List of works - Avi Chakrabartty

"Structural characterization of the minimal segment of TDP-43 competent for aggregation".

scientific article published on 15 January 2014

A prion protein epitope selective for the pathologically misfolded conformation

scientific article

ALS-causing SOD1 mutations promote production of copper-deficient misfolded species

scientific article

Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase

scientific article

All or none fibrillogenesis of a prion peptide.

scientific article

Alternate aggregation pathways of the Alzheimer beta-amyloid peptide. An in vitro model of preamyloid.

scientific article published in November 2000

Alternate aggregation pathways of the Alzheimer beta-amyloid peptide: Abeta association kinetics at endosomal pH.

scientific article

Alternate routes to conformational specificity in a Greek key beta barrel protein

scientific article

Alzheimer beta-amyloid peptides: structures of amyloid fibrils and alternate aggregation products

scientific article

Alzheimer's Abeta40 studied by NMR at low pH reveals that sodium 4,4-dimethyl-4-silapentane-1-sulfonate (DSS) binds and promotes beta-ball oligomerization.

scientific article published on 19 November 2004

Amyloid beta-protein (A beta) associated with lipid molecules: immunoreactivity distinct from that of soluble A beta.

scientific article published in December 1997

Amyotrophic lateral sclerosis is a non-amyloid disease in which extensive misfolding of SOD1 is unique to the familial form

scientific article

An Arg-rich putative prebiotic protein is as stable as its Lys-rich variant

scientific article published on 26 September 2012

Analyzing complicated protein folding kinetics rapidly by analytical Laplace inversion using a Tikhonov regularization variant.

scientific article

Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region.

scientific article

Aβ behavior on neuronal membranes: aggregation and toxicities.

scientific article

Binding of TDP-43 to the 3'UTR of its cognate mRNA enhances its solubility.

scientific article published on 11 September 2014

Binding of elongin A or a von Hippel-Lindau peptide stabilizes the structure of yeast elongin C

scientific article

CCM3/PDCD10 heterodimerizes with germinal center kinase III (GCKIII) proteins using a mechanism analogous to CCM3 homodimerization

scientific article

Calexcitin B is a new member of the sarcoplasmic calcium-binding protein family.

scientific article published on 16 April 2001

Cell surface binding and internalization of aβ modulated by degree of aggregation

scientific article

Characterization of segments from the central region of BRCA1: an intrinsically disordered scaffold for multiple protein-protein and protein-DNA interactions?

scientific article published in January 2005

Characterization of the interactions of Alzheimer beta-amyloid peptides with phospholipid membranes.

scientific article published in April 1997

Charge substitution shows that repulsive electrostatic interactions impede the oligomerization of Alzheimer amyloid peptides.

scientific article published in July 2005

Co-incorporation of A beta 40 and A beta 42 to form mixed pre-fibrillar aggregates

scientific article published on 01 February 2003

Conformation specificity and arene binding in a peptide composed only of Lys, Ile, Ala and Gly

scientific article published on 27 October 2011

Conformational coupling of Mg2+ and Ca2+ on the three-state folding of calexcitin B.

scientific article published in May 2003

Conversion of Abeta42 into a folded soluble native-like protein using a semi-random library of amphipathic helices

scientific article

Corrigendum: Substoichiometric inhibition of transthyretin misfolding by immune-targeting sparsely populated misfolding intermediates: a potential diagnostic and therapeutic for TTR amyloidoses

scientific article published on 10 June 2016

Cost-effective elimination of lipofuscin fluorescence from formalin-fixed brain tissue by white phosphor light emitting diode array

scientific article published on 4 August 2016

Crystal structure of an antifreeze polypeptide and its mechanistic implications

scientific article published in Nature

Denaturational stress induces formation of zinc-deficient monomers of Cu,Zn superoxide dismutase: implications for pathogenesis in amyotrophic lateral sclerosis.

scientific article

Determination of free energies of N-capping in alpha-helices by modification of the Lifson-Roig helix-coil therapy to include N- and C-capping.

scientific article published in March 1994

Determining composition of micron-scale protein deposits in neurodegenerative disease by spatially targeted optical microproteomics.

scientific article

Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants

scientific article

Early steps in oxidation-induced SOD1 misfolding: implications for non-amyloid protein aggregation in familial ALS.

scientific article

Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation

scientific article

Equilibrium folding intermediates of a Greek key beta-barrel protein.

scientific article

Erratum to: Multiphoton ANS fluorescence microscopy as an in vivo sensor for protein misfolding stress.

scientific article

Fibrillogenesis of Alzheimer Abeta peptides studied by fluorescence energy transfer

scientific article published on 01 June 1997

Getting specificity from simplicity in putative proteins from the prebiotic Earth

scientific article

Helix propensities of the amino acids measured in alanine-based peptides without helix-stabilizing side-chain interactions.

scientific article published on May 1994

Hyperactive antifreeze protein from winter flounder is a very long rod-like dimer of alpha-helices.

scientific article

Identification of stable helical bundles from a combinatorial library of amphipathic peptides

scientific article

Interaction of human and mouse Abeta peptides

scientific article published on 01 December 2004

Interplay of buried histidine protonation and protein stability in prion misfolding

scientific article published on 13 April 2017

Lipopeptide detergents designed for the structural study of membrane proteins

scientific article published on 13 January 2003

Low molecular weight species of TDP-43 generated by abnormal splicing form inclusions in amyotrophic lateral sclerosis and result in motor neuron death.

scientific article published on 19 March 2015

Manipulating the amyloid-beta aggregation pathway with chemical chaperones.

scientific article published in November 1999

Metal ion-dependent, reversible, protein filament formation by designed beta-roll polypeptides

scientific article

Monomeric Cu,Zn-superoxide dismutase is a common misfolding intermediate in the oxidation models of sporadic and familial amyotrophic lateral sclerosis.

scientific article

Multiphoton ANS fluorescence microscopy as an in vivo sensor for protein misfolding stress ⬇️

scientific article published on April 12, 2011

N-Terminal Helix-Cap in α-Helix 2 Modulates β-State Misfolding in Rabbit and Hamster Prion Proteins

scientific article

NMR-driven secondary and tertiary structure model of Ca2+-loaded calexcitin

scientific article published on 10 March 2006

Nonpolar contributions to conformational specificity in assemblies of designed short helical peptides.

scientific article published on May 2000

Novel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretin

scientific article published on 16 March 2016

Novel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretin

scientific article published on 2 November 2015

Phase to Phase with TDP-43.

scientific article published on 23 January 2017

Phosphatidylinositol and inositol involvement in Alzheimer amyloid-beta fibril growth and arrest

scientific article published on 01 April 1998

Physiologically Important Electrolytes as Regulators of TDP-43 Aggregation and Droplet-Phase Behavior

scientific article published on 13 December 2018

Prion disease susceptibility is affected by -structure folding propensity and local side-chain interactions in PrP

scientific article

Probing Alzheimer amyloid peptide aggregation using a cell-free fluorescent protein refolding method.

scientific article

Progress in transthyretin fibrillogenesis research strengthens the amyloid hypothesis.

scientific article

Properties of membrane-bound and solubilized forms of alkaline phosphatase from human liver

scientific article published on 01 April 1985

Protein misfolding in the late-onset neurodegenerative diseases: common themes and the unique case of amyotrophic lateral sclerosis.

scientific article published on 02 July 2013

Requirement of aggregation propensity of Alzheimer amyloid peptides for neuronal cell surface binding

scientific article

Simple Elimination of Background Fluorescence in Formalin-Fixed Human Brain Tissue for Immunofluorescence Microscopy.

scientific article published on 3 September 2017

Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers

scientific article published on 26 June 2017

Species barriers for chronic wasting disease by in vitro conversion of prion protein.

scientific article published on 25 October 2007

Stability of alpha-helices

scientific article

Structural Transitions Associated with the Interaction of Alzheimer β-Amyloid Peptides with Gangliosides ⬇️

scientific article published on February 20, 1998

Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis

scientific article

Structural factors underlying the species barrier and susceptibility to infection in prion disease.

scientific article published on April 2010

Structural studies of soluble oligomers of the Alzheimer beta-amyloid peptide

scientific article published on 01 March 2000

Structure of a simplified β-hairpin and its ATP complex.

scientific article published on 27 June 2013

Structure-function relationships in a winter flounder antifreeze polypeptide. I. Stabilization of an alpha-helical antifreeze polypeptide by charged-group and hydrophobic interactions

scientific article published on 01 July 1989

Substoichiometric inhibition of transthyretin misfolding by immune-targeting sparsely populated misfolding intermediates: a potential diagnostic and therapeutic for TTR amyloidoses

scientific article published on 28 April 2016

Targeting of monomer/misfolded SOD1 as a therapeutic strategy for amyotrophic lateral sclerosis

scientific article published on 01 June 2012

Tetrameric alkaline phosphatase in human liver plasma membranes

scientific article published in 1985

The BH3 domain of BAD fused to the Antennapedia peptide induces apoptosis via its alpha helical structure and independent of Bcl-2

scientific article published in July 2001

The PrP-like protein Doppel binds copper

scientific journal article

The effect of enhanced alpha-helicity on the activity of a winter flounder antifreeze polypeptide

scientific article published on 01 December 1991

Transthyretin amyloidosis: an under-recognized neuropathy and cardiomyopathy

scientific article published on March 2017

Two distinct conformations of Abeta aggregates on the surface of living PC12 cells.

scientific article published on May 2009

Variants of DsRed fluorescent protein: Development of a copper sensor.

scientific article published on October 2006

Wild-type Cu/Zn superoxide dismutase stabilizes mutant variants by heterodimerization.

scientific article

List of works by Avi Chakrabartty

"Structural characterization of the minimal segment of TDP-43 competent for aggregation".

A prion protein epitope selective for the pathologically misfolded conformation

ALS-causing SOD1 mutations promote production of copper-deficient misfolded species

Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase

All or none fibrillogenesis of a prion peptide.

Alternate aggregation pathways of the Alzheimer beta-amyloid peptide. An in vitro model of preamyloid.

Alternate aggregation pathways of the Alzheimer beta-amyloid peptide: Abeta association kinetics at endosomal pH.

Alternate routes to conformational specificity in a Greek key beta barrel protein

Alzheimer beta-amyloid peptides: structures of amyloid fibrils and alternate aggregation products

Alzheimer's Abeta40 studied by NMR at low pH reveals that sodium 4,4-dimethyl-4-silapentane-1-sulfonate (DSS) binds and promotes beta-ball oligomerization.

Amyloid beta-protein (A beta) associated with lipid molecules: immunoreactivity distinct from that of soluble A beta.

Amyotrophic lateral sclerosis is a non-amyloid disease in which extensive misfolding of SOD1 is unique to the familial form

An Arg-rich putative prebiotic protein is as stable as its Lys-rich variant

Analyzing complicated protein folding kinetics rapidly by analytical Laplace inversion using a Tikhonov regularization variant.

Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region.

Aβ behavior on neuronal membranes: aggregation and toxicities.

Binding of TDP-43 to the 3'UTR of its cognate mRNA enhances its solubility.

Binding of elongin A or a von Hippel-Lindau peptide stabilizes the structure of yeast elongin C

CCM3/PDCD10 heterodimerizes with germinal center kinase III (GCKIII) proteins using a mechanism analogous to CCM3 homodimerization

Calexcitin B is a new member of the sarcoplasmic calcium-binding protein family.

Cell surface binding and internalization of aβ modulated by degree of aggregation

Characterization of segments from the central region of BRCA1: an intrinsically disordered scaffold for multiple protein-protein and protein-DNA interactions?

Characterization of the interactions of Alzheimer beta-amyloid peptides with phospholipid membranes.

Charge substitution shows that repulsive electrostatic interactions impede the oligomerization of Alzheimer amyloid peptides.

Co-incorporation of A beta 40 and A beta 42 to form mixed pre-fibrillar aggregates

Conformation specificity and arene binding in a peptide composed only of Lys, Ile, Ala and Gly

Conformational coupling of Mg2+ and Ca2+ on the three-state folding of calexcitin B.

Conversion of Abeta42 into a folded soluble native-like protein using a semi-random library of amphipathic helices

Corrigendum: Substoichiometric inhibition of transthyretin misfolding by immune-targeting sparsely populated misfolding intermediates: a potential diagnostic and therapeutic for TTR amyloidoses

Cost-effective elimination of lipofuscin fluorescence from formalin-fixed brain tissue by white phosphor light emitting diode array

Crystal structure of an antifreeze polypeptide and its mechanistic implications

Denaturational stress induces formation of zinc-deficient monomers of Cu,Zn superoxide dismutase: implications for pathogenesis in amyotrophic lateral sclerosis.

Determination of free energies of N-capping in alpha-helices by modification of the Lifson-Roig helix-coil therapy to include N- and C-capping.

Determining composition of micron-scale protein deposits in neurodegenerative disease by spatially targeted optical microproteomics.

Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants

Early steps in oxidation-induced SOD1 misfolding: implications for non-amyloid protein aggregation in familial ALS.

Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation

Equilibrium folding intermediates of a Greek key beta-barrel protein.

Erratum to: Multiphoton ANS fluorescence microscopy as an in vivo sensor for protein misfolding stress.

Fibrillogenesis of Alzheimer Abeta peptides studied by fluorescence energy transfer

Getting specificity from simplicity in putative proteins from the prebiotic Earth

Helix propensities of the amino acids measured in alanine-based peptides without helix-stabilizing side-chain interactions.

Hyperactive antifreeze protein from winter flounder is a very long rod-like dimer of alpha-helices.

Identification of stable helical bundles from a combinatorial library of amphipathic peptides

Interaction of human and mouse Abeta peptides

Interplay of buried histidine protonation and protein stability in prion misfolding

Lipopeptide detergents designed for the structural study of membrane proteins

Low molecular weight species of TDP-43 generated by abnormal splicing form inclusions in amyotrophic lateral sclerosis and result in motor neuron death.

Manipulating the amyloid-beta aggregation pathway with chemical chaperones.

Metal ion-dependent, reversible, protein filament formation by designed beta-roll polypeptides

Monomeric Cu,Zn-superoxide dismutase is a common misfolding intermediate in the oxidation models of sporadic and familial amyotrophic lateral sclerosis.

Multiphoton ANS fluorescence microscopy as an in vivo sensor for protein misfolding stress ⬇️

N-Terminal Helix-Cap in α-Helix 2 Modulates β-State Misfolding in Rabbit and Hamster Prion Proteins

NMR-driven secondary and tertiary structure model of Ca2+-loaded calexcitin

Nonpolar contributions to conformational specificity in assemblies of designed short helical peptides.

Novel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretin

Novel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretin

Phase to Phase with TDP-43.

Phosphatidylinositol and inositol involvement in Alzheimer amyloid-beta fibril growth and arrest

Physiologically Important Electrolytes as Regulators of TDP-43 Aggregation and Droplet-Phase Behavior

Prion disease susceptibility is affected by -structure folding propensity and local side-chain interactions in PrP

Probing Alzheimer amyloid peptide aggregation using a cell-free fluorescent protein refolding method.

Progress in transthyretin fibrillogenesis research strengthens the amyloid hypothesis.

Properties of membrane-bound and solubilized forms of alkaline phosphatase from human liver

Protein misfolding in the late-onset neurodegenerative diseases: common themes and the unique case of amyotrophic lateral sclerosis.

Requirement of aggregation propensity of Alzheimer amyloid peptides for neuronal cell surface binding

Simple Elimination of Background Fluorescence in Formalin-Fixed Human Brain Tissue for Immunofluorescence Microscopy.

Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers

Species barriers for chronic wasting disease by in vitro conversion of prion protein.

Stability of alpha-helices

Structural Transitions Associated with the Interaction of Alzheimer β-Amyloid Peptides with Gangliosides ⬇️

Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis

Structural factors underlying the species barrier and susceptibility to infection in prion disease.

Structural studies of soluble oligomers of the Alzheimer beta-amyloid peptide

Structure of a simplified β-hairpin and its ATP complex.

Structure-function relationships in a winter flounder antifreeze polypeptide. I. Stabilization of an alpha-helical antifreeze polypeptide by charged-group and hydrophobic interactions

Substoichiometric inhibition of transthyretin misfolding by immune-targeting sparsely populated misfolding intermediates: a potential diagnostic and therapeutic for TTR amyloidoses

Targeting of monomer/misfolded SOD1 as a therapeutic strategy for amyotrophic lateral sclerosis

Tetrameric alkaline phosphatase in human liver plasma membranes