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List of works by Severo Salvadori

6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides.

scientific article

A convenient synthesis of N-Fmoc-N,N′-bis-Boc-7-guanyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (Fmoc-N,N′-bis-Boc-7-guanyl-Tic-OH, GTIC)

A diastereoselective synthesis of Cebranopadol, a novel analgesic showing NOP/mu mixed agonism

scientific article

A new convenient synthetic method and preliminary pharmacological characterization of triazinediones as prokineticin receptor antagonists

scientific article published on 14 May 2014

A new ligand for the urotensin II receptor

scientific article published on October 2002

A new opioid designed multiple ligand derived from the micro opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic

scientific article

A new selective antagonist of the nociceptin receptor.

scientific article published on January 1998

A novel and facile synthesis of tetra branched derivatives of nociceptin/orphanin FQ.

scientific article published on 13 May 2014

Activation of DOR attenuates anoxic K+ derangement via inhibition of Na+ entry in mouse cortex.

scientific article published on 17 January 2008

Address and message sequences for the nociceptin receptor: a structure-activity study of nociceptin-(1-13)-peptide amide.

scientific article published on June 1997

Antagonism in opioid peptides: the role of conformation

scientific article published on January 2004

Anxiolytic- and antidepressant-like activities of H-Dmt-Tic-NH-CH(CH2-COOH)-Bid (UFP-512), a novel selective delta opioid receptor agonist.

scientific article

Bivalent opioid peptides synthesized from μ selective monomers display preferential selectivity for δ receptors

Blockade of nociceptin/orphanin FQ receptor signaling in rat substantia nigra pars reticulata stimulates nigrostriatal dopaminergic transmission and motor behavior.

scientific article

Blockade of nociceptin/orphanin FQ transmission attenuates symptoms and neurodegeneration associated with Parkinson's disease.

scientific article published in October 2005

Blockade of nociceptin/orphanin FQ-NOP receptor signalling produces antidepressant-like effects: pharmacological and genetic evidences from the mouse forced swimming test.

scientific article

Characterization of the locomotor activity-inhibiting effect of nociceptin/orphanin FQ in mice.

scientific article

Conformation-activity relationship of neuropeptide S and some structural mutants: helicity affects their interaction with the receptor

scientific article published on 15 August 2007

Conformational analysis of potent and very selective delta opioid dipeptide antagonists.

scientific article published on December 1995

Conformational properties of deltorphin: new features of the delta-opioid receptor.

scientific article

Conformationally constrained opioid ligands: the Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffold

scientific article

Conversion of enkephalin and dermorphin into delta-selective opioid antagonists by single-residue substitution.

scientific article published on August 1994

Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1).

scientific article published on December 2005

Crystal structures of dipeptides containing the Dmt-Tic pharmacophore

scientific article published in December 2002

Daily Intravesical Instillation of 1 mg Nociceptin/Orphanin FQ for the Control of Neurogenic Detrusor Overactivity: A Multicenter, Placebo Controlled, Randomized Exploratory Study

article by Massimo Lazzeri et al published November 2006 in Journal of Urology

Dermorphin decreases plasma LH levels in human: Evidence for a modulatory role of gonadal steroids

scientific article published on 01 September 1985

Dermorphin-induced hyperexcitability in hippocampal CA3 and CA1 in vitro.

scientific article published in October 1994

Design of mu selective opioid dipeptide antagonists.

scientific article published in November 1997

Design of δ-opioid peptide antagonists for emerging drug applications

article by Lawrence H Lazarus et al published June 1998 in Drug Discovery Today

Design, Synthesis, and Biological Characterization of Novel Mitochondria Targeted Dichloroacetate-Loaded Compounds with Antileukemic Activity

scientific article published on 11 December 2015

Development and characterisation of novel fentanyl-delta opioid receptor antagonist based bivalent ligands.

scientific article published on 13 February 2015

Differential effects of deltorphin on arginine and galanin-induced growth hormone secretion in healthy man

scientific article published on 01 July 1995

Direct influence of C-terminally substituted amino acids in the Dmt-Tic pharmacophore on delta-opioid receptor selectivity and antagonism

scientific article published in July 2004

Dmt and opioid peptides: a potent alliance

scientific article

Dmt-Tic-NH-CH2-Bid (UFP-502), a potent DOP receptor agonist: in vitro and in vivo studies.

scientific article published on 11 September 2006

Effect of dermorphin on behavior and hippocampal electrical activity in rabbits.

scientific article published in January 1993

Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore.

scientific article published on September 2006

Effect of the three-dimensional structure on the deamidation reaction of ribonuclease A

scientific article published on 01 November 1999

Effect of δ-opioid receptor activation on BDNF-TrkB vs. TNF-α in the mouse cortex exposed to prolonged hypoxia

scientific article published on 31 July 2013

Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties

scientific article published in January 2002

Evolution of the Bifunctional Lead μ Agonist / δ Antagonist Containing the Dmt-Tic Opioid Pharmacophore

scientific article

Further Studies on Nociceptin-Related Peptides: Discovery of a New Chemical Template with Antagonist Activity on the Nociceptin Receptor

scientific article published on 01 July 2000

Further studies at neuropeptide s position 5: discovery of novel neuropeptide S receptor antagonists

scientific article published on July 2009

Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic

scientific article

Further studies on the Dmt-Tic pharmacophore: hydrophobic substituents at the C-terminus endow delta antagonists to manifest mu agonism or mu antagonism.

scientific article

Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore.

scientific article published on 22 February 2007

Further studies on the pharmacological profile of the neuropeptide S receptor antagonist SHA 68.

scientific article

HIV-1 protease inhibitors containing an N-hydroxyamino acid core structure.

scientific article

Highly selective fluorescent analogue of the potent delta-opioid receptor antagonist Dmt-Tic.

scientific article

Hydrogen sulfide induced disruption of Na+ homeostasis in the cortex

scientific article

Identification of an achiral analogue of J-113397 as potent nociceptin/orphanin FQ receptor antagonist.

scientific article published on 3 October 2005

In vitro activity of dermaseptin S1 derivatives against genital pathogens

scientific article

In vitro and in vivo pharmacological characterization of nociceptin/orphanin FQ tetrabranched derivatives.

scientific article

In vitro and in vivo pharmacological characterization of the neuropeptide s receptor antagonist [D-Cys(tBu)5]neuropeptide S

scientific article

In vitro and in vivo pharmacological characterization of the novel UT receptor ligand [Pen5,DTrp7,Dab8]urotensin II(4-11) (UFP-803)

scientific article

In vitro and in vivo pharmacological profile of UFP-512, a novel selective delta-opioid receptor agonist; correlations between desensitization and tolerance.

scientific article

In vitro and in vivo pharmacological profile of UFP-512, a novel selective δ-opioid receptor agonist; correlations between desensitization and tolerance

scientific article published on 10 December 2007

In vitro and in vivo studies on UFP-112, a novel potent and long lasting agonist selective for the nociceptin/orphanin FQ receptor

scientific article

Influence of the side chain next to C-terminal benzimidazole in opioid pseudopeptides containing the Dmt-Tic pharmacophore

scientific article

Inhibition of the development of morphine tolerance by a potent dual mu-delta-opioid antagonist, H-Dmt-Tic-Lys-NH-CH2-Ph

scientific article published on October 2008

Interaction of calmodulin with the phosphofructokinase target sequence

scientific article published in November 2004

Interaction of sweet proteins with their receptor. A conformational study of peptides corresponding to loops of brazzein, monellin and thaumatin

scientific article

Inverse agonism by Dmt-Tic analogues and HS 378, a naltrindole analogue.

scientific article

Modeling of overloaded gradient elution of nociceptin/orphanin FQ in reversed-phase liquid chromatography

scientific article published in June 2005

N-carbamidoyl-4-((3-ethyl-2,4,4-trimethylcyclohexyl)methyl)benzamide enhances staurosporine cytotoxic effects likely inhibiting the protective action of Magmas toward cell apoptosis

scientific article published on 14 May 2014

Na+ mechanism of delta-opioid receptor induced protection from anoxic K+ leakage in the cortex

scientific article published on March 2009

Neurobiology, pharmacology, and medicinal chemistry of neuropeptide S and its receptor

scientific article published on September 2010

Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice

scientific article

Neuropeptide S selectively inhibits the release of 5-HT and noradrenaline from mouse frontal cortex nerve endings.

scientific article published on 3 April 2009

New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands

scientific article

New delta-opioid antagonists as pharmacological probes.

scientific article published on February 1998

New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores

scientific article published on September 2006

Nociceptin binding sites in frog (Rana esculenta) brain membranes.

scientific article

Nociceptin/Orphanin FQ(1-13)NH2 analogues modified in the Phe1-Gly2 peptide bond

scientific article

Nociceptin/orphanin FQ receptor ligands.

scientific article

Nonpeptide/peptide chimeric ligands for the nociceptin/orphanin FQ receptor: design, synthesis and in vitro pharmacological activity.

scientific article

Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds

scientific article

Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic

scientific article

Optimization of peptides that target human thymidylate synthase to inhibit ovarian cancer cell growth

scientific article published on 12 February 2014

Orally administered H-Dmt-Tic-Lys-NH-CH2-Ph (MZ-2), a potent mu/delta-opioid receptor antagonist, regulates obese-related factors in mice

scientific article published on July 2009

PC1, a non-peptide PKR1-preferring antagonist, reduces pain behavior and spinal neuronal sensitization in neuropathic mice

scientific article published on 27 November 2014

Pain peptides. Solution structure of orphanin FQ2.

scientific article

Parallel bioassay of 39 tachykinins on 11 smooth muscle preparations. Structure and receptor selectivity/affinity relationship.

scientific article

Peptides and proteins in a confined environment: NMR spectra at natural isotopic abundance

scholarly article by Annalisa Pastore published in January 2007

Perspectives of protein kinase C (PKC) inhibitors as anti-cancer agents.

scientific article published on April 2009

Pharmacological characterisation of [(pX)Phe 4 ]nociceptin(1-13)NH 2 analogues

scholarly article by Anna Rizzi et al published 1 June 2002 in Naunyn-Schmiedeberg's Archives of Pharmacology

Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)amide analogues. 1. In vitro studies.

scientific article

Pharmacological characterization of the nociceptin receptor which mediates reduction of alcohol drinking in rats

scientific article published in January 2002

Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist Compound 24.

scientific article published on 12 May 2009

Pharmacological profile of hemokinin 1: a novel member of the tachykinin family

scientific article published on 01 June 2002

Pharmacological profile of nociceptin/orphanin FQ receptors

scientific article

Pharmacological profile of nociceptin/orphanin FQ receptors regulating 5-hydroxytryptamine release in the mouse neocortex

scientific article published in March 2004

Pharmacology of [Tyr1]nociceptin analogs: receptor binding and bioassay studies

scientific article published on 01 September 1999

Physicochemical stability of cabazitaxel and docetaxel solutions

Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists

scientific article published in December 2005

Potent delta-opioid receptor agonists containing the Dmt-Tic pharmacophore

scientific article published in December 2002

Preparation of mono-radioiodinated tracers for study of the in vivo metabolism of atrial natriuretic peptide in humans

scientific article published on 01 September 1995

Prerequisite for His(4) in deltorphin A for highδ opioid receptor selectivity

scientific article

Probing the shape of a hydrophobic pocket in the active site of delta-opioid antagonists.

scientific article published in July 2001

Prokineticin 2 upregulation in the peripheral nervous system has a major role in triggering and maintaining neuropathic pain in the chronic constriction injury model

scientific article published on 5 January 2015

Prokineticin receptor 1 antagonist PC-10 as a biomarker for imaging inflammatory pain

scientific article published on 18 March 2011

Prolactin releasing and luteinizing hormone inhibiting activity of dermorphin shorter homologues in the rat

scientific article published on 01 May 1985

Proteinase-activated receptor-1 (PAR-1) activation contracts the isolated human renal artery in vitro

scientific article published in May 2003

Proton magnetic resonance studies on dermorphin and its peptide fragments

article

Rational design of dynorphin A analogues with δ-receptor selectivity and antagonism for δ- and κ-receptors

scientific article published on 01 January 1998

Relationship between receptor affinity and topography of N-terminally extended and bridged [Tyr1-->Asp4]deltorphin C analogues: novel probes for the delta-opioid receptor.

scientific article

Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compounds

scientific article

Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502)

scientific article published on 23 December 2007

Selective delta-opioid receptor antagonist N,N(CH3)2-Dmt-Tic-OH does not reduce ethanol intake in alcohol-preferring AA rats

scientific article

Solution conformation of nociceptin.

scientific article published in April 1997

Solution structure of amyloid beta-peptide (25-35) in different media

scientific article

Solution structure of nociceptin peptides

scientific article

Solution structure of the Alzheimer amyloid beta-peptide (1-42) in an apolar microenvironment. Similarity with a virus fusion domain

scientific article

Stereospecificity of amino acid side chains in deltorphin defines binding to opioid receptors

scientific article published on April 3, 1992

Stimulatory Effect of Dermorphin, a New Synthetic Potent Opiate-Like Peptide, on Human Growth Hormone Secretion

Structural and biological exploration of phe(3)-phe(4)-modified endomorphin-2 peptidomimetics

scientific article

Structure activity studies of nociceptin/orphanin FQ(1-13)-NH2 derivatives modified in position 5.

scientific article

Structure-activity relationship study of position 4 in the urotensin-II receptor ligand U-II(4-11).

scientific article published on 31 July 2007

Structure-activity relationship study on Tyr9 of urotensin-II(4-11): identification of a partial agonist of the UT receptor

scientific article

Structure-activity relationship study on human urotensin II

scholarly article by Remo Guerrini published in January 2005

Structure-activity relationships of nociceptin and related peptides: comparison with dynorphin A.

scientific article

Structure-activity studies on neuropeptide S: identification of the amino acid residues crucial for receptor activation

scientific article

Structure-activity studies on the nociceptin/orphanin FQ receptor antagonist 1-benzyl-N-{3-[spiroisobenzofuran-1(3H),4'-piperidin-1-yl]propyl} pyrrolidine-2-carboxamide.

scientific article published on 2 June 2009

Structure-activity study at positions 3 and 4 of human neuropeptide S.

scientific article

Structure–activity studies on nociceptin/orphanin FQ: from full agonist, to partial agonist, to pure antagonist

scientific article published on 01 November 1999

Structure−Activity Study of the Nociceptin(1−13)-NH2N-Terminal Tetrapeptide and Discovery of a Nociceptin Receptor Antagonist

Synthesis and antimicrobial activity of dermaseptin S1 analogues

scientific article published on 20 July 2008

Synthesis and biological activity of human neuropeptide S analogues modified in position 2.

scientific article

Synthesis and biological activity of human neuropeptide S analogues modified in position 5: identification of potent and pure neuropeptide S receptor antagonists

scientific article

Synthesis and biological activity of nociceptin/orphanin FQ analogues substituted in position 7 or 11 with Calpha,alpha-dialkylated amino acids.

scientific article published on 24 April 2007

Synthesis and opioid activity of N,N-dimethyl-Dmt-Tic-NH-CH(R)-R' analogues: acquisition of potent delta antagonism

scientific article

Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides.

scientific article published in August 1997

Synthesis and separation of the enantiomers of the neuropeptide S receptor antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68).

scientific article

Synthesis of a potent and selective (18)F-labeled delta-opioid receptor antagonist derived from the Dmt-Tic pharmacophore for positron emission tomography imaging

scientific article published on March 2008

Synthesis ofN α-FmocN,N′-bis-Boc-5-, 6- and 8-guanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid (5-GTIC, 6-GTIC and 8-GTIC)

article

Synthesis, pharmacological evaluation and conformational investigation of endomorphin-2 hybrid analogues

scholarly article by Giordano Lesma et al published 4 November 2012 in Molecular Diversity

Synthetic tetrapeptides related to dermorphin: potent long lasting analgesic action following subcutaneous administration.

scientific article

The SH3 domain of nebulin binds selectively to type II peptides: theoretical prediction and experimental validation

scientific article

The chemokine Bv8/prokineticin 2 is up-regulated in inflammatory granulocytes and modulates inflammatory pain

scholarly article

The effects of neuropeptide S on general anesthesia in rats

scientific journal article

The interaction of highly helical structural mutants with the NOP receptor discloses the role of the address domain of nociceptin/orphanin FQ.

scientific article

The tachykinin peptide family

scientific article (publication date: June 2002)

Topographical conformations of the deltorphins predicate .delta. opioid receptor affinity

scientific article published in 1993

Triazine compounds as antagonists at Bv8-prokineticin receptors

scientific article

Tryptophan replacement in the nociceptin/orphanin FQ receptor ligand Ac-RYYRWK-NH2.

scientific article published in July 2005

UFP-101 antagonizes the spinal antinociceptive effects of nociceptin/orphanin FQ: Behavioral and electrophysiological studies in mice

scientific article published on 11 December 2006

UFP-112 a potent and long-lasting agonist selective for the Nociceptin/Orphanin FQ receptor

scientific article published on 18 May 2010

Ultraselective antagonists of the d-opioid receptor

Unique high-affinity synthetic mu-opioid receptor agonists with central- and systemic-mediated analgesia

scientific article

Urantide mimics urotensin-II induced calcium release in cells expressing recombinant UT receptors.

scientific article published in September 2004

Urodynamic effects of intravesical nociceptin/orphanin FQ in neurogenic detrusor overactivity: a randomized, placebo-controlled, double-blind study

scientific article published in May 2003

Urotensin II stimulates plasma extravasation in mice via UT receptor activation.

scientific article

What peptides these deltorphins be.

scientific article

[(pF)Phe4,Arg14,Lys15]N/OFQ-NH2 (UFP-102), a highly potent and selective agonist of the nociceptin/orphanin FQ receptor.

scientific article published on 27 October 2004

[Dmt1]N/OFQ(1-13)-NH2: a potent nociceptin/orphanin FQ and opioid receptor universal agonist.

scientific article published on January 2013

α,β-Dehydro-amino acid residues in the design of peptide structures. Molecular and crystal structures of two folded dehydro peptides

scientific article published on 01 February 1992

δ-Opioid receptor activation modified microRNA expression in the rat kidney under prolonged hypoxia.

scientific article

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