List of works - Heidi M McBride

A Mitofusin-2-dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver.

scientific article

A brain-enriched Drp1 isoform associates with lysosomes, late endosomes, and the plasma membrane

scientific article published in Journal of Biological Chemistry

A new mitofusin topology places the redox-regulated C terminus in the mitochondrial intermembrane space.

scientific article published on 6 December 2017

A new pathway for mitochondrial quality control: mitochondrial-derived vesicles

scientific article

A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function

scientific article (publication date: 19 September 1997)

A novel cell-free mitochondrial fusion assay amenable for high-throughput screenings of fusion modulators.

scientific article

A signal-anchor sequence selective for the mitochondrial outer membrane ⬇️

scientific article published on December 1, 1992

A vesicular transport pathway shuttles cargo from mitochondria to lysosomes.

scientific article

Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking.

scientific article published on 23 November 2011

Cell biology: Double agents for mitochondrial division

scientific article published on 23 November 2016

Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis

scientific article

Emerging roles of mitochondria in the evolution, biogenesis, and function of peroxisomes

scientific article published on 26 September 2013

Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis.

scientific article

Formation of mitochondrial-derived vesicles is an active and physiologically relevant mitochondrial quality control process in the cardiac system.

scientific article published on 17 June 2016

Genome-wide RNAi screen identifies ATPase inhibitory factor 1 (ATPIF1) as essential for PARK2 recruitment and mitophagy

scientific article

Golgi-derived PI(4)P-containing vesicles drive late steps of mitochondrial division

scientific article published on 01 March 2020

Hepatic SR-BI-mediated cholesteryl ester selective uptake occurs with unaltered efficiency in the absence of cellular energy.

scientific article published on 7 December 2005

Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72

scientific article published on 15 October 2019

Import and insertion of proteins into the mitochondrial outer membrane.

scientific article

In vivo and in vitro examination of the functional significances of novel lamin gene mutations in heart failure patients

scientific article

Insertion of an uncharged polypeptide into the mitochondrial inner membrane does not require a trans-bilayer electrochemical potential: effects of positive charges

scientific article published on 01 July 1995

Intestinal infection triggers Parkinson's disease-like symptoms in Pink1-/- mice

scientific article published on 17 July 2019

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

scientific article

MAPL SUMOylation of Drp1 Stabilizes an ER/Mitochondrial Platform Required for Cell Death

scientific article published on 01 September 2015

MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission

scientific article

MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control

scientific article published in 2021

Mammalian polynucleotide phosphorylase is an intermembrane space RNase that maintains mitochondrial homeostasis

scientific article

Mitochondria and endomembrane origins.

scientific article

Mitochondria and the culture of the Borg: understanding the integration of mitochondrial function within the reticulum, the cell, and the organism.

scientific article published on 07 September 2010

Mitochondria: more than just a powerhouse

scientific article (publication date: 25 July 2006)

Mitochondrial Dynamics: ER Actin Tightens the Drp1 Noose.

scientific article published in March 2016

Mitochondrial dynamics and physiology.

scientific article published on 7 November 2012

Mitochondrial hyperfusion during oxidative stress is coupled to a dysregulation in calcium handling within a C2C12 cell model.

scientific article

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment ⬇️

scientific article published on April 1, 2012

Mitochondrial vesicles: an ancient process providing new links to peroxisomes.

scientific article published on 05 May 2009

Mitochondrial-ER tethering: the inheritance of a functional unit.

scientific article published on 5 December 2011

Mitofusin 2 protects cerebellar granule neurons against injury-induced cell death.

scientific article published on 30 May 2007

Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes.

scientific article

OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand

scientific article

Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13

scientific article (publication date: 6 August 1999)

Open questions: seeking a holistic approach for mitochondrial research

scientific article published on 5 February 2015

Parkinson's Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation.

scientific article published on 21 June 2016

Positioning mitochondrial plasticity within cellular signaling cascades.

scientific article published on 23 July 2008

Processing-dependent trafficking of Sonic hedgehog to the regulated secretory pathway in neurons

scientific journal article

ROMO1 is an essential redox-dependent regulator of mitochondrial dynamics.

scientific article published on 28 January 2014

Rab proteins as membrane organizers

scientific article

Reconstitution of mitochondria derived vesicle formation demonstrates selective enrichment of oxidized cargo

scientific article

SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome

scientific article published on 7 July 2016

SPG7 variant escapes phosphorylation-regulated processing by AFG3L2, elevates mitochondrial ROS, and is associated with multiple clinical phenotypes

scientific article

Specific contribution of lamin A and lamin C in the development of laminopathies.

scientific article published on 10 May 2008

Staying cool in difficult times: Mitochondrial dynamics, quality control and the stress response ⬇️

scientific article published on 07 June 2012

Structural and mechanistic basis of Parl activity and regulation.

scientific article published on 18 March 2011

Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system.

scientific article published on 25 July 2016

The Keap1-Nrf2 Stress Response Pathway Promotes Mitochondrial Hyperfusion Through Degradation of the Mitochondrial Fission Protein Drp1.

scientific article published on 11 May 2017

The SUMO protease SENP5 is required to maintain mitochondrial morphology and function

scientific article published on 06 March 2007

The dynamic interacting landscape of MAPL reveals essential functions for SUMOylation in innate immunity.

scientific article

The enigma of an interconnected mitochondrial reticulum: new insights into mitochondrial fusion

scientific article published on 25 June 2019

The interaction and cellular localization of HSP27 and ERβ are modulated by 17β-estradiol and HSP27 phosphorylation

article

The intracellular redox state is a core determinant of mitochondrial fusion ⬇️

scientific article published on September 4, 2012

The mitochondria-endoplasmic reticulum contact sites: a signalling platform for cell death

scientific article published on 5 April 2017

The mitochondrial inner membrane GTPase, optic atrophy 1 (Opa1), restores mitochondrial morphology and promotes neuronal survival following excitotoxicity.

scientific article published on November 2010

mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1.

scientific article published on 13 September 2017

List of works by Heidi M McBride

A Mitofusin-2-dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver.

A brain-enriched Drp1 isoform associates with lysosomes, late endosomes, and the plasma membrane

A new mitofusin topology places the redox-regulated C terminus in the mitochondrial intermembrane space.

A new pathway for mitochondrial quality control: mitochondrial-derived vesicles

A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function

A novel cell-free mitochondrial fusion assay amenable for high-throughput screenings of fusion modulators.

A signal-anchor sequence selective for the mitochondrial outer membrane ⬇️

A vesicular transport pathway shuttles cargo from mitochondria to lysosomes.

Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking.

Cell biology: Double agents for mitochondrial division

Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis

Emerging roles of mitochondria in the evolution, biogenesis, and function of peroxisomes

Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis.

Formation of mitochondrial-derived vesicles is an active and physiologically relevant mitochondrial quality control process in the cardiac system.

Genome-wide RNAi screen identifies ATPase inhibitory factor 1 (ATPIF1) as essential for PARK2 recruitment and mitophagy

Golgi-derived PI(4)P-containing vesicles drive late steps of mitochondrial division

Hepatic SR-BI-mediated cholesteryl ester selective uptake occurs with unaltered efficiency in the absence of cellular energy.

Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72

Import and insertion of proteins into the mitochondrial outer membrane.

In vivo and in vitro examination of the functional significances of novel lamin gene mutations in heart failure patients

Insertion of an uncharged polypeptide into the mitochondrial inner membrane does not require a trans-bilayer electrochemical potential: effects of positive charges

Intestinal infection triggers Parkinson's disease-like symptoms in Pink1-/- mice

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

MAPL SUMOylation of Drp1 Stabilizes an ER/Mitochondrial Platform Required for Cell Death

MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission

MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control

Mammalian polynucleotide phosphorylase is an intermembrane space RNase that maintains mitochondrial homeostasis

Mitochondria and endomembrane origins.

Mitochondria and the culture of the Borg: understanding the integration of mitochondrial function within the reticulum, the cell, and the organism.

Mitochondria: more than just a powerhouse

Mitochondrial Dynamics: ER Actin Tightens the Drp1 Noose.

Mitochondrial dynamics and physiology.

Mitochondrial hyperfusion during oxidative stress is coupled to a dysregulation in calcium handling within a C2C12 cell model.

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment ⬇️

Mitochondrial vesicles: an ancient process providing new links to peroxisomes.

Mitochondrial-ER tethering: the inheritance of a functional unit.

Mitofusin 2 protects cerebellar granule neurons against injury-induced cell death.

Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes.

OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand

Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13

Open questions: seeking a holistic approach for mitochondrial research

Parkinson's Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation.

Positioning mitochondrial plasticity within cellular signaling cascades.

Processing-dependent trafficking of Sonic hedgehog to the regulated secretory pathway in neurons

ROMO1 is an essential redox-dependent regulator of mitochondrial dynamics.

Rab proteins as membrane organizers

Reconstitution of mitochondria derived vesicle formation demonstrates selective enrichment of oxidized cargo

SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome

SPG7 variant escapes phosphorylation-regulated processing by AFG3L2, elevates mitochondrial ROS, and is associated with multiple clinical phenotypes

Specific contribution of lamin A and lamin C in the development of laminopathies.

Staying cool in difficult times: Mitochondrial dynamics, quality control and the stress response ⬇️

Structural and mechanistic basis of Parl activity and regulation.

Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system.

The Keap1-Nrf2 Stress Response Pathway Promotes Mitochondrial Hyperfusion Through Degradation of the Mitochondrial Fission Protein Drp1.

The SUMO protease SENP5 is required to maintain mitochondrial morphology and function

The dynamic interacting landscape of MAPL reveals essential functions for SUMOylation in innate immunity.

The enigma of an interconnected mitochondrial reticulum: new insights into mitochondrial fusion

The interaction and cellular localization of HSP27 and ERβ are modulated by 17β-estradiol and HSP27 phosphorylation

The intracellular redox state is a core determinant of mitochondrial fusion ⬇️

The mitochondria-endoplasmic reticulum contact sites: a signalling platform for cell death

The mitochondrial inner membrane GTPase, optic atrophy 1 (Opa1), restores mitochondrial morphology and promotes neuronal survival following excitotoxicity.

mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1.