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List of works by Niall Barron

A Bioinformatics Pipeline for the Identification of CHO Cell Differential Gene Expression from RNA-Seq Data.

scientific article

A proteomic profiling dataset of recombinant Chinese hamster ovary cells showing enhanced cellular growth following miR-378 depletion

scientific article published on 27 November 2018

Antimicrobial Peptide Production and Purification.

scientific article

CHO cell culture longevity and recombinant protein yield are enhanced by depletion of miR-7 activity via sponge decoy vectors

scientific article published on 10 December 2013

CHO microRNA engineering is growing up: recent successes and future challenges

scientific article published on 02 August 2013

Clonal variation in productivity and proteolytic clipping of an Fc-fusion protein in CHO cells: Proteomic analysis suggests a role for defective protein folding and the UPR

scientific article published on 31 May 2018

Conditional Knockdown of Endogenous MicroRNAs in CHO Cells Using TET-ON-SanDI Sponge Vectors.

scientific article

Conserved microRNA function as a basis for Chinese hamster ovary cell engineering

scientific article published on 21 December 2014

Continuous translation of circularized mRNA improves recombinant protein titer

scientific article published on 04 January 2019

Copper phenanthrene oxidative chemical nucleases.

scientific article published on 7 May 2014

Decreasing Txnip mRNA and protein levels in pancreatic MIN6 cells reduces reactive oxygen species and restores glucose regulated insulin secretion

scientific article

Depletion of endogenous miRNA-378-3p increases peak cell density of CHO DP12 cells and is correlated with elevated levels of ubiquitin carboxyl-terminal hydrolase 14

scientific article published on 31 October 2018

Detecting de novo insulin synthesis in embryonic stem cell-derived populations.

scientific article published on 30 December 2006

Detection and cloning of LINE-1 elements in CHO cells

scientific article published on 03 March 2007

Detection and cloning of LINE-1 elements in CHO cells.

scientific article

Development and characterization of a Chinese hamster ovary cell-specific oligonucleotide microarray.

scientific article published on 6 May 2011

Directed differentiation of mouse embryonic stem cells into pancreatic-like or neuronal- and glial-like phenotypes.

scientific article

Engineering CHO cell growth and recombinant protein productivity by overexpression of miR-7.

scientific article

Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor coactivator-1 mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle.

scientific article published on 22 March 2010

Exploring the Potential Application of Short Non-Coding RNA-Based Genetic Circuits in Chinese Hamster Ovary Cells

scientific article published on 29 January 2018

Genetic and Epigenetic Variation across Genes Involved in Energy Metabolism and Mitochondria of Chinese Hamster Ovary Cell Lines

scientific article published on 20 May 2019

Identification of a novel, functional role for S100A13 in invasive lung cancer cell lines.

scientific article published on 3 December 2007

Impact of miR-7 over-expression on the proteome of Chinese hamster ovary cells.

scientific article published on 15 March 2012

Improved yield of rhEPO in CHO cells with synthetic 5' UTR

scientific article published on 30 November 2018

Improvements in single-use bioreactor film material composition leads to robust and reliable Chinese hamster ovary cell performance

scientific article published on 06 May 2019

Increased growth rate and productivity following stable depletion of miR-7 in a mAb producing CHO cell line causes an increase in proteins associated with the Akt pathway and ribosome biogenesis

scientific article published on 11 January 2019

Initial identification of low temperature and culture stage induction of miRNA expression in suspension CHO-K1 cells.

scientific article

Leaky Expression of the TET-On System Hinders Control of Endogenous miRNA Abundance

scientific article published on 18 July 2018

MiR-7 triggers cell cycle arrest at the G1/S transition by targeting multiple genes including Skp2 and Psme3.

scientific article

MicroRNAs: tiny targets for engineering CHO cell phenotypes? ⬇️

scientific article published on September 25, 2010

Microarray and proteomics expression profiling identifies several candidates, including the valosin-containing protein (VCP), involved in regulating high cellular growth rate in production CHO cell lines.

scientific article

Microarray expression profiling identifies genes regulating sustained cell specific productivity (S-Qp) in CHO K1 production cell lines.

scientific article

Parallel mRNA, proteomics and miRNA expression analysis in cell line models of the intestine.

scientific article published in November 2017

Potent oxidative DNA cleavage by the di-copper cytotoxin: [Cu2(μ-terephthalate)(1,10-phen)4]2+.

scientific article

Predicting cell-specific productivity from CHO gene expression.

scientific article published on 27 November 2010

Process-relevant concentrations of the leachable bDtBPP impact negatively on CHO cell production characteristics.

scientific article published on 24 August 2016

Radical-induced purine lesion formation is dependent on DNA helical topology.

scientific article

Re-programming CHO cell metabolism using miR-23 tips the balance towards a highly productive phenotype.

scientific article published on 24 June 2015

Regulating bioactivity of Cu2+ bis-1,10-phenanthroline artificial metallonucleases with sterically functionalized pendant carboxylates.

scientific article published on 6 November 2013

Resistance to multiple steroids in two sisters.

scientific article published in January 2001

Resistance to several steroids in two sisters

scientific article published on 01 December 1999

Short communication: Ethanol production from cellulose at 45°C using a batch-fed system containing alginate-immobilized Kluyveromyces marxianus IMB3

scientific article published on 01 January 1996

Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo

scientific article

Targeted genetic modification of cell lines for recombinant protein production.

scientific article

Targeting miRNAs with CRISPR/Cas9 to Improve Recombinant Protein Production of CHO Cells

scientific article published on 01 January 2018

The human L1 element: a potential biomarker in cancer prognosis, current status and future directions.

scientific article published on June 2011

Towards next generation CHO cell biology: Bioinformatics methods for RNA-Seq-based expression profiling

scientific article published on 09 June 2015

Transcriptomic analysis of IgG4 Fc-fusion protein degradation in a panel of clonally-derived CHO cell lines using RNASeq

scientific article published on 21 March 2019

Ultra-deep next generation mitochondrial genome sequencing reveals widespread heteroplasmy in Chinese hamster ovary cells

scientific article published on 7 February 2017

Understanding biopharmaceutical production at single nucleotide resolution using ribosome footprint profiling.

scientific article published on 19 February 2018

Utilization and evaluation of CHO-specific sequence databases for mass spectrometry based proteomics.

scientific article published on 2 March 2012

[Cu(o-phthalate)(phenanthroline)] Exhibits Unique Superoxide-Mediated NCI-60 Chemotherapeutic Action through Genomic DNA Damage and Mitochondrial Dysfunction

scientific article published on 21 October 2015

miR-CATCH Identifies Biologically Active miRNA Regulators of the Pro-Survival Gene XIAP, in Chinese Hamster Ovary Cells

scientific article

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