List of works - Chudi O Ndubaku

Bio-inspired synthesis of xishacorenes A, B, and C, and a new congener from fuscol

scientific article published on 03 July 2019

Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window

scientific article

Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety.

scientific article

Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors

scientific article published on 24 May 2019

Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and ro

scientific article published on 3 June 2013

Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and in Silico Techniques.

scientific article published on 22 November 2017

Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity

scientific article

Discovery of selective 4-Amino-pyridopyrimidine inhibitors of MAP4K4 using fragment-based lead identification and optimization

scientific article

Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase β isoform

scientific article

Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors

scientific article

Inhibiting the deubiquitinating enzymes (DUBs).

scientific article

MAP4K4 regulates integrin-FERM binding to control endothelial cell motility

scientific article published on 18 March 2015

Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity

scientific article published on 01 December 2018

NK cells mediate clearance of CD8+ T cell-resistant tumors in response to STING agonists

scientific article published on 01 March 2020

Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis

scientific article published on 29 June 2015

Structure-Guided Rescaffolding of Selective Antagonists of BCL-X L

scientific article

Targeting inhibitor of apoptosis proteins for therapeutic intervention.

scientific article

The Design and Identification of Brain Penetrant Inhibitors of Phosphoinositide 3-Kinase α ⬇️

scientific article published on September 11, 2012

USP7 small-molecule inhibitors interfere with ubiquitin binding

scientific article published on 18 October 2017

List of works by Chudi O Ndubaku

Bio-inspired synthesis of xishacorenes A, B, and C, and a new congener from fuscol

Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window

Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety.

Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors

Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and ro

Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and in Silico Techniques.

Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity

Discovery of selective 4-Amino-pyridopyrimidine inhibitors of MAP4K4 using fragment-based lead identification and optimization

Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase β isoform

Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors

Inhibiting the deubiquitinating enzymes (DUBs).

MAP4K4 regulates integrin-FERM binding to control endothelial cell motility

Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity

NK cells mediate clearance of CD8+ T cell-resistant tumors in response to STING agonists

Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis

Structure-Guided Rescaffolding of Selective Antagonists of BCL-X L

Targeting inhibitor of apoptosis proteins for therapeutic intervention.

The Design and Identification of Brain Penetrant Inhibitors of Phosphoinositide 3-Kinase α ⬇️

USP7 small-molecule inhibitors interfere with ubiquitin binding