List of works - Mariangela Biava

1,5-Diaryl-2-ethyl pyrrole derivatives as antimycobacterial agents: design, synthesis, and microbiological evaluation.

scientific article published on 13 June 2009

1,5-Diarylpyrrole-3-acetic acids and esters as novel classes of potent and highly selective cyclooxygenase-2 inhibitors

scientific article

1,5-Diphenylpenta-2,4-dien-1-ones as potent and selective monoamine oxidase-B inhibitors

scientific article published on 15 November 2012

1,5-Diphenylpyrrole derivatives as antimycobacterial agents. Probing the influence on antimycobacterial activity of lipophilic substituents at the phenyl rings.

scientific article published in June 2008

A Flow-Based Synthesis of 2-Aminoadamantane-2-carboxylic Acid

A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity

scientific article published on 26 April 2013

A fast virtual screening approach to identify structurally diverse inhibitors of trypanothione reductase

scientific article published on 19 July 2011

A novel antimycobacterial compound acts as an intracellular iron chelator

scientific article

An alternative synthetic approach for the synthesis of biologically relevant 1,4-disubstituted pyrazolo[3,4-d]pyrimidines

Antifungal agents, Part 11. Biphenyl analogues of naftifine: synthesis and antifungal activities.

scientific article

Antimycobacterial Agents. Novel Diarylpyrrole Derivatives of BM212 Endowed with High Activity toward Mycobacterium tuberculosis and Low Cytotoxicity

scientific article published on 01 August 2006

Antimycobacterial activity of new ortho-, meta- and para-toluidine derivatives

scientific article

Antimycobacterial compounds. New pyrrole derivatives of BM212.

scientific article published in March 2004

Antimycobacterial compounds. Optimization of the BM 212 structure, the lead compound for a new pyrrole derivative class

scientific article published in February 2005

Antiproliferative effect of two novel COX-2 inhibitors on human keratinocytes

scientific article published on 26 February 2013

Building a pharmacophore model for a novel class of antitubercular compounds.

scientific article

C-9 Alkenylidine bridged macrolides: WO2008061189

scientific article published on 01 June 2009

Characterization of the biotransformation pathways of clomiphene, tamoxifen and toremifene as assessed by LC-MS/(MS) following in vitro and excretion studies

scientific article published on 23 April 2013

Chondroprotective effect of three different classes of anti-inflammatory agents on human osteoarthritic chondrocytes exposed to IL-1β.

scientific article published on 17 August 2015

Correction to Novel Analgesic/Anti-Inflammatory Agents: 1,5-Diarylpyrrole Nitrooxyalkyl Ethers and Related Compounds as Cyclooxygenase-2 Inhibiting Nitric Oxide Donors

Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity

scientific article

Design, synthesis, and in vitro hMAO-B inhibitory evaluation of some 1-methyl-3,5-diphenyl-4,5-dihydro-1H-pyrazoles.

scientific article

Developing pyrrole-derived antimycobacterial agents: a rational lead optimization approach

scientific article published on 21 February 2011

Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors

scientific article published on 18 December 2013

Enlarging the NSAIDs family: ether, ester and acid derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents.

scientific article published on January 2011

Flow Synthesis and Biological Studies of an Analgesic Adamantane Derivative That Inhibits P2X7-Evoked Glutamate Release

scientific article

Fyn Kinase in Brain Diseases and Cancer: The Search for Inhibitors ⬇️

scientific article published on January 1, 2011

HPLC enantioseparation and absolute configuration of novel anti-inflammatory pyrrole derivatives

scientific article published on 01 June 2008

Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents

scientific article

Identification of a novel pyrrole derivative endowed with antimycobacterial activity and protection index comparable to that of the current antitubercular drugs streptomycin and rifampin

scientific article published on 19 September 2010

Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells.

scientific article

Importance of the thiomorpholine introduction in new pyrrole derivatives as antimycobacterial agents analogues of BM 212.

scientific article published in February 2003

Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection

scientific article

Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme

scientific article published on 18 October 2012

In vitro effects of VA441, a new selective cyclooxygenase-2 inhibitor, on human osteoarthritic chondrocytes exposed to IL-1β.

scientific article published on 8 August 2012

Inhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallography

scientific article

MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212

scientific article

N-((1,3-Diphenyl-1H-pyrazol-4-yl)methyl)anilines: A novel class of anti-RSV agents

scientific article published on 9 April 2015

New oxazolidinone derivatives as antibacterial agents with improved activity

New pyrrole derivatives as antimycobacterial agents analogs of BM212

scientific article

Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors

scientific article published on 11 April 2013

Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties

scientific article published on 31 October 2011

Novel ester and acid derivatives of the 1,5-diarylpyrrole scaffold as anti-inflammatory and analgesic agents. Synthesis and in vitro and in vivo biological evaluation

scientific article published in January 2010

Overcoming drug resistance in TB: an update

scientific article published on 20 November 2020

Pharmacophore Assessment Through 3-D QSAR: Evaluation of the Predictive Ability on New Derivatives by the Application on a Series of Antitubercular Agents

scientific article published on 17 May 2013

Scale-Up of Flow-Assisted Synthesis of C2-Symmetric Chiral PyBox Ligands

Synthesis and antimycotic activity of new (1H-1,2,4-triazol-1-yl-methyl)benzeneamine derivatives

Synthesis, biological evaluation and docking analysis of a new series of methylsulfonyl and sulfamoyl acetamides and ethyl acetates as potent COX-2 inhibitors

scientific article published on 26 December 2014

Synthesis, biological evaluation, and enzyme docking simulations of 1,5-diarylpyrrole-3-alkoxyethyl ethers as selective cyclooxygenase-2 inhibitors endowed with anti-inflammatory and antinociceptive activity

scientific article published on 4 July 2008

Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents

scientific article published on 24 July 2008

The novel anti-inflammatory agent VA694, endowed with both NO-releasing and COX2-selective inhibiting properties, exhibits NO-mediated positive effects on blood pressure, coronary flow and endothelium in an experimental model of hypertension and end

scientific article

List of works by Mariangela Biava

1,5-Diaryl-2-ethyl pyrrole derivatives as antimycobacterial agents: design, synthesis, and microbiological evaluation.

1,5-Diarylpyrrole-3-acetic acids and esters as novel classes of potent and highly selective cyclooxygenase-2 inhibitors

1,5-Diphenylpenta-2,4-dien-1-ones as potent and selective monoamine oxidase-B inhibitors

1,5-Diphenylpyrrole derivatives as antimycobacterial agents. Probing the influence on antimycobacterial activity of lipophilic substituents at the phenyl rings.

A Flow-Based Synthesis of 2-Aminoadamantane-2-carboxylic Acid

A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity

A fast virtual screening approach to identify structurally diverse inhibitors of trypanothione reductase

A novel antimycobacterial compound acts as an intracellular iron chelator

An alternative synthetic approach for the synthesis of biologically relevant 1,4-disubstituted pyrazolo[3,4-d]pyrimidines

Antifungal agents, Part 11. Biphenyl analogues of naftifine: synthesis and antifungal activities.

Antimycobacterial Agents. Novel Diarylpyrrole Derivatives of BM212 Endowed with High Activity toward Mycobacterium tuberculosis and Low Cytotoxicity

Antimycobacterial activity of new ortho-, meta- and para-toluidine derivatives

Antimycobacterial compounds. New pyrrole derivatives of BM212.

Antimycobacterial compounds. Optimization of the BM 212 structure, the lead compound for a new pyrrole derivative class

Antiproliferative effect of two novel COX-2 inhibitors on human keratinocytes

Building a pharmacophore model for a novel class of antitubercular compounds.

C-9 Alkenylidine bridged macrolides: WO2008061189

Characterization of the biotransformation pathways of clomiphene, tamoxifen and toremifene as assessed by LC-MS/(MS) following in vitro and excretion studies

Chondroprotective effect of three different classes of anti-inflammatory agents on human osteoarthritic chondrocytes exposed to IL-1β.

Correction to Novel Analgesic/Anti-Inflammatory Agents: 1,5-Diarylpyrrole Nitrooxyalkyl Ethers and Related Compounds as Cyclooxygenase-2 Inhibiting Nitric Oxide Donors

Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity

Design, synthesis, and in vitro hMAO-B inhibitory evaluation of some 1-methyl-3,5-diphenyl-4,5-dihydro-1H-pyrazoles.

Developing pyrrole-derived antimycobacterial agents: a rational lead optimization approach

Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors

Enlarging the NSAIDs family: ether, ester and acid derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents.

Flow Synthesis and Biological Studies of an Analgesic Adamantane Derivative That Inhibits P2X7-Evoked Glutamate Release

Fyn Kinase in Brain Diseases and Cancer: The Search for Inhibitors ⬇️

HPLC enantioseparation and absolute configuration of novel anti-inflammatory pyrrole derivatives

Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents

Identification of a novel pyrrole derivative endowed with antimycobacterial activity and protection index comparable to that of the current antitubercular drugs streptomycin and rifampin

Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells.

Importance of the thiomorpholine introduction in new pyrrole derivatives as antimycobacterial agents analogues of BM 212.

Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection

Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme

In vitro effects of VA441, a new selective cyclooxygenase-2 inhibitor, on human osteoarthritic chondrocytes exposed to IL-1β.

Inhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallography

MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212

N-((1,3-Diphenyl-1H-pyrazol-4-yl)methyl)anilines: A novel class of anti-RSV agents

New oxazolidinone derivatives as antibacterial agents with improved activity

New pyrrole derivatives as antimycobacterial agents analogs of BM212

Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors

Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties

Novel ester and acid derivatives of the 1,5-diarylpyrrole scaffold as anti-inflammatory and analgesic agents. Synthesis and in vitro and in vivo biological evaluation

Overcoming drug resistance in TB: an update

Pharmacophore Assessment Through 3-D QSAR: Evaluation of the Predictive Ability on New Derivatives by the Application on a Series of Antitubercular Agents

Scale-Up of Flow-Assisted Synthesis of C2-Symmetric Chiral PyBox Ligands

Synthesis and antimycotic activity of new (1H-1,2,4-triazol-1-yl-methyl)benzeneamine derivatives

Synthesis, biological evaluation and docking analysis of a new series of methylsulfonyl and sulfamoyl acetamides and ethyl acetates as potent COX-2 inhibitors

Synthesis, biological evaluation, and enzyme docking simulations of 1,5-diarylpyrrole-3-alkoxyethyl ethers as selective cyclooxygenase-2 inhibitors endowed with anti-inflammatory and antinociceptive activity

Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents

The novel anti-inflammatory agent VA694, endowed with both NO-releasing and COX2-selective inhibiting properties, exhibits NO-mediated positive effects on blood pressure, coronary flow and endothelium in an experimental model of hypertension and end