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List of works by Birgitte Holst

A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors

scientific article published on 17 November 2009

A gut feeling for obesity: 7TM sensors on enteroendocrine cells

scientific article published in December 2008

A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled ...

scientific article

A second disulfide bridge from the N-terminal domain to extracellular loop 2 dampens receptor activity in GPR39.

scientific article published on 12 August 2008

ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations

scientific article published on 09 January 2019

Acute disruption of glucagon secretion or action does not improve glucose tolerance in an insulin-deficient mouse model of diabetes

scientific article published on 5 November 2015

Acylation type determines ghrelin's effects on energy homeostasis in rodents

scientific article

Ago-allosteric modulation and other types of allostery in dimeric 7TM receptors

scientific article

Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act?

scientific article

An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor

scientific article published on 05 September 2012

An enteroendocrine full package solution

scientific article published on 01 June 2010

Anxiolytic-Like Effects of Increased Ghrelin Receptor Signaling in the Amygdala.

scientific article published on 17 November 2015

Bioorthogonal Labeling of Ghrelin Receptor to Facilitate Studies of Ligand-Dependent Conformational Dynamics

scientific article published on 3 November 2015

C4.4A gene ablation is compatible with normal epidermal development and causes modest overt phenotypes

scientific article published on 12 May 2016

Characterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involved

scientific article (publication date: 20 July 2011)

Common structural basis for constitutive activity of the ghrelin receptor family

scientific article

Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation

scientific article published on March 2004

Deficiency of the GPR39 receptor is associated with obesity and altered adipocyte metabolism

scientific journal article

Development of potent and proteolytically stable human neuromedin U receptor agonists.

scientific article published on 14 December 2017

Dietary fat decreases intestinal levels of the anorectic lipids through a fat sensor

scientific article published on 19 October 2010

Dietary non-esterified oleic Acid decreases the jejunal levels of anorectic N-acylethanolamines

scientific article

Distinct in vitro interaction pattern of dopamine receptor subtypes with adaptor proteins involved in post-endocytotic receptor targeting

scientific article

Divalent Metal Transporter 1 Regulates Iron-Mediated ROS and Pancreatic β Cell Fate in Response to Cytokines

article

Effects of Peripheral Neurotensin on Appetite Regulation and Its Role in Gastric Bypass Surgery

scientific article

Exploring the Behavioral and Metabolic Phenotype Generated by Re-Introduction of the Ghrelin Receptor in the Ventral Tegmental Area.

scientific article published on 26 April 2017

FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver

scientific article published on 22 December 2015

Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity

scientific article

Functional and genetic epidemiological characterisation of the FFAR4 (GPR120) p.R270H variant in the Danish population

scientific article published on 11 April 2016

Functionally biased signalling properties of 7TM receptors - opportunities for drug development for the ghrelin receptor

scientific article published on December 2013

G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction

scientific journal article

GPR119, a Major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Coacting in Synergy With FFA1 (GPR40).

scientific article published on 25 October 2016

GPR39 (zinc receptor) knockout mice exhibit depression-like behavior and CREB/BDNF down-regulation in the hippocampus

scientific article

GPR39 Zn(2+)-sensing receptor: a new target in antidepressant development?

scientific article

GPR39 signaling is stimulated by zinc ions but not by obestatin

scientific article

GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissue

scientific article

GPR40 (FFAR1) - Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo

scientific article

Ghrelin receptor inverse agonists: identification of an active peptide core and its interaction epitopes on the receptor

scientific article published on 23 June 2006

Ghrelin receptor mutations--too little height and too much hunger

scientific article

Ghrelin-mediated improvements in the metabolic phenotype in the R6/2 mouse model of Huntington's disease

scientific article published on 08 April 2019

Ghrelin-mediated inhibition of the TSH-stimulated function of differentiated human thyrocytes ex vivo

scientific article published on 20 September 2017

Ghrelin.

scientific article

Hepatic NAD+ levels and NAMPT abundance are unaffected during prolonged high-fat diet consumption in C57BL/6JBomTac mice

scientific article published in February 2018

High constitutive signaling of the ghrelin receptor--identification of a potent inverse agonist

scientific article (publication date: November 2003)

High molecular weight PEGylation of human pancreatic polypeptide at position 22 improves stability and reduces food intake in mice

scientific article published on 21 August 2016

Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism

scientific article published on 19 March 2007

Immune malfunction in the GPR39 zinc receptor of knockout mice: Its relationship to depressive disorder

scientific article

Impaired oxidative capacity due to decreased CPT1b levels as a contributing factor to fat accumulation in obesity

scientific article published on 8 April 2015

Importance of constitutive activity and arrestin-independent mechanisms for intracellular trafficking of the ghrelin receptor

scientific article published on 23 August 2007

Improving membrane binding as a design strategy for amphipathic peptide hormones: 2-helix variants of PYY3-36

scientific article published on 01 August 2012

In vivo characterization of high Basal signaling from the ghrelin receptor

scientific article published on 9 October 2009

Increased susceptibility to diet-induced obesity in GPRC6A receptor knockout mice

scientific article published on 15 April 2013

Investigation of the GPR39 zinc receptor following inhibition of monoaminergic neurotransmission and potentialization of glutamatergic neurotransmission.

scientific article published on 24 April 2015

L-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances

scientific article published on 27 December 2011

Ligand binding and micro-switches in 7TM receptor structures

scientific article published on 16 April 2009

Long-Acting Neurotensin Synergizes With Liraglutide to Reverse Obesity Through a Melanocortin-Dependent Pathway

scientific article published on 01 April 2019

Long-acting lipidated analogue of human pancreatic polypeptide is slowly released into circulation

scientific article

MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans

scientific article

Melanocortin 4 receptor mutations in obese Czech children: studies of prevalence, phenotype development, weight reduction response, and functional analysis

scientific article published on 19 June 2007

Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation

scientific article published on 27 March 2006

Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors

scientific article published on 18 September 2002

Model-Based Discovery of Synthetic Agonists for the Zn2+-Sensing G-Protein-Coupled Receptor 39 (GPR39) Reveals Novel Biological Functions

scientific article

Modifying the conserved C-terminal tyrosine of the peptide hormone PYY3-36 to improve Y2 receptor selectivity

scientific article published in November 2009

Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop

scientific article published on 30 July 2012

Modulation of the constitutive activity of the ghrelin receptor by use of pharmacological tools and mutagenesis

scientific article published on January 1, 2010

Molecular basis for agonism in the BB3 receptor: an epitope located on the interface of transmembrane-III, -VI, and -VII.

scientific article

Molecular mechanism of 7TM receptor activation--a global toggle switch model

scientific article

Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39.

scientific article

Molecular mechanism of agonism and inverse agonism in the melanocortin receptors: Zn(2+) as a structural and functional probe

scientific article

NK1 Receptor Fused to beta -Arrestin Displays a Single-Component, High-Affinity Molecular Phenotype

scientific article published on 01 July 2002

Natural agonist enhancing bis-His zinc-site in transmembrane segment V of the tachykinin NK3 receptor

scientific article published on 01 November 1998

Neuromedin U inhibits food intake partly by inhibiting gastric emptying

scientific article

Neurotensin Is Coexpressed, Coreleased, and Acts Together With GLP-1 and PYY in Enteroendocrine Control of Metabolism

scientific article published on 15 October 2015

Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling

scientific article published on 19 May 2005

Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor

scientific article

PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance

scientific article (publication date: 2013)

Pannexin-2-deficiency sensitizes pancreatic β-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo.

scientific article published on 5 April 2017

Partial agonism through a zinc-Ion switch constructed between transmembrane domains III and VII in the tachykinin NK(1) receptor

scientific article published on 01 August 2000

Peptide hormone isoforms: N-terminally branched PYY3-36 isoforms give improved lipid and fat-cell metabolism in diet-induced obese mice

scientific article published on 01 November 2010

PheVI:09 (Phe6.44) as a sliding microswitch in seven-transmembrane (7TM) G protein-coupled receptor activation

scientific article published on 7 November 2012

Physiological and pathological impact of blood sampling by retro-bulbar sinus puncture and facial vein phlebotomy in laboratory mice.

scientific article

RhoA in tyrosine hydroxylase neurones regulates food intake and body weight via altered sensitivity to peripheral hormones

scientific article published on 01 July 2019

Risperidone treatment increases CB1 receptor binding in rat brain

scientific article published on 3 October 2009

Safety, tolerability and pharmacokinetics of intravenous ghrelin for cancer-related anorexia/cachexia: a randomised, placebo-controlled, double-blind, double-crossover study

scientific article

Short-term effects of dietary advanced glycation end products in rats

scientific article published on 01 February 2016

Stability, liposome interaction, and in vivo pharmacology of ghrelin in liposomal suspensions.

scientific article

Studies of relationships between variation of the human G protein-coupled receptor 40 Gene and Type 2 diabetes and insulin release.

scientific article published in January 2005

Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice

scientific article

Synthesis and evaluation of novel lipidated neuromedin U analogs with increased stability and effects on food intake

scientific article published on 17 December 2014

Synthesis and in Vitro Evaluation of Stabilized and Selective Neuromedin U-1 Receptor Agonists

scientific article published on 23 April 2018

The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity

scientific article published in January 2018

The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo

scientific article published on 20 November 2014

Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission

scientific article published on 07 September 2020

Two active molecular phenotypes of the tachykinin NK1 receptor revealed by G-protein fusions and mutagenesis.

scientific article

Unique interaction pattern for a functionally biased ghrelin receptor agonist

scientific article published on 14 March 2011

Y5 neuropeptide Y receptor overexpression in mice neither affects anxiety- and depression-like behaviours nor seizures but confers moderate hyperactivity

scientific article published on 17 February 2012

β-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced Hyperglycemia

scientific article

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