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List of works by Paul N Span

-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate

scientific article published on 20 May 2019

18F-FLT PET during radiotherapy or chemoradiotherapy in head and neck squamous cell carcinoma is an early predictor of outcome

scientific article

18S is an appropriate housekeeping gene for in vitro hypoxia experiments.

scientific article published on 20 July 2010

3 Alpha-hydroxysteroid oxidoreductase activities in dihydrotestosterone degradation and back-formation in rat prostate and epididymis

scientific article published on 01 June 1996

4-protein signature predicting tamoxifen treatment outcome in recurrent breast cancer.

scientific article published on 7 August 2015

A 26-gene hypoxia signature predicts benefit from hypoxia-modifying therapy in laryngeal cancer but not bladder cancer

scientific article published on 02 July 2013

A prospective randomized trial evaluating tissue effects of finasteride therapy in benign prostatic hyperplasia.

scientific article

ACLY (ATP Citrate Lyase) Mediates Radioresistance in Head and Neck Squamous Cell Carcinomas and is a Novel Predictive Radiotherapy Biomarker

scientific article published on 07 December 2019

ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma

scientific article

AKT inhibition as a strategy for targeting hypoxic HPV-positive HNSCC

scientific article published on 30 April 2020

Accelerated radiotherapy with carbogen and nicotinamide for laryngeal cancer: results of a phase III randomized trial

scientific article published on 16 April 2012

Activation of AKT by hypoxia: a potential target for hypoxic tumors of the head and neck.

scientific article

Addressing the dichotomy between individual and societal approaches to personalised medicine in oncology

scientific article published on 03 May 2019

Adrenal Steroid Metabolites Accumulating in Congenital Adrenal Hyperplasia Lead to Transactivation of the Glucocorticoid Receptor

scientific article

Analysis of expression of chorionic gonadotrophin transcripts in prostate cancer by quantitative Taqman and a modified molecular beacon RT-PCR

scientific article published on 01 March 2002

Annexin-A1 and caldesmon are associated with resistance to tamoxifen in estrogen receptor positive recurrent breast cancer

scientific article published on 9 December 2015

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences

scientific article published on 01 February 2019

BRAFV600E Inhibitor Radiosensitizes Thyroid Cancer-Letter

scientific article published on 01 November 2019

Biology of hypoxia.

scientific article published in March 2015

Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration

scientific article published on 26 September 2016

Breast cancer size estimation with MRI in BRCA mutation carriers and other high risk patients.

scientific article published on 6 April 2013

Can FDG PET predict radiation treatment outcome in head and neck cancer? Results of a prospective study.

scientific article

Carbonic anhydrase IX expression is more predictive than prognostic in breast cancer.

scientific article published on 27 March 2007

Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: association with treatment outcome

scientific article published on July 2003

Cathepsins B, L and cystatin C in cyst fluid of ovarian tumors.

scientific article

ChIP-Seq of ERalpha and RNA polymerase II defines genes differentially responding to ligands

scientific article published on 04 April 2009

Changes in DNA Damage Repair Gene Expression and Cell Cycle Gene Expression Do Not Explain Radioresistance in Tamoxifen-Resistant Breast Cancer

scientific article published on 18 April 2019

Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B

scientific article published on 28 September 2020

Clinical significance of the nuclear receptor co-regulator DC-SCRIPT in breast cancer: an independent retrospective validation study.

scientific article

Collective invasion in ductal and lobular breast cancer associates with distant metastasis.

scientific article published on 11 September 2017

Comparability versus statistical correctness.

scientific article published on 14 August 2013

Comparative proteome analysis revealing an 11-protein signature for aggressive triple-negative breast cancer

scientific article published on 07 January 2014

Complex of urokinase-type plasminogen activator with its type 1 inhibitor predicts poor outcome in 576 patients with lymph node-negative breast carcinoma.

scientific article

Components of the plasminogen activator system and their complexes in renal cell and bladder cancer: comparison between normal and matched cancerous tissues

scientific article published on 01 July 2008

Computed tomography-based tumour volume as a predictor of outcome in laryngeal cancer: results of the phase 3 ARCON trial.

scientific article published on 11 January 2014

Concerns about mammaglobin assays

scientific article published on 01 February 2005

Correlation of reversion-inducing cysteine-rich protein with kazal motifs (RECK) and extracellular matrix metalloproteinase inducer (EMMPRIN), with MMP-2, MMP-9, and survival in colorectal cancer

scientific article published on 19 July 2005

Corrigendum: Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells

scientific article published on May 2016

Crosstalk and DC-SCRIPT: expanding nuclear receptor modulation.

scientific article published on 15 May 2010

Cyclin-E is a strong predictor of endocrine therapy failure in human breast cancer.

scientific article published in July 2003

Dasatinib Inhibits DNA Repair after Radiotherapy Specifically in pSFK-Expressing Tumor Areas in Head and Neck Xenograft Tumors.

scientific article published on August 2013

Development of an ELISA for measurement of BCAR1 protein in human breast cancer tissue.

scientific article published on August 2004

Dietary fatty acid composition during pregnancy and lactation in the rat programs growth and glucose metabolism in the offspring.

scientific article published on 5 September 2002

Differences in metabolism between adeno- and squamous cell non-small cell lung carcinomas: spatial distribution and prognostic value of GLUT1 and MCT4.

scientific article published on 6 December 2011

Differential expression of p120-catenin 1 and 3 isoforms in epithelial tissues

scientific article published in Scientific Reports

Differential subcellular distribution of rat prostatic steroid 5alpha-reductase isozyme activities

scientific article published on 01 March 1996

Diffusion-weighted MR imaging in liver metastases of colorectal cancer: reproducibility and biological validation.

scientific article

Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma.

scientific article

Do the survivin (BIRC5) splice variants modulate or add to the prognostic value of total survivin in breast cancer?

scientific article published on 27 July 2006

Downregulation of matrix Gla protein is a biomarker for tamoxifen-resistant and radioresistant breast cancer

scientific article published on 18 July 2019

Downregulation of serine protease HTRA1 is associated with poor survival in breast cancer

scientific article

EGFR-inhibition enhances apoptosis in irradiated human head and neck xenograft tumors independent of effects on DNA repair.

scientific article published on 23 September 2013

Early identification of treatment resistance in GTN

scientific article published on 01 October 2007

Effect of hypoxia on the expression of αB-crystallin in head and neck squamous cell carcinoma

scientific article

Effectiveness and toxicity of hypofractionated high-dose intensity-modulated radiotherapy versus 2- and 3-dimensional radiotherapy in incurable head and neck cancer

scientific article published on 02 September 2015

Elevated levels of vascular endothelial growth factor in serum of patients with D+ HUS.

scientific article

Engineered microparticles delivering oxygen to enhance radiotherapy efficacy.

scientific article published on 7 December 2016

Erratum: Corrigendum: Signatures of mutational processes in human cancer

scientific article published in Nature

Evaluation of the ability of adjuvant tamoxifen-benefit gene signatures to predict outcome of hormone-naive estrogen receptor-positive breast cancer patients treated with tamoxifen in the advanced setting.

scientific article published on 10 July 2014

Exploring Levels of Hexosamine Biosynthesis Pathway Intermediates and Protein Kinase C Isoforms in Muscle and Fat Tissue of Zucker Diabetic Fatty Rats ⬇️

scientific article published on April 1, 2003

Expression of E-cadherin and vimentin correlates with metastasis formation in head and neck squamous cell carcinoma patients

scientific article published on 22 June 2011

Expression of carbonic anhydrase IX suggests poor response to therapy in rectal cancer.

scientific article published on 30 June 2009

Expression of the BRCA1 complex member BRE predicts disease free survival in breast cancer.

scientific article

Expression of the transcription factor Ets-1 is an independent prognostic marker for relapse-free survival in breast cancer.

scientific article published in December 2002

Ferritin heavy chain in triple negative breast cancer: a favorable prognostic marker that relates to a cluster of differentiation 8 positive (CD8+) effector T-cell response

scientific article

Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells

scientific article published on 11 May 2015

From eels to the importance of cancer biobanks

scientific article published on November 2015

GATA transcription factors in testicular adrenal rest tumours.

scientific article published on 16 October 2017

Glucocorticoid Activity of Adrenal Steroid Precursors in Untreated Patients With Congenital Adrenal Hyperplasia

scientific article published on 01 November 2019

Glucose and glutamine metabolism in relation to mutational status in NSCLC histological subtypes

scientific article published on 30 October 2019

Glucose metabolism in NSCLC is histology-specific and diverges the prognostic potential of 18FDG-PET for adenocarcinoma and squamous cell carcinoma

scientific article published in October 2014

Gonadal function in adult male patients with congenital adrenal hyperplasia

scientific article published on 16 January 2018

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HER2, chromosome 17 polysomy and DNA ploidy status in breast cancer; a translational study

scientific article published on 12 August 2019

HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion

scientific article

HPV, hypoxia and radiation response in head and neck cancer.

scientific article

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

scientific article published on 13 March 2017

Haptoglobin phenotype is not a predictor of recurrence free survival in high-risk primary breast cancer patients.

scientific article

Harmonisation of multi-centre real-time reverse-transcribed PCR results of a candidate prognostic marker in breast cancer: an EU-FP6 supported study of members of the EORTC - PathoBiology Group.

scientific article

High occurrence of aberrant lymph node spread on magnetic resonance lymphography in prostate cancer patients with a biochemical recurrence after radical prostatectomy

scientific article published on 02 June 2011

High survivin predicts a poor response to endocrine therapy, but a good response to chemotherapy in advanced breast cancer

scientific article published on 16 March 2006

Hotspot mutations in PIK3CA associate with first-line treatment outcome for aromatase inhibitors but not for tamoxifen ⬇️

scientific article published on April 17, 2013

Hypoxia regulation of phosphokinases and the prognostic value of pAKT in breast cancer.

scientific article

Hypoxia, metabolism, and growth factor signaling in head and neck squamous cell carcinoma: correlation between primary and xenograft tumors

scientific article published on 06 November 2013

Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT

scientific article published on 11 May 2015

Hypoxic activation of the PERK/eIF2α arm of the unfolded protein response promotes metastasis through induction of LAMP3.

scientific article published on 17 September 2013

Hypoxic regulation and prognostic value of LAMP3 expression in breast cancer.

scientific article published on 11 February 2011

Hypoxic regulation of the PERK/ATF4/LAMP3-arm of the unfolded protein response in head and neck squamous cell carcinoma.

scientific article published on 27 June 2014

Identification and partial characterization of two steroid 5 alpha-reductase isozymes in the canine prostate

scientific article published on 01 February 1998

Identifying estrogen receptor target genes.

scientific article published on 08 May 2007

Implications of Progesterone Metabolism in MA-10 Cells for Accurate Measurement of the Rate of Steroidogenesis ⬇️

scientific article published on December 1, 2001

Improved metastasis-free survival in nonadjuvantly treated postmenopausal breast cancer patients with chemokine receptor 5 del32 frameshift mutations

scientific article published on 20 May 2014

Inhibition of CDK4/CDK6 Enhances Radiosensitivity of HPV Negative Head and Neck Squamous Cell Carcinomas

scientific article published on 02 July 2019

Inhibition of protein kinase CbetaII increases glucose uptake in 3T3-L1 adipocytes through elevated expression of glucose transporter 1 at the plasma membrane.

scientific article published on 17 April 2003

Interferon-Stimulated Genes Are Involved in Cross-resistance to Radiotherapy in Tamoxifen-Resistant Breast Cancer

scientific article published on 16 April 2018

International biobanks: do or do not?

scientific article published on 22 September 2015

Is survivin expression nevertheless related to disease outcome in breast cancer?

scientific article published on 21 September 2006

Isocitrate dehydrogenase 1-mutated human gliomas depend on lactate and glutamate to alleviate metabolic stress

scientific article published on 12 July 2018

Kinetic analysis of rat steroid 5alpha-reductase activity in prostate and epididymis homogenates at neutral pH: evidence for type I activity in epididymis

scientific article published on 01 January 1996

Kinetic analysis of steroid 5alpha-reductase activity at neutral pH in benign prostatic hyperplastic tissue: evidence for type I isozyme activity in the human prostate

scientific article published on 01 January 1996

LAMP3 is involved in tamoxifen resistance in breast cancer cells through the modulation of autophagy.

scientific article published on 16 January 2014

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

scientific article

Magnetic Resonance Lymphography Findings in Patients With Biochemical Recurrence After Prostatectomy and the Relation With the Stephenson Nomogram ⬇️

scientific article published on April 18, 2012

Mammaglobin RT-qPCR for breast cancer metastasis detection in sentinel lymph nodes

scientific article published on 01 November 2010

Mammaglobin as molecular marker of breast cancer (micro)metastases.

scientific article

Matrix metalloproteinase inhibitor reversion-inducing cysteine-rich protein with Kazal motifs: a prognostic marker for good clinical outcome in human breast carcinoma

scientific article published on 01 June 2003

Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion

scientific article

Matrix metalloproteinase-8 is a regulator of the clinical aggressiveness of mammary tumours

scientific article published on 13 May 2008

Methylated genes as new cancer biomarkers.

scientific article

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

scientific article

Molecular beacon reverse transcription-PCR of human chorionic gonadotropin-beta-3, -5, and -8 mRNAs has prognostic value in breast cancer

scientific article published on 01 July 2003

Molecular characterization of testicular adrenal rest tumors in congenital adrenal hyperplasia: lesions with both adrenocortical and Leydig cell features

scientific article published on 08 December 2014

Molecular profiling of platinum resistant ovarian cancer.

scientific article published in April 2006

Monitoring hypoxia and vasculature during bevacizumab treatment in a murine colorectal cancer model.

scientific article published in May 2014

Monitoring the effects of bevacizumab beyond progression in a murine colorectal cancer model: a functional imaging approach.

scientific article published on 17 January 2013

Multicenter validation of a gene expression-based prognostic signature in lymph node-negative primary breast cancer.

scientific article published on 27 February 2006

Mutational mechanisms of amplifications revealed by analysis of clustered rearrangements in breast cancers

scientific article published on 01 November 2018

Occurrence of postmenopausal-like acidic follicle-stimulating hormone (FSH) isoforms precedes the rise of FSH before menopause

scientific article published on 09 August 2008

Overexpression of the natural antisense hypoxia-inducible factor-1alpha transcript is associated with malignant pheochromocytoma/paraganglioma

scientific article published on 28 April 2011

P120 Catenin Isoforms Differentially Associate with Breast Cancer Invasion and Metastasis

scientific article published on 29 September 2019

P120 and E-cadherin: Double-edged swords in tumor metastasis

scientific article published on 29 July 2019

Parathyroid hormone-related protein regulates tumor-relevant genes in breast cancer cells.

scientific article published on 21 March 2006

Partial sequencing and tissue distribution of the canine isoforms of steroid 5alpha-reductase type I and type II.

scientific article published in August 2000

Phlorizin treatment prevents the decrease in plasma insulin levels but not the progressive histopathological changes in the pancreatic islets during aging of Zucker diabetic fatty rats.

scientific article published in June 2003

Polyisocyanide Hydrogels as a Tunable Platform for Mammary Gland Organoid Formation

scientific article published on 26 July 2020

Poor prognosis of constitutive γ-H2AX expressing triple-negative breast cancers is associated with telomere length.

scientific article

Predicting and Understanding Cancer Response to Treatment

scientific article published on 29 May 2018

Predictive value of hypoxia, proliferation and tyrosine kinase receptors for EGFR-inhibition and radiotherapy sensitivity in head and neck cancer models.

scientific article published on 28 February 2013

Prognostic relevance of uPAR-del4/5 and TIMP-3 mRNA expression levels in breast cancer.

scientific article

Prognostic significance of nuclear expression of UMP-CMP kinase in triple negative breast cancer patients.

scientific article published on 25 August 2016

Quality-of-life after radiotherapy for advanced laryngeal cancer: Results of a phase III trial of the Dutch Head and Neck Society.

scientific article

Quantification of patient-specific assay interference in different formats of enzyme-linked immunoassays for therapeutic monoclonal antibodies

scientific article published on 01 December 2014

Quantitative detection of peripheral thyroglobulin mRNA has limited clinical value in the follow-up of thyroid cancer patients.

scientific article

Quantitative reverse transcription-PCR assay for detection of mRNA encoding full-length human tissue kallikrein 7: prognostic relevance of KLK7 mRNA expression in breast cancer

scientific article published on 20 April 2006

Radiation oncology enters the era of individualised medicine

scientific article published on 18 December 2016

Radiotherapy and cGAS/STING signaling: Impact on MDSCs in the tumor microenvironment

scientific article published in 2021

Rat steroid 5 alpha-reductase kinetic characteristics: extreme pH-dependency of the type II isozyme in prostate and epididymis homogenates

scientific journal article

Re: p27(Kip1) and cyclin E expression and breast cancer survival after treatment with adjuvant chemotherapy

scientific article published on 01 May 2007

Reduced adrenal response to bacterial lipopolysaccharide in interleukin-6-deficient mice.

scientific article published in November 2001

Regulation of GLUT1-mediated glucose uptake by PKClambda-PKCbeta(II) interactions in 3T3-L1 adipocytes.

scientific article published on December 2004

Roles and Regulation of Epithelial Splicing Regulatory Proteins 1 and 2 in Epithelial-Mesenchymal Transition.

scientific article published on 30 July 2016

Screening for interference in immunoassays

scientific article published on 01 October 2003

Selective MET Kinase Inhibition in MET-Dependent Glioma Models Alters Gene Expression and Induces Tumor Plasticity.

scientific article published on 27 July 2017

Selectivity of finasteride as an in vivo inhibitor of 5alpha-reductase isozyme enzymatic activity in the human prostate

scientific article published on 01 January 1999

Serial plasma concentrations of atrial natriuretic peptide, plasma renin activity, aldosterone, and antidiuretic hormone in neonates on extracorporeal membrane oxygenation.

scientific article published in January 2002

Somatic mutations reveal asymmetric cellular dynamics in the early human embryo

scientific article

Spatial relationship of phosphorylated epidermal growth factor receptor and activated AKT in head and neck squamous cell carcinoma.

scientific article

Staining Against Phospho-H2AX (γ-H2AX) as a Marker for DNA Damage and Genomic Instability in Cancer Tissues and Cells.

scientific article published in January 2016

Survivin is an independent prognostic marker for risk stratification of breast cancer patients

scientific article published on 13 September 2004

TRIB3 protein denotes a good prognosis in breast cancer patients and is associated with hypoxia sensitivity.

scientific article

Targeted MS Assay Predicting Tamoxifen Resistance in Estrogen-Receptor-Positive Breast Cancer Tissues and Sera.

scientific article

Targeting glucose and glutamine metabolism combined with radiation therapy in non-small cell lung cancer

scientific article published on 15 October 2018

Targeting hypoxia, HIF-1, and tumor glucose metabolism to improve radiotherapy efficacy.

scientific article published on October 2012

Targeting oxidative phosphorylation to increase the efficacy of radio- and immune- combination therapy

scientific article published on 08 January 2021

Testicular Adrenal Rest Tumors: Current Insights on Prevalence, Characteristics, Origin, and Treatment

scientific article published on 01 August 2019

Testicular tumors in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency show functional features of adrenocortical tissue

scientific article published on 26 June 2007

The 76-gene signature defines high-risk patients that benefit from adjuvant tamoxifen therapy.

scientific article published on 23 September 2008

The CYP2C19*2 genotype predicts tamoxifen treatment outcome in advanced breast cancer patients

scientific article published on 10 August 2011

The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer.

scientific article published on 07 October 2016

The PERK/ATF4/LAMP3-arm of the unfolded protein response affects radioresistance by interfering with the DNA damage response.

scientific article published on 25 July 2013

The Role of Hypoxia and the Immune System in Tumor Radioresistance

scientific article published on 14 October 2019

The balance between extracellular cathepsins and cystatin C is of importance for ovarian cancer

scientific article published on 12 May 2010

The circular RNome of primary breast cancer

scientific article published on 28 January 2019

The effect of carbogen breathing and nicotinamide added to standard (chemo)radiation treatment of advanced cervical cancer in Indonesia.

scientific article published in November 2014

The mechanical microenvironment in cancer: How physics affects tumours

scientific article published on 04 September 2015

The prognostic value of BCAR1 in patients with primary breast cancer.

scientific article published on September 2004

The topography of mutational processes in breast cancer genomes

scientific article published on 02 May 2016

The unfolded protein response as a target for cancer therapy

scientific article published on 25 July 2014

Therapeutic targeting of autophagy in cancer. Part I: molecular pathways controlling autophagy.

scientific article published on 29 May 2014

Therapeutic targeting of autophagy in cancer. Part II: pharmacological modulation of treatment-induced autophagy

scientific article

Tissue inhibitors of metalloproteinase expression in human breast cancer: TIMP-3 is associated with adjuvant endocrine therapy success.

scientific article published in April 2004

Treatment outcome and toxicity of intensity-modulated (chemo) radiotherapy in stage III non-small cell lung cancer patients

scientific article

Tribbles homolog 3 denotes a poor prognosis in breast cancer and is involved in hypoxia response.

scientific article published on 24 August 2011

Tumor microenvironmental changes induced by the sulfamate carbonic anhydrase IX inhibitor S4 in a laryngeal tumor model

scientific article

Vascular endothelial growth factor is associated with the efficacy of endocrine therapy in patients with advanced breast carcinoma ⬇️

scientific article published on November 15, 2003

αB-crystallin expression is correlated with phospho-ERK1/2 expression in human breast cancer.

scientific article published on October 2013

γ-H2AX foci in peripheral blood lymphocytes to quantify radiation-induced DNA damage after 177Lu-DOTA-octreotate peptide receptor radionuclide therapy

scientific article published on 26 February 2015

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