List of works - Michael J DeVito

2,3,7,8-Tetrachlorodibenzo-p-dioxin in Pregnant Long Evans Rats: Disposition to Maternal and Embryo/Fetal Tissues,

scientific article published on 01 October 1998

A pharmacokinetic model of cis- and trans-permethrin disposition in rats and humans with aggregate exposure application.

scientific article

An Intuitive Approach for Predicting Potential Human Health Risk with the Tox21 10k Library

scientific article published on 15 August 2017

An assessment of dioxin exposure across gestation and lactation using a PBPK model and new data from Seveso

scientific article

Antiestrogenic action of 2,3,7,8-tetrachlorodibenzo-p-dioxin: tissue-specific regulation of estrogen receptor in CD1 mice

scientific article published on 01 April 1992

Comparative ability of various PCBs, PCDFs, and TCDD to induce cytochrome P450 1A1 and 1A2 activity following 4 weeks of treatment

scientific article published on 01 January 1993

Comparative responsiveness of hypothyroxinemia and hepatic enzyme induction in Long-Evans rats versus C57BL/6J mice exposed to TCDD-like and phenobarbital-like polychlorinated biphenyl congeners

scientific article published in August 2002

Coordinated changes in xenobiotic metabolizing enzyme gene expression in aging male rats.

scientific article

Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat.

scientific article

Development of a quantitative model incorporating key events in a hepatotoxic mode of action to predict tumor incidence.

scientific article published on 27 January 2010

Development of a quantitative model of pregnane X receptor (PXR) mediated xenobiotic metabolizing enzyme induction

scientific article

Development of a refined database of mammalian relative potency estimates for dioxin-like compounds.

scientific article

Developmental triclosan exposure decreases maternal and neonatal thyroxine in rats

scientific article

Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: a dynamic and kinetic evaluation of a putative mode-of-action

scientific article

Dioxins: model chemicals for assessing receptor-mediated toxicity.

scientific article published on September 1995

Dose-response assessment of the dermal toxicity of Virginia cedarwood oil in F344/N rats and B6C3F1/N mice

scientific article published on 18 October 2016

Dose-response relationships for disposition and hepatic sequestration of polyhalogenated dibenzo-p-dioxins, dibenzofurans, and biphenyls following subchronic treatment in mice

scientific article published on 01 December 1998

Dose-response relationships for induction of CYP1A1 and CYP1A2 enzyme activity in liver, lung, and skin in female mice following subchronic exposure to polychlorinated biphenyls.

scientific article

Dose-response relationships for polyhalogenated dioxins and dibenzofurans following subchronic treatment in mice. I. CYP1A1 and CYP1A2 enzyme activity in liver, lung, and skin

scientific article published on 01 December 1997

Dose-response relationships in mice following subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: CYP1A1, CYP1A2, estrogen receptor, and protein tyrosine phosphorylation

scientific article published on 01 January 1994

EGF and TGF-alpha expression influence the developmental toxicity of TCDD: dose response and AhR phenotype in EGF, TGF-alpha, and EGF + TGF-alpha knockout mice

scientific article

Employing a Mechanistic Model for the MAPK Pathway to Examine the Impact of Cellular all or None Behavior on Overall Tissue Response.

scientific article

Environmentally relevant mixing ratios in cumulative assessments: a study of the kinetics of pyrethroids and their ester cleavage metabolites in blood and brain; and the effect of a pyrethroid mixture on the motor activity of rats

scientific article published on 12 March 2014

Environmentally relevant mixtures in cumulative assessments: an acute study of toxicokinetics and effects on motor activity in rats exposed to a mixture of pyrethroids

scientific article

Environmentally relevant pyrethroid mixtures: A study on the correlation of blood and brain concentrations of a mixture of pyrethroid insecticides to motor activity in the rat.

scientific article published on 18 June 2016

Evidence for dose-additive effects of pyrethroids on motor activity in rats

scientific article

F344/NTac Rats Chronically Exposed to Bromodichloroacetic Acid Develop Mammary Adenocarcinomas With Mixed Luminal/Basal Phenotype and Tgfβ Dysregulation.

scientific article published on 2 March 2015

From the Cover: Three-Dimensional (3D) HepaRG Spheroid Model With Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening.

scientific article

Genomic Profiling Reveals Unique Molecular Alterations in Hepatoblastomas and Adjacent Hepatocellular Carcinomas in B6C3F1 Mice.

scientific article

Human and animal evidence of potential transgenerational inheritance of health effects: An evidence map and state-of-the-science evaluation

article

In vitro metabolism of thyroxine by rat and human hepatocytes.

scientific article published on 31 October 2013

In vivo acute exposure to polychlorinated biphenyls: effects on free and total thyroxine in rats.

scientific article published in September 2009

Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework.

scientific article

Induction of cytochrome P450 isoenzymes after toxicokinetic interactions between 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,2',4,4',5,5'-hexachlorobiphenyl in the liver of the mouse

scientific article published on 01 May 1995

Induction of oxidative stress in brain tissues of mice after subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

scientific article published in March 1998

Interactive effects between 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,2',4,4',5,5'-hexachlorobiphenyl in female B6C3F1 mice: tissue distribution and tissue-specific enzyme induction

scientific article published on 01 November 1996

Lack of antiandrogenic effects in adult male rats following acute exposure to 2,2-bis(4-chlorophenyl)-1,1-dichloroethylene (p,p'-DDE).

scientific article published in May 2002

Mixtures research at NIEHS: an evolving program.

scientific article

Opposite effects of 2,2',4,4',5,5'-hexachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin on the antibody response to sheep erythrocytes in mice

scientific article published on 01 June 1997

Pargyline and naltrexone fail to antagonize the gustatory avoidance response induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

scientific article published in November 1986

Physiologically based pharmacokinetic model for developmental exposures to TCDD in the rat.

scientific article published on 31 March 2004

Physiologically based pharmacokinetic modeling of deltamethrin: development of a rat and human diffusion-limited model.

scientific article published on 3 March 2010

Polybrominated dibenzo-p-dioxins, dibenzofurans, and biphenyls: inclusion in the toxicity equivalency factor concept for dioxin-like compounds

scientific article published on 14 March 2013

Possible mechanisms of thyroid hormone disruption in mice by BDE 47, a major polybrominated diphenyl ether congener.

scientific article published on 22 September 2007

Relative potencies of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls derived from hepatic porphyrin accumulation in mice

scientific article published on 01 May 1996

Relative potency for altered humoral immunity induced by polybrominated and polychlorinated dioxins/furans in female B6C3F1/N mice.

scientific article

Repeated dose toxicity and relative potency of 1,2,3,4,6,7-hexachloronaphthalene (PCN 66) 1,2,3,5,6,7-hexachloronaphthalene (PCN 67) compared to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) for induction of CYP1A1, CYP1A2 and thymic atrophy in female H

scientific article published on 15 November 2012

Screening methods for thyroid hormone disruptors.

scientific article

Short-term exposure to triclosan decreases thyroxine in vivo via upregulation of hepatic catabolism in Young Long-Evans rats

scientific article

Short-term in vivo exposure to the water contaminant triclosan: Evidence for disruption of thyroxine

scientific article published on 27 April 2007

Species differences in the in vitro metabolism of deltamethrin and esfenvalerate: differential oxidative and hydrolytic metabolism by humans and rats

scientific article published on 19 July 2006

Subcellular localization of TCDD differs between the liver, lungs, and kidneys after acute and subchronic exposure: species/dose comparisons and possible mechanism

scientific article published on 01 December 1996

Subchronic Exposure of [3H]- 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in female B6C3F1 mice: relationship of steady-state levels to disposition and metabolism.

scientific article

The effects of 2,2',4,4',5,5'-hexachlorobiphenyl cotreatment on the disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice

scientific article published on 01 October 1995

The importance of pharmacokinetics in determining the relative potency of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzofuran

scientific article published on 01 January 1995

The next generation of risk assessment multi-year study - highlights of findings, applications to risk assessment, and future directions

journal article published in 2016

Three-Dimensional (3D) HepaRG Spheroid Model With Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening.

scientific article published in November 2017

Thyroid-hormone-disrupting chemicals: evidence for dose-dependent additivity or synergism

scientific article

Tissue time course and bioavailability of the pyrethroid insecticide bifenthrin in the Long-Evans rat.

scientific article published on 14 September 2015

Use of a physiologically based pharmacokinetic model for rats to study the influence of body fat mass and induction of CYP1A2 on the pharmacokinetics of TCDD.

scientific article

Use of toxic equivalency factors for risk assessment for dioxins and related compounds.

scientific article

List of works by Michael J DeVito

2,3,7,8-Tetrachlorodibenzo-p-dioxin in Pregnant Long Evans Rats: Disposition to Maternal and Embryo/Fetal Tissues,

A pharmacokinetic model of cis- and trans-permethrin disposition in rats and humans with aggregate exposure application.

An Intuitive Approach for Predicting Potential Human Health Risk with the Tox21 10k Library

An assessment of dioxin exposure across gestation and lactation using a PBPK model and new data from Seveso

Antiestrogenic action of 2,3,7,8-tetrachlorodibenzo-p-dioxin: tissue-specific regulation of estrogen receptor in CD1 mice

Comparative ability of various PCBs, PCDFs, and TCDD to induce cytochrome P450 1A1 and 1A2 activity following 4 weeks of treatment

Comparative responsiveness of hypothyroxinemia and hepatic enzyme induction in Long-Evans rats versus C57BL/6J mice exposed to TCDD-like and phenobarbital-like polychlorinated biphenyl congeners

Coordinated changes in xenobiotic metabolizing enzyme gene expression in aging male rats.

Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat.

Development of a quantitative model incorporating key events in a hepatotoxic mode of action to predict tumor incidence.

Development of a quantitative model of pregnane X receptor (PXR) mediated xenobiotic metabolizing enzyme induction

Development of a refined database of mammalian relative potency estimates for dioxin-like compounds.

Developmental triclosan exposure decreases maternal and neonatal thyroxine in rats

Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: a dynamic and kinetic evaluation of a putative mode-of-action

Dioxins: model chemicals for assessing receptor-mediated toxicity.

Dose-response assessment of the dermal toxicity of Virginia cedarwood oil in F344/N rats and B6C3F1/N mice

Dose-response relationships for disposition and hepatic sequestration of polyhalogenated dibenzo-p-dioxins, dibenzofurans, and biphenyls following subchronic treatment in mice

Dose-response relationships for induction of CYP1A1 and CYP1A2 enzyme activity in liver, lung, and skin in female mice following subchronic exposure to polychlorinated biphenyls.

Dose-response relationships for polyhalogenated dioxins and dibenzofurans following subchronic treatment in mice. I. CYP1A1 and CYP1A2 enzyme activity in liver, lung, and skin

Dose-response relationships in mice following subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: CYP1A1, CYP1A2, estrogen receptor, and protein tyrosine phosphorylation

EGF and TGF-alpha expression influence the developmental toxicity of TCDD: dose response and AhR phenotype in EGF, TGF-alpha, and EGF + TGF-alpha knockout mice

Employing a Mechanistic Model for the MAPK Pathway to Examine the Impact of Cellular all or None Behavior on Overall Tissue Response.

Environmentally relevant mixing ratios in cumulative assessments: a study of the kinetics of pyrethroids and their ester cleavage metabolites in blood and brain; and the effect of a pyrethroid mixture on the motor activity of rats

Environmentally relevant mixtures in cumulative assessments: an acute study of toxicokinetics and effects on motor activity in rats exposed to a mixture of pyrethroids

Environmentally relevant pyrethroid mixtures: A study on the correlation of blood and brain concentrations of a mixture of pyrethroid insecticides to motor activity in the rat.

Evidence for dose-additive effects of pyrethroids on motor activity in rats

F344/NTac Rats Chronically Exposed to Bromodichloroacetic Acid Develop Mammary Adenocarcinomas With Mixed Luminal/Basal Phenotype and Tgfβ Dysregulation.

From the Cover: Three-Dimensional (3D) HepaRG Spheroid Model With Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening.

Genomic Profiling Reveals Unique Molecular Alterations in Hepatoblastomas and Adjacent Hepatocellular Carcinomas in B6C3F1 Mice.

Human and animal evidence of potential transgenerational inheritance of health effects: An evidence map and state-of-the-science evaluation

In vitro metabolism of thyroxine by rat and human hepatocytes.

In vivo acute exposure to polychlorinated biphenyls: effects on free and total thyroxine in rats.

Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework.

Induction of cytochrome P450 isoenzymes after toxicokinetic interactions between 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,2',4,4',5,5'-hexachlorobiphenyl in the liver of the mouse

Induction of oxidative stress in brain tissues of mice after subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Interactive effects between 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,2',4,4',5,5'-hexachlorobiphenyl in female B6C3F1 mice: tissue distribution and tissue-specific enzyme induction

Lack of antiandrogenic effects in adult male rats following acute exposure to 2,2-bis(4-chlorophenyl)-1,1-dichloroethylene (p,p'-DDE).

Mixtures research at NIEHS: an evolving program.

Opposite effects of 2,2',4,4',5,5'-hexachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin on the antibody response to sheep erythrocytes in mice

Pargyline and naltrexone fail to antagonize the gustatory avoidance response induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Physiologically based pharmacokinetic model for developmental exposures to TCDD in the rat.

Physiologically based pharmacokinetic modeling of deltamethrin: development of a rat and human diffusion-limited model.

Polybrominated dibenzo-p-dioxins, dibenzofurans, and biphenyls: inclusion in the toxicity equivalency factor concept for dioxin-like compounds

Possible mechanisms of thyroid hormone disruption in mice by BDE 47, a major polybrominated diphenyl ether congener.

Relative potencies of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls derived from hepatic porphyrin accumulation in mice

Relative potency for altered humoral immunity induced by polybrominated and polychlorinated dioxins/furans in female B6C3F1/N mice.

Repeated dose toxicity and relative potency of 1,2,3,4,6,7-hexachloronaphthalene (PCN 66) 1,2,3,5,6,7-hexachloronaphthalene (PCN 67) compared to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) for induction of CYP1A1, CYP1A2 and thymic atrophy in female H

Screening methods for thyroid hormone disruptors.

Short-term exposure to triclosan decreases thyroxine in vivo via upregulation of hepatic catabolism in Young Long-Evans rats

Short-term in vivo exposure to the water contaminant triclosan: Evidence for disruption of thyroxine

Species differences in the in vitro metabolism of deltamethrin and esfenvalerate: differential oxidative and hydrolytic metabolism by humans and rats

Subcellular localization of TCDD differs between the liver, lungs, and kidneys after acute and subchronic exposure: species/dose comparisons and possible mechanism

Subchronic Exposure of [3H]- 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in female B6C3F1 mice: relationship of steady-state levels to disposition and metabolism.

The effects of 2,2',4,4',5,5'-hexachlorobiphenyl cotreatment on the disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice

The importance of pharmacokinetics in determining the relative potency of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzofuran

The next generation of risk assessment multi-year study - highlights of findings, applications to risk assessment, and future directions

Three-Dimensional (3D) HepaRG Spheroid Model With Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening.

Thyroid-hormone-disrupting chemicals: evidence for dose-dependent additivity or synergism

Tissue time course and bioavailability of the pyrethroid insecticide bifenthrin in the Long-Evans rat.

Use of a physiologically based pharmacokinetic model for rats to study the influence of body fat mass and induction of CYP1A2 on the pharmacokinetics of TCDD.

Use of toxic equivalency factors for risk assessment for dioxins and related compounds.