List of works - Modesto de Candia

A New Class of 1-Aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline Derivatives as Reversers of P-Glycoprotein-Mediated Multidrug Resistance in Tumor Cells

scientific article published on 04 July 2018

A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles.

scientific article published in June 2017

Biarylmethoxy isonipecotanilides as potent and selective inhibitors of blood coagulation factor Xa

Delivery of Proapoptotic Agents in Glioma Cell Lines by TSPO Ligand-Dextran Nanogels

scientific article published on 11 April 2018

Ester derivatives of annulated tetrahydroazocines: a new class of selective acetylcholinesterase inhibitors.

scientific article

Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: inhibitors of factor Xa and platelet aggregation.

scientific article published in February 2009

Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways

scientific article published on 16 June 2015

How a β-D-glucoside side chain enhances binding affinity to thrombin of inhibitors bearing 2-chlorothiophene as P1 moiety: crystallography, fragment deconstruction study, and evaluation of antithrombotic properties

scientific article

Inhibition of 6-hydroxydopamine-induced oxidative damage by 4,5-dihydro-3H-2-benzazepine N-oxides.

scientific article

Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity

Insights into structure-activity relationships from lipophilicity profiles of pyridin-2(1H)-one analogs of the cardiotonic agent milrinone

scientific article published in September 2005

Interplay between Ionization and Tautomerism in Bioactive β-Enamino Ester-Containing Cyclic Compounds: Study of Annulated 1,2,3,6-Tetrahydroazocine Derivatives

scientific article published on 27 December 2019

Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides.

scientific article published on 30 June 2017

Investigation of platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids

scientific article (publication date: 3 April 2003)

Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides

scientific article

New azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity.

scientific article published on 13 September 2016

New organic nitrate-containing benzyloxy isonipecotanilide derivatives with vasodilatory and anti-platelet activity

scientific article published on 10 March 2015

Novel factor Xa inhibitors: a patent review

scientific article

Oxazepam-Dopamine Conjugates Increase Dopamine Delivery into Striatum of Intact Rats

scientific article published on 05 August 2017

Pharmaceutical development of novel lactate-based 6-fluoro-l-DOPA formulations

scientific article published on 4 October 2016

Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease

scientific article published on 07 December 2020

Protein crystallography and fragment-based drug design.

scientific article

Structure-property relationship study of the HPLC enantioselective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase

scientific article

Synthesis and biological evaluation of direct thrombin inhibitors bearing 4-(piperidin-1-yl)pyridine at the P1 position with potent anticoagulant activity

scientific article published on 22 October 2013

The position of fluorine in CP-118,954 affects AChE inhibition potency and PET imaging quantification for AChE expression in the rat brain.

scientific article published on 14 August 2017

β-D-glucosyl conjugates of highly potent inhibitors of blood coagulation factor Xa bearing 2-chorothiophene as a P1 motif

scientific article published on 31 July 2012

List of works by Modesto de Candia

A New Class of 1-Aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline Derivatives as Reversers of P-Glycoprotein-Mediated Multidrug Resistance in Tumor Cells

A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles.

Biarylmethoxy isonipecotanilides as potent and selective inhibitors of blood coagulation factor Xa

Delivery of Proapoptotic Agents in Glioma Cell Lines by TSPO Ligand-Dextran Nanogels

Ester derivatives of annulated tetrahydroazocines: a new class of selective acetylcholinesterase inhibitors.

Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: inhibitors of factor Xa and platelet aggregation.

Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways

How a β-D-glucoside side chain enhances binding affinity to thrombin of inhibitors bearing 2-chlorothiophene as P1 moiety: crystallography, fragment deconstruction study, and evaluation of antithrombotic properties

Inhibition of 6-hydroxydopamine-induced oxidative damage by 4,5-dihydro-3H-2-benzazepine N-oxides.

Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity

Insights into structure-activity relationships from lipophilicity profiles of pyridin-2(1H)-one analogs of the cardiotonic agent milrinone

Interplay between Ionization and Tautomerism in Bioactive β-Enamino Ester-Containing Cyclic Compounds: Study of Annulated 1,2,3,6-Tetrahydroazocine Derivatives

Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides.

Investigation of platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids

Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides

New azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity.

New organic nitrate-containing benzyloxy isonipecotanilide derivatives with vasodilatory and anti-platelet activity

Novel factor Xa inhibitors: a patent review

Oxazepam-Dopamine Conjugates Increase Dopamine Delivery into Striatum of Intact Rats

Pharmaceutical development of novel lactate-based 6-fluoro-l-DOPA formulations

Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease

Protein crystallography and fragment-based drug design.

Structure-property relationship study of the HPLC enantioselective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase

Synthesis and biological evaluation of direct thrombin inhibitors bearing 4-(piperidin-1-yl)pyridine at the P1 position with potent anticoagulant activity

The position of fluorine in CP-118,954 affects AChE inhibition potency and PET imaging quantification for AChE expression in the rat brain.

β-D-glucosyl conjugates of highly potent inhibitors of blood coagulation factor Xa bearing 2-chorothiophene as a P1 motif