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List of works by Yang-Xin Fu

A STING-activating nanovaccine for cancer immunotherapy

scientific article published on 24 April 2017

A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response.

scientific article

A dendritic-cell-stromal axis maintains immune responses in lymph nodes

scientific article

A mouse model for HBV immunotolerance and immunotherapy.

scientific article published on 30 September 2013

A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8+ T-cell response and effective tumor control

scientific article published on 28 August 2019

A novel dendritic cell targeting HPV16 E7 synthetic vaccine in combination with PD-L1 blockade elicits therapeutic antitumor immunity in mice.

scientific article published on 10 March 2016

A novel method for synthetic vaccine construction based on protein assembly

scientific article

A role for lymphotoxin in the acquisition of Ly49 receptors during NK cell development.

scientific article published in October 2004

Active immunotherapy combined with blockade of a coinhibitory pathway achieves regression of large tumor masses in cancer-prone mice

scientific article published on 17 May 2011

Adapting conventional cancer treatment for immunotherapy

scientific article published on 24 February 2016

Adaptive immune cells temper initial innate responses

scientific article published on 23 September 2007

Adenovirally delivered IFN-β exerts antitumor effects through transient T-lymphocyte depletion and Ag-specific T-cell proliferation

scientific article published on 13 March 2012

Androgen receptor antagonists compromise T cell response against prostate cancer leading to early tumor relapse

scientific article published on April 2016

Anti-HER2/Neu passive-aggressive immunotherapy

scientific article published on January 2014

Antigen persistence and the control of local T cell memory by migrant respiratory dendritic cells after acute virus infection

scientific article

Attenuation by targeting the B- and T-cell attenuator.

scientific article published on November 2011

Author Correction: A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8+ T-cell response and effective tumor control

scientific article published on 01 April 2020

Author Correction: Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling

scientific article published on 16 September 2020

B and T lymphocyte attenuator tempers early infection immunity

scientific article

B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashion.

scientific article

B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism.

scientific article

Blockade of lymphotoxin pathway exacerbates autoimmune arthritis by enhancing the Th1 response

scientific article published on 01 October 2005

CD160 is essential for NK-mediated IFN-γ production

scientific article

CD160 serves as a negative regulator of NKT cells in acute hepatic injury

scientific article published on 22 July 2019

CD95 promotes tumour growth

scientific article

Cetuximab-mediated tumor regression depends on innate and adaptive immune responses.

scientific article published on 18 September 2012

Clinical Experiences With Anti-CD137 and Anti-PD1 Therapeutic Antibodies ⬇️

scientific article published on October 1, 2010

Co-stimulation agonists as a new immunotherapy for autoimmune diseases.

scientific article published on November 2003

Commensal bacteria protect against food allergen sensitization

scientific article

Comparative impacts of glutathione peroxidase-1 gene knockout on oxidative stress induced by reactive oxygen and nitrogen species in mouse hepatocytes

scientific article

Complementary role of CD4+ T cells and secondary lymphoid tissues for cross-presentation of tumor antigen to CD8+ T cells.

scientific article

Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo

scientific article

Coordinating antigen cytosolic delivery and danger signaling to program potent cross-priming by micelle-based nanovaccine.

scientific article published on 04 April 2017

Coordinating development of medullary thymic epithelial cells

scientific article published on 01 September 2008

Coordination between NF-kappaB family members p50 and p52 is essential for mediating LTbetaR signals in the development and organization of secondary lymphoid tissues

scientific article

Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease

scientific article published on 11 November 2002

Cutting Edge: Lymphotoxin Signaling Is Essential for Clearance of Salmonella from the Gut Lumen and Generation of Anti-Salmonella Protective Immunity.

scientific article

Cutting edge: B and T lymphocyte attenuator signaling on NKT cells inhibits cytokine release and tissue injury in early immune responses.

scientific article published on 17 June 2009

Cytokine regulation of secondary lymphoid organ development.

scientific article published in June 1998

Cytokines that target immune killer cells against tumors

scientific article published on 10 June 2020

De novo prediction of cancer-associated T cell receptors for noninvasive cancer detection

scientific article published on 01 August 2020

Decreased macrophage-mediated cytotoxicity in mammary-tumor-bearing mice is related to alteration of nitric-oxide production and/or release.

scientific article

Deficiency of CD40 Reveals an Important Role for LIGHT in Anti-Leishmania Immunity

scientific article published on 29 May 2015

Deflating the Lymph Node ⬇️

scientific article published on January 28, 2011

Development and maturation of secondary lymphoid tissues.

scientific article

Differential regulation of breast cancer bone metastasis by PARP1 and PARP2

scientific article published on 27 March 2020

Direct and indirect roles of the LTbetaR pathway in central tolerance induction.

scientific article

Distinct Roles of Lymphotoxin α and the Type I Tumor Necrosis Factor (TNF) Receptor in the Establishment of Follicular Dendritic Cells from Non–Bone Marrow–derived Cells ⬇️

scientific article published on December 15, 1997

Do adaptive immune cells suppress or activate innate immunity?

scientific article published on 06 December 2008

Dual-targeting nanoparticle vaccine elicits a therapeutic antibody response against chronic hepatitis B

scientific article published on 02 March 2020

Dynamic programmed death 1 expression by virus-specific CD8 T cells correlates with the outcome of acute hepatitis B.

scientific article published on 22 March 2008

Effective anti-neu-initiated antitumor responses require the complex role of CD4+ T cells.

scientific article published on 30 January 2013

Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity

scientific article

Enhanced induction of dendritic cell maturation and HLA-A*0201-restricted CEA-specific CD8(+) CTL response by exosomes derived from IL-18 gene-modified CEA-positive tumor cells.

scientific article published on 26 September 2006

Enhanced local delivery with reduced systemic toxicity: delivery, delivery, and delivery.

scientific article published in August 2006

Essential role of lymph nodes in contact hypersensitivity revealed in lymphotoxin-alpha-deficient mice.

scientific article published in June 2001

Facilitating T Cell Infiltration in Tumor Microenvironment Overcomes Resistance to PD-L1 Blockade

scientific journal article

Food-induced asthma in China: an analysis in 40 cases.

scientific article published in January 1991

From DNA Damage to Nucleic Acid Sensing: A Strategy to Enhance Radiation Therapy

scientific article published on 11 September 2015

GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation

scientific article

Gadd45beta promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling

scientific article published on May 2008

Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora.

scientific article published on 15 August 2013

Growth-factor receptor-bound protein-2 (Grb2) signaling in B cells controls lymphoid follicle organization and germinal center reaction.

scientific article

Hepatitis B virus infection and immunopathogenesis in a humanized mouse model: induction of human-specific liver fibrosis and M2-like macrophages

scientific article

Host STING-dependent MDSC mobilization drives extrinsic radiation resistance.

scientific article published on 23 November 2017

Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis

scientific article published on 30 September 2020

Hypofractionated EGFR tyrosine kinase inhibitor limits tumor relapse through triggering innate and adaptive immunity

scientific article published on 01 August 2019

IgE regulates T helper cell differentiation through FcgammaRIII mediated dendritic cell cytokine modulation.

scientific article

Immunology. Autoreactive B cells migrate into T cell territory

scientific article published on 01 September 2002

Immunoregulation by tumor necrosis factor superfamily member LIGHT

scientific article

Immunotherapy and tumor microenvironment

scientific article published on 15 October 2015

Increasing tumor antigen expression overcomes "ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cells

scientific article published on 01 December 2002

Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection

scientific article published on 09 January 2014

Innate Lymphoid Cells Control Early Colonization Resistance against Intestinal Pathogens through ID2-Dependent Regulation of the Microbiota.

scientific article published on April 2015

Innate and adaptive immune cells in the tumor microenvironment

scientific article

Innate lymphoid cells facilitate NK cell development through a lymphotoxin-mediated stromal microenvironment

scientific article

Innate lymphotoxin receptor mediated signaling promotes HSV-1 associated neuroinflammation and viral replication.

scientific article published on 20 May 2015

Interaction of mature CD3+CD4+ T cells with dendritic cells triggers the development of tertiary lymphoid structures in the thyroid.

scientific article

Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2

scientific article published on 15 July 2021

Intratumoral Delivery of IL-21 Overcomes Anti-Her2/Neu Resistance through Shifting Tumor-Associated Macrophages from M2 to M1 Phenotype.

scientific article published on 15 April 2015

Intratumoral heterogeneity impacts the response to anti-neu antibody therapy.

scientific article

Investigation of Antigen-Specific T-Cell Receptor Clusters in Human Cancers

scientific article published on 12 December 2019

Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice.

scientific article published on 02 January 2014

LIGHT delivery to tumors by mesenchymal stem cells mobilizes an effective antitumor immune response.

scientific article

LIGHT induces distinct signals to clear an AAV-expressed persistent antigen in the mouse liver and to induce liver inflammation

scientific article

LIGHT regulates inflamed draining lymph node hypertrophy.

scientific article

LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms.

scientific article published on 27 February 2007

LIGHT/TNFSR14 can regulate hepatic lipase expression by hepatocytes independent of T cells and Kupffer cells

scientific article

LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity

scientific article published on 25 March 2019

Linking the microbiota and metabolic disease with lymphotoxin ⬇️

scientific article published on May 8, 2013

Lipopolysaccharide and interferon-gamma-induced nitric oxide production and protein oxidation in mouse peritoneal macrophages are affected by glutathione peroxidase-1 gene knockout.

scientific article

Low-dose X-ray radiotherapy-radiodynamic therapy via nanoscale metal-organic frameworks enhances checkpoint blockade immunotherapy

scientific article published on 26 March 2018

Lymphoid microenvironment in the gut for immunoglobulin A and inflammation.

scientific article

Lymphotoxin beta receptor (Lt betaR): dual roles in demyelination and remyelination and successful therapeutic intervention using Lt betaR-Ig protein.

scientific article

Lymphotoxin beta receptor signaling limits mucosal damage through driving IL-23 production by epithelial cells.

scientific article

Lymphotoxin beta receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice

scientific article

Lymphotoxin beta receptor-Ig fusion protein treatment blocks actively induced, but not adoptively transferred, uveitis in Lewis rats

scientific article published on 01 June 2003

Lymphotoxin beta receptor-dependent control of lipid homeostasis

scientific article published on 01 April 2007

Lymphotoxin controls the IL-22 protection pathway in gut innate lymphoid cells during mucosal pathogen challenge.

scientific article

Lymphotoxin is required for maintaining physiological levels of serum IgE that minimizes Th1-mediated airway inflammation.

scientific article

Lymphotoxin organizes contributions to host defense and metabolic illness from innate lymphoid cells

scientific article published on 24 December 2013

Lymphotoxin pathway directs thymic Aire expression

scientific article published on 28 September 2003

Lymphotoxin regulates commensal responses to enable diet-induced obesity

scientific article

Lymphotoxin signalling in immune homeostasis and the control of microorganisms.

scientific article published on April 2013

Membrane lymphotoxin is required for resistance to Theiler's virus infection.

scientific article published in August 2003

Multimodality therapy of an acquired factor V inhibitor

scientific article published on 01 April 1996

NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance

scientific article published on 19 July 2019

New immune therapy targets tumor-associated environment: from bone marrow to tumor site.

scientific article published on 12 December 2011

OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3 ⬇️

scientific article published on January 20, 2013

OX40 signaling favors the induction of T(H)9 cells and airway inflammation

scientific article published on 29 July 2012

PD-1 Shapes B Cells as Evildoers in the Tumor Microenvironment.

scientific article published on May 2016

PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade

scientific article published on 24 September 2020

Phagocytosis checkpoints as new targets for cancer immunotherapy

scientific article published on 28 August 2019

Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion

scientific article published in Nature

Priming of naive T cells inside tumors leads to eradication of established tumors

scientific article published on 04 January 2004

Proinflammatory IL-17 induces iBALT development ⬇️

scientific article published on September 19, 2011

Promoting immune responses by LIGHT in the face of abundant regulatory T cell inhibition.

scientific article published on 30 December 2009

Proteolysis-targeting chimera against BCL-X<sub>L</sub> destroys tumor-infiltrating regulatory T cells

scientific article published on 24 February 2021

RIG-I-like receptor LGP2 is required for tumor control by radiation therapy

scientific article published on 21 October 2020

Radiation and anti-PD-L1 antibody combinatorial therapy induces T cell-mediated depletion of myeloid-derived suppressor cells and tumor regression

scientific article

Radiation-induced equilibrium is a balance between tumor cell proliferation and T cell-mediated killing

scientific article published on 29 April 2013

Radiation-induced tumor dormancy reflects an equilibrium between the proliferation and T lymphocyte-mediated death of malignant cells.

scientific article published on 09 July 2013

Radiation-inducible immunotherapy for cancer: senescent tumor cells as a cancer vaccine

scientific article

Radiotherapy and immune checkpoint blockade: potential interactions and future directions.

scientific article published on 16 June 2015

Recruitment and activation of naive T cells in the islets by lymphotoxin beta receptor-dependent tertiary lymphoid structure

scientific article published on 24 August 2006

Response to Field.

scientific article published in December 2006

Route of immunization with peptide-pulsed dendritic cells controls the distribution of memory and effector T cells in lymphoid tissues and determines the pattern of regional tumor control

scientific article

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.

scientific article

Secondary lymphoid organs are important but not absolutely required for allograft responses

scientific article published on 01 March 2003

Signaling via LTbetaR on the lamina propria stromal cells of the gut is required for IgA production

scientific article published on 13 May 2002

Small molecular drugs reshape tumor microenvironment to synergize with immunotherapy

scientific article published on 07 December 2020

T cell-derived lymphotoxin limits Th1 response during HSV-1 infection

scientific article published in Scientific Reports

T cell-derived lymphotoxin regulates liver regeneration

scientific article

TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis.

scientific article published on 22 April 2013

Targeting CD137 enhances the efficacy of cetuximab.

scientific article

Targeting IFNα to tumor by anti-PD-L1 creates feedforward antitumor responses to overcome checkpoint blockade resistance

scientific article published in Nature Communications

Targeting and utilizing primary tumors as live vaccines: changing strategies ⬇️

scientific article published on November 21, 2011

Targeting innate sensing in the tumor microenvironment to improve immunotherapy

scientific article published on 16 December 2019

Targeting lymphotoxin-mediated negative selection to prevent prostate cancer in mice with genetic predisposition.

scientific article published on 23 September 2009

The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells ⬇️

scientific article published on December 15, 2011

The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy

scientific article published on 08 March 2019

The ETS1 transcription factor is required for the development and cytokine-induced expansion of ILC2.

scientific article published on 11 April 2016

The Role of Adaptive Immunity in the Efficacy of Targeted Cancer Therapies

scientific article published on 6 January 2016

The complementation of lymphotoxin deficiency with LIGHT, a newly discovered TNF family member, for the restoration of secondary lymphoid structure and function

scientific article published on 01 July 2002

The complicated role of NF-kappaB in T-cell selection.

scientific article published on March 2010

The efficacy of radiotherapy relies upon induction of type i interferon-dependent innate and adaptive immunity

scientific article

The human BCL6 transgene promotes the development of lymphomas in the mouse

scholarly article

The regulation of T cell homeostasis and autoimmunity by T cell–derived LIGHT ⬇️

scientific article published on December 1, 2001

The requirement of CD8+ T cells to initiate and augment acute cardiac inflammatory response to high blood pressure

scientific article published on 05 March 2014

The role of LIGHT in T cell-mediated immunity.

scientific article published in January 2004

The role of core TNF/LIGHT family members in lymph node homeostasis and remodeling ⬇️

scientific article published on November 1, 2011

The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses

scientific article

The role of tumor-associated macrophages in breast cancer progression ⬇️

scientific article published on May 14, 2013

The tragic fate of group 3 innate lymphoid cells during HIV-1 infection.

scientific article

Therapeutic activity of high-dose intratumoral IFN-β requires direct effect on the tumor vasculature.

scientific article published on 12 September 2014

Tissue-resident CD4<sup>+</sup> T helper cells assist the development of protective respiratory B and CD8<sup>+</sup> T cell memory responses

scientific article published on 01 January 2021

Tolerogenic properties of lymphatic endothelial cells are controlled by the lymph node microenvironment

scientific article

Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling

scientific article published on 30 March 2020

Tumor immunity meets autoimmunity: antigen levels and dendritic cell maturation.

scientific article published on December 2003

Tumor masses support naive T cell infiltration, activation, and differentiation into effectors

scientific article

Tumor necrosis factor family members and inflammatory bowel disease.

scientific article

Tumor-reprogrammed resident T cells resist radiation to control tumors

scientific article published on 02 September 2019

Type I interferon response and innate immune sensing of cancer

scientific article

ZMYND8 expression in breast cancer cells blocks T-lymphocyte surveillance to promote tumor growth

scientific article published on 04 November 2020

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