List of works - Darell D. Bigner

-OMICS AND PROGNOSTIC MARKERS

scientific article published on 21 October 2011

125I-labeled anti-epidermal growth factor receptor-vIII single-chain Fv exhibits specific and high-level targeting of glioma xenografts.

scientific article published on June 1999

2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations

scientific article

A controlled study of efficacy of interstitial or external irradiation in a virus-induced brain-tumor model in rats

scientific article published in December 1989

A genetically modified allogeneic cellular vaccine generates MHC class I-restricted cytotoxic responses against tumor-associated antigens and protects against CNS tumors in vivo ⬇️

scientific article published on September 1, 1997

A genetically tractable model of human glioma formation.

scientific article published in May 2001

A glial fibrillary acidic protein-expressing and tumorigenic cell line derived from an avian sarcoma virus-induced rat astrocytoma

scientific article published on November 1986

A mechanism underlying the lack of a blood-brain barrier to peroxidase in virally induced brain tumors

scientific article

A model for human medulloblastoma. Growth, morphology, and chromosomal analysis in vitro and in athymic mice

scientific article

A monoclonal antibody IMab-1 specifically recognizes IDH1R132H, the most common glioma-derived mutation

scientific article published on 07 October 2009

A new ganglioside of the lactotetraose series, GalNAc-3'-isoLM1, detected in human meconium.

scientific article published in July 1989

A novel bispecific antibody recruits T cells to eradicate tumors in the "immunologically privileged" central nervous system

scientific article published on April 2013

A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth

scientific article published on June 2007

A novel method for volumetric MRI response assessment of enhancing brain tumors

scientific article

A novel recombinant immunotoxin-based therapy targeting wild-type and mutant EGFR improves survival in murine models of glioblastoma

scientific article published on 22 October 2013

A panel of antibodies useful in the cytologic diagnosis of metastatic melanoma

scientific article published on 01 May 1990

A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma: the ACT III study

scientific article

A pial window model for the intracranial study of human glioma microvascular function

scientific article published on May 1995

A pilot study of IL-2Rα blockade during lymphopenia depletes regulatory T-cells and correlates with enhanced immunity in patients with glioblastoma

scientific article (publication date: 2012)

A pilot study: 131I-antitenascin monoclonal antibody 81c6 to deliver a 44-Gy resection cavity boost

scientific article

A preliminary study utilizing viable HLA mismatched cultured glioma cells as adjuvant therapy for patients with malignant gliomas

scientific article

A rapidly dividing human medulloblastoma cell line (D283 MED) expresses all three neurofilament subunits

scientific article published in February 1987

A rationally designed fully human EGFRvIII:CD3-targeted bispecific antibody redirects human T cells to treat patient-derived intracerebral malignant glioma.

scientific article published on 27 April 2018

A review of VEGF/VEGFR-targeted therapeutics for recurrent glioblastoma

scientific article

A serially transplantable human giant cell glioblastoma that maintains a near-haploid stem line.

scientific article published in October 1985

A sphingosine kinase inhibitor induces cell death in temozolomide resistant glioblastoma cells

scientific article published on 12 July 2009

A structural basis for a phosphoramide mustard-induced DNA interstrand cross-link at 5'-d(GAC)

scientific article

A word of caution in the use of neuron-specific enolase expression in tumor diagnosis

scientific article published on 01 July 1984

AAL881, a novel small molecule inhibitor of RAF and vascular endothelial growth factor receptor activities, blocks the growth of malignant glioma

scientific article published on September 2006

AJAP1 expression modulates glioma cell motility and correlates with tumor growth and survival

scientific article published in November 2017

AT-21FINAL RESULTS OF A PHASE 1 TRIAL OF AN ONCOLYTIC POLIO/RHINOVIRUS RECOMBINANT (PVSRIPO) AGAINST RECURRENT GLIOBLASTOMA (GBM).

scientific article

Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells

scientific article

Abstracts

article by L. Bie et al published 1 April 2013 in Neuro-Oncology

Acknowledgment to Reviewers for Neuro-Oncology

scientific article published in April 2006

Acknowledgment to Reviewers for Neuro-Oncology

scientific article published in April 2004

Acknowledgment to Reviewers for Neuro-Oncology.

scientific article published in April 2005

Activity of 9-dimethylaminomethyl-10-hydroxycamptothecin against pediatric and adult central nervous system tumor xenografts

scientific article published in January 1994

Activity of VNP40101M (Cloretazine) in the treatment of CNS tumor xenografts in athymic mice

scientific article published on 23 May 2007

Activity of intrathecal 4-hydroperoxycyclophosphamide in a nude rat model of human neoplastic meningitis.

scientific article published on March 1990

Activity of irofulven (6-hydroxymethylacylfulvene) in the treatment of glioblastoma multiforme-derived xenografts in athymic mice

scientific article published in November 2001

Activity of temozolomide in the treatment of central nervous system tumor xenografts

scientific article

Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities

scientific article published on 2 November 2017

Affinity-matured anti-glycoprotein NMB recombinant immunotoxins targeting malignant gliomas and melanomas

scientific article

Affinity-matured recombinant immunotoxin targeting gangliosides 3'-isoLM1 and 3',6'-isoLD1 on malignant gliomas

scientific article published on 25 July 2013

Alterations of the TP53 gene in human gliomas

scientific article

Altered expression of ganglioside phenotypes of human gliomas in vivo and in vitro ⬇️

scientific article published on February 1, 1994

Altered telomeres in tumors with ATRX and DAXX mutations

scientific article

Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts.

scientific article published in April 1988

Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts

scientific article published on April 1990

An epidermal growth factor receptor variant III-targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme

scientific article

An improved method of preparing Schmidt-Ruppin Rous sarcoma virus for brain tumor induction in mammals

scientific article published in April 1970

An integrated genomic analysis of human glioblastoma multiforme

scientific article

Analysis of DNA mismatch repair proteins in human medulloblastoma.

scientific article published in June 1998

Anaplastic human gliomas grown in athymic mice. Morphology and glial fibrillary acidic protein expression ⬇️

scientific article published on December 1, 1981

Anti-EGFRvIII monoclonal antibody armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligands ⬇️

scientific article published on October 1, 2010

Anti-GM2 monoclonal antibodies induce necrosis in GM2-rich cultures of a human glioma cell line

scientific article published on September 1991

Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma ⬇️

scientific article published on June 1, 1990

Antibody, T-cell and dendritic cell immunotherapy for malignant brain tumors

scientific article

Antiepidermal growth factor variant III scFv fragment: effect of radioiodination method on tumor targeting and normal tissue clearance

scientific article published on January 2006

Antigenic heterogeneity of human anaplastic gliomas and glioma-derived cell lines defined by monoclonal antibodies

scientific article published in May 1985

Antigens shared by rat schwannomas, neuroblastomas, and a testicular interstitial cell carcinoma ⬇️

scientific article published on September 1, 1977

Antitenascin antibody 81C6 armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligands

scientific article published on 17 January 2007

Antitenascin-C monoclonal antibody radioimmunotherapy for malignant glioma patients

scientific article published on May 2007

Antitumor efficacy of D2C7-(scdsFv)-PE38KDEL, a novel immunotoxin targeting EGFRwt and EGFRvIII, by convection-enhanced delivery in orthotopic brain tumor mouse models

scientific article published on 7 November 2013

Application of a panel of antiganglioside monoclonal antibodies to cytologic specimens

scientific article published on September 1, 1992

Application of mutagen sensitivity assay in a glioma case-control study.

scientific article

Applications of monoclonal antibodies in the diagnosis and treatment of primary brain tumors

scientific article published on July 1985

Aptamers selected against the unglycosylated EGFRvIII ectodomain and delivered intracellularly reduce membrane-bound EGFRvIII and induce apoptosis

scientific article

Aspects of immunobiology and immunotherapy and uses of monoclonal antibodies and biologic immune modifiers in human gliomas

scientific article

Assessment of type of allergy and antihistamine use in the development of glioma

scientific article

Association between glioma and history of allergies, asthma, and eczema: a case-control study with three groups of controls

scientific article published on 31 March 2009

BCNU-sequestration by metallothioneins may contribute to resistance in a medulloblastoma cell line

scientific article

BLyS levels correlate with vaccine-induced antibody titers in patients with glioblastoma lymphodepleted by therapeutic temozolomide

scientific article

Bevacizumab continuation beyond initial bevacizumab progression among recurrent glioblastoma patients

scientific article

Bevacizumab plus irinotecan in recurrent WHO grade 3 malignant gliomas

scientific article published on November 2008

Bevacizumab plus irinotecan in recurrent glioblastoma multiforme

scientific article published in October 2007

Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway

scientific article published on 04 March 2009

Biology of gliomas: potential clinical implications of glioma cellular heterogeneity.

scientific article published in September 1981

Bispecific antibodies engage T cells for antitumor immunotherapy

scientific article

Blood-brain barrier disruption in immature Fischer 344 rats

scientific article published in April 1984

Bone marrow-derived dendritic cells pulsed with tumor homogenate induce immunity against syngeneic intracerebral glioma

scientific article

Bone marrow-generated dendritic cells pulsed with tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumors

scientific article

Bone-related genes expressed in advanced malignancies induce invasion and metastasis in a genetically defined human cancer model

scientific article published on 17 February 2003

Brain Tumours

Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations

scientific article published on September 2004

Brain tumor types induced by the Schmidt-Ruppin strain of Rous sarcoma virus in inbred Fischer rats

scientific article published in January 1973

Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (iressa).

scientific article published on November 2002

Brain tumors induced in dogs by the Schmidt-Ruppin strain of Rous sarcoma virus. Neuropathological and immunological observations

scientific article published in October 1969

Busulfan therapy of central nervous system xenografts in athymic mice

scientific article published in January 1994

Buthionine sulfoximine-mediated depletion of glutathione in intracranial human glioma-derived xenografts.

scientific article published in November 1988

CAR T Cells Targeting Podoplanin Reduce Orthotopic Glioblastomas in Mouse Brains

scientific article

Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs.

scientific article published in September 2017

Carotid artery injections in 40- to 99-g Fischer rats: technical note and evaluation of blood flow by various injection techniques

scientific article published in April 1984

Cell surface localization and density of the tumor-associated variant of the epidermal growth factor receptor, EGFRvIII ⬇️

scientific article published on September 15, 1997

Cellular Immunity in Rats With Primary Brain Tumors: Inhibition of Macrophage Migration by Soluble Extracts of Avian Sarcoma Virus-Induced Tumors2 ⬇️

scientific article published on June 1, 1976

Cellular redox modulator, ortho Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) in the treatment of brain tumors

scientific article

Central nervous system

scientific article published on January 2010

Cerebral physiology in dogs after brain-tumor induction with Schmidt-Ruppin Rous sarcoma virus: experiences with radioiodinated normal and antiviral immunoglobulin G.

scientific article published in September 1969

Chaperone proteins and brain tumors: potential targets and possible therapeutics

scientific article published on July 2005

Characterization of a spontaneous murine astrocytoma and abrogation of its tumorigenicity by cytokine secretion

scientific article

Characterization of cDNA encoding mouse DNA repair protein O6-methylguanine-DNA methyltransferase and high-level expression of the wild-type and mutant proteins in Escherichia coli

scientific article published on February 25, 1992

Characterization of chromosome 17 abnormalities in medulloblastomas

scientific article published on April 2000

Characterization of new gangliosides of the lactotetraose series in murine xenografts of a human glioma cell line.

scientific article published in May 1986

Characterization of the binding epitope of the monoclonal antibody DMAb-1 to ganglioside GM2 ⬇️

scientific article published on April 17, 1990

Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts.

scientific article published on December 1990

Characterization of the mechanisms of busulfan resistance in a human glioblastoma multiforme xenograft ⬇️

scientific article published on January 1, 1997

Characterization of three restricted specificity monoclonal antibodies raised against the human glioma cell line D-54 MG ⬇️

scientific article published on June 1, 1984

Chemotherapy and novel therapeutic approaches in malignant glioma

scientific article

Chemotherapy and radiation therapy of human medulloblastoma in athymic nude mice.

scientific article published in July 1983

Chemotherapy of brain tumors

scientific article published on 01 September 1977

Chemotherapy of subcutaneous and intracranial human medulloblastoma xenografts in athymic nude mice

scientific article (publication date: 1986)

Chimeric anti-tenascin antibody 81C6: increased tumor localization compared with its murine parent.

scientific article published in May 1996

Chromosomal composition of four permanent cultured cell lines derived from human gliomas

scientific article published on December 1983

Chromosomal composition of malignant human gliomas through serial subcutaneous transplantation in athymic mice.

scientific article published in July 1989

Chromosomal evolution in malignant human gliomas starts with specific and usually numerical deviations

scientific article published on June 1986

Chromosomal progression of malignant human gliomas from biopsy to establishment as permanent lines in vitro

scientific article

Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25.

scientific article

Circulating glycoconjugates in CSF of meningioma patients

scientific article published in September 1990

Clinical experience with alpha-particle emitting 211At: treatment of recurrent brain tumor patients with 211At-labeled chimeric antitenascin monoclonal antibody 81C6

scientific article

Clinical utility of a patient-specific algorithm for simulating intracerebral drug infusions

scientific article published on 13 April 2007

Clinico-pathological description of three paediatric medulloblastoma cases with MLL2/3 gene mutations

scientific article

Colocalization of gadolinium-diethylene triamine pentaacetic acid with high-molecular-weight molecules after intracerebral convection-enhanced delivery in humans

scientific article

Combination chemotherapy in vitro exploiting glutamine metabolism of human glioma and medulloblastoma

scientific article published in September 1985

Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition.

scientific article

Compact point-detection fluorescence spectroscopy system for quantifying intrinsic fluorescence redox ratio in brain cancer diagnostics

scientific article

Comparative genomic hybridization analysis of astrocytomas: prognostic and diagnostic implications

scientific article published on August 2004

Comparative localization of glioma-reactive monoclonal antibodies in vivo in an athymic mouse human glioma xenograft model.

scientific article published in May 1987

Comparative localization of murine monoclonal antibody Me1-14 F(ab')2 fragment and whole IgG2a in human glioma xenografts

scientific article

Comparative permeability of different glioma models to horseradish peroxidase

scientific article published on January 1, 1981

Comparison of intratumoral bolus injection and convection-enhanced delivery of radiolabeled antitenascin monoclonal antibodies

scientific article published on 15 April 2006

Comparison of intravenous versus intracarotid therapy with 1,3-bis(2-chloroethyl)-1-nitrosourea in a rat brain tumor model

scientific article published in November 1985

Comparison of monoclonal antibody delivery to intracranial glioma xenografts by intravenous and intracarotid administration.

scientific article published in April 1987

Comparison of various methods for delivering radiolabeled monoclonal antibody to normal rat brain

scientific article published in November 1984

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

article

Comprehensive Characterization of Cancer Driver Genes and Mutations

article

Comprehensive molecular cytogenetic investigation of chromosomal abnormalities in human medulloblastoma cell lines and xenograft

scientific article published in April 2002

Computed tomography of virally induced canine brain tumors: a preliminary report.

scientific article published on August 1981

Concurrent measurements of blood flow and transcapillary transport in xenotransplanted human gliomas in immunosuppressed rats.

scientific article published in July 1987

Consistency of primary brain tumor diagnoses and codes in cancer surveillance systems

scientific article published on January 2004

Construction of an immunotoxin, D2C7-(scdsFv)-PE38KDEL, targeting EGFRwt and EGFRvIII for brain tumor therapy

scientific article published on 15 July 2013

Contained indirect viable-cell membrane immunofluorescence microassay for surface antigen analysis of cells infected with hazardous viruses ⬇️

scientific article published on January 1, 1977

Convection enhanced delivery of macromolecules for brain tumors

scientific article

Correction: Reversing the Warburg effect as a treatment for glioblastoma

scientific article published in Journal of Biological Chemistry

Correlated virological and ultrastructural study of Schmidt-Ruppin Rous sarcoma virus-induced dog brain tumors

scientific article published in January 1971

Correlation of neuropathologic findings, computerized tomographic and high-resolution ultrasound scans of canine avian sarcoma virus-induced brain tumors

scientific article

Cyclophosphamide resistance in medulloblastoma.

scientific article published on October 1992

Cyclophosphamide therapy of medulloblastoma: from the laboratory to the clinic and back again (and again and again).

scientific article published on January 1995

Cytogenetics and molecular genetics: their status and role in understanding the behavior of central nervous system neoplasms

scientific article published on January 1990

Cytogenetics of human brain tumors

scientific article published on July 1990

Cytopathologic characteristics of permanent cell lines derived from anaplastic human gliomas

scientific article published on September 1, 1979

Cytosine methylation and suppression of O6-methylguanine-DNA methyltransferase expression in human rhabdomyosarcoma cell lines and xenografts

scientific article published on January 1, 1992

DNA content and chromosomal composition of malignant human gliomas.

scientific article

DNA content and chromosomes in permanent cultured cell lines derived from malignant human gliomas.

scientific article published in October 1987

DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma

scientific article published in December 1998

Decoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells

scientific article published on November 2010

Deletion of p16 and p15 genes in brain tumors

scientific article (publication date: 15 December 1994)

Deletion or epigenetic silencing of AJAP1 on 1p36 in glioblastoma

scientific article published on 12 January 2012

Deletion-mutant epidermal growth factor receptor in human gliomas: Effect of type II mutation on receptor function ⬇️

scientific article published on August 15, 1991

Demonstration of complex antigenic heterogeneity in a human glioma cell line and eight derived clones by specific monoclonal antibodies ⬇️

scientific article published on July 1, 1983

Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma

scientific article

Design of a novel small peptide targeted against a tumor-specific receptor

scientific article published on August 2000

Detection of amino-terminal extracellular domain of somatostatin receptor 2 by specific monoclonal antibodies and quantification of receptor density in medulloblastoma

scientific article

Detection of glioma-associated gangliosides GM2, GD2, GD3, 3'-isoLM1 3',6'-isoLD1 in central nervous system tumors in vitro and in vivo using epitope-defined monoclonal antibodies.

scientific article

Detection of humoral response in patients with glioblastoma receiving EGFRvIII-KLH vaccines.

scientific article

Determination of gangliosides in six human primary medulloblastomas.

scientific article published in October 1990

Development and validation of a cell-based fluorescent method for measuring antibody affinity

scientific article published on 23 December 2016

Development of a model of melphalan-induced gastrointestinal toxicity in mice

scientific article published on 01 January 1993

Development of a real-time RT-PCR assay for detecting EGFRvIII in glioblastoma samples

scientific article

Development of novel targeted therapies in the treatment of malignant glioma

scientific article published on May 2004

Differential retention of rhodamine 123 by avian sarcoma virus-induced glioma and normal brain tissue of the rat in vivo

scientific article

Differentiation characteristics of newly established medulloblastoma cell lines (D384 Med, D425 Med, and D458 Med) and their transplantable xenografts

scientific article published on June 1991

Dihydrofolate reductase in primary brain tumors, cell cultures of central nervous system origin, and normal brain during fetal and neonatal growth

scientific article

Disialoganglioside GD2 in human neuroectodermal tumor cell lines and gliomas

scientific article published on January 1991

Distribution and dosimetry of I-123-labeled monoclonal antibody 81C6 in patients with anaplastic glioma

scientific article published on June 1, 1993

Distribution of type VI collagen in human gliomas: comparison with fibronectin and glioma-mesenchymal matrix glycoprotein

scientific article

Dosimetry and dose-response relationships in newly diagnosed patients with malignant gliomas treated with iodine-131-labeled anti-tenascin monoclonal antibody 81C6 therapy

scientific article

Dosimetry and radiographic analysis of 131I-labeled anti-tenascin 81C6 murine monoclonal antibody in newly diagnosed patients with malignant gliomas: a phase II study.

scientific article

Dosimetry of 131I-labeled 81C6 monoclonal antibody administered into surgically created resection cavities in patients with malignant brain tumors

scientific article published in April 1999

EGF mutant receptor vIII as a molecular target in cancer therapy

scientific article

EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis

scientific article

EGFR/EGFRvIII-targeted immunotoxin therapy for the treatment of glioblastomas via convection-enhanced delivery

scientific article published on January 2016

EGFRvIII as a promising target for antibody-based brain tumor therapy

scientific article

EGFRvIII-specific chimeric antigen receptor T cells migrate to and kill tumor deposits infiltrating the brain parenchyma in an invasive xenograft model of glioblastoma

scientific article

EGFRvIII-targeted immunotoxin induces antitumor immunity that is inhibited in the absence of CD4+ and CD8+ T cells

scientific article

EGFRvIII-targeted vaccination therapy of malignant glioma

scientific article

ET-28COMBINATION THERAPY WITH MET TYROSINE KINASE INHIBITOR EMD1214063 AND BEVACIZUMAB.

scientific article

Effect of CYP3A-inducing anti-epileptics on sorafenib exposure: results of a phase II study of sorafenib plus daily temozolomide in adults with recurrent glioblastoma

scientific article

Effect of epidermal growth factor on glioma cell growth, migration, and invasion in vitro.

scientific article published on September 1990

Effect of glutamate analogues on brain tumor cell lines

scientific article published in October 1985

Effect of methylprednisolone on radiotherapy of F344 rats with avian sarcoma virus induced gliomas

scientific article

Effects of adrenal cortical steroids and osmotic blood-brain barrier opening on methotrexate delivery to gliomas in the rodent: the factor of the blood-brain barrier ⬇️

scientific article published on July 1, 1982

Effects of glutathione or polyamine depletion on in vivo thermosensitization

scientific article published on 01 March 1992

Efficacy of intracerebral microinfusion of trastuzumab in an athymic rat model of intracerebral metastatic breast cancer.

scientific article published on November 2003

Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan

Elevated expression of podoplanin and its clinicopathological, prognostic, and therapeutic values in squamous non-small cell lung cancer.

scientific article

Endogenous expression of transforming growth factor beta1 inhibits growth and tumorigenicity and enhances Fas-mediated apoptosis in a murine high-grade glioma model

scientific article published in January 1998

Endothelial cell surface expression and binding of factor VIII/von Willebrand factor.

scientific article published in May 1981

Enhanced delivery of a monoclonal antibody F(ab')2 fragment to subcutaneous human glioma xenografts using local hyperthermia.

scientific article published in March 1990

Enhanced melphalan cytotoxicity following buthionine sulfoximine-mediated glutathione depletion in a human medulloblastoma xenograft in athymic mice.

scientific article published in May 1988

Enhanced tumor localization and in vivo stability of a monoclonal antibody radioiodinated using N-succinimidyl 3-(tri-n-butylstannyl)benzoate.

scientific article published in October 1989

Enhancement of irinotecan (CPT-11) activity against central nervous system tumor xenografts by alkylating agents

scientific article published on January 1998

Enhancement of melphalan activity by inhibition of DNA polymerase-alpha and DNA polymerase-beta.

scientific article

Enhancement of melphalan-induced gastrointestinal toxicity in mice treated with regional hyperthermia and BSO-mediated glutathione depletion

scientific article published on January 1, 1992

Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme.

scientific article

Epidermal growth factor ligand-independent, unregulated, cell-transforming potential of a naturally occurring human mutant EGFRvIII gene.

scientific article published on October 1995

Epidermal growth factor receptor VIII peptide vaccination is efficacious against established intracerebral tumors ⬇️

scientific article published on September 15, 2003

Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation

scientific article published on 12 July 2010

Establishment and characterization of the human medulloblastoma cell line and transplantable xenograft D283 Med.

scientific article published in November 1985

Establishment of a melphalan-resistant rhabdomyosarcoma xenograft with cross-resistance to vincristine and enhanced sensitivity following buthionine sulfoximine-mediated glutathione depletion.

scientific article

Evaluation of an internalizing monoclonal antibody labeled using N-succinimidyl 3-[131I]iodo-4-phosphonomethylbenzoate ([131I]SIPMB), a negatively charged substituent bearing acylation agent

scientific article

Evaluation of anti-podoplanin rat monoclonal antibody NZ-1 for targeting malignant gliomas

scientific article

Evaluation of the lipid-soluble diaminopyrimidines, metoprine and etoprine, in the avian sarcoma virus rat glioma model

scientific article published on January 1, 1982

Ex vivo generation of dendritic cells from cryopreserved, post-induction chemotherapy, mobilized leukapheresis from pediatric patients with medulloblastoma

scientific article published on 27 August 2015

Exercise interest and preferences among patients diagnosed with primary brain cancer

scientific article published on 4 July 2006

Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas

scientific article

Exomic sequencing of four rare central nervous system tumor types

scientific article published on April 2013

Experimental allergic encephalomyelitis in Lewis rats bearing avian sarcoma virus-induced brain tumors ⬇️

scientific article published on June 1, 1982

Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents ⬇️

scientific article published on August 1, 1988

Experimental chemotherapy of human medulloblastoma with classical alkylators

scientific article published on June 1986

Experimental gliomas: An autoradiographic study of the endothelial component ⬇️

scientific article published on March 1, 1980

Expression of O6-alkylguanine-DNA alkyltransferase in Mer+ and Mer- human cell extracts probed with specific monoclonal antibodies

scientific article published on 01 January 1989

Expression of O6-methylguanine-DNA methyltransferase in malignant human glioma cell lines.

scientific article published in September 1991

Expression of human fetal brain antigens by human tumors of neuroectodermal origin as defined by monoclonal antibodies ⬇️

scientific article published on January 1, 1982

Expression of murine leukemia virus structural antigens on the surface of chemically induced murine sarcomas

scientific article

Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas

scientific article published on 01 July 1993

Factors influencing the cell type of brain tumors induced in dogs by Schmidt-Ruppin Rous sarcoma virus

scientific article published in October 1972

Fibronectin and glial fibrillary acidic protein expression in normal human brain and anaplastic human gliomas.

scientific article published in January 1982

Five new epitope-defined monoclonal antibodies reactive with GM2 and human glioma and medulloblastoma cell lines.

scientific article published in December 1989

Flunarizine enhancement of melphalan activity against drug-sensitive/resistant rhabdomyosarcoma

scientific article

Fluorine-18-labeled monoclonal antibody fragments: a potential approach for combining radioimmunoscintigraphy and positron emission tomography

scientific article published in August 1992

Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas

scientific article

GD3 expression by cultured human tumor cells of neuroectodermal origin

scientific article

GMab-1, a high-affinity anti-3'-isoLM1/3',6'-isoLD1 IgG monoclonal antibody, raised in lacto-series ganglioside-defective knockout mice

scientific article published on 26 November 2009

GNOSIS: guidelines for neuro-oncology: standards for investigational studies-reporting of phase 1 and phase 2 clinical trials

scientific article published on October 2005

Ganglioside mapping of a human medulloblastoma xenograft

scientific article published in January 1989

Gangliosides in the human glioma cell line U-118 MG grown in culture or as xenografts in nude rats

scientific article published on August 1990

Gene Amplification in Malignant Human Gliomas: Clinical and Histopathologic Aspects ⬇️

scientific article published on May 1, 1988

Gene expression profiling and genetic markers in glioblastoma survival.

scientific article published in May 2005

General immunocompetence of rats bearing avian sarcoma virus-induced intracranial tumors ⬇️

scientific article published on January 1, 1978

Generation and characterization of a mouse/human chimeric antibody directed against extracellular matrix protein tenascin

scientific article published on 01 July 1994

Generation of anti-idiotypic reagents in the EGFRvIII tumor-associated antigen system

scientific article published on 8 December 2001

Glial fibrillary acidic protein synthesized in vitro using messenger RNA from a human glioma cell line.

scientific article published in January 1983

Glial-mesenchymal tropism of in vivo avian sarcoma virus neuro-oncogenesis in rats ⬇️

scientific article published on January 19, 1978

Glioblastoma Multiforme Oncogenomics and Signaling Pathways

scientific article published on April 2009

Glioblastoma multiforme and the epidermal growth factor receptor

scientific article

Glioblastoma multiforme: a review of where we have been and where we are going

scientific article published on August 2009

Glioblastoma proto-oncogene SEC61gamma is required for tumor cell survival and response to endoplasmic reticulum stress

scientific article

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

scientific article (publication date: 7 December 2006)

Glioma-associated antigen expression in oligodendroglial neoplasms. Tenascin and epidermal growth factor receptor

scientific article published on August 2000

Glioma-associated antigens defined by monoclonal antibodies against an avian sarcoma virus-induced rat astrocytoma

scientific article published in December 1986

Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways

scientific article

Glycolipids and glycosyltransferases in permanent cell lines established from human medulloblastomas ⬇️

scientific article published on February 5, 1991

Glycoprotein nonmetastatic melanoma protein B, a potential molecular therapeutic target in patients with glioblastoma multiforme

scientific article

Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma

scientific article

Grey matter edema: the marginal zone of autochthonous virally-induced gliomas

scientific article published in October 1972

Growth and chemotherapeutic response in athymic mice of tumors arising from human glioma-derived cell lines.

scientific article published in July 1981

Growth effects of epidermal growth factor (EGF) and a monoclonal antibody against the EGF receptor on four glioma cell lines

scientific article

Growth, morphology, and serial transplantation of anaplastic human gliomas in athymic mice

scientific article published in January 1983

HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea ⬇️

scientific article

HG-06INHIBITION OF EPIGENETIC REGULATION AS A THERAPY FOR PEDIATRIC HIGH GRADE GLIOMA.

scientific article published on 21 April 2015

Heat shock protein 70-binding protein 1 is highly expressed in high-grade gliomas, interacts with multiple heat shock protein 70 family members, and specifically binds brain tumor cell surfaces

scientific article published on July 2009

Heterogeneity of Genotypic and phenotypic characteristics of fifteen permanent cell lines derived from human gliomas.

scientific article published in May 1981

Heterotransplantation of Human Craniopharyngiomas in Athymic “Nude” Mice ⬇️

scientific article published on April 1, 1979

How heterogeneous are gliomas?

scientific article published on January 1, 1981

Human IgG2 constant region enhances in vivo stability of anti-tenascin antibody 81C6 compared with its murine parent.

scientific article published in October 1998

Human exposure to selected animal neurocarcinogens: a biomarker-based assessment and implications for brain tumor epidemiology

scientific article published on March 2009

Human fetal brain antigen expression common to tumors of neuroectodermal tissue origin ⬇️

scientific article published on August 1, 1982

Human glioma-mesenchymal extracellular matrix antigen defined by monoclonal antibody ⬇️

scientific article published on June 1, 1983

Hydroxyurea synchronization increases mitotic yield in human glioma cell lines.

scientific article published in January 1987

Hyperimmunization of non-human primates with BCG-CW and cultured human glioma-derived cells. Production of reactive antisera and absence of EAE induction.

scientific article published in September 1981

Hyperthermia-Induced Enhancement of Melphalan Activity against a Melphalan-Resistant Human Rhabdomyosarcoma Xenograft

scientific article published on 01 February 1992

Hyperthermic modulation of radiolabelled antibody uptake in a human glioma xenograft and normal tissues.

scientific article published in January 1995

IDENTIFICATION AND PRELIMINARY TREATMENT DATA OF XENOGRAFTS REPRESENTING TCGA-DEFINED SUBTYPES.

scientific article published in July 2014

IDH1 MUTATIONS AS A IMMUNOTHERAPEUTIC TARGET FOR BRAIN TUMORS.

scientific article published in July 2014

IDH1 and IDH2 mutations in gliomas

scientific article

IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma

scientific article published on 03 June 2016

IMCT-19COMBINATION OF ANTITUMOR IMMUNOTHERAPY TARGETED AGAINST CYTOMEGALOVIRUS (CMV) PLUS REGULATORY T-CELL INHIBITION IN PATIENTS WITH NEWLY-DIAGNOSED GLIOBLASTOMA MULTIFORME (GBM).

scientific article

IT-10SYNERGISTIC CELLULAR INTERACTIONS IN ADOPTIVE IMMUNOTHERAPY LEADS TO IMMUNOLOGIC REJECTION OF MALIGNANT GLIOMA.

scientific article

IT-34PILOT STUDY OF COMBINATION OF ANTITUMOR IMMUNOTHERAPY TARGETED AGAINST CYTOMEGALOVIRUS (CMV) PLUS REGULATORY T-CELL INHIBITION IN PATIENTS WITH NEWLY-DIAGNOSED GLIOBLASTOMA MULTIFORME (GBM).

scientific article published in November 2014

Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid

scientific article

Identification of an amplified, highly expressed gene in a human glioma

scientific article

Identification of microbial DNA in human cancer

scientific article

Identification of nitrosourea-resistant human rhabdomyosarcomas by in situ immunostaining of O6-methylguanine-DNA methyltransferase.

scientific article published in January 1993

Identification of p18 INK4c as a tumor suppressor gene in glioblastoma multiforme

scientific article

Identifying potential tumor markers and antigens by database mining and rapid expression screening

scientific article

Imaging of convection enhanced delivery of toxins in humans

scientific article

Immune responses of breast cancer patients to mutated epidermal growth factor receptor (EGF-RvIII, Delta EGF-R, and de2-7 EGF-R).

scientific article

Immunoaffinity purification of human O6-alkylguanine-DNA alkyltransferase using newly developed monoclonal antibodies

scientific article published on January 1990

Immunobiologic aspects of the brain and human gliomas. A review

scientific article published in February 1980

Immunobiology of human gliomas

scientific article published on March 1986

Immunobiology of malignant astrocytomas

scientific article

Immunobiology of primary intracranial tumors ⬇️

scientific article published on July 1, 1977

Immunobiology of primary intracranial tumors. Part 1: studies of the cellular and humoral general immune competence of brain-tumor patients

scientific article published on April 1977

Immunobiology of primary intracranial tumors. Part 7: Active immunization of patients with anaplastic human glioma cells: a pilot study

scientific article

Immunobiology of primary intracranial tumors. Part 8: Serological responses to active immunization of patients with anaplastic gliomas

scientific article

Immunochemical and biochemical characterization of a glioma-associated extracellular matrix glycoprotein

scientific article published in January 1985

Immunofluorescent analysis of expression of the RNA tumor virus major glycoprotein, gp71, on surfaces of virus-producing murine and other mammalian species cell lines ⬇️

scientific article published on March 1, 1977

Immunofluorescent analysis of expression of the RNA tumor virus major glycoprotein, gp71, on the surfaces of normal murine cells ⬇️

scientific article published on March 1, 1977

Immunohistochemical detection of factor VIII/von Willebrand factor in hyperplastic endothelial cells in glioblastoma multiforme and mixed glioma-sarcoma

scientific article published on September 1, 1982

Immunohistochemical detection of the DNA repair enzyme O6-methylguanine-DNA methyltransferase in formalin-fixed, paraffin-embedded astrocytomas.

scientific article published in May 1998

Immunohistochemical study of glial fibrillary acidic protein in avian sarcoma virus-induced gliomas in dogs

scientific article

Immunohistochemistry of the glial fibrillary acidic protein: basic and applied considerations

scientific article

Immunolocalization of laminin in neoplasms of the central and peripheral nervous systems

scientific article

Immunolocalization of monoclonal antibody-defined extracellular matrix antigens in human brain tumors

scientific article

Immunologic Escape After Prolonged Progression-Free Survival With Epidermal Growth Factor Receptor Variant III Peptide Vaccination in Patients With Newly Diagnosed Glioblastoma ⬇️

scientific article published on October 4, 2010

Immunological responses in a patient with glioblastoma multiforme treated with sequential courses of temozolomide and immunotherapy: case study

scientific article published on 13 December 2007

Immunoreactivity, pharmacokinetics and bone marrow dosimetry of intrathecal radioimmunoconjugates

scientific article published on August 1992

Immunotherapy against angiogenesis-associated targets: evidence and implications for the treatment of malignant glioma

scientific article published on May 2008

Immunotherapy and monoclonal antibody therapies

scientific article published on June 1992

Immunotherapy of brain tumors

scientific article published on January 2012

Immunotoxin Therapy for Lung Cancer

scientific article published on January 2017

Immunotoxins that target an oncogenic mutant epidermal growth factor receptor expressed in human tumors.

scientific article published on August 1995

Improved efficacy against malignant brain tumors with EGFRwt/EGFRvIII targeting immunotoxin and checkpoint inhibitor combinations.

scientific article published on 29 May 2019

Improved targeting of an anti-epidermal growth factor receptor variant III monoclonal antibody in tumor xenografts after labeling using N-succinimidyl 5-iodo-3-pyridinecarboxylate

scientific article published on April 1997

Improved techniques for staining and enumerating focus formation in viral infectivity assays

scientific article published on July 1974

Improved therapeutic efficacy of a monoclonal antibody radioiodinated using N-succinimidyl-3-(tri-n-butylstannyl)benzoate ⬇️

scientific article published on August 15, 1991

Improved xenograft targeting of tumor-specific anti-epidermal growth factor receptor variant III antibody labeled using N-succinimidyl 4-guanidinomethyl-3-iodobenzoate

scientific article published in January 2002

In Tribute to Mike Traynor (1939-2009)

scientific article

In memoriam Lucien J. Rubinstein, M.D. (1924-1990).

scientific article published in October 1990

In vitro and in vivo behavior of radiolabeled chimeric anti-EGFRvIII monoclonal antibody: comparison with its murine parent

scientific article published on October 1997

In vitro versus in vivo correlations of chemosensitivity of human medulloblastoma.

scientific article published in November 1984

In vivo growth conditions suppress the expression of ganglioside GM2 and favour that of lacto series gangliosides in the human glioma D-54MG cell line

scientific article published on June 1996

In vivo imaging of intracranial human glioma xenografts comparing specific with nonspecific radiolabeled monoclonal antibodies

scientific article published in February 1986

In vivo measurement of regional brain tissue pH using positron emission tomography

scientific article published in 1984

Increased binding affinity enhances targeting of glioma xenografts by EGFRvIII-specific scFv

scientific article

Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification

scientific article

Increased melphalan activity in intracranial human medulloblastoma and glioma xenografts following buthionine sulfoximine-mediated glutathione depletion.

scientific article published in April 1989

Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma

scientific article published in March 2006

Induction of lethal experimental allergic encephalomyelitis in nonhuman primates and guinea pigs with human glioblastoma multiforme tissue

scientific article published in July 1981

Induction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cells

scientific article

Induction of viral, 7-methyl-guanosine cap-independent translation and oncolysis by mitogen-activated protein kinase-interacting kinase-mediated effects on the serine/arginine-rich protein kinase

scientific article

Influence of age at inoculation on avian oncornavirus-induced brain tumor incidence, tumor morphology, and postinoculation survival in F344 rats ⬇️

scientific article published on June 1, 1977

Influence of glutamine on the growth of human glioma and medulloblastoma in culture.

scientific article published in September 1985

Infrequent p53 gene mutations in medulloblastomas.

scientific article published in September 1991

Integrated genomic analyses identify ERRFI1 and TACC3 as glioblastoma-targeted genes

scientific article

Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea-resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea

scientific article published in January 1997

Intraarterial administration of melphalan for treatment of intracranial human glioma xenografts in athymic rats ⬇️

scientific article published on September 1, 1995

Intraarterial therapy of human glioma xenografts in athymic rats using 4-hydroperoxycyclophosphamide

scientific article published in May 1993

Intracerebral growth of a human glioma tumor line in athymic mice and treatment with procarbazine, 1,3-bis(2-chloroethyl)-1-nitrosourea, aziridinylbenzoquinone, and cis-platinum

scientific article published in June 1983

Intracerebral infusate distribution by convection-enhanced delivery in humans with malignant gliomas: descriptive effects of target anatomy and catheter positioning

scientific article published in February 2007

Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors

scientific article published on 10 April 2008

Intracerebral transplantation of a human glioma line in immunosuppressed rats

scientific article published in March 1984

Intrathecal administration of single-chain immunotoxin, LMB-7 [B3(Fv)-PE38], produces cures of carcinomatous meningitis in a rat model

scientific article

Intrathecal busulfan treatment of human neoplastic meningitis in athymic nude rats.

scientific article published in January 1999

Intrathecal melphalan therapy of human neoplastic meningitis in athymic nude rats

scientific article published on September 1994

Intravenous adenosine selectively increases blood flow to xenotransplanted intracerebral gliomas

scientific article

Invasiveness of human glioma cell lines in vitro: relation to tumorigenicity in athymic mice

scientific article published in January 1987

Investigation of a synthetic peptide as immunogen for a variant epidermal growth factor receptor associated with gliomas.

scientific article published in July 1993

Iodine-125 interstitial irradiation of virally induced dog brain tumours

scientific article published in December 1984

Iodine-131-labeled antitenascin monoclonal antibody 81C6 treatment of patients with recurrent malignant gliomas: phase I trial results

scientific article published in June 1998

Irinotecan therapy in adults with recurrent or progressive malignant glioma

scientific article

Isocitrate dehydrogenase 1: what it means to the neurosurgeon: a review

scientific article published on 12 April 2013

KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation

scientific article

Kinetics and glial fibrillary acidic (GFA) protein production in a transplantable human giant cell glioblastoma (D-212 MG) of near haploid karyotype maintained in an organ culture system. An immunohistochemistry study

scientific article

L-amino acid oxidase (LOX) modulation of melphalan activity against intracranial glioma

scientific article published in January 1997

L-buthionine-sulfoximine-mediated radiosensitization in experimental interstitial radiotherapy of intracerebral D-54 MG glioma xenografts in athymic mice

scientific article published in February 1990

LAB-CELL BIOLOGY AND SIGNALING

LAB-TUMOR MODELS (IN VIVO/IN VITRO)

Labeling monoclonal antibodies and F(ab')2 fragments with the alpha-particle-emitting nuclide astatine-211: preservation of immunoreactivity and in vivo localizing capacity

scientific article

Lactotetraose series ganglioside 3',6'-isoLD1 in tumors of central nervous and other systems in vitro and in vivo.

scientific article

Local hyperthermia improves uptake of a chimeric monoclonal antibody in a subcutaneous xenograft model.

scientific article published in January 1997

Local production of TGF beta1 inhibits cerebral edema, enhances TNF-alpha induced apoptosis and improves survival in a murine glioma model

scientific article published on June 1998

Localization of factor VIII/von Willebrand factor and glial fibrillary acidic protein in the hemangioblastoma: implications for stromal cell histogenesis

scientific article published on 01 January 1982

Localization of fluorine-18-labeled Mel-14 monoclonal antibody F(ab')2 fragment in a subcutaneous xenograft model ⬇️

scientific article published on September 15, 1992

Long term response in a patient with neoplastic meningitis secondary to melanoma treated with (131)I-radiolabeled antichondroitin proteoglycan sulfate Mel-14 F(ab')(2): a case study

scientific article published in May 2001

Long-term Survival in Glioblastoma with Cytomegalovirus pp65-Targeted Vaccination

scientific article published on April 2017

Loss of heterozygosity for 10q loci in human gliomas

scientific article published in July 1992

Loss of phosphatase and tensin homologue increases transforming growth factor beta-mediated invasion with enhanced SMAD3 transcriptional activity

scientific article published on December 2005

Lymphocyte subpopulations and responsiveness in rats bearing intracranial tumors induced by avian sarcoma virus

scientific article

M. Stephen Mahaley, Jr., M.D., Ph.D., 1932-1992

scientific article published on December 1, 1992

MEDULLOBLASTOMA

MRP3: a molecular target for human glioblastoma multiforme immunotherapy

scientific article

Malignant brainstem gliomas in adults: clinicopathological characteristics and prognostic factors

scientific article published on 17 May 2014

Mechanism of anti-glioma activity and in vivo efficacy of the cannabinoid ligand KM-233.

scientific article published on 9 August 2012

Mechanisms of resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea in human medulloblastoma and rhabdomyosarcoma.

scientific article published in July 2002

Medical diagnostic radiation exposures and risk of gliomas

scientific article

Medulloblastoma cell-substrate interaction in vitro

scientific article published on January 1, 1991

Medulloblastoma: tumor biological and clinical perspectives

scientific article published on August 1991

Melphalan transport, glutathione levels, and glutathione-S-transferase activity in human medulloblastoma ⬇️

scientific article published on October 1, 1988

Melphalan-induced toxicity in nude mice following pretreatment with buthionine sulfoximine.

scientific article published in January 1991

Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft ⬇️

scientific article published on July 15, 1997

Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a phase II study

scientific article

MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B.

scientific article published on January 2016

Mibefradil, a novel therapy for glioblastoma multiforme: cell cycle synchronization and interlaced therapy in a murine model

scientific article

Microvascular abnormalities in virally-induced canine brain tumors. Structural bases for altered blood-brain barrier function

scientific article

Mismatch repair deficiency does not mediate clinical resistance to temozolomide in malignant glioma

scientific article

Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase

scientific article published on January 1999

Molecular genetic aspects of oligodendrogliomas including analysis by comparative genomic hybridization

scientific article published on August 1999

Molecular markers of prognosis in astrocytic tumors

scientific article

Molecular pathogenesis of malignant gliomas

scientific article

Monitoring radiographic brain tumor progression

scientific article

Monoclonal antibodies for brain tumour treatment

scientific article published in September 2004

Monoclonal antibodies reactive with epitopes restricted to glial fibrillary acidic proteins of several species

scientific article published in January 1985

Monoclonal antibodies to growth factors and growth factor receptors: their diagnostic and therapeutic potential in brain tumors

scientific article published on December 1997

Monoclonal antibodies to malignant human gliomas

scientific article

Monoclonal antibody and F(ab')2 fragment delivery to tumor in patients with glioma: comparison of intracarotid and intravenous administration.

scientific article published in July 1990

Monoclonal antibody blockade of IL-2 receptor α during lymphopenia selectively depletes regulatory T cells in mice and humans

scientific article

Monoclonal antibody localization in subcutaneous and intracranial human glioma xenografts: paired-label and imaging analysis

scientific article published in May 1984

Monoclonal antibody therapy of human gliomas: current status and future approaches

scientific article

Morphologic observations of brain tumors in PD4 hamsters induced by four strains of avian sarcoma virus

scientific article published in January 1973

Mouse/human chimeric Me1-14 antibody: genomic cloning of the variable region genes, linkage to human constant region genes, expression, and characterization

scientific article published on April 1994

Multiple DNA repair mechanisms and alkylator resistance in the human medulloblastoma cell line D-283 Med (4-HCR).

scientific article published on January 1999

Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase--a key enzyme in lacto-neolacto ganglioside synthesis

scientific article

Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression

scientific article published on February 2017

Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting

scientific article published on September 2006

Mutant metabolic enzymes are at the origin of gliomas

scientific article published on December 2009

Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma

scientific article published on December 2008

Mutations in CIC and FUBP1 contribute to human oligodendroglioma

scientific article (publication date: 9 September 2011)

Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas

scientific article

Mutations of PIK3CA in Anaplastic Oligodendrogliomas, High-Grade Astrocytomas, and Medulloblastomas

Mutations of the BRAF gene in human cancer

scientific article (publication date: 27 June 2002)

Myeloablative temozolomide enhances CD8⁺ T-cell responses to vaccine and is required for efficacy against brain tumors in mice

scientific article

N-succinimidyl 3-[211At]astato-4-guanidinomethylbenzoate: an acylation agent for labeling internalizing antibodies with alpha-particle emitting 211At

scientific article published in May 2003

NEURO/MEDICAL ONCOLOGY

NEXT-GENERATION RECOMBINANT IMMUNOTOXINS FOR GLIOBLASTOMAS AND MELANOMAS TREATMENT.

scientific article published in July 2014

Neurological disorders with abnormalities of immunoglobulin metabolism.

scientific article

Novel human IgG2b/murine chimeric antitenascin monoclonal antibody construct radiolabeled with 131I and administered into the surgically created resection cavity of patients with malignant glioma: phase I trial results

scientific article

Novel role of hematopoietic stem cells in immunologic rejection of malignant gliomas

scientific article published on 22 January 2015

O (4)-benzylfolic acid inactivates O (6)-alkylguanine-DNA alkyltransferase in brain tumor cell lines

scientific article published on 27 February 2007

O6-alkylguanine-DNA alkyltransferase and sensitivity to procarbazine in human brain-tumor xenografts

scientific article published in April 1989

O6-benzylguanine-mediated enhancement of chemotherapy.

scientific article published in September 2002

O6-benzylguanine-mediated enhancement of nitrosourea activity in Mer- central nervous system tumor xenografts--implications for clinical trials.

scientific article published in January 2000

ONCOLYTIC POLIO/RHINOVIRUS RECOMBINANT (PVSRIPO) IN RECURRENT GLIOBLASTOMA (GBM): FIRST PHASE I CLINICAL TRIAL EVALUATING THE INTRATUMORAL ADMINISTRATION.

scientific article published in July 2014

ONCOLYTIC POLIOVIRUS IMMUNOTHERAPY OF GLIOBLASTOMA.

scientific article published in July 2014

OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas

scientific article published on 22 December 2009

Occurrence of lacto series gangliosides 3'-isoLM1 and 3',6'-isoLD1 in human gliomas in vitro and in vivo

scientific article published on November 1991

Oncogene amplification in pediatric brain tumors.

scientific article published in May 1990

Oncogenes and anti-oncogenes in human central nervous system tumors

scientific article published on 01 November 1994

Oncolytic polio virotherapy of cancer

scientific article

Oncolytic poliovirus directs tumor antigen presentation and T cell activation in vitro.

scientific article published on 4 November 2015

Overall survival of newly diagnosed glioblastoma patients receiving carmustine wafers followed by radiation and concurrent temozolomide plus rotational multiagent chemotherapy

scientific article

PTEN gene mutations are seen in high-grade but not in low-grade gliomas.

scientific article published in October 1997

Partial purification and characterization of a murine glioma-associated antigen defined by syngeneic rat monoclonal antibodies.

scientific article published in December 1986

Patient-derived DIPG cells preserve stem-like characteristics and generate orthotopic tumors

scientific article published on 28 July 2017

Patterns of the early, gross chromosomal changes in malignant human gliomas.

scientific article published in January 1984

Peripheral polyneuropathy, high and low molecular weight IgM, and amyloidosis

scientific article published in April 1971

Permeability of different experimental brain tumor models to horseradish peroxidase.

scientific article published on March 1982

Pharmacokinetics and tumor localization of 131I-labeled anti-tenascin monoclonal antibody 81C6 in patients with gliomas and other intracranial malignancies.

scientific article published in May 1989

Phase 1 trial of gefitinib plus sirolimus in adults with recurrent malignant glioma

scientific article

Phase 1 trial of irinotecan plus BCNU in patients with progressive or recurrent malignant glioma

scientific article published on April 2004

Phase 1 trial study of 131I-labeled chimeric 81C6 monoclonal antibody for the treatment of patients with non-Hodgkin lymphoma

scientific article published on 20 April 2004

Phase 2 trial of BCNU plus irinotecan in adults with malignant glioma

scientific article published on April 2004

Phase I studies of treatment of malignant gliomas and neoplastic meningitis with 131I-radiolabeled monoclonal antibodies anti-tenascin 81C6 and anti-chondroitin proteoglycan sulfate Me1-14 F (ab')2--a preliminary report

scientific article published on 01 January 1995

Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma

scientific article published in November 1998

Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma

scientific article

Phase I trial of temozolomide plus O6-benzylguanine 5-day regimen with recurrent malignant glioma

scientific article

Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma

scientific article

Phase I trial results of iodine-131-labeled antitenascin monoclonal antibody 81C6 treatment of patients with newly diagnosed malignant gliomas.

scientific article published in November 2000

Phase II study of Cloretazine for the treatment of adults with recurrent glioblastoma multiforme

scientific article

Phase II trial of Gliadel plus O6-benzylguanine in adults with recurrent glioblastoma multiforme

scientific article published on February 2009

Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma

scientific article published in February 2007

Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma

scientific article published on May 2002

Phase II trial of gefitinib in recurrent glioblastoma

scientific article published on 24 November 2003

Phase II trial of murine (131)I-labeled antitenascin monoclonal antibody 81C6 administered into surgically created resection cavities of patients with newly diagnosed malignant gliomas

scientific article published in March 2002

Phase II trial of temozolomide in patients with progressive low-grade glioma

scientific article

Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma

scientific article

Phenotypic analysis of four human medulloblastoma cell lines and transplantable xenografts

scientific article published on January 1989

Phosphorylation of Glutathione S-Transferase P1 (GSTP1) by Epidermal Growth Factor Receptor (EGFR) Promotes Formation of the GSTP1-c-Jun N-terminal kinase (JNK) Complex and Suppresses JNK Downstream Signaling and Apoptosis in Brain Tumor Cells

scientific article published in October 2015

Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft

scientific article published in September 2005

Positive therapeutic interaction between thiopurines and alkylating drugs in human glioma xenografts.

scientific article published in January 1991

Positively charged templates for labeling internalizing antibodies: comparison of N-succinimidyl 5-iodo-3-pyridinecarboxylate and the D-amino acid peptide KRYRR.

scientific article

Preclinical toxicity evaluation of a novel immunotoxin, D2C7-(scdsFv)-PE38KDEL, administered via intracerebral convection-enhanced delivery in rats

scientific article published on 4 January 2016

Preparation and characterization of anti-tenascin monoclonal antibody-streptavidin conjugates for pretargeting applications.

scientific article published in September 1999

Primary brain tumor incidence rates in four United States regions, 1985-1989: a pilot study

scientific article published in January 1996

Primary brain tumours in Fischer 344 rats chronically exposed to acrylonitrile in their drinking-water

scientific article published in February 1986

Production and characterization of antipeptide antibodies against human O6-methylguanine-DNA methyltransferase

scientific article published on 01 July 1991

Production and characterization of two ependymoma xenografts

scientific article published on May 1996

Production and characterization of two human glioma xenograft-localizing monoclonal antibodies

scientific article published in November 1986

Production and quality control assessment of a GLP-grade immunotoxin, D2C7-(scdsFv)-PE38KDEL, for a phase I/II clinical trial

scientific article published on 24 December 2016

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

scientific article

Prognostic applications of the epidermal growth factor receptor and its ligand, transforming growth factor-alpha

scientific article published in June 1998

Prognostic implications of chromosome 17p deletions in human medulloblastomas

scientific article published on 01 January 1995

Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

scientific article published on 11 March 2016

Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malig

scientific article published in October 2003

Proteasome inhibition with bortezomib induces cell death in GBM stem-like cells and temozolomide-resistant glioma cell lines, but stimulates GBM stem-like cells' VEGF production and angiogenesis

scientific article

Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy

scientific article

Proteomic and immunologic analyses of brain tumor exosomes

scientific article published on 24 December 2008

QOL-20LOW-DOSE NALTREXONE IN NEWLY DIAGNOSED HIGH-GRADE GLIOMA: PLACEBO-CONTROLLED, DOUBLE-BLIND, RANDOMIZED PILOT STUDY.

scientific article

Quantitative analysis of O6-alkylguanine-DNA alkyltransferase in malignant glioma

scientific article published in October 2006

R-type virus-like particles in avian sarcoma virus-induced rat central nervous system tumors

scientific article published on June 1975

Radioimmunotargeting of malignant glioma by monoclonal antibody D2C7 reactive against both wild-type and variant III mutant epidermal growth factor receptors

scientific article published on 29 September 2011

Radioimmunotherapy of intracerebral human glioma xenografts with 131I-labeled F(ab')2 fragments of monoclonal antibody Mel-14.

scientific article published on March 1990

Radioimmunotherapy of neoplastic meningitis in rats using an alpha-particle-emitting immunoconjugate

scientific article published on 01 September 1994

Radioimmunotherapy with alpha-particle emitting radioimmunoconjugates

scientific article published on January 1996

Radioiodination of a monoclonal antibody using N-succinimidyl 5-iodo-3-pyridinecarboxylate

scientific article published on 01 October 1993

Radioiodination of internalizing monoclonal antibodies using N-succinimidyl 5-iodo-3-pyridinecarboxylate.

scientific article published on November 1996

Radioiodination via D-amino acid peptide enhances cellular retention and tumor xenograft targeting of an internalizing anti-epidermal growth factor receptor variant III monoclonal antibody.

scientific article published on August 2000

Radiotoxicity of systematically administered [211At]astatide in B6C3F1 and BALB/c (nu/nu) mice: a long-term survival study with histologic analysis

scientific article published on 01 April 1996

Radiotoxicity of systemically administered 211At-labeled human/mouse chimeric monoclonal antibody: a long-term survival study with histologic analysis

scientific article

Randomized comparison of diaziquone and carmustine in the treatment of adults with anaplastic glioma

scientific article published in January 1993

Rapid Reprogramming of Primary Human Astrocytes into Potent Tumor-Initiating Cells with Defined Genetic Factors

scientific article published on 30 June 2016

Rate of buthionine sulfoximine entry into brain and xenotransplanted human gliomas.

scientific article

Re: Toxicity of intrathecal melphalan

scientific article published on June 1994

Recent advances in the biology of central nervous system tumors.

scientific article published in December 1997

Recent advances in the treatment of malignant astrocytoma

scientific article

Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII) ⬇️

scientific article published on June 15, 1997

Recombinant anti-podoplanin (NZ-1) immunotoxin for the treatment of malignant brain tumors

scientific article

Recombinant immunotoxins specific for a mutant epidermal growth factor receptor: targeting with a single chain antibody variable domain isolated by phage display

scientific article published on December 1996

Recombinant oncolytic poliovirus, PVSRIPO, has potent cytotoxic and innate inflammatory effects, mediating therapy in human breast and prostate cancer xenograft models

scientific article published on 28 October 2016

Recombinant single-chain variable fragment antibodies against extracellular epitopes of human multidrug resistance protein MRP3 for targeting malignant gliomas

scientific article

Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis

scientific article published on 17 October 2013

Recurrent Glioblastoma Treated with Recombinant Poliovirus.

scientific article

Redox properties of cytochrome oxidase and vascular reactivity of astrocytomas and neuroblastomas in vivo ⬇️

scientific article published on May 1, 1979

Regional localization of a glioma-associated antigen defined by monoclonal antibody 81C6 in vivo: kinetics and implications for diagnosis and therapy

scientific article published in August 1987

Regional measurements of blood flow in experimental RG-2 rat gliomas

scientific article published in July 1983

Regional measurements of blood-to-tissue transport in experimental RG-2 rat gliomas.

scientific article published in July 1983

Regional treatment of epidermal growth factor receptor vIII-expressing neoplastic meningitis with a single-chain immunotoxin, MR-1.

scientific article

Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody

scientific article published on 22 October 2013

Relationship between gene amplification and chromosomal deviations in malignant human gliomas

scientific article published in November 1987

Relationship of in vitro morphologic and growth characteristics of established human glioma-derived cell lines to their tumorigenicity in athymic nude mice.

scientific article published in July 1981

Relationship of the demonstration of intermediate filament protein to kinetics of three human neuroepithelial tumor cell lines. Lack of neural-related proteins in most cells in S phase: a double-labeled immunohistochemical study on matrix cultures.

scientific article

Relevance for neurobiology and neurooncology of antigens of malignant gliomas as defined by monoclonal antibodies

scientific article published on January 1988

Repair analysis of 4-hydroperoxycyclophosphamide-induced DNA interstrand crosslinking in the c-myc gene in 4-hydroperoxycyclophosphamide-sensitive and -resistant medulloblastoma cell lines

scientific article

Resistance to tyrosine kinase inhibition by mutant epidermal growth factor receptor variant III contributes to the neoplastic phenotype of glioblastoma multiforme

scientific article published on May 2004

Reversing the Warburg effect as a treatment for glioblastoma

scientific article published on 13 February 2013

SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility.

scientific article

Salvage radioimmunotherapy with murine iodine-131-labeled antitenascin monoclonal antibody 81C6 for patients with recurrent primary and metastatic malignant brain tumors: phase II study results.

scientific article published in January 2006

Sample type bias in the analysis of cancer genomes

scientific article published on 30 June 2009

Schedule-dependent activity of irinotecan plus BCNU against malignant glioma xenografts

scientific article published in January 2000

Schedule-dependent activity of temozolomide plus CPT-11 against a human central nervous system tumor-derived xenograft.

scientific article published in October 2000

Secreted protein acidic, rich in cysteine (SPARC), mediates cellular survival of gliomas through AKT activation

scientific article

Selection of novel affinity-matured human chondroitin sulfate proteoglycan 4 antibody fragments by yeast display

scientific article published on 28 July 2017

Sequential adsorption analysis of antibodies to neuroectodermal cells by an indirect quantitative method

scientific article published in June 1976

Simultaneous measurements of blood flow and blood-to-tissue transport in xenotransplanted medulloblastomas.

scientific article published in March 1987

Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types

scientific article

Some structural aspects of dog brain tumors induced with the Schmidt-Ruppin strain of the Rous sarcoma virus

scientific article published in January 1972

Spatial distribution of proliferating cells in avian sarcoma virus-induced gliomas ⬇️

scientific article published on February 1, 1983

Specific chromosomal abnormalities characterize four established cell lines derived from malignant human gliomas

scientific article published on January 1986

Specific chromosomal abnormalities in malignant human gliomas

scientific article published in January 1988

Specific imaging of human brain tumor xenografts utilizing radiolabelled monoclonal antibodies (MAbs).

scientific article published in December 1986

Specificity and sensitivity of immunohistochemical detection of factor VIII/von Willebrand factor antigen in formalin-fixed paraffin-embedded tissue

scientific article published on 01 April 1982

Specificity, cross-reactivity, and affinity of 125I-labeled antiglioma antibodies for monolayers of cultured glioma cells.

scientific article

Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor

scientific article (publication date: 15 August 2006)

Structural and immunological comparison of indigenous human O6-methylguanine-DNA methyltransferase with that encoded by a cloned cDNA

scientific article published on 01 January 1991

Structural chromosomal abnormalities in human medulloblastoma

scientific article published in January 1988

Study of glial fibrillary acidic protein in a human glioma cell line grown in culture and as a solid tumor

scientific article published in February 1983

Subcutaneous vaccination with irradiated, cytokine-producing tumor cells stimulates CD8+ cell-mediated immunity against tumors located in the "immunologically privileged" central nervous system

scientific article published on September 1996

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

scientific article

Successful laboratory growth and analysis of CUSA-obtained medulloblastoma samples. Technical note.

scientific article published in May 1990

Successful treatment of childhood pilocytic astrocytomas metastatic to the leptomeninges with high-dose cyclophosphamide.

scientific article published in July 1996

Surface antigenic characteristics of human glial brain tumor cells

scientific article published on December 1977

Surface antigens of human glioma cells shared with normal adult and fetal brain ⬇️

scientific article published on August 1, 1979

Surface morphology of normal and neoplastic rat cells ⬇️

scientific article published on July 1, 1977

Survival analysis of presumptive prognostic markers among oligodendrogliomas.

scientific article published in October 2005

Susceptibility of inbred Fischer rats to brain tumor induction by Rous sarcoma virus

scientific article

Sustained radiographic and clinical response in patient with bifrontal recurrent glioblastoma multiforme with intracerebral infusion of the recombinant targeted toxin TP-38: case study

scientific article published on January 2005

Sym004-induced EGFR elimination is associated with profound anti-tumor activity in EGFRvIII patient-derived glioblastoma models.

scientific article published on 21 March 2018

Synergism between BCNU and irradiation in the treatment of anaplastic gliomas. An in vivo study using the avian sarcoma virus-induced glioma model

scientific article published on November 1979

Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors

scientific article published in PLoS ONE

Synergistic interactions between cyclophosphamide or melphalan and VP-16 in a human rhabdomyosarcoma xenograft

scientific article published on January 1990

Synthesis of radioiodinated N-succinimidyl iodobenzoate: optimization for use in antibody labelling

scientific article published on 01 January 1989

Systemic CTLA-4 blockade ameliorates glioma-induced changes to the CD4+ T cell compartment without affecting regulatory T-cell function

scientific article published in April 2007

Systemic anti-CD25 monoclonal antibody administration safely enhances immunity in murine glioma without eliminating regulatory T cells

scientific article published on July 2006

T Cell Exhaustion Signatures Vary with Tumor Type and are Severe in Glioblastoma

scientific article published on 7 February 2018

TERT PROMOTER MUTATIONS OCCUR FREQUENTLY IN GLIOMAS AND A SUBSET OF TUMORS DERIVED FROM CELLS WITH LOW RATES OF SELF-RENEWAL.

scientific article published in July 2014

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

scientific article published on 31 October 2013

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

scientific article published on 25 March 2013

Targeted alpha-particle radiotherapy with 211At-labeled monoclonal antibodies

scientific article

Targeting SPARC expression decreases glioma cellular survival and invasion associated with reduced activities of FAK and ILK kinases

scientific article published on 8 January 2007

Temozolomide delivered by intracerebral microinfusion is safe and efficacious against malignant gliomas in rats.

scientific article

Tenascin and microvessel stromal changes in patients with non-Hodgkin's lymphoma are isolated to the sites of disease and vary in correlation to disease activity.

scientific article published in October 2005

Tenascin expression in human glioma cell lines and normal tissues

scientific article published on January 1, 1992

Tenascin expression in prostatic hyperplasia, intraepithelial neoplasia, and carcinoma

scientific article published on 01 September 1993

Tenascin-C, over expressed in lung cancer down regulates effector functions of tumor infiltrating lymphocytes

scientific article published in January 2005

Tenascin/hexabrachion in human skin: biochemical identification and localization by light and electron microscopy

scientific article

Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients

scientific article published on 11 March 2015

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

article

The GLI gene is a member of the Kruppel family of zinc finger proteins

scientific article

The GLI-Kruppel family of human genes

scientific article

The Induction of Intracranial Neoplasms by the Inoculation of Avian Sarcoma Virus in Perinatal and Adult Rats ⬇️

scientific article published on July 1, 1975

The Somatic Genomic Landscape of Glioblastoma

article

The addition of bevacizumab to standard radiation therapy and temozolomide followed by bevacizumab, temozolomide, and irinotecan for newly diagnosed glioblastoma

scientific article

The biology of malignant gliomas--a comprehensive survey

scientific article published on May 1, 1984

The class III variant of the epidermal growth factor receptor (EGFRvIII): characterization and utilization as an immunotherapeutic target.

scientific article published in April 1998

The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of rapamycin (RAD001) decreases glioma proliferation and invasion

scientific article published on 31 August 2007

The effect of an amino acid-lowering diet on the rate of melphalan entry into brain and xenotransplanted glioma ⬇️

scientific article published on October 15, 1992

The effect ofl-amino acid oxidase on activity of melphalan against an intracranial xenograft ⬇️

scientific article published on 01 January 1995

The fine structure of canine gliomas and intracranial sarcomas induced by the Schmidt-Ruppin strain of the Rous sarcoma virus

scientific article published in July 1971

The fine structure of intracranial neoplasms induced by the inoculation of avian sarcoma virus in neonatal and adult rats ⬇️

scientific article published on April 1, 1976

The gene expression profiles of medulloblastoma cell lines resistant to preactivated cyclophosphamide

scientific article

The genetic landscape of anaplastic astrocytoma

scientific article

The genetic landscape of the childhood cancer medulloblastoma

scientific article

The heat shock response and chaperones/heat shock proteins in brain tumors: surface expression, release, and possible immune consequences.

scientific article

The history, evolution, and clinical use of dendritic cell-based immunization strategies in the therapy of brain tumors

scientific article

The immunohistochemical application of three anti-GFAP monoclonal antibodies to formalin-fixed, paraffin-embedded, normal and neoplastic brain tissues.

scientific article published in November 1986

The integrated landscape of driver genomic alterations in glioblastoma

scientific article published on 05 August 2013

The lens epithelium contains glial fibrillary acidic protein (GFAP).

scientific article published in June 1985

The ligand binding domain of the epidermal growth factor receptor is not required for receptor dimerization

scientific article published on 01 March 1992

The localisation of radiolabelled murine monoclonal antibody 81C6 and its Fab fragment in human glioma xenografts in athymic mice

scientific article

The morphologic response of cell lines derived from human gliomas to dibutyryl adenosine 3':5'-cyclic monophosphate.

scientific article published in May 1981

The origin of O6-methylguanine-DNA methyltransferase in Chinese hamster ovary cells transfected with human DNA.

scientific article published on September 1991

The potential of monoclonal antibodies as carriers of radiation and drugs for immunodetection and therapy of brain tumors.

scientific article

The radiation dose-response relationship in a human glioma xenograft and an evaluation of the influence of glutathione depletion by buthionine sulfoximine

scientific article published on January 1, 1992

The role of angiogenesis in Group 3 medulloblastoma pathogenesis and survival

scientific article published on 3 April 2017

The role of the subependymal plate in avian sarcoma virus brain tumor induction: comparison of incipient tumors in neonatal and adult rats

scientific article

The role of the subependymal plate in glial tumorigenesis ⬇️

scientific article published on September 26, 1977

The somatic genomic landscape of glioblastoma

scientific article

The use of a panel of monoclonal antibodies in the evaluation of cytologic specimens from the central nervous system

scientific article

Therapeutic activity of 7-[(2-trimethylsilyl)ethyl)]-20 (S)-camptothecin against central nervous system tumor-derived xenografts in athymic mice

scientific article published in July 2001

Therapeutic activity of the topoisomerase I inhibitor J-107088 [6-N-(1-hydroxymethyla-2-hydroxyl) ethylamino-12,13-dihydro-13-(beta-D-glucopyranosyl) -5H-indolo[2,3-a]-pyrrolo[3,4-c]-carbazole-5,7(6H)-dione]] against pediatric and adult central nerv

scientific article

Therapeutic analysis of in vitro and in vivo brain tumor models

scientific article published on May 1991

Therapeutic analysis of melphalan-resistant human rhabdomyosarcoma xenograft TE-671 MR ⬇️

scientific article published on August 1, 1991

Therapeutic aspects of chaperones/heat-shock proteins in neuro-oncology

scientific article

Therapeutic efficacy of antiglioma mesenchymal extracellular matrix 131I-radiolabeled murine monoclonal antibody in a human glioma xenograft model

scientific article published in February 1988

Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against pediatric and adult central nervous system tumor xenografts

scientific article published in January 1997

Therapeutic efficacy of vinorelbine against pediatric and adult central nervous system tumors

scientific article published in January 1998

Therapeutic profile of the human glioma line D-54 MG in athymic mice

scientific article

Tissue distribution and radiation dosimetry of astatine-211-labeled chimeric 81C6, an α-particle-emitting immunoconjugate ⬇️

scientific article published on April 1, 1997

Toxin-based targeted therapy for malignant brain tumors

scientific article

Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines

scientific article (publication date: 3 December 1999)

Treatment of HER2-positive breast carcinomatous meningitis with intrathecal administration of alpha-particle-emitting (211)At-labeled trastuzumab

scientific article published on August 2009

Treatment of autochthonous rat brain tumors with fractionated radiotherapy. The effects of graded radiation doses and of combined therapy with BCNU or steroids.

scientific article published in July 1980

Treatment of autochthonous rat brain tumors with steroid plus heparin: a brief report.

scientific article published in January 1987

Treatment of five subcutaneous human glioma tumor lines in athymic mice with carmustine, procarbazine, and mithramycin

scientific article published on September 1, 1983

Treatment of human glioma and medulloblastoma tumor lines in athymic mice with diaziquone and diaziquone-based drug combinations.

scientific article published in June 1984

Treatment of intracranial human glioma xenografts with 131I-labeled anti-tenascin monoclonal antibody 81C6.

scientific article published in May 1988

Treatment of patients with pineoblastoma with high dose cyclophosphamide

scientific article

Tumor antigens in astrocytic gliomas

scientific article published on November 1995

Tumor resection cavity administered iodine-131-labeled antitenascin 81C6 radioimmunotherapy in patients with malignant glioma: neuropathology aspects

scientific article

Tumor-specific anti-epidermal growth factor receptor variant III monoclonal antibodies: use of the tyramine-cellobiose radioiodination method enhances cellular retention and uptake in tumor xenografts ⬇️

scientific article published on October 1, 1995

Tumor-specific immunotherapy targeting the EGFRvIII mutation in patients with malignant glioma

scientific article published on 09 June 2008

Tumorigenic cell culture lines from a spontaneous VM/Dk murine astrocytoma (SMA).

scientific article published on January 1980

Two approaches for enhancing radioimmunotherapy: alpha emitters and hyperthermia

scientific article published on January 1996

Tyrosine phosphorylation of the human glutathione S-transferase P1 by epidermal growth factor receptor

scientific article published on 02 March 2009

Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors

scientific article

Using the theory of planned behavior to understand the determinants of exercise intention in patients diagnosed with primary brain cancer

scientific article published in March 2007

Utility of EGFR and PTEN numerical aberrations in the evaluation of diffusely infiltrating astrocytomas. Laboratory investigation.

scientific article published in February 2008

Validation of an Immunohistochemistry Assay for Detection of CD155, the Poliovirus Receptor, in Malignant Gliomas

scientific article

Vasoactive drugs produce selective changes in flow to experimental brain tumors

scientific article published on December 1985

Virus-cell relationships in dog brain tumors induced with Schmidt-Ruppin Rous sarcoma virus

scientific article published in January 1972

Virus-induced experimental brain tumors and putative associations of viruses with human brain tumors: a review

scientific article published on January 1, 1976

Viruses and oncogenes in brain tumors

scientific article published on May 1997

Work exposures to animal neurocarcinogens

scientific article published in January 2006

ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumors

scientific article published on November 2005

[Significance of monoclonal antibodies in diagnosis and therapy of tumors of the central nervous system]

scientific article published on 01 October 1990

miR-33a promotes glioma-initiating cell self-renewal via PKA and NOTCH pathways

scientific article

List of works by Darell D. Bigner

-OMICS AND PROGNOSTIC MARKERS

125I-labeled anti-epidermal growth factor receptor-vIII single-chain Fv exhibits specific and high-level targeting of glioma xenografts.

2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations

A controlled study of efficacy of interstitial or external irradiation in a virus-induced brain-tumor model in rats

A genetically modified allogeneic cellular vaccine generates MHC class I-restricted cytotoxic responses against tumor-associated antigens and protects against CNS tumors in vivo ⬇️

A genetically tractable model of human glioma formation.

A glial fibrillary acidic protein-expressing and tumorigenic cell line derived from an avian sarcoma virus-induced rat astrocytoma

A mechanism underlying the lack of a blood-brain barrier to peroxidase in virally induced brain tumors

A model for human medulloblastoma. Growth, morphology, and chromosomal analysis in vitro and in athymic mice

A monoclonal antibody IMab-1 specifically recognizes IDH1R132H, the most common glioma-derived mutation

A new ganglioside of the lactotetraose series, GalNAc-3'-isoLM1, detected in human meconium.

A novel bispecific antibody recruits T cells to eradicate tumors in the "immunologically privileged" central nervous system

A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth

A novel method for volumetric MRI response assessment of enhancing brain tumors

A novel recombinant immunotoxin-based therapy targeting wild-type and mutant EGFR improves survival in murine models of glioblastoma

A panel of antibodies useful in the cytologic diagnosis of metastatic melanoma

A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma: the ACT III study

A pial window model for the intracranial study of human glioma microvascular function

A pilot study of IL-2Rα blockade during lymphopenia depletes regulatory T-cells and correlates with enhanced immunity in patients with glioblastoma

A pilot study: 131I-antitenascin monoclonal antibody 81c6 to deliver a 44-Gy resection cavity boost

A preliminary study utilizing viable HLA mismatched cultured glioma cells as adjuvant therapy for patients with malignant gliomas

A rapidly dividing human medulloblastoma cell line (D283 MED) expresses all three neurofilament subunits

A rationally designed fully human EGFRvIII:CD3-targeted bispecific antibody redirects human T cells to treat patient-derived intracerebral malignant glioma.

A review of VEGF/VEGFR-targeted therapeutics for recurrent glioblastoma

A serially transplantable human giant cell glioblastoma that maintains a near-haploid stem line.

A sphingosine kinase inhibitor induces cell death in temozolomide resistant glioblastoma cells

A structural basis for a phosphoramide mustard-induced DNA interstrand cross-link at 5'-d(GAC)

A word of caution in the use of neuron-specific enolase expression in tumor diagnosis

AAL881, a novel small molecule inhibitor of RAF and vascular endothelial growth factor receptor activities, blocks the growth of malignant glioma

AJAP1 expression modulates glioma cell motility and correlates with tumor growth and survival

AT-21FINAL RESULTS OF A PHASE 1 TRIAL OF AN ONCOLYTIC POLIO/RHINOVIRUS RECOMBINANT (PVSRIPO) AGAINST RECURRENT GLIOBLASTOMA (GBM).

Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells

Abstracts

Acknowledgment to Reviewers for Neuro-Oncology

Acknowledgment to Reviewers for Neuro-Oncology

Acknowledgment to Reviewers for Neuro-Oncology.

Activity of 9-dimethylaminomethyl-10-hydroxycamptothecin against pediatric and adult central nervous system tumor xenografts

Activity of VNP40101M (Cloretazine) in the treatment of CNS tumor xenografts in athymic mice

Activity of intrathecal 4-hydroperoxycyclophosphamide in a nude rat model of human neoplastic meningitis.

Activity of irofulven (6-hydroxymethylacylfulvene) in the treatment of glioblastoma multiforme-derived xenografts in athymic mice

Activity of temozolomide in the treatment of central nervous system tumor xenografts

Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities

Affinity-matured anti-glycoprotein NMB recombinant immunotoxins targeting malignant gliomas and melanomas

Affinity-matured recombinant immunotoxin targeting gangliosides 3'-isoLM1 and 3',6'-isoLD1 on malignant gliomas

Alterations of the TP53 gene in human gliomas

Altered expression of ganglioside phenotypes of human gliomas in vivo and in vitro ⬇️

Altered telomeres in tumors with ATRX and DAXX mutations

Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts.

Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts

An epidermal growth factor receptor variant III-targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme

An improved method of preparing Schmidt-Ruppin Rous sarcoma virus for brain tumor induction in mammals

An integrated genomic analysis of human glioblastoma multiforme

Analysis of DNA mismatch repair proteins in human medulloblastoma.

Anaplastic human gliomas grown in athymic mice. Morphology and glial fibrillary acidic protein expression ⬇️

Anti-EGFRvIII monoclonal antibody armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligands ⬇️

Anti-GM2 monoclonal antibodies induce necrosis in GM2-rich cultures of a human glioma cell line

Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma ⬇️

Antibody, T-cell and dendritic cell immunotherapy for malignant brain tumors

Antiepidermal growth factor variant III scFv fragment: effect of radioiodination method on tumor targeting and normal tissue clearance

Antigenic heterogeneity of human anaplastic gliomas and glioma-derived cell lines defined by monoclonal antibodies

Antigens shared by rat schwannomas, neuroblastomas, and a testicular interstitial cell carcinoma ⬇️

Antitenascin antibody 81C6 armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligands

Antitenascin-C monoclonal antibody radioimmunotherapy for malignant glioma patients

Antitumor efficacy of D2C7-(scdsFv)-PE38KDEL, a novel immunotoxin targeting EGFRwt and EGFRvIII, by convection-enhanced delivery in orthotopic brain tumor mouse models

Application of a panel of antiganglioside monoclonal antibodies to cytologic specimens

Application of mutagen sensitivity assay in a glioma case-control study.

Applications of monoclonal antibodies in the diagnosis and treatment of primary brain tumors

Aptamers selected against the unglycosylated EGFRvIII ectodomain and delivered intracellularly reduce membrane-bound EGFRvIII and induce apoptosis

Aspects of immunobiology and immunotherapy and uses of monoclonal antibodies and biologic immune modifiers in human gliomas

Assessment of type of allergy and antihistamine use in the development of glioma

Association between glioma and history of allergies, asthma, and eczema: a case-control study with three groups of controls

BCNU-sequestration by metallothioneins may contribute to resistance in a medulloblastoma cell line

BLyS levels correlate with vaccine-induced antibody titers in patients with glioblastoma lymphodepleted by therapeutic temozolomide

Bevacizumab continuation beyond initial bevacizumab progression among recurrent glioblastoma patients

Bevacizumab plus irinotecan in recurrent WHO grade 3 malignant gliomas

Bevacizumab plus irinotecan in recurrent glioblastoma multiforme

Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway

Biology of gliomas: potential clinical implications of glioma cellular heterogeneity.

Bispecific antibodies engage T cells for antitumor immunotherapy