List of works - Simon E Ward

3,4-Dihydro-2H-benzoxazinones as dual-acting 5-HT1A receptor antagonists and serotonin reuptake inhibitors.

scientific article published on 15 November 2006

AMPA receptor-positive allosteric modulators for the treatment of schizophrenia: an overview of recent patent applications

scientific article published on January 2015

Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives

scientific article

Challenges for and current status of research into positive modulators of AMPA receptors.

scientific article

Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan

scientific article published on 18 December 2014

Current and Future Perspectives in Psychiatric Drug Discovery.

scientific article published on July 2009

Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.

scientific article

Discovery of 1-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, selective, and orally active 5-HT1A/B/D receptor antagonist.

scientific article published on 5 November 2010

Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator

scientific article

Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists.

scientific article published on 24 April 2008

Discovery of the first potent, selective 5-hydroxytryptamine1D receptor antagonist.

scientific article published in May 2005

Integration of Lead Optimization with Crystallography for a Membrane-Bound Ion Channel Target: Discovery of a New Class of AMPA Receptor Positive Allosteric Modulators ⬇️

scientific article published on December 3, 2010

Metal-free selective mono-halodecarboxylation of heteroarenes under mild conditions.

scientific article published on 20 June 2018

N-substituted pyrrolidines and tetrahydrofurans as novel AMPAR positive modulators.

scientific article published on 17 September 2010

Recent advances in the discovery of selective AMPA receptor positive allosteric modulators.

scientific article published on January 2010

Recent advances in the discovery of selective and non-selective 5-HT(1D) receptor ligands.

scientific article published on January 2010

Studies on a series of potent, orally bioavailable, 5-HT(1) receptor ligands

scientific article published on 30 June 2007

Synthesis of polyprenylated acylphloroglucinols using bridgehead lithiation: the total synthesis of racemic clusianone and a formal synthesis of racemic garsubellin A.

scientific article published on 26 May 2007

Synthetic studies towards garsubellin A: synthesis of model systems and potential mimics by regioselective lithiation of bicyclo[3.3.1]nonane-2,4,9-trione derivatives from catechinic acid

scientific article published on 15 May 2007

TDP1/TOP1 Ratio as a Promising Indicator for the Response of Small Cell Lung Cancer to Topotecan

scientific article published on July 2014

Therapeutic opportunities within the DNA damage response

scientific article

Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase

scientific article published on 11 April 2022

What does the aromatic ring number mean for drug design?

scientific article

List of works by Simon E Ward

3,4-Dihydro-2H-benzoxazinones as dual-acting 5-HT1A receptor antagonists and serotonin reuptake inhibitors.

AMPA receptor-positive allosteric modulators for the treatment of schizophrenia: an overview of recent patent applications

Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives

Challenges for and current status of research into positive modulators of AMPA receptors.

Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan

Current and Future Perspectives in Psychiatric Drug Discovery.

Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.

Discovery of 1-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, selective, and orally active 5-HT1A/B/D receptor antagonist.

Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator

Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists.

Discovery of the first potent, selective 5-hydroxytryptamine1D receptor antagonist.

Integration of Lead Optimization with Crystallography for a Membrane-Bound Ion Channel Target: Discovery of a New Class of AMPA Receptor Positive Allosteric Modulators ⬇️

Metal-free selective mono-halodecarboxylation of heteroarenes under mild conditions.

N-substituted pyrrolidines and tetrahydrofurans as novel AMPAR positive modulators.

Recent advances in the discovery of selective AMPA receptor positive allosteric modulators.

Recent advances in the discovery of selective and non-selective 5-HT(1D) receptor ligands.

Studies on a series of potent, orally bioavailable, 5-HT(1) receptor ligands

Synthesis of polyprenylated acylphloroglucinols using bridgehead lithiation: the total synthesis of racemic clusianone and a formal synthesis of racemic garsubellin A.

Synthetic studies towards garsubellin A: synthesis of model systems and potential mimics by regioselective lithiation of bicyclo[3.3.1]nonane-2,4,9-trione derivatives from catechinic acid

TDP1/TOP1 Ratio as a Promising Indicator for the Response of Small Cell Lung Cancer to Topotecan

Therapeutic opportunities within the DNA damage response

Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase

What does the aromatic ring number mean for drug design?