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List of works by Frederick J Raal

A double mutant LDL receptor allele in a Cypriot family with heterozygous familial hypercholesterolemia ⬇️

scientific article published on July 1, 1997

A longitudinal study of stavudine-associated toxicities in a large cohort of South African HIV infected subjects

scientific article

Acute Suppurative Thyroiditis Secondary to Escherichia coli Infection

scientific article published in 2021

Cardiovascular risk factor burden in Africa and the Middle East: the Africa Middle East Cardiovascular Epidemiological (ACE) study

scientific article

Carotid intima-media thickness is a predictor of coronary artery disease in South African black patients.

scientific article published on July 2009

Comparison between surrogate indices of insulin sensitivity and resistance, and the hyperinsulinaemic euglycaemic glucose clamp in urban South African blacks with and without coronary artery disease

scientific article published on 22 February 2010

CpG hotspot mutations at the LDL receptor locus are a frequent cause of familial hypercholesterolemia among South African Indians ⬇️

scientific article published on June 1, 1997

Defining severe familial hypercholesterolaemia and the implications for clinical management: a consensus statement from the International Atherosclerosis Society Severe Familial Hypercholesterolemia Panel

scientific article published on 27 May 2016

Demographic and Clinical Factors Associated with Development of Type 2 Diabetes: A Review of the Literature

scientific article published on 31 March 2020

Different lipid profiles according to ethnicity in the Heart of Soweto study cohort of de novo presentations of heart disease

scientific article published on August 2012

Effect of Alirocumab on Lipoprotein(a) Over ≥1.5 Years (from the Phase 3 ODYSSEY Program).

scientific article

Efficacy and Safety of Alirocumab in Patients with Heterozygous Familial Hypercholesterolemia and LDL-C of 160 mg/dl or Higher

scientific article

Efficacy and safety of alirocumab in reducing lipids and cardiovascular events

scientific article

Efficacy and safety of evolocumab in reducing lipids and cardiovascular events.

scientific article

Efficacy and safety of longer-term administration of evolocumab (AMG 145) in patients with hypercholesterolemia: 52-week results from the Open-Label Study of Long-Term Evaluation Against LDL-C (OSLER) randomized trial

scientific article

Elevated PCSK9 levels in untreated patients with heterozygous or homozygous familial hypercholesterolemia and the response to high-dose statin therapy

scientific article published on 24 April 2013

Expanded-dose simvastatin is effective in homozygous familial hypercholesterolaemia ⬇️

scientific article published on December 1, 1997

Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment.

scientific article

Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society

scientific article

Familial hypercholesterolaemia: A global call to arms

scientific article published on 18 September 2015

Familial hypercholesterolemia treatments: Guidelines and new therapies

article published in 2018

Familial hypercholesterolemia: potential diagnostic value of mutation screening in a pediatric population of South Africa ⬇️

scientific article published on July 1, 1998

Fewer bone histomorphometric abnormalities with intermittent than with continuous slow-release sodium fluoride therapy ⬇️

scientific article published on January 1, 1997

Future Directions to Establish Lipoprotein(a) as a Treatment for Atherosclerotic Cardiovascular Disease

scientific article published on 09 February 2016

High-Dose Statin Therapy Does Not Induce Insulin Resistance in Patients with Familial Hypercholesterolemia ⬇️

scientific article published on July 20, 2012

Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society

scientific article

Homozygous familial hypercholesterolemia: current perspectives on diagnosis and treatment

scientific article published on 16 February 2012

Insights Into PCSK9, Low-Density Lipoprotein Receptor, and Low-Density Lipoprotein Cholesterol Metabolism ⬇️

scientific article published on May 20, 2013

Insulin receptor substrate-1 gene variants in lipoatrophic diabetes mellitus and non-insulin-dependent diabetes mellitus: a study of South African black and white subjects ⬇️

scientific article published on 01 November 1997

Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation

scientific article

Integrated guidance on the care of familial hypercholesterolemia from the International FH Foundation

scientific article published on 16 January 2014

Leptin, adiponectin, and high-sensitivity C-reactive protein in relation to the metabolic syndrome in urban South African blacks with and without coronary artery disease

scientific article

Lipid-Lowering Drug Therapy for CVD Prevention: Looking into the Future

scientific article

Lipid-lowering efficacy of the PCSK9 inhibitor evolocumab (AMG 145) in patients with type 2 diabetes: a meta-analysis of individual patient data

scientific article

Lomitapide for homozygous familial hypercholesterolaemia ⬇️

scientific article published on November 2, 2012

Long-term Low-Density Lipoprotein Cholesterol-Lowering Efficacy, Persistence, and Safety of Evolocumab in Treatment of Hypercholesterolemia: Results Up to 4 Years From the Open-Label OSLER-1 Extension Study.

scientific article published on 14 March 2017

Long-term safety, tolerability, and efficacy of evolocumab in patients with heterozygous familial hypercholesterolemia

scientific article published on 22 September 2017

Long-term treatment with evolocumab added to conventional drug therapy, with or without apheresis, in patients with homozygous familial hypercholesterolaemia: an interim subset analysis of the open-label TAUSSIG study

scientific article published on 16 February 2017

Low-density lipoprotein cholesterol-lowering effects of AMG 145, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemia: the Reduction of LDL-C with PCSK9 In

scientific article

Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel

scientific article published on 24 April 2017

Lower levels of high-density lipoprotein cholesterol in urban Africans presenting with communicable versus non-communicable forms of heart disease: the 'Heart of Soweto' hospital registry study

scientific article

Microalbuminuria is not associated with cardiovascular disease in patients with homozygous familial hypercholesterolaemia ⬇️

scientific article published on 01 March 1995

Mipomersen, an antisense oligonucleotide to apolipoprotein B-100, reduces lipoprotein(a) in various populations with hypercholesterolemia: results of 4 phase III trials

scientific article

Multi-ethnic differences in HbA1c, blood pressure, and low-density-lipid cholesterol control among South Africans living with type 2 diabetes, after a 4-year follow-up.

scientific article

New therapies for reducing low-density lipoprotein cholesterol

scientific article

Nonstatin Low-Density Lipoprotein-Lowering Therapy and Cardiovascular Risk Reduction-Statement From ATVB Council

scientific article

Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC) ⬇️

scientific article published in October 2018

PCSK9 Inhibitors: From Nature's Lessons to Clinical Utility

scientific article published on 12 February 2020

PCSK9 inhibition-mediated reduction in Lp(a) with evolocumab: an analysis of 10 clinical trials and the LDL receptor's role

scientific article published on 21 April 2016

Pathogenesis and management of the dyslipidemia of the metabolic syndrome

scientific article published on April 2009

Phenotype diversity among patients with homozygous familial hypercholesterolemia: A cohort study

scientific article

Polygenic familial hypercholesterolaemia: does it matter? ⬇️

scientific article published on February 22, 2013

Pooling and expanding registries of familial hypercholesterolaemia to assess gaps in care and improve disease management and outcomes: Rationale and design of the global EAS Familial Hypercholesterolaemia Studies Collaboration

scientific article published on 06 December 2016

Postprandial hyperglycemia in urban South African blacks with and without coronary artery disease

scientific article published on February 2009

Prevalence of dyslipidaemia in statin-treated patients in South Africa: results of the DYSlipidaemia International Study (DYSIS)

scientific article published on September 2013

Quality of care delivered to type 2 diabetes mellitus patients in public and private sector facilities in Johannesburg, South Africa

article

Quantity versus quality of LDL cholesterol in patients with familial hypercholesterolemia—which is more important? ⬇️

scientific article published on December 1, 2001

Reduction of low-density lipoprotein cholesterol by monoclonal antibody inhibition of PCSK9.

scientific article published on January 2014

Retrospective analysis of cohort database: Phenotypic variability in a large dataset of patients confirmed to have homozygous familial hypercholesterolemia

scientific article published on 11 April 2016

Statins and other lipid-lowering therapy and pregnancy outcomes in homozygous familial hypercholesterolaemia: A retrospective review of 39 pregnancies

Suboptimal Control of Lipid Levels: Results from 29 Countries Participating in the Centralized Pan-Regional Surveys on the Undertreatment of Hypercholesterolaemia (CEPHEUS).

scientific article published on 2 December 2015

Targeting LDL: is lower better and is it safe?

scientific article

The Agenda for Familial Hypercholesterolemia: A Scientific Statement From the American Heart Association

scientific article

The cardiovascular health of the nation - should we be advocating a low-carbohydrate, high-fat diet? ⬇️

scientific article published on June 20, 2012

The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management

scientific article

Treatment Gaps Found in the Management of Type 2 Diabetes at a Community Health Centre in Johannesburg, South Africa.

scientific article published on 10 October 2017

What matters most in pediatric familial hypercholesterolemia, genotype or phenotype?

scientific article published on 27 March 2014

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