Search filters

List of works by Jacques Genest jr.

2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult - 2009 recommendations

scientific article published on October 2009

2012 update of the Canadian Cardiovascular Society guidelines for the diagnosis and treatment of dyslipidemia for the prevention of cardiovascular disease in the adult

scientific article published on February 2013

2016 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult

scientific article

A COMPREHENSIVE SAFETY ANALYSIS OF 6026 PATIENTS FROM PHASE 2 AND 3 SHORT AND LONG TERM CLINICAL TRIALS WITH EVOLOCUMAB (AMG 145)

article

A cluster randomized controlled Trial to Evaluate an Ambulatory primary care Management program for patients with dyslipidemia: the TEAM study

scientific article

A new method for measurement of total plasma PCSK9: clinical applications

scientific article published on January 2010

A novel nonsense apolipoprotein A-I mutation (apoA-I(E136X)) causes low HDL cholesterol in French Canadians

scientific article

A randomized trial of rosuvastatin in the prevention of venous thromboembolism

scientific article published on 29 March 2009

ABCA1 Agonist Mimetic Peptide CS-6253 Induces Microparticles Release From Different Cell Types by ABCA1-Efflux-Dependent Mechanism.

scientific article

APOE p.Leu167del mutation in familial hypercholesterolemia.

scientific article

ATP binding cassette A1 (ABCA1) mediates microparticle formation during high-density lipoprotein (HDL) biogenesis

scientific article published on 17 January 2017

Access Denied: The Controversy of Commercial Genetic Databases. ⬇️

scientific article

Analysis of lipid transfer activity between model nascent HDL particles and plasma lipoproteins: implications for current concepts of nascent HDL maturation and genesis

scientific article

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

scientific article published on 27 August 2017

Anxiety, depression, and health-related quality of life in heterozygous familial hypercholesterolemia: A systematic review and meta-analysis

scholarly article by Leo E. Akioyamen et al published June 2018 in Journal of Psychosomatic Research

Aortic Calcification Progression in Heterozygote Familial Hypercholesterolemia

scientific article published on 10 February 2017

Aortic calcification: Novel insights from familial hypercholesterolemia and potential role for the low-density lipoprotein receptor

scientific article published on 18 September 2012

Aortic calcifications in familial hypercholesterolemia: potential role of the low-density lipoprotein receptor gene

scientific article

Apolipoprotein A-I activates cellular cAMP signaling through the ABCA1 transporter

scientific article

Approach to the diagnosis and management of lipoprotein disorders

scientific article published on April 2009

Baseline characteristics of participants in the JUPITER trial, a randomized placebo-controlled primary prevention trial of statin therapy among individuals with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein

scientific article published on 24 October 2007

Biogenesis and speciation of nascent apoA-I-containing particles in various cell lines

scientific article

C-reactive protein and cholesterol are equally strong predictors of cardiovascular risk and both are important for quality clinical care

scientific article published in February 2013

Canadian Cardiovascular Society position statement on familial hypercholesterolemia

scientific article

Canadian Cardiovascular Society position statement--recommendations for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease

scientific article published on September 2006

Carboxyl-terminal disulfide bond of acid sphingomyelinase is critical for its secretion and enzymatic function.

scientific article

Cardiometabolic risk in Canada: a detailed analysis and position paper by the cardiometabolic risk working group

scientific article published on March 2011

Cellular cholesterol homeostasis in vascular endothelial cells

scientific article

Cellular phospholipid and cholesterol efflux in high-density lipoprotein deficiency

scientific article published in March 2003

Cellular physiology of cholesterol efflux in vascular endothelial cells

scientific article

Cholesterol trapping in Niemann-Pick disease type B fibroblasts can be relieved by expressing the phosphotyrosine binding domain of GULP ⬇️

scientific article published on February 22, 2012

Chronic Inflammatory Diseases and Cardiovascular Risk: A Systematic Review ⬇️

scientific article published on March 1, 2011

Chylomicrons: When you can't direct the wind, adjust the sail.

scientific article published on 5 February 2019

Combination of statin and ezetimibe for the treatment of dyslipidemias and the prevention of coronary artery disease

scientific article published on August 2006

Comparison of treatment of severe high-density lipoprotein cholesterol deficiency in men with daily atorvastatin (20 mg) versus fenofibrate (200 mg) versus extended-release niacin (2 g).

scientific article

Compound heterozygosity at the sphingomyelin phosphodiesterase-1 (SMPD1) gene is associated with low HDL cholesterol

scientific article published on 27 February 2003

Defining severe familial hypercholesterolaemia and the implications for clinical management: a consensus statement from the International Atherosclerosis Society Severe Familial Hypercholesterolemia Panel

scientific article published on 27 May 2016

Desmocollin 1 is abundantly expressed in atherosclerosis and impairs high-density lipoprotein biogenesis

scientific article

Detection of atherosclerotic cardiovascular disease influences the perceived need for aggressive lipid management

scientific article published on 3 June 2017

Diabetes is associated with an increased risk of cardiovascular disease in patients with familial hypercholesterolemia

scientific article published in 2018

Diagnosis, Prevention, and Management of Statin Adverse Effects and Intolerance: Canadian Consensus Working Group Update (2016).

scientific article published on 14 January 2016

Diagnosis, prevention, and management of statin adverse effects and intolerance: Canadian Working Group Consensus update

scientific article

Diagnosis, prevention, and management of statin adverse effects and intolerance: proceedings of a Canadian Working Group Consensus Conference

scientific article

Disorders of high‐density lipoprotein biogenesis

ESI-MS quantitation of increased sphingomyelin in Niemann-Pick disease type B HDL.

scientific article published in March 2005

Effect of ABCA1 mutations on risk for myocardial infarction

scientific article published on October 2008

Effect of fenofibrate-mediated increase in plasma homocysteine on the progression of coronary artery disease in type 2 diabetes mellitus

scientific article published in April 2004

Estrogen-associated severe hypertriglyceridemia with pancreatitis

scientific article

Evidence for a gene influencing high-density lipoprotein cholesterol on chromosome 4q31.21.

scientific article published in December 2005

Exome sequencing identifies 2 rare variants for low high-density lipoprotein cholesterol in an extended family

scientific article

Exome sequencing in suspected monogenic dyslipidemias

scientific article

Familial Hypercholesterolemia: Awareness, Appraisal, and Action

scientific article published on 14 November 2016

Familial hypercholesterolemia in Canada: Initial results from the FH Canada national registry

article

Familial hypercholesterolemia: experience from the French-Canadian population

scientific article published on 19 January 2018

Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects

scientific article

Functional mutations of the ABCA1 gene in subjects of French-Canadian descent with HDL deficiency

scientific article

Genetic and Pharmacological Manipulation of Urotensin II Ameliorate the Metabolic and Atherosclerosis Sequalae in Mice ⬇️

scientific article published on June 21, 2012

Genetic lipoprotein disorders and coronary atherosclerosis

scientific article

Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels

scientific article

Genetics of cholesterol efflux

scientific article published on June 2012

Genetics of high-density lipoproteins

scientific article

HDL cholesterol and ASCVD risk stratification: A debate.

scientific article

HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trial

scientific article published on 23 July 2010

HDL, Atherosclerosis, and Emerging Therapies ⬇️

scientific article published on May 28, 2013

HDL-C: clinical equipoise and vascular endothelial function ⬇️

scientific article published on March 1, 2013

HDLs and the pathogenesis of atherosclerosis

scientific article published on 19 March 2018

Harmonization of guidelines for the prevention and treatment of cardiovascular disease: the C-CHANGE Initiative

scientific article

High density lipoproteins: Measurement techniques and potential biomarkers of cardiovascular risk

scientific article

High-Density Lipoproteins: Biology, Epidemiology, and Clinical Management

scientific article

High-density lipoprotein mediated cellular cholesterol efflux in acute coronary syndromes

scientific article published on 2 October 2013

High-density lipoproteins and cardiovascular disease: 2010 update

scientific article published on March 2010

High-density lipoproteins: multifunctional vanguards of the cardiovascular system

scientific article published on May 2004

Homocysteine lowering with folic acid and B vitamins in vascular disease

scientific article

Identification and Treatment of Patients with Homozygous Familial Hypercholesterolaemia: Information and Recommendations from a Middle East Advisory Panel.

scientific article

Identification and management of cardiometabolic risk in Canada: a position paper by the cardiometabolic risk working group (executive summary).

scientific article published on March 2011

Identification of a novel human cellular HDL biosynthesis defect.

scientific article published on 24 June 2009

Identification of an ABCA1-dependent phospholipid-rich plasma membrane apolipoprotein A-I binding site for nascent HDL formation: implications for current models of HDL biogenesis

article

Imputation of Baseline LDL Cholesterol Concentration in Patients with Familial Hypercholesterolemia on Statins or Ezetimibe

scientific article published on 16 October 2017

Increased sphingomyelin content impairs HDL biogenesis and maturation in human Niemann-Pick disease type B.

scientific article published on 30 November 2005

Inflammation modulation and cardiovascular disease prevention.

scientific article

International open-label studies to assess the efficacy and safety of single-pill amlodipine/atorvastatin in attaining blood pressure and lipid targets recommended by country-specific guidelines: the JEWEL programme.

scientific article published in August 2009

Lipoprotein(a) Induces Human Aortic Valve Interstitial Cell Calcification

Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) in acute coronary syndrome: relationship with low-density lipoprotein cholesterol

scientific article

Membrane microdomains and the regulation of HDL biogenesis

scientific article published on 11 November 2017

Membrane microdomains modulate oligomeric ABCA1 function: impact on apoAI-mediated lipid removal and phosphatidylcholine biosynthesis ⬇️

scientific article published on August 16, 2011

Molecular and cellular physiology of apolipoprotein A-I lipidation by the ATP-binding cassette transporter A1 (ABCA1).

scientific article

Molecular interactions between apoE and ABCA1: impact on apoE lipidation

scientific article

Monoclonal Antibodies for the Treatment of Hypercholesterolemia: Targeting PCSK9.

scientific article published on 3 May 2016

New insights into the biogenesis of human high-density lipoproteins

scientific article

Novel Apo E-Derived ABCA1 Agonist Peptide (CS-6253) Promotes Reverse Cholesterol Transport and Induces Formation of preβ-1 HDL In Vitro

scientific article

Novel Approaches for HDL-Directed Therapies

scientific article published on 4 November 2017

Number needed to treat with rosuvastatin to prevent first cardiovascular events and death among men and women with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein: justification for the use of statins in prev

scientific article published on 22 September 2009

Official document of the International Society of Atherosclerosis: general recommendations for treatment of dyslipidemia. Executive summary

scientific article published on 26 October 2013

Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC) ⬇️

scientific article published in October 2018

Pathological significance of lipoprotein(a) in aortic valve stenosis

scientific article published on 15 March 2018

Pooled Safety Analysis of Evolocumab in Over 6000 Patients From Double-Blind and Open-Label Extension Studies

scientific article

Posttranslational modification of proprotein convertase subtilisin/kexin type 9 is differentially regulated in response to distinct cardiometabolic treatments as revealed by targeted proteomics

scientific article published on 3 April 2018

Prevalence of dyslipidemia in statin-treated patients in Canada: Results of the DYSlipidemia International Study (DYSIS) ⬇️

scientific article published on November 1, 2010

Proprotein convertase subtilisin/kexin type 9 (PCSK9): lessons learned from patients with hypercholesterolemia

scientific article published on 23 September 2014

Quantitative analysis of ABCA1-dependent compartmentalization and trafficking of apolipoprotein A-I: implications for determining cellular kinetics of nascent high density lipoprotein biogenesis

scientific article published on 24 January 2008

RVX-208: a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo

scientific article published in June 2010

Rationale and design of the familial hypercholesterolemia foundation CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia registry

scientific article

Reaching recommended lipid and blood pressure targets with amlodipine/atorvastatin combination in patients with coronary heart disease

scientific article (publication date: 15 January 2005)

Recommendations for the management of dyslipidemia and the prevention of cardiovascular disease: summary of the 2003 update

scientific article

Reducing Vascular Calcification by Anti-IL-1β Monoclonal Antibody in a Mouse Model of Familial Hypercholesterolemia

scientific article published on 22 April 2015

Reducing the burden of disease and death from familial hypercholesterolemia: a call to action

scientific article published on 16 September 2014

Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial

scientific article published on 28 March 2009

Regional distribution and metabolic effect of PCSK9 insLEU and R46L gene mutations and apoE genotype

scientific article published on 3 June 2013

Residual macrovascular risk in 2013: what have we learned?

scientific article

Risk factors for cardiovascular disease in heterozygous familial hypercholesterolemia: a systematic review and meta-analysis

scientific article published on 07 November 2018

Role of inflammation in the pathogenesis of atherosclerosis and therapeutic interventions

article

Rosuvastatin for primary prevention among individuals with elevated high-sensitivity c-reactive protein and 5% to 10% and 10% to 20% 10-year risk. Implications of the Justification for Use of Statins in Prevention: an Intervention Trial Evaluating R

scientific article published on 24 August 2010

Rosuvastatin, proprotein convertase subtilisin/kexin type 9 concentrations, and LDL cholesterol response: the JUPITER trial

scientific article

Secretory vesicular transport from the Golgi is altered during ATP-binding cassette protein A1 (ABCA1)-mediated cholesterol efflux

scientific article

Severe hyperhomocysteinemia due to cystathionine β-synthase deficiency, and Factor V Leiden mutation in a patient with recurrent venous thrombosis

scientific article

Severe xanthomatosis in heterozygous familial hypercholesterolemia

scientific article published in 2018

Simplified Canadian Definition for Familial Hypercholesterolemia

article

Smashing Low-Density Lipoprotein Levels and Preventing Coronary Allograft Vasculopathy: One Heart Transplant Patient at a Time.

scientific article

Sphingomyelin phosphodiesterase-1 (SMPD1) coding variants do not contribute to low levels of high-density lipoprotein cholesterol

scientific article

Statin therapy in Canadian patients with hypercholesterolemia: the Canadian Lipid Study -- Observational (CALIPSO).

scientific article published in November 2005

Structural and functional properties of human plasma high density-sized lipoprotein containing only apoE particles

scientific article published on March 2003

Structural modification of plasma HDL by phospholipids promotes efficient ABCA1-mediated cholesterol release

scientific article published on 16 January 2005

Surgical strategies for severe calcification of the aorta (porcelain aorta) in two patients with homozygous familial hypercholesterolemia

scientific article published on December 2007

The Essential Role of Primary Caregiver in Early Detection of Familial Hypercholesterolemia and Cardiovascular Prevention.

scientific article

The HDL proteome in acute coronary syndromes shifts to an inflammatory profile ⬇️

scientific article published on July 23, 2011

The LDLR deficient mouse as a model for aortic calcification and quantification by micro-computed tomography

scientific article published on 26 August 2011

The Urotensin II System and Carotid Atherosclerosis: A Role in Vascular Calcification

scientific article published on 07 June 2016

The WWOX gene modulates high-density lipoprotein and lipid metabolism

scientific article

The analysis by Manuel and colleagues creates controversy with headlines, not data

scientific article published in April 2005

The genetics of dilated cardiomyopathy: a prioritized candidate gene study of LMNA, TNNT2, TCAP, and PLN

scientific article

The new dyslipidemia guidelines: what is the debate?

scientific article

Treatment options for low high-density lipoproteins

scientific article published on April 2014

Urotensin II receptor knockout mice on an ApoE knockout background fed a high-fat diet exhibit an enhanced hyperlipidemic and atherosclerotic phenotype

scientific article published on 20 August 2009

WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels

scientific article published on August 2008

cAMP induces ABCA1 phosphorylation activity and promotes cholesterol efflux from fibroblasts

scientific article published on December 2002

Paulina is supported by:

About Paulina

Help