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List of works by Orla Howe

A novel form of ataxia oculomotor apraxia characterized by oxidative stress and apoptosis resistance

article published in 2007

Apoptosis is signalled early by low doses of ionising radiation in a radiation-induced bystander effect.

scientific article published in January 2013

Aprataxin, a novel protein that protects against genotoxic stress

scientific article

Bis-phenanthroline copper(ii) phthalate complexes are potent in vitro antitumour agents with ‘self-activating’ metallo-nuclease and DNA binding properties

scientific article published on 16 December 2010

Cell Death Mechanisms Associated with G2Radiosensitivity in Patients with Prostate Cancer and Benign Prostatic Hyperplasia

scientific article published on 01 November 2005

Competitive evaluation of data mining algorithms for use in classification of leukocyte subtypes with Raman microspectroscopy

scientific article published on April 2015

Copper(II) complexes of coumarin-derived Schiff base ligands: Pro- or antioxidant activity in MCF-7 cells?

scientific article published on 05 May 2019

Copper(II) complexes of salicylic acid combining superoxide dismutase mimetic properties with DNA binding and cleaving capabilities display promising chemotherapeutic potential with fast acting in vitro cytotoxicity against cisplatin sensitive and r

scientific article published on 28 February 2012

Cu(ii) phenanthroline-phenazine complexes dysregulate mitochondrial function and stimulate apoptosis

scientific article published on 01 January 2020

DNA cleavage reactions of the dinuclear chemotherapeutic agent copper(II) bis-1,10- phenanthroline terephthalate

scientific article published on 01 January 2012

Do Radiation-Induced Bystander Effects Correlate to the Intrinsic Radiosensitivity of Individuals and Have Clinical Significance?

scientific article published on 01 May 2009

Doxorubicin kinetics and effects on lung cancer cell lines using in vitro Raman micro-spectroscopy: binding signatures, drug resistance and DNA repair.

scientific article published on 21 June 2017

Evaluation of the potential of Raman microspectroscopy for prediction of chemotherapeutic response to cisplatin in lung adenocarcinoma

scientific article published on 7 October 2010

Identification of Key Proteins in Human Epithelial Cells Responding to Bystander Signals From Irradiated Trout Skin.

scientific article

In vitro evaluation of the cytotoxicity of a folate-modified β-cyclodextrin as a new anti-cancer drug delivery system

In-vivo evaluation of the response of Galleria mellonella larvae to novel copper(II) phenanthroline-phenazine complexes

scientific article published on 01 June 2018

Non-thermal atmospheric plasma induces ROS-independent cell death in U373MG glioma cells and augments the cytotoxicity of temozolomide

scientific article published on 4 February 2016

Prediction of DNA damage and G2 chromosomal radio-sensitivity ex vivo in peripheral blood mononuclear cells with label-free Raman micro-spectroscopy

scientific article published on 29 March 2018

Quantitative reagent-free detection of fibrinogen levels in human blood plasma using Raman spectroscopy

scientific article published on 02 March 2012

Radiation and chemotherapy bystander effects induce early genomic instability events: telomere shortening and bridge formation coupled with mitochondrial dysfunction.

scientific article published on 18 June 2009

Radical-induced DNA damage by cytotoxic square-planar copper(II) complexes incorporating o-phthalate and 1,10-phenanthroline or 2,2'-dipyridyl.

scientific article

Raman Spectroscopy As A Potential Rapid Screening Tool For Venous Thromboembolism

Regulating bioactivity of Cu2+ bis-1,10-phenanthroline artificial metallonucleases with sterically functionalized pendant carboxylates.

scientific article published on 6 November 2013

Silver nanoparticles induce pro-inflammatory gene expression and inflammasome activation in human monocytes

scientific article published on 10 March 2016

Targeting the folate receptor: improving efficacy in inorganic medicinal chemistry.

scientific article published on 9 February 2018

Tetrameric and polymeric silver complexes of the omeprazole scaffold; synthesis, structure, in vitro and in vivo antimicrobial activities and DNA interaction

scientific article published on 31 May 2018

The Antibacterial Activity of Metal Complexes Containing 1,10- phenanthroline: Potential as Alternative Therapeutics in the Era of Antibiotic Resistance

scientific article

The Antibacterial and Anti-biofilm Activity of Metal Complexes Incorporating 3,6,9-Trioxaundecanedioate and 1,10-Phenanthroline Ligands in Clinical Isolates of Pseudomonas Aeruginosa from Irish Cystic Fibrosis Patients

scientific article published on 05 October 2020

The G2 chromosomal radiosensitivity assay

scientific article published on 01 September 2002

Vibrational spectroscopy in sensing radiobiological effects: analyses of targeted and non-targeted effects in human keratinocytes

scientific article published on 04 April 2016

Water-soluble and photo-stable silver(I) dicarboxylate complexes containing 1,10-phenanthroline ligands: Antimicrobial and anticancer chemotherapeutic potential, DNA interactions and antioxidant activity

scientific article published on 2 March 2016

Water-soluble bis(1,10-phenanthroline) octanedioate Cu2+ and Mn2+ complexes with unprecedented nano and picomolar in vitro cytotoxicity: promising leads for chemotherapeutic drug development

article

[Cu(o-phthalate)(phenanthroline)] Exhibits Unique Superoxide-Mediated NCI-60 Chemotherapeutic Action through Genomic DNA Damage and Mitochondrial Dysfunction

scientific article published on 21 October 2015

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