List of works - Marc Mansour

A role for aberrant Notch signaling in acute myeloid leukemia?

scientific article published on 01 November 2006

A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing.

scientific article

APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL

scientific article published on 6 March 2017

Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia.

scientific article published on 7 March 2017

Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice.

scientific article published on 23 July 2015

Allogeneic transplantation for hepatosplenic alphabeta T-cell lymphoma

scientific article published on 01 May 2005

BCL2-specific inhibitor ABT-199 synergizes strongly with cytarabine against the early immature LOUCY cell line but not more-differentiated T-ALL cell lines

scientific article

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

scientific article published on 21 May 2007

Cyclin C is a haploinsufficient tumour suppressor

scientific article

Discovery of a secreted tumor suppressor provides a promising therapeutic strategy for follicular lymphoma

scientific article published on 01 November 2011

HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia

scientific article

High incidence of Notch-1 mutations in adult patients with T-cell acute lymphoblastic leukemia

scientific article published on 01 March 2006

Impact of NOTCH1/FBXW7 mutations on outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on the MRC UKALL 2003 trial.

scientific article published on 3 July 2012

In trans early mosaic mutational escape and novel phenotypic features of germline SAMD9 mutation

scientific article published on 03 January 2020

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

scientific article published on September 2008

JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia.

scientific article published on 25 June 2018

KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.

scientific article published on 04 February 2013

Notch signaling: switching an oncogene to a tumor suppressor.

scientific article published on 07 March 2014

Notch-1 mutations are secondary events in some patients with T-cell acute lymphoblastic leukemia

scientific article published on 01 December 2007

Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia

scientific article published in May 2014

Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

scientific article

Oncogenic Kras and Notch-1 cooperate in T-cell acute lymphoblastic leukemia/lymphoma ⬇️

scientific article published on 01 April 2009

Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia.

scientific article

Ribonucleoprotein HNRNPA2B1 interacts with and regulates oncogenic KRAS in pancreatic ductal adenocarcinoma cells.

scientific article

Small genomic insertions form enhancers that misregulate oncogenes

scientific article published on 09 February 2017

Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

scientific article

Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss

scientific article published on 30 July 2021

Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain.

scientific article published on 27 April 2016

T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII/ECOG 2993)

scientific article

TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia

scientific article published on 3 October 2017

Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia

scientific article

The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis.

scientific article published on 15 February 2016

The role of noncoding mutations in blood cancers

scientific article published on 26 November 2019

WT1 mutations in T-ALL

scientific article published on 03 June 2009

List of works by Marc Mansour

A role for aberrant Notch signaling in acute myeloid leukemia?

A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing.

APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL

Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia.

Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice.

Allogeneic transplantation for hepatosplenic alphabeta T-cell lymphoma

BCL2-specific inhibitor ABT-199 synergizes strongly with cytarabine against the early immature LOUCY cell line but not more-differentiated T-ALL cell lines

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

Cyclin C is a haploinsufficient tumour suppressor

Discovery of a secreted tumor suppressor provides a promising therapeutic strategy for follicular lymphoma

HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia

High incidence of Notch-1 mutations in adult patients with T-cell acute lymphoblastic leukemia

Impact of NOTCH1/FBXW7 mutations on outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on the MRC UKALL 2003 trial.

In trans early mosaic mutational escape and novel phenotypic features of germline SAMD9 mutation

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia.

KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.

Notch signaling: switching an oncogene to a tumor suppressor.

Notch-1 mutations are secondary events in some patients with T-cell acute lymphoblastic leukemia

Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia

Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

Oncogenic Kras and Notch-1 cooperate in T-cell acute lymphoblastic leukemia/lymphoma ⬇️

Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia.

Ribonucleoprotein HNRNPA2B1 interacts with and regulates oncogenic KRAS in pancreatic ductal adenocarcinoma cells.

Small genomic insertions form enhancers that misregulate oncogenes

Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss

Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain.

T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII/ECOG 2993)

TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia

Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia

The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis.

The role of noncoding mutations in blood cancers

WT1 mutations in T-ALL