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List of works by Roberto Perrone

1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Δ(8)-Δ(7) sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity

scientific article published on January 2011

1-aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3

scientific article published on 01 August 1996

11C-labeling of n-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors.

scientific article

2-Aminopyridine derivatives as potential σ(2) receptor antagonists

scientific article published on 13 August 2012

4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators

scientific article published on 2 February 2008

A new method for evaluating sigma(2) ligand activity in the isolated guinea-pig bladder

scientific article published on 17 July 2003

Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments

scientific article published on 16 May 2013

Analogues of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with added polar functionality and reduced lipophilicity for potential use as positron emission tomography radiotracers

scientific article published on 13 January 2011

Arylamides hybrids of two high-affinity σ2 receptor ligands as tools for the development of PET radiotracers

scientific article published on 30 May 2011

Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2.

scientific article published in June 2015

Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins

scientific article

Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET.

scientific article published on November 2005

EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives

scientific article published on January 2011

Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum

scientific article published on 20 May 2008

Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28).

scientific article

Fluorescent derivatives of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a tool for uptake and cellular localization studies in pancreatic tumor cells

scientific article

Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay

scientific article published on 11 September 2007

Interaction of the sigma(2) receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer

scientific article

Investigation of σ receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines

scientific article published on 29 January 2013

Is the sigma2 receptor a histone binding protein?

scientific article

LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor

scientific article

Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors

scientific article

Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters

scientific article

Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties.

scientific article published on 17 September 2013

PET radiotracers for imaging P-glycoprotein: the challenge for early diagnosis in AD.

scientific article published on 31 October 2013

Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological, and diagnostic potentials

scientific article published on March 2010

Potent and selective tariquidar bioisosters as potential PET radiotracers for imaging P-gp

scientific article published on 5 January 2013

Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein

scientific article

Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: hints for collateral sensitivity

scientific article published on 19 September 2013

Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives

scientific article

Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as σ1 receptor ligands

scientific article published on 17 October 2011

Synthesis, radiolabeling and in vivo evaluation of [(11)C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT(7) receptor

scientific article published on 29 March 2014

The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells

scientific article

Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters

scientific article published on 10 April 2013

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