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List of works by Christopher J Tonkin

A CRISPR upgrade unlocks Toxoplasma gene function

scientific article published in 2022

A forward genetic screen identifies a negative regulator of rapid Ca2+-dependent cell egress (MS1) in the intracellular parasite Toxoplasma gondii.

scientific article published on 3 March 2017

A malaria parasite formin regulates actin polymerization and localizes to the parasite-erythrocyte moving junction during invasion

scientific article (publication date: 13 March 2008)

A novel family of Apicomplexan glideosome-associated proteins with an inner membrane-anchoring role

scientific article (publication date: 11 September 2009)

Alterations in local chromatin environment are involved in silencing and activation of subtelomeric var genes in Plasmodium falciparum

scientific article

An apically located hybrid guanylate cyclase-ATPase is critical for the initiation of Ca2+ signaling and motility in Toxoplasma gondii

scientific article published on 16 April 2019

An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

scientific article published on 18 November 2015

Analysis of Ca2+ mediated signaling regulating Toxoplasma infectivity reveals complex relationships between key molecules.

scientific article published on 26 October 2016

Aspartyl Protease 5 Matures Dense Granule Proteins That Reside at the Host-Parasite Interface in Toxoplasma gondii

scientific article published on 30 October 2018

Characterization of the ATP4 ion pump in Toxoplasma gondii

scientific article published on 05 February 2019

Characterization of two putative protein translocation components in the apicoplast of Plasmodium falciparum

scientific article (publication date: August 2009)

Development of a Novel CD4+ TCR Transgenic Line That Reveals a Dominant Role for CD8+ Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria

scientific article published on 30 October 2017

Development of the endoplasmic reticulum, mitochondrion and apicoplast during the asexual life cycle of Plasmodium falciparum.

scientific article published in July 2005

Disassembly activity of actin-depolymerizing factor (ADF) is associated with distinct cellular processes in apicomplexan parasites.

scientific article

Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum

scientific article published in January 2003

Elucidating the mitochondrial proteome of reveals the presence of a divergent cytochrome oxidase

scientific article published on 11 September 2018

Environmental Sensing and Regulation of Motility in Toxoplasma

scientific article published on 05 December 2020

Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2Rγnull Mouse Model of Malaria

scientific article published on 26 February 2019

Identification of potent phosphodiesterase inhibitors that demonstrate cyclic nucleotide-dependent functions in apicomplexan parasites.

scientific article published on 4 February 2015

Impaired social behaviour and molecular mediators of associated neural circuits during chronic Toxoplasma gondii infection in female mice

scientific article published on 23 February 2019

MYR1-Dependent Effectors Are the Major Drivers of a Host Cell's Early Response to Toxoplasma, Including Counteracting MYR1-Independent Effects.

scientific article published on 3 April 2018

Microbiology. A tail of division

scientific article published on 01 January 2011

Mitochondrial metabolism of glucose and glutamine is required for intracellular growth of Toxoplasma gondii.

scientific article

Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes

scientific article

N-terminal positively charged amino acids, but not their exact position, are important for apicoplast transit peptide fidelity in Toxoplasma gondii

scientific article published on 28 August 2006

Phosphorylation of αSNAP is Required for Secretory Organelle Biogenesis in Toxoplasma gondii

scientific article

Plasmodium falciparum subtilisin-like ookinete protein SOPT plays an important and conserved role during ookinete infection of the Anopheles stephensi midgut

scientific article published on 01 August 2018

Potential epigenetic regulatory proteins localise to distinct nuclear sub-compartments in Plasmodium falciparum

scientific article (publication date: 2010)

Protein Kinase A Is Essential for Invasion of Plasmodium falciparum into Human Erythrocytes. ⬇️

scientific article published on 8 October 2019

Protein O-fucosyltransferase 2–mediated O-glycosylation of the adhesin MIC2 is dispensable for Toxoplasma gondii tachyzoite infection

scientific article published in Journal of Biological Chemistry

Protein kinase A negatively regulates Ca2+ signalling in Toxoplasma gondii

scientific article published on 12 September 2018

Protein targeting to the malaria parasite plastid.

scientific article published on 13 November 2007

Quantitative in vivo analyses reveal calcium-dependent phosphorylation sites and identifies a novel component of the Toxoplasma invasion motor complex

scientific article

Rhomboid proteases in invasion and replication of Apicomplexa.

scientific article

Role of the ER and Golgi in protein export by Apicomplexa

scientific article published on 25 March 2016

Sequencing and analysis of JC virus DNA from natalizumab-treated PML patients. ⬇️

scientific article published on July 2011

Spatial localisation of actin filaments across developmental stages of the malaria parasite

scientific article (publication date: 2012)

Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex

scientific article published in Nature

Toxoplasmosis: A pathway to neuropsychiatric disorders

scientific article published on 23 November 2018

Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast

scientific article published in March 2004

Truncated Latrunculins as Actin Inhibitors Targeting Plasmodium falciparum Motility and Host Cell Invasion.

scientific article published on 02 December 2016

Two Essential Light Chains Regulate the MyoA Lever Arm To Promote Toxoplasma Gliding Motility

scientific article

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