List of works - Robert O Messing

A Corticotropin Releasing Factor Network in the Extended Amygdala for Anxiety

scientific article published on 10 December 2018

A Pathway-Based Genomic Approach to Identify Medications: Application to Alcohol Use Disorder

scientific article published on 16 December 2019

A Selective Role for Lmo4 in Cue-Reward Learning.

scientific article

A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits

scientific article

A blocker of N- and T-type voltage-gated calcium channels attenuates ethanol-induced intoxication, place preference, self-administration, and reinstatement

scientific article

A semisynthetic epitope for kinase substrates.

scientific article

Abstinence-dependent dissociable central amygdala microcircuits control drug craving

scientific article published on 23 March 2020

Alcohol dependence: molecular and behavioral evidence.

scientific article published on 25 May 2014

Alcohol-induced stress in painful alcoholic neuropathy

scientific article published on 17 December 2007

Amygdala protein kinase C epsilon regulates corticotropin-releasing factor and anxiety-like behavior

scientific journal article

An inhibitory fragment derived from protein kinase Cepsilon prevents enhancement of nerve growth factor responses by ethanol and phorbol esters.

scientific article

Apremilast Alters Behavioral Responses to Ethanol in Mice: I. Reduced Consumption and Preference

scientific article published on 22 February 2018

Apremilast Alters Behavioral Responses to Ethanol in Mice: II. Increased Sedation, Intoxication, and Reduced Acute Functional Tolerance

scientific article published on 22 February 2018

Binge Drinking With Protein Kinase C Epsilon: A Role for Mammalian Target of Rapamycin Complex 2?

scientific article published on March 2016

Chronic ethanol exposure induces an N-type calcium channel splice variant with altered channel kinetics.

scientific article published in January 2005

Cloning of a novel isoform of the mouse NBMPR-sensitive equilibrative nucleoside transporter (ENT1) lacking a putative phosphorylation site

scientific journal article

Comparative effects of chronic exposure to ethanol and calcium channel antagonists on calcium channel antagonist receptors in cultured neural (PC12) cells.

scientific article published in July 1989

Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake.

scientific article published on 30 June 2013

D-Serine and D-Cycloserine Reduce Compulsive Alcohol Intake in Rats

scientific article

Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase Cepsilon.

scientific article

Deletion of N-type calcium channels alters ethanol reward and reduces ethanol consumption in mice.

scientific article published in November 2004

Deletion of Tlr3 reduces acute tolerance to alcohol and alcohol consumption in the intermittent access procedure in male mice

scientific article published on 30 June 2020

Differential regulation of alcohol consumption and reward by the transcriptional cofactor LMO4

scientific article published on 06 March 2020

Divergent contractile and structural responses of the murine PKC-epsilon null pulmonary circulation to chronic hypoxia

scientific article published on 05 August 2005

Divergent contractile and structural responses of the murine protein kinase C-epsilon null pulmonary circulation to chronic hypoxia

scientific article published on 01 December 2005

Early editorial manuscript screening versus obligate peer review: a randomized trial.

scientific article published on April 2007

Epilepsy genetics: yet more exciting news

scientific article published on 01 December 2007

Ethanol enhances growth factor activation of mitogen-activated protein kinases by a protein kinase C-dependent mechanism

scientific article

Ethanol regulates calcium channel subunits by protein kinase C delta -dependent and -independent mechanisms.

scientific article published on August 2000

Ethanol regulates calcium channels in clonal neural cells.

scientific article published on August 1986

Ethanol-induced component of 45Ca2+ uptake in PC12 cells is sensitive to Ca2+ channel modulating drugs

scientific article published on 01 April 1987

Fighting decision fatigue

scientific article published on 01 January 2012

GABAA receptor trafficking is regulated by protein kinase C(epsilon) and the N-ethylmaleimide-sensitive factor

scientific article

Generation and characterization of ATP analog-specific protein kinase Cδ.

scientific article

Genomic organization and expression of the mouse equilibrative, nitrobenzylthioinosine-sensitive nucleoside transporter 1 (ENT1) gene.

scientific article

Have the Annals editors added value?

scientific article published on 01 November 2013

How Should Addiction-Related Research at the National Institutes of Health be Reorganized?

scientific article

Identification of lipocalin-2 as a PKCδ phosphorylation substrate in neutrophils.

scientific article published on 20 March 2015

Immunological studies in patients with acquired immune deficiency syndrome

scientific article published on 01 January 1984

Inactivation of 45Ca2+ uptake by prior depolarization of PC12 cells

scientific article published on 01 December 1985

Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats

scientific article published on 18 March 2019

Increased response to morphine in mice lacking protein kinase C epsilon

scientific article

Increased sensitivity to the aversive effects of ethanol in PKCepsilon null mice revealed by place conditioning.

scientific article published in April 2007

Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer

scientific article published on July 2011

Inhibition of calcium flux and calcium channel antagonist binding in the PC12 neural cell line by phorbol esters and protein kinase C

scientific article published on 01 May 1986

Interaction of calmodulin inhibitors and protein kinase C inhibitors with voltage-dependent calcium channels

scientific article published on 01 February 1987

Intracellular signaling pathways that regulate behavioral responses to ethanol

scientific article

Killing the Buζζ: accumbal PKMζ blunts cocaine seeking and reward

scientific article published on 18 November 2018

Ligand requirements for involvement of PKCε in synergistic analgesic interactions between spinal μ and δ opioid receptors.

scientific article

Mouse model of middle cerebral artery occlusion.

scientific article

Neurobiological mechanisms contributing to alcohol-stress-anxiety interactions.

scientific article

Neurological reactions in HIV-infected patients treated with trichosanthin.

scientific article

Neurotoxic catecholamine metabolite in nociceptors contributes to painful peripheral neuropathy

scientific journal article

Neutrophil protein kinase Cdelta as a mediator of stroke-reperfusion injury.

scientific article

Novel Small-Molecule Inhibitors of Protein Kinase C Epsilon Reduce Ethanol Consumption in Mice.

scientific article

PKC-delta promotes renal tubular cell apoptosis associated with proteinuria.

scientific article

PKCepsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice.

scholarly article

PKCepsilon regulates behavioral sensitivity, binding and tolerance to the CB1 receptor agonist WIN55,212-2.

scientific article

PKCδ-targeted intervention relieves chronic pain in a murine sickle cell disease model

scientific article published on 27 June 2016

PKCε phosphorylates α4β2 nicotinic ACh receptors and promotes recovery from desensitization

scientific article

PKCε phosphorylation of the sodium channel NaV1.8 increases channel function and produces mechanical hyperalgesia in mice.

scientific article

Peripheral systems: neuropathy

scientific article

Prkcz null mice show normal learning and memory

scientific article

Promoting activity of (α4)3(β2)2 nicotinic cholinergic receptors reduces ethanol consumption

scientific article published on 08 August 2019

Protein kinase C epsilon modulates nicotine consumption and dopamine reward signals in the nucleus accumbens ⬇️

scientific article published on September 12, 2011

Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits

scientific journal article

Protein kinase C epsilon suppresses Abeta production and promotes activation of alpha-secretase.

scientific article published in July 2001

Protein kinase C isozymes in stroke.

scientific article

Protein kinase Cdelta mediates ethanol-induced up-regulation of L-type calcium channels.

scientific article published in June 1998

Protein kinases and addiction.

scientific article

Quo vadis? Peering into the future

scientific article

Regulation of neuronal voltage-gated calcium channels by ethanol.

scientific article

Responses to ethanol in C57BL/6 versus C57BL/6 × 129 hybrid mice.

scientific article published on January 2012

SEB-3, a CRF receptor-like GPCR, regulates locomotor activity states, stress responses and ethanol tolerance in Caenorhabditis elegans

scientific article

Severity of alcohol-induced painful peripheral neuropathy in female rats: role of estrogen and protein kinase (A and Cepsilon).

scientific article published on 3 January 2007

Should the reorganization of addiction-related research across all the National Institutes of Health be structural?--The devil is truly in the details

scientific article

Signaling pathways mediating alcohol effects.

scientific article published on January 2013

Specific modulation of Na+ channels in hippocampal neurons by protein kinase C epsilon.

scientific article published in January 2005

Status report: the Annals in 2010.

scientific article published in January 2010

Structural and Functional Characterization of an Anesthetic Binding Site in the Second Cysteine-Rich Domain of Protein Kinase Cδ∗

scientific article

The Corticotropin Releasing Factor Receptor 1 in Alcohol Use Disorder: Still a Valid Drug Target?

scientific article

The N-type calcium channel is a novel target for treating alcohol use disorders

scientific article (publication date: 2009)

The anticonvulsant levetiracetam potentiates alcohol consumption in non-treatment seeking alcohol abusers.

scientific article published on April 2012

The identification and characterization of novel PKCepsilon phosphorylation sites provide evidence for functional cross-talk within the PKC superfamily

scientific journal article

The mouse RACK1 gene is regulated by nuclear factor-kappa B and contributes to cell survival

scientific article published on 01 December 2003

The phorbol derivatives thymeleatoxin and 12-deoxyphorbol-13-O-phenylacetate-10-acetate cause translocation and down-regulation of multiple protein kinase C isozymes

scientific article published on 01 March 1993

The role of the equilibrative nucleoside transporter 1 (ENT1) in transport and metabolism of ribavirin by human and wild-type or Ent1-/- mouse erythrocytes.

scientific article published on 22 January 2009

The substrates and binding partners of protein kinase Cepsilon

scientific article

The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference.

scientific article published on 18 July 2004

nPKCepsilon, a P2Y2-R downstream effector in regulated mucin secretion from airway goblet cells

scientific journal article

List of works by Robert O Messing

A Corticotropin Releasing Factor Network in the Extended Amygdala for Anxiety

A Pathway-Based Genomic Approach to Identify Medications: Application to Alcohol Use Disorder

A Selective Role for Lmo4 in Cue-Reward Learning.

A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits

A blocker of N- and T-type voltage-gated calcium channels attenuates ethanol-induced intoxication, place preference, self-administration, and reinstatement

A semisynthetic epitope for kinase substrates.

Abstinence-dependent dissociable central amygdala microcircuits control drug craving

Alcohol dependence: molecular and behavioral evidence.

Alcohol-induced stress in painful alcoholic neuropathy

Amygdala protein kinase C epsilon regulates corticotropin-releasing factor and anxiety-like behavior

An inhibitory fragment derived from protein kinase Cepsilon prevents enhancement of nerve growth factor responses by ethanol and phorbol esters.

Apremilast Alters Behavioral Responses to Ethanol in Mice: I. Reduced Consumption and Preference

Apremilast Alters Behavioral Responses to Ethanol in Mice: II. Increased Sedation, Intoxication, and Reduced Acute Functional Tolerance

Binge Drinking With Protein Kinase C Epsilon: A Role for Mammalian Target of Rapamycin Complex 2?

Chronic ethanol exposure induces an N-type calcium channel splice variant with altered channel kinetics.

Cloning of a novel isoform of the mouse NBMPR-sensitive equilibrative nucleoside transporter (ENT1) lacking a putative phosphorylation site

Comparative effects of chronic exposure to ethanol and calcium channel antagonists on calcium channel antagonist receptors in cultured neural (PC12) cells.

Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake.

D-Serine and D-Cycloserine Reduce Compulsive Alcohol Intake in Rats

Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase Cepsilon.

Deletion of N-type calcium channels alters ethanol reward and reduces ethanol consumption in mice.

Deletion of Tlr3 reduces acute tolerance to alcohol and alcohol consumption in the intermittent access procedure in male mice

Differential regulation of alcohol consumption and reward by the transcriptional cofactor LMO4

Divergent contractile and structural responses of the murine PKC-epsilon null pulmonary circulation to chronic hypoxia

Divergent contractile and structural responses of the murine protein kinase C-epsilon null pulmonary circulation to chronic hypoxia

Early editorial manuscript screening versus obligate peer review: a randomized trial.

Epilepsy genetics: yet more exciting news

Ethanol enhances growth factor activation of mitogen-activated protein kinases by a protein kinase C-dependent mechanism

Ethanol regulates calcium channel subunits by protein kinase C delta -dependent and -independent mechanisms.

Ethanol regulates calcium channels in clonal neural cells.

Ethanol-induced component of 45Ca2+ uptake in PC12 cells is sensitive to Ca2+ channel modulating drugs

Fighting decision fatigue

GABAA receptor trafficking is regulated by protein kinase C(epsilon) and the N-ethylmaleimide-sensitive factor

Generation and characterization of ATP analog-specific protein kinase Cδ.

Genomic organization and expression of the mouse equilibrative, nitrobenzylthioinosine-sensitive nucleoside transporter 1 (ENT1) gene.

Have the Annals editors added value?

How Should Addiction-Related Research at the National Institutes of Health be Reorganized?

Identification of lipocalin-2 as a PKCδ phosphorylation substrate in neutrophils.

Immunological studies in patients with acquired immune deficiency syndrome

Inactivation of 45Ca2+ uptake by prior depolarization of PC12 cells

Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats

Increased response to morphine in mice lacking protein kinase C epsilon

Increased sensitivity to the aversive effects of ethanol in PKCepsilon null mice revealed by place conditioning.

Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer

Inhibition of calcium flux and calcium channel antagonist binding in the PC12 neural cell line by phorbol esters and protein kinase C

Interaction of calmodulin inhibitors and protein kinase C inhibitors with voltage-dependent calcium channels

Intracellular signaling pathways that regulate behavioral responses to ethanol

Killing the Buζζ: accumbal PKMζ blunts cocaine seeking and reward

Ligand requirements for involvement of PKCε in synergistic analgesic interactions between spinal μ and δ opioid receptors.

Mouse model of middle cerebral artery occlusion.

Neurobiological mechanisms contributing to alcohol-stress-anxiety interactions.

Neurological reactions in HIV-infected patients treated with trichosanthin.

Neurotoxic catecholamine metabolite in nociceptors contributes to painful peripheral neuropathy

Neutrophil protein kinase Cdelta as a mediator of stroke-reperfusion injury.

Novel Small-Molecule Inhibitors of Protein Kinase C Epsilon Reduce Ethanol Consumption in Mice.

PKC-delta promotes renal tubular cell apoptosis associated with proteinuria.

PKCepsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice.

PKCepsilon regulates behavioral sensitivity, binding and tolerance to the CB1 receptor agonist WIN55,212-2.

PKCδ-targeted intervention relieves chronic pain in a murine sickle cell disease model

PKCε phosphorylates α4β2 nicotinic ACh receptors and promotes recovery from desensitization

PKCε phosphorylation of the sodium channel NaV1.8 increases channel function and produces mechanical hyperalgesia in mice.

Peripheral systems: neuropathy

Prkcz null mice show normal learning and memory

Promoting activity of (α4)3(β2)2 nicotinic cholinergic receptors reduces ethanol consumption

Protein kinase C epsilon modulates nicotine consumption and dopamine reward signals in the nucleus accumbens ⬇️

Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits

Protein kinase C epsilon suppresses Abeta production and promotes activation of alpha-secretase.

Protein kinase C isozymes in stroke.

Protein kinase Cdelta mediates ethanol-induced up-regulation of L-type calcium channels.

Protein kinases and addiction.

Quo vadis? Peering into the future

Regulation of neuronal voltage-gated calcium channels by ethanol.

Responses to ethanol in C57BL/6 versus C57BL/6 × 129 hybrid mice.

SEB-3, a CRF receptor-like GPCR, regulates locomotor activity states, stress responses and ethanol tolerance in Caenorhabditis elegans

Severity of alcohol-induced painful peripheral neuropathy in female rats: role of estrogen and protein kinase (A and Cepsilon).

Should the reorganization of addiction-related research across all the National Institutes of Health be structural?--The devil is truly in the details

Signaling pathways mediating alcohol effects.

Specific modulation of Na+ channels in hippocampal neurons by protein kinase C epsilon.

Status report: the Annals in 2010.