List of works - Laura Gasparini

A large genomic deletion leads to enhancer adoption by the lamin B1 gene: a second path to autosomal dominant adult-onset demyelinating leukodystrophy (ADLD)

scientific article published on 20 February 2015

Activity of flurbiprofen and chemically related anti-inflammatory drugs in models of Alzheimer's disease

scientific article published on 28 January 2005

Advanced imaging of tau pathology in Alzheimer Disease: New perspectives from super resolution microscopy and label-free nanoscopy.

scientific article published on 21 June 2016

Analysis of alpha-2-macroglobulin-2 allele as a risk factor in Alzheimer's disease.

scientific article published in September 2001

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription.

scholarly article

Beta-amyloid and glutamate receptors

scientific article published on 19 March 2008

CLIC1 functional expression is required for cAMP-induced neurite elongation in post-natal mouse retinal ganglion cells

scientific article published on 12 August 2014

Detection of the presenilin 1 COOH-terminal fragment in the extracellular compartment: a release enhanced by apoptosis

scientific journal article

Does insulin dysfunction play a role in Alzheimer's disease?

scientific article

Dominant β-catenin mutations cause intellectual disability with recognizable syndromic features

scientific article

Dynamic regulation of microglial functions by the non-steroidal anti-inflammatory drug NCX 2216: implications for chronic treatments of neurodegenerative diseases.

scientific article published on 22 November 2005

Early behavioural markers of disease in P301S tau transgenic mice

scientific article published on 11 December 2009

Effect of energy shortage and oxidative stress on amyloid precursor protein metabolism in COS cells.

scientific article published on August 1997

Effects of antiepileptic drugs on hippocampal neurons coupled to micro-electrode arrays

scientific article

Frontotemporal dementia with tau pathology.

scientific article published on January 2007

Inhibition of energy metabolism down-regulates the Alzheimer related presenilin 2 gene.

scientific article published in September 2003

Interaction of tau protein with the dynactin complex

scientific article

Lamin B1 levels modulate differentiation into neurons during embryonic corticogenesis

scientific article

Lamin B1 overexpression increases nuclear rigidity in autosomal dominant leukodystrophy fibroblasts

scientific article

Lamin B1 protein is required for dendrite development in primary mouse cortical neurons

scientific article

Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy

scientific article (publication date: 2016)

Modulation of beta-amyloid metabolism by non-steroidal anti-inflammatory drugs in neuronal cell cultures.

scientific article published on January 2004

Modulation of iNOS expression by a nitric oxide-releasing derivative of the natural antioxidant ferulic acid in activated RAW 264.7 macrophages.

scientific article published on 27 January 2006

Modulation of presenilin-1 processing by nitric oxide during apoptosis induced by serum withdrawal and glucose deprivation.

scientific article published in January 1999

N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain

scientific article published on 13 November 2019

NO-donor thiacarbocyanines as multifunctional agents for Alzheimer's disease

scientific article published on 3 June 2015

Oct-1 recruitment to the nuclear envelope in adult-onset autosomal dominant leukodystrophy

scientific article published on 20 December 2012

Peripheral cells as an investigational tool for Alzheimer's disease.

scientific article

Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease ⬇️

scientific article published on January 1, 1998

Potential roles of insulin and IGF-1 in Alzheimer's disease.

scientific article

Presenilin 1 protein directly interacts with Bcl-2

scientific article (publication date: 22 October 1999)

Resting microglia react to Aβ42 fibrils but do not detect oligomers or oligomer-induced neuronal damage

scientific article published on 29 May 2014

Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.

scientific article

Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice: effects on axonal viability.

scientific article published on 7 April 2009

Tau-Driven Neuronal and Neurotrophic Dysfunction in a Mouse Model of Early Tauopathy.

scientific article published on February 2016

Tauopathy-induced retinal dysfunction in the P301S mutant human tau transgenic mouse.

scientific article published on 4 October 2013

Testing pathophysiological hypotheses of Alzheimer's disease and pharmacological modulation of amyloid precursor protein metabolism: the contribution from the studies on cultured fibroblasts from affected donors.

scientific article published on January 1997

List of works by Laura Gasparini

A large genomic deletion leads to enhancer adoption by the lamin B1 gene: a second path to autosomal dominant adult-onset demyelinating leukodystrophy (ADLD)

Activity of flurbiprofen and chemically related anti-inflammatory drugs in models of Alzheimer's disease

Advanced imaging of tau pathology in Alzheimer Disease: New perspectives from super resolution microscopy and label-free nanoscopy.

Analysis of alpha-2-macroglobulin-2 allele as a risk factor in Alzheimer's disease.

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription.

Beta-amyloid and glutamate receptors

CLIC1 functional expression is required for cAMP-induced neurite elongation in post-natal mouse retinal ganglion cells

Detection of the presenilin 1 COOH-terminal fragment in the extracellular compartment: a release enhanced by apoptosis

Does insulin dysfunction play a role in Alzheimer's disease?

Dominant β-catenin mutations cause intellectual disability with recognizable syndromic features

Dynamic regulation of microglial functions by the non-steroidal anti-inflammatory drug NCX 2216: implications for chronic treatments of neurodegenerative diseases.

Early behavioural markers of disease in P301S tau transgenic mice

Effect of energy shortage and oxidative stress on amyloid precursor protein metabolism in COS cells.

Effects of antiepileptic drugs on hippocampal neurons coupled to micro-electrode arrays

Frontotemporal dementia with tau pathology.

Inhibition of energy metabolism down-regulates the Alzheimer related presenilin 2 gene.

Interaction of tau protein with the dynactin complex

Lamin B1 levels modulate differentiation into neurons during embryonic corticogenesis

Lamin B1 overexpression increases nuclear rigidity in autosomal dominant leukodystrophy fibroblasts

Lamin B1 protein is required for dendrite development in primary mouse cortical neurons

Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy

Modulation of beta-amyloid metabolism by non-steroidal anti-inflammatory drugs in neuronal cell cultures.

Modulation of iNOS expression by a nitric oxide-releasing derivative of the natural antioxidant ferulic acid in activated RAW 264.7 macrophages.

Modulation of presenilin-1 processing by nitric oxide during apoptosis induced by serum withdrawal and glucose deprivation.

N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain

NO-donor thiacarbocyanines as multifunctional agents for Alzheimer's disease

Oct-1 recruitment to the nuclear envelope in adult-onset autosomal dominant leukodystrophy

Peripheral cells as an investigational tool for Alzheimer's disease.

Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease ⬇️

Potential roles of insulin and IGF-1 in Alzheimer's disease.

Presenilin 1 protein directly interacts with Bcl-2

Resting microglia react to Aβ42 fibrils but do not detect oligomers or oligomer-induced neuronal damage

Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.

Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice: effects on axonal viability.

Tau-Driven Neuronal and Neurotrophic Dysfunction in a Mouse Model of Early Tauopathy.

Tauopathy-induced retinal dysfunction in the P301S mutant human tau transgenic mouse.

Testing pathophysiological hypotheses of Alzheimer's disease and pharmacological modulation of amyloid precursor protein metabolism: the contribution from the studies on cultured fibroblasts from affected donors.