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List of works by Juan Carlos Leza

Activation of the cholinergic anti-inflammatory system in peripheral blood mononuclear cells from patients with borderline personality disorder.

scientific article

Activity of inducible and neuronal nitric oxide synthases in colonic mucosa predicts progression of ulcerative colitis.

scientific article

Anti-inflammatory effects of Mangifera indica L. extract in a model of colitis

scientific article published on October 2010

Antioxidant defense system and family environment in adolescents with family history of psychosis

scientific article

Aspirin inhibits stress-induced increase in plasma glutamate, brain oxidative damage and ATP fall in rats

scientific article (publication date: 11 February 2002)

Astrocyte-derived MCP-1 mediates neuroprotective effects of noradrenaline.

scientific article published in January 2009

BDNF and NGF Signalling in Early Phases of Psychosis: Relationship With Inflammation and Response to Antipsychotics After 1 Year.

scientific article

Bacterial translocation affects intracellular neuroinflammatory pathways in a depression-like model in rats.

scientific article published on 11 December 2015

Basal low antioxidant capacity correlates with cognitive deficits in early onset psychosis. A 2-year follow-up study

scientific article published on 24 April 2014

Behavioral, neurochemical and morphological changes induced by the overexpression of munc18-1a in brain of mice: relevance to schizophrenia.

scientific article

Birth weight, working memory and epigenetic signatures in IGF2 and related genes: a MZ twin study

scientific article

Building up careers in translational neuroscience and mental health research: Education and training in the Centre for Biomedical Research in Mental Health

scientific article

CCL2/MCP-1 modulation of microglial activation and proliferation.

scientific article published on 5 July 2011

Cannabinoid/agonist WIN 55,212-2 reduces cardiac ischaemia–reperfusion injury in Zucker diabetic fatty rats: role of CB2 receptors and iNOS/eNOS.

scientific article published on May 2011

Cerebrospinal fluid and plasma concentrations of nitric oxide metabolites are increased in dementia with Lewy bodies.

scientific article published in November 2002

Chronic Stress Induces the Expression of Inducible Nitric Oxide Synthase in Rat Brain Cortex

scientific article published on 01 February 2000

Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABA(A) receptors

scientific article

Chronic immobilisation stress ameliorates clinical score and neuroinflammation in a MOG-induced EAE in Dark Agouti rats: mechanisms implicated.

scientific article

Cognition and psychopathology in first-episode psychosis: are they related to inflammation?

scientific article

Cognitive impairment is related to oxidative stress and chemokine levels in first psychotic episodes

scientific article published on 22 March 2012

Colonic bacterial translocation as a possible factor in stress-worsening experimental stroke outcome.

scientific article published on 4 February 2009

Comparison of the anti-inflammatory effect of aripiprazole and risperidone in 75 drug-naïve first episode psychosis individuals: A 3 months randomized study

scientific article published on 23 June 2018

Comparison of the antinociceptive effects of ibuprofen arginate and ibuprofen in rat models of inflammatory and neuropathic pain

scientific article published on 20 October 2011

Corticosterone basal levels and vulnerability to LPS-induced neuroinflammation in the rat brain.

scientific article

Decreased glutathione levels predict loss of brain volume in children and adolescents with first-episode psychosis in a two-year longitudinal study

scientific article published on 23 February 2012

Depressive-like states heighten the aversion to painful stimuli in a rat model of comorbid chronic pain and depression

scientific article published in September 2012

Discrimination between Alzheimer's Disease and Late Onset Bipolar Disorder Using Multivariate Analysis

scientific article published on 14 December 2015

Down-regulation of neuronal nitric oxide synthase by nitric oxide after oxygen-glucose deprivation in rat forebrain slices.

scientific article

Dual effects of noradrenaline on astroglial production of chemokines and pro-inflammatory mediators

scientific article published on 9 July 2013

Dual role of nitric oxide in adult neurogenesis

scientific article published on 20 April 2005

Dysregulated peripheral endocannabinoid system signaling is associated with cognitive deficits in first-episode psychosis.

scientific article published on 6 January 2016

Early responses to deep brain stimulation in depression are modulated by anti-inflammatory drugs.

scientific article published on 28 May 2013

Editorial [Hot Topic: Stress-Induced Deleterious Consequences in the Gastrointestinal Tract. (Guest Editors: Juan C. Leza and Luis Menchen)]

scientific article published on 01 June 2008

Effects of peroxisome proliferator-activated receptor gamma agonists on brain glucose and glutamate transporters after stress in rats

scientific article published on 22 November 2006

Effects of the antipsychotic paliperidone on stress-induced changes in the endocannabinoid system in rat prefrontal cortex.

scientific article published on 18 March 2016

Endogenous cannabinoid system regulates intestinal barrier function in vivo through cannabinoid type 1 receptor activation

Evidence of activation of the Toll-like receptor-4 proinflammatory pathway in patients with schizophrenia

scientific article published on 12 April 2016

Expression and Functionality Study of 9 Toll-Like Receptors in 33 Drug-Naïve Non-Affective First Episode Psychosis Individuals: A 3-Month Study

scientific article published on 25 August 2020

Expression and function of tumour necrosis factor-alpha-converting enzyme in the central nervous system

scientific article

Expression of nitrotyrosine and oxidative consequences in the trabecular meshwork of patients with primary open-angle glaucoma

scientific article

Fructose-1,6-bisphosphate inhibits the expression of inducible nitric oxide synthase caused by oxygen-glucose deprivation through the inhibition of glutamate release in rat forebrain slices

scientific article published on 01 September 2000

Glucocorticoid receptor gene (NR3C1) methylation processes as mediators of early adversity in stress-related disorders causality: A critical review.

scientific article published on 11 June 2015

Gut microbiota, innate immune pathways, and inflammatory control mechanisms in patients with major depressive disorder

scientific article published on 21 December 2021

Immature rat brain slices exposed to oxygen-glucose deprivation as an in vitro model of neonatal hypoxic-ischemic encephalopathy

scientific article published in June 2005

Implication of Glutamate in the Expression of Inducible Nitric Oxide Synthase After Oxygen and Glucose Deprivation in Rat Forebrain Slices

scientific article published on 01 May 2000

Implication of TNF-alpha convertase (TACE/ADAM17) in inducible nitric oxide synthase expression and inflammation in an experimental model of colitis

scientific journal article

In vitro ischemic tolerance involves upregulation of glutamate transport partly mediated by the TACE/ADAM17-tumor necrosis factor-alpha pathway.

scientific article published in February 2004

Increased vulnerability to 6-hydroxydopamine lesion and reduced development of dyskinesias in mice lacking CB1 cannabinoid receptors.

scientific article published on 5 May 2009

Inducible nitric oxide synthase activity is expressed not only in inflamed but also in normal colonic mucosa in patients with ulcerative colitis: a potential prognostic marker

scientific article published on 01 May 2000

Induction of cyclooxygenase-2 accounts for restraint stress-induced oxidative status in rat brain.

scientific article

Inflammation in schizophrenia: A question of balance.

scientific article

Inflammatory activation and cholinergic anti-inflammatory system in eating disorders

scientific article published on 25 April 2013

Inhibition of glutamate release by delaying ATP fall accounts for neuroprotective effects of antioxidants in experimental stroke.

scientific article published on 18 September 2003

Inhibition of glutamate release via recovery of ATP levels accounts for a neuroprotective effect of aspirin in rat cortical neurons exposed to oxygen-glucose deprivation

scientific article (publication date: 2002)

Inhibition of iNOS activity by 1400W decreases glutamate release and ameliorates stroke outcome after experimental ischemia

scientific article

Inhibition of morphine withdrawal by lamotrigine: involvement of nitric oxide.

scientific article published in March 1996

Innate immune receptor Toll-like receptor 4 signalling in neuropsychiatric diseases

scientific article published on 19 February 2016

Involvement of IL-1beta in acute stress-induced worsening of cerebral ischaemia in rats

scientific article published on 23 March 2007

Is there a role for the nuclear receptor PPARγ in neuropsychiatric diseases?

scientific article published on 27 August 2010

Mangiferin decreases inflammation and oxidative damage in rat brain after stress

scientific journal article

Mechanisms of the neuroprotective effect of aspirin after oxygen and glucose deprivation in rat forebrain slices

scientific article published on 01 April 2000

Modulation of the antioxidant nuclear factor (erythroid 2-derived)-like 2 pathway by antidepressants in rats.

scientific article published on 11 December 2015

Morphine-induced changes in cerebral and cerebellar nitric oxide synthase activity

scientific article published on 01 October 1995

N-(3-(aminomethyl)benzyl)acetamidine, an inducible nitric oxide synthase inhibitor, decreases colonic inflammation induced by trinitrobenzene sulphonic acid in rats.

scientific article published in June 2001

Neuronal expression of inducible nitric oxide synthase after oxygen and glucose deprivation in rat forebrain slices.

scientific article published in February 1998

Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport

scientific article

Neuroprotective effect of aspirin by inhibition of glutamate release after permanent focal cerebral ischaemia in rats

scientific article (publication date: October 2001)

Nitric oxide synthase activity in human squamous cell carcinoma of the head and neck

scientific article published on 01 January 1999

Noradrenaline induces CX3CL1 production and release by neurons.

scientific article

Oleoylethanolamide prevents neuroimmune HMGB1/TLR4/NF-kB danger signaling in rat frontal cortex and depressive-like behavior induced by ethanol binge administration.

scientific article published on 9 February 2016

Origin and consequences of brain Toll-like receptor 4 pathway stimulation in an experimental model of depression.

scientific article published on 3 November 2011

Paliperidone prevents brain toll-like receptor 4 pathway activation and neuroinflammation in rat models of acute and chronic restraint stress.

scientific article

Paliperidone reverts Toll-like receptor 3 signaling pathway activation and cognitive deficits in a maternal immune activation mouse model of schizophrenia

scientific article

Peripheral endocannabinoid system dysregulation in first-episode psychosis

scientific article published on 04 July 2013

Peroxisome proliferator-activated receptor gamma activation decreases neuroinflammation in brain after stress in rats

scientific journal article

Plasma antioxidant capacity is reduced in Asperger syndrome.

scientific article

Polymorphisms of the IL-1 gene complex are associated with alcohol dependence in Spanish Caucasians: data from an association study

scientific article

Postnatal changes in the nitric oxide system of the rat cerebral cortex after hypoxia during delivery.

scientific article published in May 2003

Pro-/anti-inflammatory dysregulation in patients with first episode of psychosis: toward an integrative inflammatory hypothesis of schizophrenia

scientific article published on 13 March 2013

Pro-/antiinflammatory dysregulation in early psychosis: results from a 1-year follow-up study

scientific article

Regulation of CCL2/MCP-1 production in astrocytes by desipramine and atomoxetine: involvement of α2 adrenergic receptors

scientific article

Regulation of MCP-1 production in brain by stress and noradrenaline-modulating drugs.

scientific article published on 28 January 2010

Regulatory role of cannabinoid receptor 1 in stress-induced excitotoxicity and neuroinflammation.

scientific article

Regulatory role of the cannabinoid CB2 receptor in stress-induced neuroinflammation in mice

scientific article

Relationship between cyclooxygenase-2 and nitric oxide synthase-2 in rat cortex after stress

scientific article published in September 2003

Restraint stress increases neuroinflammation independently of amyloid β levels in amyloid precursor protein/PS1 transgenic mice

scientific article published on 02 December 2010

Risperidone Ameliorates Prefrontal Cortex Neural Atrophy and Oxidative/Nitrosative Stress in Brain and Peripheral Blood of Rats with Neonatal Ventral Hippocampus Lesion

scientific article published on 13 September 2019

Risperidone normalizes increased inflammatory parameters and restores anti-inflammatory pathways in a model of neuroinflammation.

scientific article

Role of nitric oxide after brain ischaemia

scientific article

Stress Increases the Negative Effects of Chronic Pain on Hippocampal Neurogenesis.

scientific article published on 27 July 2015

Stress as a neuroinflammatory condition in brain: damaging and protective mechanisms.

scientific article published on 11 April 2008

Stress increases susceptibility to oxidative/nitrosative mucosal damage in an experimental model of colitis in rats.

scientific article published in October 2004

Stress mediators regulate brain prostaglandin synthesis and peroxisome proliferator-activated receptor-gamma activation after stress in rats

scientific article

Stress-induced increase in extracellular sucrose space in rats is mediated by nitric oxide

scientific article published in May 2002

Stress-induced neuroinflammation: mechanisms and new pharmacological targets.

scientific article published on December 2008

Stress-induced neuroinflammation: role of the Toll-like receptor-4 pathway.

scientific article published on 18 August 2012

Stress-induced oxidative changes in brain

scientific article published on October 2006

Suppression of Immune Parameters in Animal Models of Morphine Dependence

scientific article published on 01 May 1995

Systemic administration of oleoylethanolamide protects from neuroinflammation and anhedonia induced by LPS in rats

scientific article

TACE/ADAM17-TNF-alpha pathway in rat cortical cultures after exposure to oxygen-glucose deprivation or glutamate

scientific journal article

TNF-alpha accounts for short-term persistence of oxidative status in rat brain after two weeks of repeated stress.

scientific article

TNF-alpha converting enzyme (TACE) protein expression in different clinical subtypes of multiple sclerosis

scientific article published on 6 March 2006

TNFR1 upregulation mediates tolerance after brain ischemic preconditioning.

scientific article

The Atypical Antipsychotic Paliperidone Regulates Endogenous Antioxidant/Anti-Inflammatory Pathways in Rat Models of Acute and Chronic Restraint Stress

scientific article published on 27 May 2016

The Role of PPARγ on Restoration of Colonic Homeostasis After Experimental Stress-Induced Inflammation and Dysfunction

scientific article published on 21 February 2007

The anti-inflammatory prostaglandin 15d-PGJ2 and its nuclear receptor PPARgamma are decreased in schizophrenia

scientific article published on 18 February 2011

The anti-inflammatory prostaglandin 15d-PGJ2 decreases oxidative/nitrosative mediators in brain after acute stress in rats.

scientific article

The effects of physical and psychological stress on the gastro-intestinal tract: lessons from animal models

scientific article published on June 2008

The effects of stress on homeostasis in JCR-LA-cp rats: the role of nitric oxide ⬇️

scientific article published on September 1, 1998

The increase in TNF-alpha levels is implicated in NF-kappaB activation and inducible nitric oxide synthase expression in brain cortex after immobilization stress.

scientific article published in February 2002

The nonthiazolidinedione PPARgamma agonist L-796,449 is neuroprotective in experimental stroke.

scientific article

The relationship between prepulse inhibition and general psychopathology in patients with schizophrenia treated with long-acting risperidone.

scientific article published on 28 October 2009

Therapeutic antidepressant potential of a conjugated siRNA silencing the serotonin transporter after intranasal administration

scientific article published on 23 June 2015

Toll-like 4 receptor inhibitor TAK-242 decreases neuroinflammation in rat brain frontal cortex after stress

scientific article published on 11 January 2014

Toll-like receptor 4 is involved in subacute stress-induced neuroinflammation and in the worsening of experimental stroke

scientific article

Toward Omics-Based, Systems Biomedicine, and Path and Drug Discovery Methodologies for Depression-Inflammation Research

scientific article published on 02 May 2015

Up-regulation of neuronal NO synthase immunoreactivity in opiate dependence and withdrawal

scientific article published on 01 January 2000

Upregulation of TACE/ADAM17 after ischemic preconditioning is involved in brain tolerance

scientific article published in November 2002

Use of brain slices in the study of pathogenic role of inducible nitric oxide synthase in cerebral ischemia-reperfusion.

scientific article

[Inflammatory/anti-inflammatory mechanisms in the brain following exposure to stress]

scientific article published on 01 June 2008

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