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List of works by Angela Greco

9p21 locus analysis in high-risk gastrointestinal stromal tumors characterized for c-kit and platelet-derived growth factor receptor alpha gene alterations.

scientific article

A new mutation in the KIT ATP pocket causes acquired resistance to imatinib in a gastrointestinal stromal tumor patient

scientific article

Alternative mutations of BRAF, RET and NTRK1 are associated with similar but distinct gene expression patterns in papillary thyroid cancer.

scientific article published in September 2004

Analysis of SHP-1-mediated down-regulation of the TRK-T3 oncoprotein identifies Trk-fused gene (TFG) as a novel SHP-1-interacting protein.

scientific article

Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells.

scientific article

Are two better than one? A novel double-mutant KIT in GIST that responds to Imatinib

scientific article published on 21 March 2013

Biological activity of the thyroid TRK-T3 oncogene requires signalling through Shc

scientific article

Biological activity of the thyroid TRK-T3 oncogene requires signalling through Shc

scientific article published on 26 May 2016

Characterization of the NTRK1 genomic region involved in chromosomal rearrangements generating TRK oncogenes.

scientific article published in November 1993

Concomitant downregulation of proliferation/survival pathways dependent on FGF-R3, JAK2 and BCMA in human multiple myeloma cells by multi-kinase targeting.

scientific article

DUSP6/MKP3 is overexpressed in papillary and poorly differentiated thyroid carcinoma and contributes to neoplastic properties of thyroid cancer cells.

scientific article published on 21 January 2013

Detection of novel mRNA splice variants of human ING4 tumor suppressor gene.

scientific article

Detection of overexpressed and phosphorylated wild-type kit receptor in surgical specimens of small cell lung cancer

scientific article published in December 2004

Evidence of oncogene-induced senescence in thyroid carcinogenesis.

scientific article published in December 2011

Expression of ligand-activated KIT and platelet-derived growth factor receptor beta tyrosine kinase receptors in synovial sarcoma

scientific article published on February 2004

Functional analyses and molecular modeling of two c-Kit mutations responsible for imatinib secondary resistance in GIST patients

article

Functional characterization of NTRK1 mutations identified in melanoma

scientific article published on 26 June 2014

Functional characterization of the MTC-associated germline RET-K666E mutation: evidence of oncogenic potential enhanced by the G691S polymorphism.

scientific article published on 25 July 2011

Functional mapping of receptor tyrosine kinases in myxoid liposarcoma.

scientific article published on 3 June 2010

Gain of function mutations of RTK conserved residues display differential effects on NTRK1 kinase activity.

scientific article

Genetic profiling of advanced radioactive iodine-resistant differentiated thyroid cancer and correlation with axitinib efficacy.

scientific article published on 29 January 2015

Growth-inhibitory effect of STI571 on cells transformed by the COL1A1/PDGFB rearrangement.

scientific article published on May 2001

H2AX phosphorylation and kinetics of radiation-induced DNA double strand break repair in human primary thyrocytes.

scientific article published in March 2009

Histopathology, Immunohistochemistry and Molecular Biology of Follicular Epithelium-Derived Pediatric Thyroid Carcinomas

scientific article published on 01 January 2016

Identification of thyroid tumor cell vulnerabilities through a siRNA-based functional screening

scientific article published on 25 September 2015

Imatinib mesylate in chordoma

scientific article

Immunomodulatory Factors Control the Fate of Melanoma Tumor Initiating Cells.

scientific article published on 14 June 2016

Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene

scientific article

Integrated ligand-receptor bioinformatic and in vitro functional analysis identifies active TGFA/EGFR signaling loop in papillary thyroid carcinomas

scientific article

KRAS and BRAF mutations predict primary resistance to imatinib in gastrointestinal stromal tumors

scientific article published on 26 January 2012

Loss of function effect of RET mutations causing Hirschsprung disease.

scientific article published on May 1995

Metallothionein 1G acts as an oncosupressor in papillary thyroid carcinoma

scientific article

Metallothionein 1G and zinc sensitize human colorectal cancer cells to chemotherapy

scientific article published on 14 March 2014

Molecular spectrum of BRAF, NRAS and KRAS gene mutations in plasma cell dyscrasias: implication for MEK-ERK pathway activation

scientific article

Multikinase inhibitors in thyroid cancer.

scientific article

Novel Pathogenic Mechanisms of Congenital Insensitivity to Pain with Anhidrosis Genetic Disorder Unveiled by Functional Analysis of Neurotrophic Tyrosine Receptor Kinase Type 1/Nerve Growth Factor Receptor Mutations

scientific article published in Journal of Biological Chemistry

Oncogenic rearrangements of the NTRK1/NGF receptor.

scientific article

PDGFRalpha, PDGFRbeta and KIT expression/activation in conventional chondrosarcoma.

scientific article published on April 2006

Proximity ofTPRandNTRK1Rearranging Loci in Human Thyrocytes

scientific article published on 01 April 2005

RET inhibition: implications in cancer therapy.

scientific article published on 06 March 2013

Rearrangements of NTRK1 gene in papillary thyroid carcinoma.

scientific article

Refined localization of the human TPR gene to chromosome 1q25 by in situ hybridization.

scientific article published on October 1994

Role of STAT3 in in vitro transformation triggered by TRK oncogenes

scientific article

Role of TFG sequences outside the coiled-coil domain in TRK-T3 oncogenic activation.

scientific article published on February 2003

S100A11 overexpression contributes to the malignant phenotype of papillary thyroid carcinoma.

scientific article published on 8 August 2013

T670X KIT mutations in gastrointestinal stromal tumors: making sense of missense

scientific article published on 27 January 2009

TIMP3 regulates migration, invasion and in vivo tumorigenicity of thyroid tumor cells.

scientific article published on 21 February 2011

TRK-A, HER-2/neu, and KIT Expression/Activation Profiles in Salivary Gland Carcinoma

scientific article published on September 2008

Targeting Non-Oncogene Addiction: Focus on Thyroid Cancer

scientific article published on 04 January 2020

The M581V mutation, associated with a mild form of congenital insensitivity to pain with anhidrosis, causes partial inactivation of the NTRK1 receptor.

scientific article published on October 2002

The TFG protein, involved in oncogenic rearrangements, interacts with TANK and NEMO, two proteins involved in the NF-kappaB pathway.

scientific article published on July 2006

The modifier role of RET-G691S polymorphism in hereditary medullary thyroid carcinoma: functional characterization and expression/penetrance studies

scientific article

The molecular and gene/miRNA expression profiles of radioiodine resistant papillary thyroid cancer

scientific article published on 16 November 2020

The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 alpha (HIF-1alpha) activity: involvement in myeloma-induced angio

scientific article published on 11 September 2007

The signaling adapters fibroblast growth factor receptor substrate 2 and 3 are activated by the thyroid TRK oncoproteins.

scientific article

miR-451a is underexpressed and targets AKT/mTOR pathway in papillary thyroid carcinoma.

scientific article published on 08 February 2016