List of works - Nicolas Renault

3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis.

scientific article

4-Oxo-1,4-dihydropyridines as selective CB2 cannabinoid receptor ligands: structural insights into the design of a novel inverse agonist series

scientific article published on 27 October 2010

A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect β-secretase inhibitors

scholarly article by Marion Gay et al published November 2018 in European Journal of Medicinal Chemistry

Antagonists of the adenosine A2A receptor based on a 2-arylbenzoxazole scaffold: Investigation of the C5- and C7-positions to enhance affinity.

scientific article published on 5 December 2017

Conformational Restriction Leading to a Selective CB2 Cannabinoid Receptor Agonist Orally Active Against Colitis.

scientific article published on 4 December 2014

Design and synthesis of 2,6-disubstituted-8-amino imidazo[1,2a]pyridines, a promising privileged structure

scientific article published on 30 April 2018

Design and synthesis of fused tetrahydroisoquinoline-iminoimidazolines

scientific article published on 19 October 2015

Design, synthesis and biological evaluation of potent FAAH inhibitors

scientific article published on 23 April 2016

Design, synthesis and evaluation of 2-aryl benzoxazoles as promising hit for the A2A receptor.

scientific article published in December 2017

Free resources to assist structure-based virtual ligand screening experiments

scientific article

Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population

scientific article published on 27 July 2011

Genetic, molecular and functional analyses of complement factor I deficiency

scientific article

Homology modeling of MT1 and MT2 receptors

scientific article published on 14 December 2007

Importance of the second extracellular loop for melatonin MT1 receptor function and absence of melatonin binding in GPR50.

scientific article published on 12 September 2017

Molecular modelling of phthalates – PPARs interactions

scientific article published in January 2008

Mutations in components of complement influence the outcome of Factor I-associated atypical hemolytic uremic syndrome

scientific article

New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis

scientific article published on 06 May 2011

New phenylaniline derivatives as modulators of amyloid protein precursor metabolism

scholarly article by Marion Gay published in May 2018

Novel structural insights for drug design of selective 5-HT(2C) inverse agonists from a ligand-biased receptor model

scientific article published on 12 August 2010

Relationships between Th1 or Th2 iNKT cell activity and structures of CD1d-antigen complexes: meta-analysis of CD1d-glycolipids dynamics simulations

scientific article

Structural insight into PPARgamma ligands binding.

scientific article published on January 2009

Switching invariant natural killer T (iNKT) cell response from anticancerous to anti-inflammatory effect: molecular bases.

scientific article published on 12 February 2014

Synthesis and Biological Evaluation of N-[2-(4-Hydroxyphenylamino)-pyridin-3-yl]-4-methoxy-benzenesulfonamide (ABT-751) Tricyclic Analogues as Antimitotic and Antivascular Agents with Potent in Vivo Antitumor Activity.

scientific article published on 18 August 2016

Synthesis of triazoloquinazolinone based compounds as tubulin polymerization inhibitors and vascular disrupting agents.

scientific article published on 22 March 2016

Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators.

scientific article published on 27 February 2012

The end of a myth: cloning and characterization of the ovine melatonin MT(2) receptor.

scientific article published on 08 October 2009

Toward the Discovery of a Novel Class of YAP⁻TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP⁻TEAD Protein⁻Protein Interface.

scientific article published on 8 May 2018

Update on melatonin receptors: IUPHAR Review 20.

scientific article published on 17 June 2016

Virtual screening of CB(2) receptor agonists from bayesian network and high-throughput docking: structural insights into agonist-modulated GPCR features.

scientific article

List of works by Nicolas Renault

3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis.

4-Oxo-1,4-dihydropyridines as selective CB2 cannabinoid receptor ligands: structural insights into the design of a novel inverse agonist series

A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect β-secretase inhibitors

Antagonists of the adenosine A2A receptor based on a 2-arylbenzoxazole scaffold: Investigation of the C5- and C7-positions to enhance affinity.

Conformational Restriction Leading to a Selective CB2 Cannabinoid Receptor Agonist Orally Active Against Colitis.

Design and synthesis of 2,6-disubstituted-8-amino imidazo[1,2a]pyridines, a promising privileged structure

Design and synthesis of fused tetrahydroisoquinoline-iminoimidazolines

Design, synthesis and biological evaluation of potent FAAH inhibitors

Design, synthesis and evaluation of 2-aryl benzoxazoles as promising hit for the A2A receptor.

Free resources to assist structure-based virtual ligand screening experiments

Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population

Genetic, molecular and functional analyses of complement factor I deficiency

Homology modeling of MT1 and MT2 receptors

Importance of the second extracellular loop for melatonin MT1 receptor function and absence of melatonin binding in GPR50.

Molecular modelling of phthalates – PPARs interactions

Mutations in components of complement influence the outcome of Factor I-associated atypical hemolytic uremic syndrome

New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis

New phenylaniline derivatives as modulators of amyloid protein precursor metabolism

Novel structural insights for drug design of selective 5-HT(2C) inverse agonists from a ligand-biased receptor model

Relationships between Th1 or Th2 iNKT cell activity and structures of CD1d-antigen complexes: meta-analysis of CD1d-glycolipids dynamics simulations

Structural insight into PPARgamma ligands binding.

Switching invariant natural killer T (iNKT) cell response from anticancerous to anti-inflammatory effect: molecular bases.

Synthesis and Biological Evaluation of N-[2-(4-Hydroxyphenylamino)-pyridin-3-yl]-4-methoxy-benzenesulfonamide (ABT-751) Tricyclic Analogues as Antimitotic and Antivascular Agents with Potent in Vivo Antitumor Activity.

Synthesis of triazoloquinazolinone based compounds as tubulin polymerization inhibitors and vascular disrupting agents.

Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators.

The end of a myth: cloning and characterization of the ovine melatonin MT(2) receptor.

Toward the Discovery of a Novel Class of YAP⁻TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP⁻TEAD Protein⁻Protein Interface.

Update on melatonin receptors: IUPHAR Review 20.

Virtual screening of CB(2) receptor agonists from bayesian network and high-throughput docking: structural insights into agonist-modulated GPCR features.