Search filters

List of works by Eleanor H Simpson

12th International Mouse Genome Conference.

scientific article

A comparative transcript map and candidates for mutant phenotypes in the Tyrp1 (brown) deletion complex homologous to human 9p21-23

scientific article published on 01 January 2000

A novel strategy for dissecting goal-directed action and arousal components of motivated behavior with a progressive hold-down task

scientific article published on June 2015

A possible role for the striatum in the pathogenesis of the cognitive symptoms of schizophrenia.

scientific article

An Interaction between Serotonin Receptor Signaling and Dopamine Enhances Goal-Directed Vigor and Persistence in Mice

scientific article published on 24 January 2018

COMT genotype predicts cortical-limbic D1 receptor availability measured with [11C]NNC112 and PET.

scientific article published on 4 March 2008

D2 receptor overexpression in the striatum leads to a deficit in inhibitory transmission and dopamine sensitivity in mouse prefrontal cortex.

scientific article

DRD2 C957T polymorphism interacts with the COMT Val158Met polymorphism in human working memory ability.

scientific article

Dissociating the effects of dopamine D2 receptors on effort-based versus value-based decision making using a novel behavioral approach

scientific article published on 01 April 2020

Dissociation of hedonic reaction to reward and incentive motivation in an animal model of the negative symptoms of schizophrenia

scientific article published on 14 March 2012

Genetic evidence for the bidirectional modulation of synaptic plasticity in the prefrontal cortex by D1 receptors

scientific journal article

Genomic anatomy of the Tyrp1 (brown) deletion complex

scholarly article

Identification, sequence, and mapping of the mouse multiple PDZ domain protein gene, Mpdz

scientific article published in July 1999

Impaired recruitment of dopamine neurons during working memory in mice with striatal D2 receptor overexpression

scientific article published in Nature Communications

Impaired timing precision produced by striatal D2 receptor overexpression is mediated by cognitive and motivational deficits

scientific article (publication date: August 2009)

Improving temporal cognition by enhancing motivation

scientific article

Increased dopamine D2 receptor activity in the striatum alters the firing pattern of dopamine neurons in the ventral tegmental area.

scientific article

Insights About Striatal Circuit Function and Schizophrenia From a Mouse Model of Dopamine D2 Receptor Upregulation

scientific article

Medial prefrontal lesions in mice impair sustained attention but spare maintenance of information in working memory ⬇️

scientific article published on October 16, 2012

Modeling cognitive endophenotypes of schizophrenia in mice

scientific article published on 04 May 2009

Modeling motivational deficits in mouse models of schizophrenia: behavior analysis as a guide for neuroscience

scientific article

Neural substrates underlying effort, time, and risk-based decision making in motivated behavior.

scientific article

Orbitofrontal cortex mediates the differential impact of signaled-reward probability on discrimination accuracy.

scientific article published on 23 June 2015

Pharmacologic Rescue of Motivational Deficit in an Animal Model of the Negative Symptoms of Schizophrenia ⬇️

scientific article published on March 16, 2011

Schizophrenia in translation: dissecting motivation in schizophrenia and rodents.

scientific article

Selective overexpression of dopamine D3 receptors in the striatum disrupts motivation but not cognition.

scientific article

Social behavior in a genetic model of dopamine dysfunction at different neurodevelopmental time points

scientific article

Striatal dopamine D2 receptors regulate effort but not value-based decision making and alter the dopaminergic encoding of cost

scientific article published on 20 July 2018

The Behavioral Neuroscience of Motivation: An Overview of Concepts, Measures, and Translational Applications

scientific article published on 25 November 2015

The Mouse Cer1 (Cerberus related or homologue) Gene Is Not Required for Anterior Pattern Formation

article

The effects of pharmacological modulation of the serotonin 2C receptor on goal-directed behavior in mice

scientific article published on 11 November 2015

Transient and selective overexpression of D2 receptors in the striatum causes persistent deficits in conditional associative learning

scholarly article

Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning.

scientific article published in February 2006

Transient overexpression of striatal D2 receptors impairs operant motivation and interval timing.

scientific article

Using conditional mutagenesis to study the brain.

scientific article published on December 2003

Paulina is supported by:

About Paulina

Help