List of works - Yun-Chung Leung

'Light up' protein-protein interaction through bioorthogonal incorporation of a turn-on fluorescent probe into β-lactamase

scientific article

A Thiazole Orange Derivative Targeting the Bacterial Protein FtsZ Shows Potent Antibacterial Activity

scientific article

A dual protein expression system in Bacillus subtilis.

scientific article published in December 2002

A fluorescein-labeled AmpC β-lactamase allows rapid characterization of β-lactamase inhibitors by real-time fluorescence monitoring of the β-lactamase-inhibitor interactions.

scientific article published on 25 November 2015

A highly selective FRET-based fluorescent probe for detection of cysteine and homocysteine.

scientific article

A microfluidic system with surface modified piezoelectric sensor for trapping and detection of cancer cells

scientific article published on July 2010

A modified arginine-depleting enzyme NEI-01 inhibits growth of pancreatic cancer cells

scientific article published on 30 April 2020

A switch-on fluorescence assay for bacterial β-lactamases with amyloid fibrils as fluorescence enhancer and visual tool

scientific article published in December 2010

Acid-promoted DNA-cleaving activities and total synthesis of varacin C.

scientific article published in November 2002

An efficient heat-inducible Bacillus subtilis bacteriophage 105 expression and secretion system for the production of the Streptomyces clavuligerus beta-lactamase inhibitory protein (BLIP).

scientific article published in March 2004

Antimicrobial activity of a quinuclidine-based FtsZ inhibitor and its synergistic potential with β-lactam antibiotics

scientific article published on 08 October 2014

BADAN-conjugated β-lactamases as biosensors for β-lactam antibiotic detection

scientific article published on 30 October 2020

Catalytically impaired fluorescent class C β-lactamase enables rapid and sensitive cephalosporin detection by stabilizing fluorescence signals: implications for biosensor design

scientific article published on 02 October 2014

Characterization of an insertion in the phage phi 105 genome that blocks host Bacillus subtilis lysis and provides strong expression of heterologous genes.

scientific article published in February 1995

Crystal structure of human pyridoxal kinase

scientific article

Crystallization and preliminary crystallographic studies of pyridoxal kinase from sheep brain.

scientific article published on 23 August 2002

Cyclometalated gold(III) complexes for chemoselective cysteine modification via ligand controlled C-S bond-forming reductive elimination

scientific article published on 01 October 2014

Deprivation of arginine by recombinant human arginase in prostate cancer cells ⬇️

scientific article published on April 30, 2012

Discovery of a drug-like G-quadruplex binding ligand by high-throughput docking

scientific article published on 01 June 2008

Efficient Synthesis of Amine-Linked 2,4,6-Trisubstituted Pyrimidines as a New Class of Bacterial FtsZ Inhibitors.

scientific article published on 27 October 2017

Engineered Amp C β-lactamase as a fluorescent screening tool for class C β-lactamase inhibitors

scientific article published on 21 February 2011

Evaluation of Meropenem Pharmacokinetics in an Experimental Acute Respiratory Distress Syndrome (ARDS) Model during Extracorporeal Membrane Oxygenation (ECMO) by Using a PenP β-Lactamase Biosensor.

scientific article published on 4 May 2018

Fluorescein-labeled beta-lactamase mutant for high-throughput screening of bacterial beta-lactamases against beta-lactam antibiotics

scientific article published in August 2005

Fluorescent TEM-1 β-lactamase with wild-type activity as a rapid drug sensor for in vitro drug screening

scientific article

Fluorophore-labeled beta-lactamase as a biosensor for beta-lactam antibiotics: a study of the biosensing process

scientific article published on 23 April 2008

Gold-mediated bifunctional modification of oligosaccharides via a three-component coupling reaction

scientific article published on 10 November 2011

Identification of a new class of FtsZ inhibitors by structure-based design and in vitro screening

scientific article

Immobilization of engineered arginase on gold-carbon nanotubes

scientific article published on 01 August 2012

Interaction between pyridoxal kinase and pyridoxal-5-phosphate-dependent enzymes.

scientific article published in November 2003

Investigation of synergistic antimicrobial effects of the drug combinations of meropenem and 1,2-benzisoselenazol-3(2 H )-one derivatives on carbapenem-resistant Enterobacteriaceae producing NDM-1

scientific article published on 06 June 2018

Method Based on the β-Lactamase PenPC Fluorescent Labeled for β-Lactam Antibiotic Quantification in Human Plasma

scientific article

Molecular cloning and the biochemical characterization of two novel phytases from B. subtilis 168 and B. licheniformis

scientific article published on 08 June 2002

Molecular mechanisms of substrate recognition and specificity of New Delhi metallo-β-lactamase

scientific article

Mono-PEGylation of a Thermostable Arginine-Depleting Enzyme for the Treatment of Lung Cancer

scientific article published on 14 June 2020

Multifunctional bioconjugation by Morita-Baylis-Hillman reaction in aqueous medium

scientific article published on 01 March 2012

Overexpression of the recombinant Enterobacter cloacae P99 AmpC beta-lactamase and its mutants based on a phi105 prophage system in Bacillus subtilis

scientific article published on 15 June 2007

Pegylated derivatives of recombinant human arginase (rhArg1) for sustained in vivo activity in cancer therapy: preparation, characterization and analysis of their pharmacodynamics in vivo and in vitro and action upon hepatocellular carcinoma cell (H

scientific article published on 17 April 2009

Pegylated recombinant human arginase (rhArg-peg5,000mw) inhibits the in vitro and in vivo proliferation of human hepatocellular carcinoma through arginine depletion

scientific article published on 01 January 2007

Phosphorescent proteins for bio-imaging and site selective bio-conjugation of peptides and proteins with luminescent cyclometalated iridium(III) complexes.

scientific article

Rational design of a novel fluorescent biosensor for beta-lactam antibiotics from a class A beta-lactamase

scientific article published in April 2004

Rational design of berberine-based FtsZ inhibitors with broad-spectrum antibacterial activity

scientific article (publication date: 2014)

Recombinant Bacillus caldovelox Arginase Mutant (BCA-M) Induces Apoptosis, Autophagy, Cell Cycle Arrest and Growth Inhibition in Human Cervical Cancer Cells

scientific article published on 09 October 2020

Recombinant human arginase inhibits the in vitro and in vivo proliferation of human melanoma by inducing cell cycle arrest and apoptosis.

scientific article

Remission of hepatocellular carcinoma with arginine depletion induced by systemic release of endogenous hepatic arginase due to transhepatic arterial embolisation, augmented by high-dose insulin: arginase as a potential drug candidate for hepatocell

scientific article published on 25 December 2004

Site-directed mutagenesis of beta-lactamase I: role of Glu-166.

scientific article published on May 1994

Structure-based Design, Synthesis, and Biological Evaluation of Isatin Derivatives as Potential Glycosyltransferase Inhibitors

scientific article published on 14 August 2014

Validation of the AmpC β-lactamase binding site and identification of inhibitors with novel scaffolds

scientific article published on May 4, 2012

List of works by Yun-Chung Leung

'Light up' protein-protein interaction through bioorthogonal incorporation of a turn-on fluorescent probe into β-lactamase

A Thiazole Orange Derivative Targeting the Bacterial Protein FtsZ Shows Potent Antibacterial Activity

A dual protein expression system in Bacillus subtilis.

A fluorescein-labeled AmpC β-lactamase allows rapid characterization of β-lactamase inhibitors by real-time fluorescence monitoring of the β-lactamase-inhibitor interactions.

A highly selective FRET-based fluorescent probe for detection of cysteine and homocysteine.

A microfluidic system with surface modified piezoelectric sensor for trapping and detection of cancer cells

A modified arginine-depleting enzyme NEI-01 inhibits growth of pancreatic cancer cells

A switch-on fluorescence assay for bacterial β-lactamases with amyloid fibrils as fluorescence enhancer and visual tool

Acid-promoted DNA-cleaving activities and total synthesis of varacin C.

An efficient heat-inducible Bacillus subtilis bacteriophage 105 expression and secretion system for the production of the Streptomyces clavuligerus beta-lactamase inhibitory protein (BLIP).

Antimicrobial activity of a quinuclidine-based FtsZ inhibitor and its synergistic potential with β-lactam antibiotics

BADAN-conjugated β-lactamases as biosensors for β-lactam antibiotic detection

Catalytically impaired fluorescent class C β-lactamase enables rapid and sensitive cephalosporin detection by stabilizing fluorescence signals: implications for biosensor design

Characterization of an insertion in the phage phi 105 genome that blocks host Bacillus subtilis lysis and provides strong expression of heterologous genes.

Crystal structure of human pyridoxal kinase

Crystallization and preliminary crystallographic studies of pyridoxal kinase from sheep brain.

Cyclometalated gold(III) complexes for chemoselective cysteine modification via ligand controlled C-S bond-forming reductive elimination

Deprivation of arginine by recombinant human arginase in prostate cancer cells ⬇️

Discovery of a drug-like G-quadruplex binding ligand by high-throughput docking

Efficient Synthesis of Amine-Linked 2,4,6-Trisubstituted Pyrimidines as a New Class of Bacterial FtsZ Inhibitors.

Engineered Amp C β-lactamase as a fluorescent screening tool for class C β-lactamase inhibitors

Evaluation of Meropenem Pharmacokinetics in an Experimental Acute Respiratory Distress Syndrome (ARDS) Model during Extracorporeal Membrane Oxygenation (ECMO) by Using a PenP β-Lactamase Biosensor.

Fluorescein-labeled beta-lactamase mutant for high-throughput screening of bacterial beta-lactamases against beta-lactam antibiotics

Fluorescent TEM-1 β-lactamase with wild-type activity as a rapid drug sensor for in vitro drug screening

Fluorophore-labeled beta-lactamase as a biosensor for beta-lactam antibiotics: a study of the biosensing process

Gold-mediated bifunctional modification of oligosaccharides via a three-component coupling reaction

Identification of a new class of FtsZ inhibitors by structure-based design and in vitro screening

Immobilization of engineered arginase on gold-carbon nanotubes

Interaction between pyridoxal kinase and pyridoxal-5-phosphate-dependent enzymes.

Investigation of synergistic antimicrobial effects of the drug combinations of meropenem and 1,2-benzisoselenazol-3(2 H )-one derivatives on carbapenem-resistant Enterobacteriaceae producing NDM-1

Method Based on the β-Lactamase PenPC Fluorescent Labeled for β-Lactam Antibiotic Quantification in Human Plasma

Molecular cloning and the biochemical characterization of two novel phytases from B. subtilis 168 and B. licheniformis

Molecular mechanisms of substrate recognition and specificity of New Delhi metallo-β-lactamase

Mono-PEGylation of a Thermostable Arginine-Depleting Enzyme for the Treatment of Lung Cancer

Multifunctional bioconjugation by Morita-Baylis-Hillman reaction in aqueous medium

Overexpression of the recombinant Enterobacter cloacae P99 AmpC beta-lactamase and its mutants based on a phi105 prophage system in Bacillus subtilis

Pegylated derivatives of recombinant human arginase (rhArg1) for sustained in vivo activity in cancer therapy: preparation, characterization and analysis of their pharmacodynamics in vivo and in vitro and action upon hepatocellular carcinoma cell (H

Pegylated recombinant human arginase (rhArg-peg5,000mw) inhibits the in vitro and in vivo proliferation of human hepatocellular carcinoma through arginine depletion

Phosphorescent proteins for bio-imaging and site selective bio-conjugation of peptides and proteins with luminescent cyclometalated iridium(III) complexes.

Rational design of a novel fluorescent biosensor for beta-lactam antibiotics from a class A beta-lactamase

Rational design of berberine-based FtsZ inhibitors with broad-spectrum antibacterial activity

Recombinant Bacillus caldovelox Arginase Mutant (BCA-M) Induces Apoptosis, Autophagy, Cell Cycle Arrest and Growth Inhibition in Human Cervical Cancer Cells

Recombinant human arginase inhibits the in vitro and in vivo proliferation of human melanoma by inducing cell cycle arrest and apoptosis.

Remission of hepatocellular carcinoma with arginine depletion induced by systemic release of endogenous hepatic arginase due to transhepatic arterial embolisation, augmented by high-dose insulin: arginase as a potential drug candidate for hepatocell

Site-directed mutagenesis of beta-lactamase I: role of Glu-166.

Structure-based Design, Synthesis, and Biological Evaluation of Isatin Derivatives as Potential Glycosyltransferase Inhibitors

Validation of the AmpC β-lactamase binding site and identification of inhibitors with novel scaffolds