️

scientific article published on September 1, 2003

Actin Cys374 as a nucleophilic target of α,β-unsaturated aldehydes

scientific article published on 30 November 2006

Activation Effects of Carnosine- and Histidine-Containing Dipeptides on Human Carbonic Anhydrases: A Comprehensive Study

scientific article published on 04 March 2020

Advanced glycation end products of beta2-microglobulin in uremic patients as determined by high resolution mass spectrometry

scientific article published on 28 December 2013

Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): an overview of their mechanisms of formation.

scientific article

Albumin is the main nucleophilic target of human plasma: a protective role against pro-atherogenic electrophilic reactive carbonyl species?

scientific article published on 7 March 2008

An improved expression system for the VC1 ligand binding domain of the receptor for advanced glycation end products in Pichia pastoris

scientific article

An integrated high resolution mass spectrometric and informatics approach for the rapid identification of phenolics in plant extract.

scientific article published on 3 March 2011

Anti-Elastase and Anti-Hyaluronidase Activities of Saponins and Sapogenins fromHedera helix, Aesculus hippocastanum, andRuscus aculeatus: Factors Contributing to their Efficacy in the Treatment of Venous Insufficiency

scientific article published on 01 October 1995

Antioxidant activity of nimesulide and its main metabolites

scientific article published on 01 January 1993

Antioxidant activity of polyphenols from solid olive residues of c.v. Coratina.

scientific article published on 6 January 2006

Antioxidant and photoprotective activity of a lipophilic extract containing neolignans from Krameria triandra roots.

scientific article published on March 2002

Antioxidant profile of nimesulide, indomethacin and diclofenac in phosphatidylcholine liposomes (PCL) as membrane model

article

Bioavailability of plant pigment phytochemicals in Angelica keiskei in older adults: A pilot absorption kinetic study.

scientific article

Biological functions of histidine-dipeptides and metabolic syndrome.

scientific article published on 29 January 2014

Carnosine and related dipeptides as quenchers of reactive carbonyl species: from structural studies to therapeutic perspectives.

scientific article

Chemiluminescence and LC-MS/MS analyses for the study of nitric oxide release and distribution following oral administration of nitroaspirin (NCX 4016) in healthy volunteers

scientific article (publication date: 16 April 2004)

Covalent Modifications of Albumin Cys34 as a Biomarker of Mild Oxidative Stress

Covalent modification of actin by 4-hydroxy-trans-2-nonenal (HNE): LC-ESI-MS/MS evidence for Cys374 Michael adduction

scientific article published in July 2005

D-Carnosine octylester attenuates atherosclerosis and renal disease in ApoE null mice fed a Western diet through reduction of carbonyl stress and inflammation.

scientific article

Delta12-prostaglandin J2 as a product and ligand of human serum albumin: formation of an unusual covalent adduct at His146

scientific article

Design, synthesis, ADME properties, and pharmacological activities of β-alanyl-D-histidine (D-carnosine) prodrugs with improved bioavailability

scientific article published in June 2011

Design, synthesis, and evaluation of carnosine derivatives as selective and efficient sequestering agents of cytotoxic reactive carbonyl species

scientific article published in June 2009

Detoxification of cytotoxic alpha,beta-unsaturated aldehydes by carnosine: characterization of conjugated adducts by electrospray ionization tandem mass spectrometry and detection by liquid chromatography/mass spectrometry in rat skeletal muscle.

scientific article

Development and validation of a sensitive LC-MS/MS assay for the quantification of anserine in human plasma and urine and its application to pharmacokinetic study

article

Diet enriched with procyanidins enhances antioxidant activity and reduces myocardial post-ischaemic damage in rats

scientific article published on 01 January 1999

Direct characterization of caffeoyl esters with antihyaluronidase activity in crude extracts from Echinacea angustifolia roots by fast atom bombardment tandem mass spectrometry

scientific article published on 01 October 1993

Echinacoside and caffeoyl conjugates protect collagen from free radical-induced degradation: a potential use of Echinacea extracts in the prevention of skin photodamage

scientific article published on 01 December 1995

Edaravone inhibits protein carbonylation by a direct carbonyl-scavenging mechanism: focus on reactivity, selectivity, and reaction mechanisms

scientific article published in March 2010

Editorial [Hot Topic: Advanced Analytical Strategies for Recombinant Therapeutic Proteins (Guest Editor: Giancarlo Aldini)]

scientific article published on 01 October 2011

Effect of a standardized grape seed extract on low-density lipoprotein susceptibility to oxidation in heavy smokers.

scientific article published in October 2003

Effects of UVB radiation on 4-hydroxy-2-trans-nonenal metabolism and toxicity in human keratinocytes.

scientific article published on 17 February 2007

Efficacy and age-related effects of nitric oxide-releasing aspirin on experimental restenosis.

scientific article

Efficacy of glutathione for treatment of fascioliasis. An investigation in the experimentally infested rat

scientific article published on 01 April 1993

Electron Spin Resonance and Chemiluminescence Analyses to Elucidate the Vasodilating Mechanism of Sodium Nitroprusside

scientific article published on 01 August 2006

En bloc elution of proteomes from combinatorial peptide ligand libraries

scientific article

Exploring the space of histidine containing dipeptides in search of novel efficient RCS sequestering agents

scientific article published on 30 May 2013

Fat-soluble bioactive components in colored rice varieties.

scientific article published on 27 August 2014

Fibrosis, Enzymatic and Non-Enzymatic Cross-Links in Hypertensive Heart Disease ⬇️

scientific article published on 26 October 2011

Fluorescent probes as markers of oxidative stress in keratinocyte cell lines following UVB exposure.

scientific article

Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping

scientific article published on 16 June 2011

Free radicals scavenging action and anti-enzyme activities of procyanidines from Vitis vinifera. A mechanism for their capillary protective action.

scientific article

HNE Michael adducts to histidine and histidine-containing peptides as biomarkers of lipid-derived carbonyl stress in urines: LC-MS/MS profiling in Zucker obese rats.

scientific article published on 3 November 2007

Hemoglobin glutathionylation can occur through cysteine sulfenic acid intermediate: electrospray ionization LTQ-Orbitrap hybrid mass spectrometry studies.

scientific article published on 18 May 2009

Homology Modeling of Human Serum Carnosinase, a Potential Medicinal Target, and MD Simulations of Its Allosteric Activation by Citrate

article

Human serum albumin cysteinylation is increased in end stage renal disease patients and reduced by hemodialysis: mass spectrometry studies

scientific article published on 09 January 2013

Hydroxynimesulide, the main metabolite of nimesulide, prevents hydroperoxide/hemoglobin-induced hemolysis of rat erythrocytes

scientific article published on 01 January 1997

Identification of actin as a 15-deoxy-Delta12,14-prostaglandin J2 target in neuroblastoma cells: mass spectrometric, computational, and functional approaches to investigate the effect on cytoskeletal derangement.

scientific article published on 13 February 2007

In Vitro Aging of Human Skin Fibroblasts: Age-Dependent Changes in 4-Hydroxynonenal Metabolism

scientific article published on 11 February 2020

In vitro metabolism of a nitroderivative of acetylsalicylic acid (NCX4016) by rat liver: LC and LC-MS studies

scientific article (publication date: August 2002)

Intervention strategies to inhibit protein carbonylation by lipoxidation-derived reactive carbonyls.

scientific article published on November 2007

Intravenous Infusion of Nitric Oxide in Experimental Pulmonary Hypertension: Biotransformation and Haemodynamics

scientific article published on 01 August 2007

Key factors regulating protein carbonylation by α,β unsaturated carbonyls: A structural study based on a retrospective meta-analysis.

scientific article

LC-ESI-MS/MS determination of 4-hydroxy-trans-2-nonenal Michael adducts with cysteine and histidine-containing peptides as early markers of oxidative stress in excitable tissues.

scientific article published in November 2005

Lemon peel and Limoncello liqueur: a proteomic duet

scientific article

Low plasma carnosinase activity promotes carnosinemia after carnosine ingestion in humans.

scientific article published on 11 April 2012

MS methods to study macromolecule-ligand interaction: Applications in drug discovery

scholarly article by Federico Riccardi Sirtori published in July 2018

Mass spectrometric approaches for the identification and quantification of reactive carbonyl species protein adducts ⬇️

scientific article published on April 15, 2013

Mass spectrometric characterization and HPLC determination of the main urinary metabolites of nimesulide in man

scientific article published on 01 October 1998

Mass spectrometric characterization of covalent modification of human serum albumin by 4-hydroxy-trans-2-nonenal

scientific article published on 01 September 2006

Mass spectrometric strategies and their applications for molecular mass determination of recombinant therapeutic proteins.

scientific article

Mass spectrometric strategies for the identification and characterization of human serum albumin covalently adducted by amoxicillin: ex vivo studies

scientific article published on 13 August 2014

Mass spectrometry for detection of 4-hydroxy-trans-2-nonenal (HNE) adducts with peptides and proteins.

scientific article

Metabolic profile of NO-flurbiprofen (HCT1026) in rat brain and plasma: a LC-MS study.

scientific article

Methylprednisolone‐loaded PLGA microspheres: A new formulation for sustained release via intra‐articular administration. A comparison study with methylprednisolone acetate in rats

scientific article published on 17 August 2011

Modeling of the intestinal peptide transporter hPepT1 and analysis of its transport capacities by docking and pharmacophore mapping

scientific article

Molecular recognition of T:G mismatched base pairs in DNA as studied by electrospray ionization mass spectrometry

scientific article

Molecular strategies to prevent, inhibit, and degrade advanced glycoxidation and advanced lipoxidation end products.

scientific article published on 07 May 2013

N-Acetyl-Cysteine Regenerates Albumin Cys34 by a Thiol-Disulfide Breaking Mechanism: An Explanation of Its Extracellular Antioxidant Activity

scientific article published on 28 April 2020

Nitric oxide release and distribution following oral and intraperitoneal administration of nitroaspirin (NCX 4016) in the rat

scientific article (publication date: 14 May 2004)

Nitrosylhemoglobin as a Potential Bioactive Storage form of Nitric Oxide (NO)

scientific article published on 01 August 2005

Nitrosylhemoglobin formation after infusion of NO solutions: ESR studies in pigs.

scientific article

Nitrosylhemoglobin, an unequivocal index of nitric oxide release from nitroaspirin: in vitro and in vivo studies in the rat by ESR spectroscopy

scientific article (publication date: November 2001)

Novel Therapeutic Strategy to Prevent Chemotherapy-Induced Persistent Sensory Neuropathy By TRPA1 Blockade ⬇️

scientific article published on March 11, 2013

Novel molecular approaches for improving enzymatic and nonenzymatic detoxification of 4-hydroxynonenal: toward the discovery of a novel class of bioactive compounds

scientific article published on 21 January 2014

Oxidative damage in human gingival fibroblasts exposed to cigarette smoke.

scientific article

Panax ginseng Administration in the Rat Prevents Myocardial Ischemia-Reperfusion Damage Induced by Hyperbaric Oxygen: Evidence for an Antioxidant Intervention

article

Pathophysiology of tobacco smoke exposure: recent insights from comparative and redox proteomics

scientific article

Phenolic profiles and anti-inflammatory activities of sixteen table grape (Vitis vinifera L.) varieties

scientific article published on 01 April 2019

Physiology and pathophysiology of carnosine.

scientific article

Procyanidines from Vitis vinifera seeds protect rabbit heart from ischemia/reperfusion injury: antioxidant intervention and/or iron and copper sequestering ability

scientific article published on 01 December 1996

Procyanidins from Vitis vinifera seeds inhibit the respiratory burst of activated human neutrophils and lysosomal enzyme release.

scientific article published in November 2001

Procyanidins from grape seeds protect endothelial cells from peroxynitrite damage and enhance endothelium-dependent relaxation in human artery: new evidences for cardio-protection ⬇️

scientific article published on October 17, 2003

Profiling histidine dipeptides in plasma and urine after ingesting beef, chicken or chicken broth in humans.

scientific article published on 19 April 2009

Profiling histidine-containing dipeptides in rat tissues by liquid chromatography/electrospray ionization tandem mass spectrometry.

scientific article published in December 2004

Protective Effect of Tomato-Oleoresin Supplementation on Oxidative Injury Recoveries Cardiac Function by Improving β-Adrenergic Response in a Diet-Obesity Induced Model

scientific article published on 02 September 2019

Protein carbonylation: 2,4-dinitrophenylhydrazine reacts with both aldehydes/ketones and sulfenic acids.

scientific article published on 5 March 2009

Protein haptenation by amoxicillin: High resolution mass spectrometry analysis and identification of target proteins in serum

article

Protein lipoxidation: Detection strategies and challenges

scientific article

Protein modification by acrolein: relevance to pathological conditions and inhibition by aldehyde sequestering agents.

scientific article published on August 2011

Quenching activity of carnosine derivatives towards reactive carbonyl species: Focus on α-(methylglyoxal) and β-(malondialdehyde) dicarbonyls

scientific article

Regeneration of endogenous antioxidants, ascorbic acid, alpha tocopherol, by the oligomeric procyanide fraction of Vitus vinifera L.:ESR study

scientific article published on 01 April 1997

S-Thiolation Targets Albumin in Heart Failure

scientific article published on 17 August 2020

Screening of Mpro Protease (SARS-CoV-2) Covalent Inhibitors from an Anthocyanin-Rich Blueberry Extract Using an HRMS-Based Analytical Platform

scientific article published in 2024

Screening of fibrillogenesis inhibitors of β2-microglobulin: integrated strategies by mass spectrometry capillary electrophoresis and in silico simulations

scientific article

Searching for allergens in maize kernels via proteomic tools.

scientific article published in April 2009

Separation and characterisation of beta2-microglobulin folding conformers by ion-exchange liquid chromatography and ion-exchange liquid chromatography–mass spectrometry

scientific article published on 10 February 2013

Set-up and application of an analytical approach for the quality control of purified colostrum as food supplement

scientific article published on 8 June 2016

Sparing Effect of Procyanidins fromVitis viniferaon Vitamin E:In vitroStudies ⬇️

scientific article published on May 1, 1998

Special issue on "AGEs and ALEs: chemistry, physiopathology and molecular strategies for their inhibition".

scientific article published in August 2013

Stressed degradation studies of domiphen bromide by LC-ESI-MS/MS identify a novel promising antimicrobial agent

scientific article published on 30 June 2018

Supplementation with lutein or lutein plus green tea extracts does not change oxidative stress in adequately nourished older adults

scientific article

Synergistic interactions of antioxidant nutrients in a biological model system.

scientific article published on 23 April 2009

Targeting Nrf2 and NF-κB Signaling Pathways in Cancer Prevention: The Role of Apple Phytochemicals

scientific article published in 2023

The activities of antioxidant nutrients in human plasma depend on the localization of attacking radical species

article

The carbonyl scavenger carnosine ameliorates dyslipidaemia and renal function in Zucker obese rats

scientific article

The potential of resveratrol against human gliomas.

scientific article

The protection of polyunsaturated fatty acids in micellar systems against UVB-induced photo-oxidation by procyanidins from Vitis vinifera L., and the protective synergy with vitamin E.

scientific article published in August 1998

Total antioxidant performance: a validated fluorescence assay for the measurement of plasma oxidizability.

scientific article published on 2 May 2006

Transforming dietary peptides in promising lead compounds: the case of bioavailable carnosine analogs ⬇️

scientific article published on July 1, 2012

UVB-induced hemolysis of rat erythrocytes:

scientific article published on 01 September 2000

Urinary profile of methylprednisolone acetate metabolites in patients following intra-articular and intramuscular administration

scientific article published on 19 February 2011

Water-Soluble alpha,beta-unsaturated aldehydes of cigarette smoke induce carbonylation of human serum albumin.

scientific article published in March 2010

α,β-Unsaturated aldehydes adducts to actin and albumin as potential biomarkers of carbonylation damage

scientific article published on 01 January 2007

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