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List of works by Joan Wither

A discrete cluster of urinary biomarkers discriminates between active systemic lupus erythematosus patients with and without glomerulonephritis

scientific article published on 04 October 2016

A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles

scientific article

A tyrosine sulfation-dependent HLA-I modification identifies memory B cells and plasma cells

scientific article published on 07 November 2018

Aberrant IgM signaling promotes survival of transitional T1 B cells and prevents tolerance induction in lupus-prone New Zealand black mice

scientific article published on 01 December 2005

Abrogation of pathogenic IgG autoantibody production in CD40L gene-deleted lupus-prone New Zealand Black mice

scientific article published on 17 March 2011

Activated B cells express increased levels of costimulatory molecules in young autoimmune NZB and (NZB x NZW)F(1) mice

scientific article published on 01 January 2000

Altered expression of TNF-alpha signaling pathway proteins in systemic lupus erythematosus

scientific article published in June 2010

An epitaph for sulfated insulin: immunologic profile of the last patients as they are switched from sulfated beef to human insulin

scientific article published on 01 September 1998

An intrinsic B-cell defect supports autoimmunity in New Zealand black chromosome 13 congenic mice

scientific article published on 29 December 2010

Anti-dsDNA and Antichromatin Antibody Isotypes in Serologically Active Clinically Quiescent Systemic Lupus Erythematosus

scientific article published in March 2015

Anti-nucleosome antibodies outperform traditional biomarkers as longitudinal indicators of disease activity in systemic lupus erythematosus

scientific article

Apoptotic cell-induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans

scientific article published on 14 May 2018

Association of LY9 in UK and Canadian SLE families

scientific article published on 24 January 2008

Association of systemic lupus erythematosus (SLE) genetic susceptibility loci with lupus nephritis in childhood-onset and adult-onset SLE

scientific article published on 01 January 2020

Autoreactive B cells in lupus-prone New Zealand black mice exhibit aberrant survival and proliferation in the presence of self-antigen in vivo

scientific article published on 01 February 2004

B cell activating factor (BAFF) and T cells cooperate to breach B cell tolerance in lupus-prone New Zealand Black (NZB) mice

scientific article

Bone marrow-derived human hematopoietic stem cells engraft NOD/SCID mice and traffic appropriately to an inflammatory stimulus in the joint

scientific article published on 28 January 2010

Both MHC and background gene heterozygosity alter T cell receptor repertoire selection in an antigen-specific response

scientific article published on 01 December 1995

Cancer Cells Hijack PRC2 to Modify Multiple Cytokine Pathways

scientific article

Colocalization of expansion of the splenic marginal zone population with abnormal B cell activation and autoantibody production in B6 mice with an introgressed New Zealand Black chromosome 13 interval.

scientific article published in October 2005

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

scientific article published on 21 December 2008

Development, Sensibility, and Validity of a Systemic Autoimmune Rheumatic Disease Case Ascertainment Tool

scientific article published in November 2016

Dissociation of the genetic loci leading to b1a and NKT cell expansions from autoantibody production and renal disease in B6 mice with an introgressed New Zealand Black chromosome 4 interval

scientific article published on 01 February 2007

Epistatic suppression of fatal autoimmunity in New Zealand black bicongenic mice.

scientific article published on 4 April 2011

Evaluation of clinical outcomes and renal vascular pathology among patients with lupus

scientific article

Experimental evidence that mutated-self peptides derived from mitochondrial DNA somatic mutations have the potential to trigger autoimmunity.

scientific article published on 28 June 2014

Fatigue severity in anti-nuclear antibody-positive individuals does not correlate with pro-inflammatory cytokine levels or predict imminent progression to symptomatic disease

scientific article published on 04 November 2019

Functional dissection of lupus susceptibility loci on the New Zealand black mouse chromosome 1: evidence for independent genetic loci affecting T and B cell activation.

scientific article published in August 2003

Functional interplay between intrinsic B and T cell defects leads to amplification of autoimmune disease in New Zealand black chromosome 1 congenic mice

scientific article published on 01 December 2005

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.

scientific article

Genetic engineering in primary human B cells with CRISPR-Cas9 ribonucleoproteins

scientific article published on 31 March 2018

Healthcare cost and loss of productivity in a Canadian population of patients with and without lupus nephritis.

scientific article published on 15 December 2010

IL-10 Production Is Critical for Sustaining the Expansion of CD5+ B and NKT Cells and Restraining Autoantibody Production in Congenic Lupus-Prone Mice

scientific article (publication date: 2016)

Identification of a lupus-susceptibility locus leading to impaired clearance of apoptotic debris on New Zealand Black chromosome 13.

scientific article published on 17 January 2013

Identification of a neutrophil-related gene expression signature that is enriched in adult systemic lupus erythematosus patients with active nephritis: Clinical/pathologic associations and etiologic mechanisms.

scientific article published on 9 May 2018

Identification of the SLAM Adapter Molecule EAT-2 as a Lupus-Susceptibility Gene That Acts through Impaired Negative Regulation of Dendritic Cell Signaling.

scientific article published on 2 October 2015

Immune mechanisms leading to abnormal B cell selection and activation in New Zealand Black mice

scientific article published on 01 September 2007

Immunoglobulin G subclass analysis in psoriatic arthritis

scientific article published on 15 October 2014

Impaired B cell anergy is not sufficient to breach tolerance to nuclear antigen in Vκ8/3H9 lupus-prone mice

scientific article published on 28 July 2020

Invariant NKT Cell Activation Is Potentiated by Homotypic trans-Ly108 Interactions.

scientific article published on 3 April 2017

Lack of Interferon and Proinflammatory Cyto/chemokines in Serologically Active Clinically Quiescent Systemic Lupus Erythematosus

scientific article published on 15 November 2015

Lack of association between the interferon-alpha signature and longitudinal changes in disease activity in systemic lupus erythematosus

scientific article published on 04 September 2008

Molecular basis of antigen recognition by insulin specific T cell receptor.

scientific article published in February 2004

Molecular markers of injury in kidney biopsy specimens of patients with lupus nephritis

scientific article published on March 2011

Multiple tolerance defects contribute to the breach of B cell tolerance in New Zealand Black chromosome 1 congenic mice

scientific article

Occupational and environmental exposures and risk of systemic lupus erythematosus: silica, sunlight, solvents

scientific article

Persistent proteinuria and dyslipidemia increase the risk of progressive chronic kidney disease in lupus erythematosus

scientific article published on 19 January 2011

Presence of an interferon signature in individuals who are anti-nuclear antibody positive lacking a systemic autoimmune rheumatic disease diagnosis

scientific article published on 28 February 2017

Prevalence and metric of depression and anxiety in systemic lupus erythematosus: A systematic review and meta-analysis

scientific article published on 28 June 2019

Reduced proportions of natural killer T cells are present in the relatives of lupus patients and are associated with autoimmunity

scientific article published on 10 September 2008

Rethinking Lupus Nephritis Classification on a Molecular Level

scientific article published on 23 September 2019

Suppression of autoimmunity by CD5(+) IL-10-producing B cells in lupus-prone mice.

scientific article published on 14 May 2015

T cell and dendritic cell abnormalities synergize to expand pro-inflammatory T cell subsets leading to fatal autoimmunity in B6.NZBc1 lupus-prone mice

scientific article

T-cell tolerance induction is normal in the (NZB x NZW)F1 murine model of systemic lupus erythematosus

scientific article published on 01 March 2000

TLR tolerance reduces IFN-alpha production despite plasmacytoid dendritic cell expansion and anti-nuclear antibodies in NZB bicongenic mice

scientific article

The B-cell transmembrane protein CD72 binds to and is an in vivo substrate of the protein tyrosine phosphatase SHP-1.

scientific article published on September 1998

The lupus phenotype in B6.NZBc1 congenic mice reflects interactions between multiple susceptibility loci and a suppressor locus

scientific article published on 10 February 2011

The presence of anti-nuclear antibodies alone is associated with changes in B cell activation and T follicular helper cells similar to those in systemic autoimmune rheumatic disease

scientific article published on 29 November 2018

Tolerance is overcome in beef insulin-transgenic mice by activation of low-affinity autoreactive T cells

scientific article published on 01 March 1996

Transancestral mapping and genetic load in systemic lupus erythematosus

scientific article published on 17 July 2017

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