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List of works by Niina Saarinen

Analysis by LC-MS/MS of endogenous steroids from human serum, plasma, endometrium and endometriotic tissue.

scientific article published on 31 January 2018

Antioxidant and antitumor effects of hydroxymatairesinol (HM-3000, HMR), a lignan isolated from the knots of spruce.

scientific article

Can modulation of mammary gland development by dietary factors support breast cancer prevention?

scientific article published on 14 May 2007

Changes in biomarkers of estrogen receptor and growth factor signaling pathways in MCF-7 tumors after short- and long-term treatment with soy and flaxseed.

scientific article

Chemopreventive effects of hydroxymatairesinol on uterine carcinogenesis in Donryu rats.

scientific article published in May 2004

Determination of plant and enterolignans in human serum by high-performance liquid chromatography with tandem mass spectrometric detection.

scientific article published on 7 February 2006

Dietary lariciresinol attenuates mammary tumor growth and reduces blood vessel density in human MCF-7 breast cancer xenografts and carcinogen-induced mammary tumors in rats.

scientific article published in September 2008

Dietary phytoestrogens and their role in hormonally dependent disease.

scientific article

Effect of dietary intervention on serum lignan levels in pregnant women - a controlled trial

scientific article

Enterolactone inhibits the growth of 7,12-dimethylbenz(a)anthracene-induced mammary carcinomas in the rat.

scientific article

Estradiol, tamoxifen, and flaxseed alter IL-1β and IL-1Ra levels in normal human breast tissue in vivo

scientific article published on 28 August 2012

Flaxseed and soy protein isolate, alone and in combination, differ in their effect on bone mass, biomechanical strength, and uterus in ovariectomized nude mice with MCF-7 human breast tumor xenografts

scientific article published on November 2007

Genistein alone and in combination with the mammalian lignans enterolactone and enterodiol induce estrogenic effects on bone and uterus in a postmenopausal breast cancer mouse model

scientific article published on 15 February 2006

HSD17B1 expression enhances estrogen signaling stimulated by the low active estrone, evidenced by an estrogen responsive element-driven reporter gene in vivo

scientific article published on 21 January 2015

HSD17B1 expression induces inflammation-aided rupture of mammary gland myoepithelium

scientific article published on 25 January 2018

Hydroxymatairesinol and its mammalian metabolite enterolactone reduce the growth and metastasis of subcutaneous AH109A hepatomas in rats.

scientific article

Hydroxymatairesinol and sesaminol act differently on tocopherol concentrations in rats.

scientific article

Hydroxymatairesinol, a novel enterolactone precursor with antitumor properties from coniferous tree (Picea abies).

scientific article published in January 2000

IL-10 suppresses TNF-α-induced expression of human aromatase gene in mammary adipose tissue.

scientific article published on 23 January 2018

Improved statistical modeling of tumor growth and treatment effect in preclinical animal studies with highly heterogeneous responses in vivo

scientific article

Increased adipose tissue aromatase activity improves insulin sensitivity and reduces adipose tissue inflammation in male mice

scientific article published on 27 June 2017

Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products

scientific article published on July 2015

No evidence for the in vivo activity of aromatase-inhibiting flavonoids

scientific article (publication date: September 2001)

Novel Lignan and stilbenoid mixture shows anticarcinogenic efficacy in preclinical PC-3M-luc2 prostate cancer model

scientific article

Prolonged administration of secoisolariciresinol diglycoside increases lignan excretion and alters lignan tissue distribution in adult male and female rats.

scientific article published on 14 April 2010

Role of dietary lignans in the reduction of breast cancer risk.

scientific article published on July 2007

Sesamin is one of the major precursors of mammalian lignans in sesame seed (Sesamum indicum) as observed in vitro and in rats.

scientific article

Tamoxifen and flaxseed alter angiogenesis regulators in normal human breast tissue in vivo

scientific article

Tamoxifen, flaxseed, and the lignan enterolactone increase stroma- and cancer cell-derived IL-1Ra and decrease tumor angiogenesis in estrogen-dependent breast cancer.

scientific article published on 19 November 2010

The soy effect in the disease models of nonbacterial prostatitis and obstructive voiding

scientific article published on 01 May 2007

Tools to evaluate estrogenic potency of dietary phytoestrogens:A consensus paper from the EU Thematic Network "Phytohealth" (QLKI-2002-2453)

scientific article

Transcriptional response networks for elucidating mechanisms of action of multitargeted agents

scientific article published on 11 March 2016

Urinary excretion of lignans after administration of isolated plant lignans to rats: the effect of single dose and ten-day exposures.

scientific article published in December 2004

Weight gain and inflammation regulate aromatase expression in male adipose tissue, as evidenced by reporter gene activity.

scientific article published on 6 June 2015

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