List of works - Gary R. Mirams

A Local Sensitivity Analysis Method for Developing Biological Models with Identifiable Parameters: Application to L-type Calcium Channel Modelling

A computational study of discrete mechanical tissue models

scientific article published on 15 April 2009

A local sensitivity analysis method for developing biological models with identifiable parameters: Application to cardiac ionic channel modelling

A multiple timescale analysis of a mathematical model of the Wnt/beta-catenin signalling pathway

scientific article

A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt

scientific article published on 10 August 2012

A web portal for in-silico action potential predictions

scientific article

An integrative computational model for intestinal tissue renewal.

scientific article published on 20 July 2009

Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing.

scientific article

Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG.

scientific article published on 14 February 2012

Application of stochastic phenomenological modelling to cell-to-cell and beat-to-beat electrophysiological variability in cardiac tissue

scientific article

Ca(2+) Channel Re-localization to Plasma-Membrane Microdomains Strengthens Activation of Ca(2+)-Dependent Nuclear Gene Expression.

scientific article

Calibration of ionic and cellular cardiac electrophysiology models

scientific article published on 21 February 2020

Cardiac tissue slices: preparation, handling, and successful optical mapping

scientific article

Cellular cardiac electrophysiology modeling with Chaste and CellML.

scientific article

Chaste: A test-driven approach to software development for biological modelling

article

Chaste: Cancer, Heart and Soft Tissue Environment

scientific article published on 13 March 2020

Chaste: an open source C++ library for computational physiology and biology

scientific article

Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials

scientific article published on February 2013

Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century.

scientific article published on 09 April 2016

Defining vitamin D status using multi-metabolite mathematical modelling: A pregnancy perspective

scientific article published on 26 March 2019

Distinguishing possible mechanisms for auxin-mediated developmental control in Arabidopsis: Models with two Aux/IAA and ARF proteins, and two target gene-sets ⬇️

scientific article published on October 31, 2011

Early afterdepolarisation tendency as a simulated pro-arrhythmic risk indicator

scientific article published on 14 September 2017

Evaluation of an in silico cardiac safety assay: using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge

scientific article

Evaluation of computational modelling as a preclinical proarrhythmic safety assay

Functional Curation: Potential Future Directions for SED-ML

scientific article published on 6 September 2011

Hierarchical Bayesian inference for ion channel screening dose-response data

scientific article

High-throughput functional curation of cellular electrophysiology models ⬇️

scientific article published on June 15, 2011

Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential

scientific article

In silico pro-arrhythmia assessment: Can the results of the thorough QT study be predicted?

scholarly article by Gary R. Mirams et al published November 2014 in Journal of Pharmacological and Toxicological Methods

Ion channel model reduction using manifold boundaries

scientific article published in 2022

Is it time for in silico simulation of drug cardiac side effects?

scientific article published on 01 December 2011

Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing.

scientific article

Modelling spatially regulated beta-catenin dynamics and invasion in intestinal crypts

scientific article

Models of the cardiac L‐type calcium current: A quantitative review

scientific article published in 2022

Nonclinical cardiovascular safety of pitolisant: comparing International Conference on Harmonization S7B and Comprehensive in vitro Pro-arrhythmia Assay initiative studies.

scientific article published on 23 September 2017

Novel Voltage Protocols for Determining hERG Channel Kinetics

article published in 2015

Novel approaches to assessing cardiac safety--proceedings of a workshop: regulators, industry and academia discuss the future of in silico cardiac modelling to predict the proarrhythmic safety of drugs

scientific article

Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated Guinea Pig ventricular myocytes

scientific article

Prediction of Thorough QT study results using action potential simulations based on ion channel screens

scientific article

Recent developments in using mechanistic cardiac modelling for drug safety evaluation

scientific article

Representation of Multiple Cellular Phenotypes Within Tissue-Level Simulations of Cardiac Electrophysiology

scholarly article by Louise A Bowler et al published 5 October 2018 in Bulletin of Mathematical Biology

Reproducible model development in the Cardiac Electrophysiology Web Lab

article

Reproducible model development in the cardiac electrophysiology Web Lab

article

Selective recruitment of different Ca2+-dependent transcription factors by STIM1-Orai1 channel clusters.

scientific article published on 7 June 2019

Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk ⬇️

scientific article

Sinusoidal Voltage Protocols For Rapid Characterisation Of Ion Channel Kinetics

Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics.

scientific article published on 24 March 2018

Ten simple rules for effective computational research

scientific article (publication date: March 2014)

Uncertainty and variability in computational and mathematical models of cardiac physiology

scientific article

Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?

scientific article

Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment

scientific article

Voltage protocol design for determining hERG channel kinetics

scholarly article by Kylie Beattie et al published September 2015 in Journal of Pharmacological and Toxicological Methods

cellmlmanip and chaste_codegen: automatic CellML to C++ code generation with fixes for singularities and automatically generated Jacobians

scientific article published on 15 June 2022

mRNA expression levels in failing human hearts predict cellular electrophysiological remodeling: a population-based simulation study

scientific article

List of works by Gary R. Mirams

A Local Sensitivity Analysis Method for Developing Biological Models with Identifiable Parameters: Application to L-type Calcium Channel Modelling

A computational study of discrete mechanical tissue models

A local sensitivity analysis method for developing biological models with identifiable parameters: Application to cardiac ionic channel modelling

A multiple timescale analysis of a mathematical model of the Wnt/beta-catenin signalling pathway

A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt

A web portal for in-silico action potential predictions

An integrative computational model for intestinal tissue renewal.

Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing.

Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG.

Application of stochastic phenomenological modelling to cell-to-cell and beat-to-beat electrophysiological variability in cardiac tissue

Ca(2+) Channel Re-localization to Plasma-Membrane Microdomains Strengthens Activation of Ca(2+)-Dependent Nuclear Gene Expression.

Calibration of ionic and cellular cardiac electrophysiology models

Cardiac tissue slices: preparation, handling, and successful optical mapping

Cellular cardiac electrophysiology modeling with Chaste and CellML.

Chaste: A test-driven approach to software development for biological modelling

Chaste: Cancer, Heart and Soft Tissue Environment

Chaste: an open source C++ library for computational physiology and biology

Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials

Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century.

Defining vitamin D status using multi-metabolite mathematical modelling: A pregnancy perspective

Distinguishing possible mechanisms for auxin-mediated developmental control in Arabidopsis: Models with two Aux/IAA and ARF proteins, and two target gene-sets ⬇️

Early afterdepolarisation tendency as a simulated pro-arrhythmic risk indicator

Evaluation of an in silico cardiac safety assay: using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge

Evaluation of computational modelling as a preclinical proarrhythmic safety assay

Functional Curation: Potential Future Directions for SED-ML

Hierarchical Bayesian inference for ion channel screening dose-response data

High-throughput functional curation of cellular electrophysiology models ⬇️

Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential

In silico pro-arrhythmia assessment: Can the results of the thorough QT study be predicted?

Ion channel model reduction using manifold boundaries

Is it time for in silico simulation of drug cardiac side effects?

Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing.

Modelling spatially regulated beta-catenin dynamics and invasion in intestinal crypts

Models of the cardiac L‐type calcium current: A quantitative review

Nonclinical cardiovascular safety of pitolisant: comparing International Conference on Harmonization S7B and Comprehensive in vitro Pro-arrhythmia Assay initiative studies.

Novel Voltage Protocols for Determining hERG Channel Kinetics

Novel approaches to assessing cardiac safety--proceedings of a workshop: regulators, industry and academia discuss the future of in silico cardiac modelling to predict the proarrhythmic safety of drugs

Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated Guinea Pig ventricular myocytes

Prediction of Thorough QT study results using action potential simulations based on ion channel screens

Recent developments in using mechanistic cardiac modelling for drug safety evaluation

Representation of Multiple Cellular Phenotypes Within Tissue-Level Simulations of Cardiac Electrophysiology

Reproducible model development in the Cardiac Electrophysiology Web Lab

Reproducible model development in the cardiac electrophysiology Web Lab

Selective recruitment of different Ca2+-dependent transcription factors by STIM1-Orai1 channel clusters.

Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk ⬇️

Sinusoidal Voltage Protocols For Rapid Characterisation Of Ion Channel Kinetics

Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics.

Ten simple rules for effective computational research

Uncertainty and variability in computational and mathematical models of cardiac physiology

Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?

Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment

Voltage protocol design for determining hERG channel kinetics

cellmlmanip and chaste_codegen: automatic CellML to C++ code generation with fixes for singularities and automatically generated Jacobians

mRNA expression levels in failing human hearts predict cellular electrophysiological remodeling: a population-based simulation study