List of works - Nicola J Smith

A Molecular Mechanism for Sequential Activation of a G Protein-Coupled Receptor

scientific article

Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes.

scientific article published on 25 March 2016

Allosteric modulation of heterodimeric G-protein-coupled receptors.

scientific article

Allostery at G Protein-Coupled Receptor Homo- and Heteromers: Uncharted Pharmacological Landscapes ⬇️

scientific article published on December 1, 2010

Angiotensin1-9 antagonises pro-hypertrophic signalling in cardiomyocytes via the angiotensin type 2 receptor

scientific journal article

Cardiac gene expression data and in silico analysis provide novel insights into human and mouse taste receptor gene regulation.

scientific article

Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids

scientific article

Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements.

scientific article published on 15 August 2010

Determination of the exact molecular requirements for type 1 angiotensin receptor epidermal growth factor receptor transactivation and cardiomyocyte hypertrophy.

scientific article published on 7 March 2011

Drug Discovery Opportunities at the Endothelin B Receptor-Related Orphan G Protein-Coupled Receptors, GPR37 and GPR37L1

scientific article

Effect of dominant-negative epidermal growth factor receptors on cardiomyocyte hypertrophy

Experimental challenges to targeting poorly characterized GPCRs: uncovering the therapeutic potential for free fatty acid receptors.

scientific article published on January 2011

GPCRS IN CONTEXT: SEXUAL DIMORPHISM IN THE CARDIOVASCULAR SYSTEM.

scientific article published on 16 February 2018

Hijacking epidermal growth factor receptors by angiotensin II: new possibilities for understanding and treating cardiac hypertrophy.

scientific article

Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13.

scientific article

Identifying ligands at orphan GPCRs: current status using structure-based approaches

scientific article published on 2 February 2016

Low affinity GPCRs for metabolic intermediates: challenges for pharmacologists.

scientific article published on 13 January 2012

Metalloprotease cleavage of the N terminus of the orphan G protein-coupled receptor GPR37L1 reduces its constitutive activity.

scientific article

Niclosamide blocks glucagon phosphorylation of Ser552 on β-catenin in primary rat hepatocytes via PKA signalling

scientific article published on 10 March 2016

Orphan receptor ligand discovery by pickpocketing pharmacological neighbors

scientific article published on 19 December 2016

Rapid Knockout and Reporter Mouse Line Generation and Breeding Colony Establishment Using EUCOMM Conditional-Ready Embryonic Stem Cells: A Case Study

scientific article

Regulation of serotonin 5-HT2C receptors by chronic ligand exposure.

scientific article

RhoA/ROCK signaling and pleiotropic α1A-adrenergic receptor regulation of cardiac contractility.

scientific article

Role of miRNAs and alternative mRNA 3'-end cleavage and polyadenylation of their mRNA targets in cardiomyocyte hypertrophy.

scientific article published on 23 March 2016

Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3

scientific article

Signal switching, crosstalk, and arrestin scaffolds: novel G protein-coupled receptor signaling in cardiovascular disease.

scientific article published on 3 July 2006

The G protein-coupled receptor N-terminus and receptor signalling: N-tering a new era.

scientific article published on 7 February 2017

The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1

scientific article

Using constitutive activity to define appropriate high-throughput screening assays for orphan g protein-coupled receptors.

scientific article published in January 2015

When 6 is 9: 'uncoupled' AT1 receptors turn signalling on its head.

scientific article

When simple agonism is not enough: emerging modalities of GPCR ligands.

scientific article published on 21 July 2010

List of works by Nicola J Smith

A Molecular Mechanism for Sequential Activation of a G Protein-Coupled Receptor

Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes.

Allosteric modulation of heterodimeric G-protein-coupled receptors.

Allostery at G Protein-Coupled Receptor Homo- and Heteromers: Uncharted Pharmacological Landscapes ⬇️

Angiotensin1-9 antagonises pro-hypertrophic signalling in cardiomyocytes via the angiotensin type 2 receptor

Cardiac gene expression data and in silico analysis provide novel insights into human and mouse taste receptor gene regulation.

Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids

Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements.

Determination of the exact molecular requirements for type 1 angiotensin receptor epidermal growth factor receptor transactivation and cardiomyocyte hypertrophy.

Drug Discovery Opportunities at the Endothelin B Receptor-Related Orphan G Protein-Coupled Receptors, GPR37 and GPR37L1

Effect of dominant-negative epidermal growth factor receptors on cardiomyocyte hypertrophy

Experimental challenges to targeting poorly characterized GPCRs: uncovering the therapeutic potential for free fatty acid receptors.

GPCRS IN CONTEXT: SEXUAL DIMORPHISM IN THE CARDIOVASCULAR SYSTEM.

Hijacking epidermal growth factor receptors by angiotensin II: new possibilities for understanding and treating cardiac hypertrophy.

Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13.

Identifying ligands at orphan GPCRs: current status using structure-based approaches

Low affinity GPCRs for metabolic intermediates: challenges for pharmacologists.

Metalloprotease cleavage of the N terminus of the orphan G protein-coupled receptor GPR37L1 reduces its constitutive activity.

Niclosamide blocks glucagon phosphorylation of Ser552 on β-catenin in primary rat hepatocytes via PKA signalling

Orphan receptor ligand discovery by pickpocketing pharmacological neighbors

Rapid Knockout and Reporter Mouse Line Generation and Breeding Colony Establishment Using EUCOMM Conditional-Ready Embryonic Stem Cells: A Case Study

Regulation of serotonin 5-HT2C receptors by chronic ligand exposure.

RhoA/ROCK signaling and pleiotropic α1A-adrenergic receptor regulation of cardiac contractility.

Role of miRNAs and alternative mRNA 3'-end cleavage and polyadenylation of their mRNA targets in cardiomyocyte hypertrophy.

Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3

Signal switching, crosstalk, and arrestin scaffolds: novel G protein-coupled receptor signaling in cardiovascular disease.

The G protein-coupled receptor N-terminus and receptor signalling: N-tering a new era.

The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1

Using constitutive activity to define appropriate high-throughput screening assays for orphan g protein-coupled receptors.

When 6 is 9: 'uncoupled' AT1 receptors turn signalling on its head.

When simple agonism is not enough: emerging modalities of GPCR ligands.