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List of works by Gina Lisignoli

A Novel H2S-releasing Amino-Bisphosphonate which combines bone anti-catabolic and anabolic functions.

scientific article published on 20 September 2017

A fluorescent in situ hybridization method in flow cytometry to detect HIV-1 specific RNA.

scientific article published on June 1996

A multifaced DNA ploidy analysis to determine ovarian carcinoma aggressiveness

scientific article published on 01 April 1991

Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial.

scientific article published on 23 May 2016

Adipose mesenchymal stem cells protect chondrocytes from degeneration associated with osteoarthritis

scientific article published on 04 June 2013

Adipose stromal cells mediated switching of the pro-inflammatory profile of M1-like macrophages is facilitated by PGE2: in vitro evaluation.

scientific article published on 30 January 2017

Adipose-derived mesenchymal stem cells exert antiinflammatory effects on chondrocytes and synoviocytes from osteoarthritis patients through prostaglandin E2.

scientific article

Age-independent effects of hyaluronan amide derivative and growth hormone on human osteoarthritic chondrocytes

scientific article

An elevated number of differentiated osteoblast colonies can be obtained from rat bone marrow stromal cells using a gradient isolation procedure.

scientific article published in January 2001

Analysis of mesenchymal stem cells grown on a three-dimensional HYAFF 11-based prototype ligament scaffold.

scientific article published in June 2005

Biomaterials: Foreign Bodies or Tuners for the Immune Response? ⬇️

scientific article published on 01 February 2019

Bone osteoblastic and mesenchymal stromal cells lack primarily tumoral features in multiple myeloma patients

scientific article published on 20 May 2010

CC-chemokine ligand 20/macrophage inflammatory protein-3α and CC-chemokine receptor 6 are overexpressed in myeloma microenvironment related to osteolytic bone lesions.

scientific article published in August 2008

CCL20 chemokine induces both osteoblast proliferation and osteoclast differentiation: Increased levels of CCL20 are expressed in subchondral bone tissue of rheumatoid arthritis patients

scientific article published in March 2007

CCL20/CCR6 chemokine/receptor expression in bone tissue from osteoarthritis and rheumatoid arthritis patients: different response of osteoblasts in the two groups.

scientific article published in October 2009

CXCL12 (SDF-1) and CXCL13 (BCA-1) chemokines significantly induce proliferation and collagen type I expression in osteoblasts from osteoarthritis patients

CXCL12 chemokine up-regulates bone resorption and MMP-9 release by human osteoclasts: CXCL12 levels are increased in synovial and bone tissue of rheumatoid arthritis patients.

scientific article published in May 2004

Cartilage and Bone Serum Biomarkers as Novel Tools for Monitoring Knee Osteochondritis Dissecans Treated with Osteochondral Scaffold

scientific article published on 23 December 2018

Cellular and molecular events during chondrogenesis of human mesenchymal stromal cells grown in a three-dimensional hyaluronan based scaffold

scientific article published on 8 April 2005

Chemokine expression by subchondral bone marrow stromal cells isolated from osteoarthritis (OA) and rheumatoid arthritis (RA) patients.

scientific article published on May 1999

Chitosan-based scaffold counteracts hypertrophic and fibrotic markers in chondrogenic differentiated mesenchymal stromal cells

scientific article published on 20 August 2019

Chondrogenic differentiation of murine and human mesenchymal stromal cells in a hyaluronic acid scaffold: differences in gene expression and cell morphology.

scientific article published in June 2006

Chondrogenic potential of Slug-depleted human mesenchymal stem cells

scientific article published on 20 June 2014

Chondrogenic potential of human mesenchymal stem cells and expression of Slug transcription factor

scientific article published on 21 July 2013

Clinical and Biological Signature of Osteochondritis Dissecans in a Cross-Sectional Study.

scientific article published on 28 May 2018

Co-culture of hematopoietic stem/progenitor cells with human osteblasts favours mono/macrophage differentiation at the expense of the erythroid lineage.

scientific article

Collagen type XV and the 'osteogenic status'.

scientific article

Comparison of alternative mesenchymal stem cell sources for cell banking and musculoskeletal advanced therapies

scientific article published in 2011

Different pattern of cytokine production and mRNA expression by lymphoid and non-lymphoid cells isolated from human palatine tonsil ⬇️

scientific article published on January 1, 1998

Distinct transcriptional profiles characterize bone microenvironment mesenchymal cells rather than osteoblasts in relationship with multiple myeloma bone disease.

scientific article published on 4 December 2009

Distinctive expression pattern of cystathionine-β-synthase and cystathionine-γ-lyase identifies mesenchymal stromal cells transition to mineralizing osteoblasts

scientific article published on 25 January 2017

Effect of microfragmented adipose tissue on osteoarthritic synovial macrophage factors

scientific article published on 06 September 2018

Epitope specificity of Th0/Th2 CD4+ T-lymphocyte clones induced by vaccination with rHBsAg vaccine

scientific article published on 01 June 1997

Evidence for redifferentiation of human chondrocytes grown on a hyaluronan-based biomaterial (HYAff 11): molecular, immunohistochemical and ultrastructural analysis

article

Evidence of specific characteristics and osteogenic potentiality in bone cells from tibia

article

Expression of CXC chemokines and their receptors is modulated during chondrogenic differentiation of human mesenchymal stem cells grown in three-dimensional scaffold: evidence in native cartilage.

scientific article published in January 2008

Extracellular calcium chronically induced human osteoblasts effects: specific modulation of osteocalcin and collagen type XV.

scientific article published in August 2012

Focal Defects of the Knee Articular Surface: Evidence of a Regenerative Potential Pattern in Osteochondritis Dissecans and Degenerative Lesions.

scientific article

From osteoarthritic synovium to synovial-derived cells characterization: synovial macrophages are key effector cells.

scientific article published on 4 April 2016

Gene array profile identifies collagen type XV as a novel human osteoblast-secreted matrix protein

scientific article published in August 2009

HOXB7 expression by myeloma cells regulates their pro-angiogenic properties in multiple myeloma patients.

scientific article published on 23 November 2010

Histological and immunohistochemical analysis of an allogenic bone graft engineered with autologous bone marrow mononuclear cells in the treatment of a large segmental defect of the ulna. A case report.

scientific article published in April 2008

Human osteoblasts express functional CXC chemokine receptors 3 and 5: activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and beta-N-acetylhexosaminidase release

scientific article (publication date: 2003)

Human osteoclasts express different CXC chemokines depending on cell culture substrate: molecular and immunocytochemical evidence of high levels of CXCL10 and CXCL12.

scientific article published on 5 November 2003

Hyaluronan does not affect cytokine and chemokine expression in osteoarthritic chondrocytes and synoviocytes.

scientific article

Hyaluronan-based polymer scaffold modulates the expression of inflammatory and degradative factors in mesenchymal stem cells: Involvement of Cd44 and Cd54.

scientific article published in May 2006

Hypoxia Preconditioning of Human MSCs: a Direct Evidence of HIF-1α and Collagen Type XV Correlation

scientific article published on 07 December 2018

IL1-beta and TNF-alpha induce changes in the nuclear polyphosphoinositide signalling system in osteoblasts similar to that occurring in patients with rheumatoid arthritis: an immunochemical and immunocytochemical study

scientific article published on 12 August 2003

IL1beta and TNFalpha differently modulate CXCL13 chemokine in stromal cells and osteoblasts isolated from osteoarthritis patients: evidence of changes associated to cell maturation

scientific article

Immunoelectron microscopic localization of Collagen type XV during human mesenchymal stem cells mineralization

Impact of Isolation Procedures on the Development of a Preclinical Synovial Fibroblasts/Macrophages in an In Vitro Model of Osteoarthritis

scientific article published on 10 December 2020

In vitro cultured stromal cells from human tonsils display a distinct phenotype and induce B cell adhesion and proliferation

scientific article published on 01 January 1996

Inhibition of CD95 apoptotic signaling by interferon-gamma in human osteoarthritic chondrocytes is associated with increased expression of FLICE inhibitory protein.

scientific article

Lack of anti-inflammatory and anti-catabolic effects on basal inflamed osteoarthritic chondrocytes or synoviocytes by adipose stem cell-conditioned medium.

scientific article published on November 2015

Mechano-functional assessment of human mesenchymal stem cells grown in three-dimensional hyaluronan-based scaffolds for cartilage tissue engineering.

scientific article

Mineralization behavior with mesenchymal stromal cells in a biomimetic hyaluronic acid-based scaffold.

scientific article published on 20 February 2010

Myeloma cells inhibit non-canonical wnt co-receptor ror2 expression in human bone marrow osteoprogenitor cells: effect of wnt5a/ror2 pathway activation on the osteogenic differentiation impairment induced by myeloma cells.

scientific article

Novel nano-composite biomimetic biomaterial allows chondrogenic and osteogenic differentiation of bone marrow concentrate derived cells

scientific article published on 25 March 2015

Osteoarthritic Milieu Affects Adipose-Derived Mesenchymal Stromal Cells

scientific article published on 30 August 2019

Osteoarthritis treated with mesenchymal stem cells on hyaluronan-based scaffold in rabbit

scientific article published in December 2009

Osteogenesis of large segmental radius defects enhanced by basic fibroblast growth factor activated bone marrow stromal cells grown on non-woven hyaluronic acid-based polymer scaffold

scientific article published in February 2002

Osteogenic differentiation of human MSCs: Specific occupancy of the mitochondrial DNA by NFATc1 transcription factor

scientific article published on 5 May 2015

PKC-zeta expression is lower in osteoblasts from arthritic patients: IL1-beta and TNF-alpha induce a similar decrease in non-arthritic human osteoblasts

scientific article published on 01 February 2008

Ploidy disturbances as an early indicator of intrinsic malignancy in endometrial carcinoma

scientific article published on 01 July 1993

Quantitative enzyme histochemistry of rat foetal brain and trigeminal ganglion.

scientific article published in August 1988

Quantitative immunodetection of key elements of polyphosphoinositide signal transduction in osteoblasts from arthritic patients shows a direct correlation with cell proliferation

scientific article published on 01 August 2005

Rational Design and Development of Anisotropic and Mechanically Strong Gelatin-Based Stress Relaxing Hydrogels for Osteogenic/Chondrogenic Differentiation

scientific article published on 12 July 2019

Recruitment and proliferation of T lymphocytes is supported by IFNgamma- and TNFalpha-activated human osteoblasts: Involvement of CD54 (ICAM-1) and CD106 (VCAM-1) adhesion molecules and CXCR3 chemokine receptor.

scientific article published on March 2004

Slug contributes to the regulation of CXCL12 expression in human osteoblasts

scientific article

Slug gene expression supports human osteoblast maturation

scientific article

Slug transcription factor and nuclear Lamin B1 are upregulated in osteoarthritic chondrocytes

scientific article published on 20 March 2015

Sodium hydrosulfide inhibits the differentiation of osteoclast progenitor cells via NRF2-dependent mechanism.

scientific article published on 3 July 2014

Specific concentration of hyaluronan amide derivative induces osteogenic mineralization of human mesenchymal stromal cells: Evidence of RUNX2 and COL1A1 genes modulation

scientific article published on 23 August 2019

Specific inductive potential of a novel nanocomposite biomimetic biomaterial for osteochondral tissue regeneration.

scientific article published on 12 March 2013

T cell subsets differently regulate osteogenic differentiation of human mesenchymal stromal cells in vitro

scientific article published on 07 May 2013

T cell suppression by osteoclasts in vitro

scientific article published on 01 April 2011

The expression of cystathionine gamma-lyase is regulated by estrogen receptor alpha in human osteoblasts.

scientific article published on 4 October 2017

The use of microfluorometry to study DNA in nasopharyngeal carcinomas: a possible prognostic tool?

scientific article published on 01 January 1989

Thrombospondin-1 Partly Mediates the Cartilage Protective Effect of Adipose-Derived Mesenchymal Stem Cells in Osteoarthritis.

scientific article published on 29 November 2017

Transcription factor decoy against NFATc1 in human primary osteoblasts

scientific article published on 16 May 2011

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