List of works - Oriol Casanovas

A non-contact, small animal scanner based on diffuse optical spectroscopy and diffuse correlation spectroscopy

A novel role for an RCAN3-derived peptide as a tumor suppressor in breast cancer

scientific article published on 26 April 2015

Angiogenesis and Metabolism: Entwined for Therapy Resistance

scientific article

Antiangiogenic Resistance: Novel Angiogenesis Axes Uncovered by Antiangiogenic Therapies Research

scientific article published on 01 January 2016

Antiangiogenic effect of gemcitabine following metronomic administration in a pancreas cancer model

scientific article

Antiangiogenic resistance via metabolic symbiosis

scientific article published on 14 July 2016

Antiangiogenic therapies: going beyond their limits

scientific article published on 19 December 2013

Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis

scientific article

Antitumor Effects of Anti-Semaphorin 4D Antibody Unravel a Novel Proinvasive Mechanism of Vascular-Targeting Agents

scientific article published on 25 June 2019

Anti‐angiogenesis and metastasis: a tumour and stromal cell alliance ⬇️

scientific article published on February 1, 2013

Contrasting responses of non-small cell lung cancer to antiangiogenic therapies depend on histological subtype

scientific article published on 05 February 2014

Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination

scientific article published on 11 February 2013

Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors

scientific article (publication date: October 2005)

EVI1 as a Prognostic and Predictive Biomarker of Clear Cell Renal Cell Carcinoma

scientific article published on 28 January 2020

Effectivity of pazopanib treatment in orthotopic models of human testicular germ cell tumors

scientific article

Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility

scientific article published in Nature Communications

ErbBs inhibition by lapatinib blocks tumor growth in an orthotopic model of human testicular germ cell tumor.

scientific article

Exploiting pleiotropic activities of semaphorins as multi‐target therapies for cancer ⬇️

scientific article published on February 10, 2012

Filamin B plays a key role in vascular endothelial growth factor-induced endothelial cell motility through its interaction with Rac-1 and Vav-2.

scientific article

Glycolytic phenotype and AMP kinase modify the pathologic response of tumor xenografts to VEGF neutralization

scientific article published on 5 May 2011

Haematopoietic focal adhesion kinase deficiency alters haematopoietic homeostasis to drive tumour metastasis

scientific article

Incomplete inhibition of the Rb tumor suppressor pathway in the context of inactivated p53 is sufficient for pancreatic islet tumorigenesis

scientific article published in October 2005

Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis

scientific article published on 16 September 2013

Kidney cancer PDOXs reveal patient-specific pro-malignant effects of antiangiogenics and its molecular traits

scientific article published on 05 November 2020

Limitations of therapies exposed ⬇️

scientific article published on April 4, 2012

Metronomic chemotherapy following the maximum tolerated dose is an effective anti-tumour therapy affecting angiogenesis, tumour dissemination and cancer stem cells

scientific article published on 4 June 2013

MicroRNA-497 impairs the growth of chemoresistant neuroblastoma cells by targeting cell cycle, survival and vascular permeability genes

scientific article published on 25 January 2016

Molecular biology of neuroendocrine tumors: from pathways to biomarkers and targets

scientific article published on March 2014

Molecular pathogenesis of neuroendocrine tumors: implications for current and future therapeutic approaches

scientific article published on 04 March 2013

Multi-target angiokinase inhibitors to fight resistance

scientific article published in January 2014

New drug development in digestive neuroendocrine tumors

scientific article published on 13 February 2007

Non-invasive monitoring of hypoxia-inducible factor activation by optical imaging during antiangiogenic treatment in a xenograft model of ovarian carcinoma

scientific article published on 9 June 2011

Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling

scientific journal article

Osmotic stress regulates the stability of cyclin D1 in a p38SAPK2-dependent manner

scientific article published on November 2000

P38SAPK2 phosphorylates cyclin D3 at Thr-283 and targets it for proteasomal degradation

scientific article published on September 2004

PTEN mediates Notch-dependent stalk cell arrest in angiogenesis

scientific article

Pazopanib in pretreated advanced neuroendocrine tumors: a phase II, open-label trial of the Spanish Task Force Group for Neuroendocrine Tumors (GETNE).

scientific article published on 10 June 2015

Pre-clinical longitudinal monitoring of hemodynamic response to anti-vascular chemotherapy by hybrid diffuse optics

scientific article

Progeny of Lgr5-expressing hair follicle stem cell contributes to papillomavirus-induced tumor development in epidermis

scientific article

Quantification of gold nanoparticle accumulation in tissue by two-photon luminescence microscopy

scientific article published on 01 June 2019

Relevance of Angiogenesis in Neuroendocrine Tumors

Relevance of angiogenesis in neuroendocrine tumors

scientific article published on 17 May 2012

Resistance to Antiangiogenic Therapies by Metabolic Symbiosis in Renal Cell Carcinoma PDX Models and Patients.

scientific article

Resistance to Targeted Therapies in Renal Cancer: The Importance of Changing the Mechanism of Action.

scientific article published on 15 November 2016

Scanning, non-contact, hybrid broadband diffuse optical spectroscopy and diffuse correlation spectroscopy system

scientific article published on 15 January 2016

Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice

scientific article published on 9 April 2012

Simultaneous, non-invasive measurement of local tissue hemodynamics, oxygen metabolism and gold nanorod concentration in vivo

Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing

scientific article

Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition.

scientific article

Sunitinib inhibits tumor growth and synergizes with cisplatin in orthotopic models of cisplatin-sensitive and cisplatin-resistant human testicular germ cell tumors.

scientific article published on 5 May 2009

The Cell Cycle Inhibitor p21CIPIs Phosphorylated by Cyclin A-CDK2 Complexes

scientific article published on 01 December 1997

The PDGFRβ-AKT pathway contributes to CDDP-acquired resistance in testicular germ cell tumors

scientific article published on 25 November 2013

The Protein SET Regulates the Inhibitory Effect of p21Cip1on Cyclin E-Cyclin-dependent Kinase 2 Activity

scientific article published in Journal of Biological Chemistry

The TGFβ pathway stimulates ovarian cancer cell proliferation by increasing IGF1R levels.

scientific article published on 14 June 2016

The adaptive stroma joining the antiangiogenic resistance front ⬇️

scientific article published on March 23, 2011

The p21(Cip1) protein, a cyclin inhibitor, regulates the levels and the intracellular localization of CDC25A in mice regenerating livers

scientific journal article

The truncated somatostatin receptor sst5TMD4 stimulates the angiogenic process and is associated to lymphatic metastasis and disease-free survival in breast cancer patients

scientific article published on 05 August 2016

The use of caspase inhibitors in pulsed-field gel electrophoresis may improve the estimation of radiation-induced DNA repair and apoptosis.

scientific article published on 15 January 2011

Therapeutic Benefit of Selective Inhibition of p110α PI3-Kinase in Pancreatic Neuroendocrine Tumors

scientific article

Translational research in neuroendocrine tumors: pitfalls and opportunities

scientific article published on 19 September 2016

Unraveling the Role of Angiogenesis in Cancer Ecosystems.

scientific article published on 2 July 2018

Use of a mouse model of pancreatic neuroendocrine tumors to find pericyte biomarkers of resistance to anti-angiogenic therapy

scientific article published on 29 September 2011

List of works by Oriol Casanovas

A non-contact, small animal scanner based on diffuse optical spectroscopy and diffuse correlation spectroscopy

A novel role for an RCAN3-derived peptide as a tumor suppressor in breast cancer

Angiogenesis and Metabolism: Entwined for Therapy Resistance

Antiangiogenic Resistance: Novel Angiogenesis Axes Uncovered by Antiangiogenic Therapies Research

Antiangiogenic effect of gemcitabine following metronomic administration in a pancreas cancer model

Antiangiogenic resistance via metabolic symbiosis

Antiangiogenic therapies: going beyond their limits

Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis

Antitumor Effects of Anti-Semaphorin 4D Antibody Unravel a Novel Proinvasive Mechanism of Vascular-Targeting Agents

Anti‐angiogenesis and metastasis: a tumour and stromal cell alliance ⬇️

Contrasting responses of non-small cell lung cancer to antiangiogenic therapies depend on histological subtype

Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination

Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors

EVI1 as a Prognostic and Predictive Biomarker of Clear Cell Renal Cell Carcinoma

Effectivity of pazopanib treatment in orthotopic models of human testicular germ cell tumors

Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility

ErbBs inhibition by lapatinib blocks tumor growth in an orthotopic model of human testicular germ cell tumor.

Exploiting pleiotropic activities of semaphorins as multi‐target therapies for cancer ⬇️

Filamin B plays a key role in vascular endothelial growth factor-induced endothelial cell motility through its interaction with Rac-1 and Vav-2.

Glycolytic phenotype and AMP kinase modify the pathologic response of tumor xenografts to VEGF neutralization

Haematopoietic focal adhesion kinase deficiency alters haematopoietic homeostasis to drive tumour metastasis

Incomplete inhibition of the Rb tumor suppressor pathway in the context of inactivated p53 is sufficient for pancreatic islet tumorigenesis

Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis

Kidney cancer PDOXs reveal patient-specific pro-malignant effects of antiangiogenics and its molecular traits

Limitations of therapies exposed ⬇️

Metronomic chemotherapy following the maximum tolerated dose is an effective anti-tumour therapy affecting angiogenesis, tumour dissemination and cancer stem cells

MicroRNA-497 impairs the growth of chemoresistant neuroblastoma cells by targeting cell cycle, survival and vascular permeability genes

Molecular biology of neuroendocrine tumors: from pathways to biomarkers and targets

Molecular pathogenesis of neuroendocrine tumors: implications for current and future therapeutic approaches

Multi-target angiokinase inhibitors to fight resistance

New drug development in digestive neuroendocrine tumors

Non-invasive monitoring of hypoxia-inducible factor activation by optical imaging during antiangiogenic treatment in a xenograft model of ovarian carcinoma

Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling

Osmotic stress regulates the stability of cyclin D1 in a p38SAPK2-dependent manner

P38SAPK2 phosphorylates cyclin D3 at Thr-283 and targets it for proteasomal degradation

PTEN mediates Notch-dependent stalk cell arrest in angiogenesis

Pazopanib in pretreated advanced neuroendocrine tumors: a phase II, open-label trial of the Spanish Task Force Group for Neuroendocrine Tumors (GETNE).

Pre-clinical longitudinal monitoring of hemodynamic response to anti-vascular chemotherapy by hybrid diffuse optics

Progeny of Lgr5-expressing hair follicle stem cell contributes to papillomavirus-induced tumor development in epidermis

Quantification of gold nanoparticle accumulation in tissue by two-photon luminescence microscopy

Relevance of Angiogenesis in Neuroendocrine Tumors

Relevance of angiogenesis in neuroendocrine tumors

Resistance to Antiangiogenic Therapies by Metabolic Symbiosis in Renal Cell Carcinoma PDX Models and Patients.

Resistance to Targeted Therapies in Renal Cancer: The Importance of Changing the Mechanism of Action.

Scanning, non-contact, hybrid broadband diffuse optical spectroscopy and diffuse correlation spectroscopy system

Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice

Simultaneous, non-invasive measurement of local tissue hemodynamics, oxygen metabolism and gold nanorod concentration in vivo

Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing

Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition.

Sunitinib inhibits tumor growth and synergizes with cisplatin in orthotopic models of cisplatin-sensitive and cisplatin-resistant human testicular germ cell tumors.

The Cell Cycle Inhibitor p21CIPIs Phosphorylated by Cyclin A-CDK2 Complexes

The PDGFRβ-AKT pathway contributes to CDDP-acquired resistance in testicular germ cell tumors

The Protein SET Regulates the Inhibitory Effect of p21Cip1on Cyclin E-Cyclin-dependent Kinase 2 Activity

The TGFβ pathway stimulates ovarian cancer cell proliferation by increasing IGF1R levels.

The adaptive stroma joining the antiangiogenic resistance front ⬇️

The p21(Cip1) protein, a cyclin inhibitor, regulates the levels and the intracellular localization of CDC25A in mice regenerating livers

The truncated somatostatin receptor sst5TMD4 stimulates the angiogenic process and is associated to lymphatic metastasis and disease-free survival in breast cancer patients

The use of caspase inhibitors in pulsed-field gel electrophoresis may improve the estimation of radiation-induced DNA repair and apoptosis.

Therapeutic Benefit of Selective Inhibition of p110α PI3-Kinase in Pancreatic Neuroendocrine Tumors

Translational research in neuroendocrine tumors: pitfalls and opportunities

Unraveling the Role of Angiogenesis in Cancer Ecosystems.

Use of a mouse model of pancreatic neuroendocrine tumors to find pericyte biomarkers of resistance to anti-angiogenic therapy