List of works - Sakthivel Sadayappan

A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function

scientific article (publication date: 8 July 2011)

A hypertrophic cardiomyopathy-associated MYBPC3 mutation common in populations of South Asian descent causes contractile dysfunction

scientific article

A sensitive and specific quantitation method for determination of serum cardiac myosin binding protein-C by electrochemiluminescence immunoassay.

scientific article published on 08 August 2013

Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury

scientific article published on 09 March 2019

Agonist activated PKCβII translocation and modulation of cardiac myocyte contractile function.

scientific article published on January 2013

Alterations in Multi-Scale Cardiac Architecture in Association With Phosphorylation of Myosin Binding Protein-C.

scientific article published on 15 March 2016

Altered C10 domain in cardiac myosin binding protein-C results in hypertrophic cardiomyopathy

scientific article published on 01 December 2019

Analysis of cardiac myosin binding protein-C phosphorylation in human heart muscle

scientific article

Application of an advanced maximum likelihood estimation restoration method for enhanced-resolution and contrast in second-harmonic generation microscopy

scientific article published on 08 June 2017

Assessing the multiscale architecture of muscular tissue with Q-space magnetic resonance imaging: Review.

scientific article

Association of Cardiomyopathy With MYBPC3 D389V and MYBPC3Δ25bpIntronic Deletion in South Asian Descendants

scientific article published on 11 April 2018

Association of intronic DNA methylation and hydroxymethylation alterations in the epigenetic etiology of dilated cardiomyopathy

scientific article published on 26 April 2019

Basic Cardiovascular Sciences Scientific Sessions 2018

scientific article published on 01 October 2018

Cardiac Myosin Binding Protein-C Autoantibodies are Potential Early Indicators of Cardiac Dysfunction and Patient Outcome in Acute Coronary Syndrome

scientific article

Cardiac Myosin Binding Protein-C: A Potential Early-Stage, Cardiac-Specific Biomarker of Ischemia-Reperfusion Injury ⬇️

scientific article published on February 1, 2012

Cardiac Myosin-binding Protein C and Troponin-I Phosphorylation Independently Modulate Myofilament Length-dependent Activation.

scientific article

Cardiac inflammation in genetic dilated cardiomyopathy caused by MYBPC3 mutation

scientific article published on 9 December 2016

Cardiac isoform of alpha-2 macroglobulin--a new biomarker for myocardial infarcted diabetic patients.

scientific article published on 15 August 2005

Cardiac muscle organization revealed in 3-D by imaging whole-mount mouse hearts using two-photon fluorescence and confocal microscopy.

scientific article published on November 2015

Cardiac myosin binding protein C phosphorylation affects cross-bridge cycle's elementary steps in a site-specific manner.

scientific article

Cardiac myosin binding protein-C as a central target of cardiac sarcomere signaling: a special mini review series.

scientific article

Cardiac myosin binding protein-C is a potential diagnostic biomarker for myocardial infarction.

scientific article published on 19 September 2011

Cardiac myosin binding protein-C phosphorylation in a {beta}-myosin heavy chain background

scientific article published on 23 February 2009

Cardiac myosin binding protein-C phosphorylation regulates the super-relaxed state of myosin

scientific article published on 29 May 2019

Cardiac myosin binding protein-C plays no regulatory role in skeletal muscle structure and function

scientific article

Cardiac myosin binding protein-C: redefining its structure and function ⬇️

scientific article published on June 1, 2012

Cardiac myosin-binding protein-C phosphorylation and cardiac function

scientific journal article

Cardiac transgenic and gene transfer strategies converge to support an important role for troponin I in regulating relaxation in cardiac myocytes.

scientific article published on 5 July 2007

Cardiovascular Early Careers: Past and Present.

scientific article published in July 2017

Cardiovascular Leaders Are Made, not Born

scientific article published on 01 February 2019

Ceramide-mediated depression in cardiomyocyte contractility through PKC activation and modulation of myofilament protein phosphorylation

scientific article published on 4 October 2014

Contractile dysfunction in a mouse model expressing a heterozygous MYBPC3 mutation associated with hypertrophic cardiomyopathy

scientific article published on 24 January 2014

Contractile responses to endothelin-1 are regulated by PKC phosphorylation of cardiac myosin binding protein-C in rat ventricular myocytes

scientific article

Control of in vivo left ventricular [correction] contraction/relaxation kinetics by myosin binding protein C: protein kinase A phosphorylation dependent and independent regulation

scientific article published on 05 November 2007

Dilated cardiomyopathy-mediated heart failure induces a unique skeletal muscle myopathy with inflammation

Distinct sarcomeric substrates are responsible for protein kinase D-mediated regulation of cardiac myofilament Ca2+ sensitivity and cross-bridge cycling ⬇️

scientific article

Distribution and structure-function relationship of myosin heavy chain isoforms in the adult mouse heart

scientific article published on 16 June 2007

ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity

scientific article published on 09 April 2019

Effects of a myofilament calcium sensitizer on left ventricular systolic and diastolic function in rats with volume overload heart failure

scientific article

Enhanced cardiac function in Gravin mutant mice involves alterations in the β-adrenergic receptor signaling cascade

scientific article

Epigenetic modification: a regulatory mechanism in essential hypertension

scientific article published on 13 March 2019

Featured characteristics and pivotal roles of satellite cells in skeletal muscle regeneration

scientific article published on 07 September 2019

Finding the missing link: disulfide-containing proteins via a high-throughput proteomics approach.

scientific article

GSK3β phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: short communication

scientific article

Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice.

scientific article

Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload

scientific article published on 01 January 2019

Hypertrophic cardiomyopathy clinical phenotype is independent of gene mutation and mutation dosage

scientific article

Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin

scientific article published on 01 January 2019

In vivo and in vitro cardiac responses to beta-adrenergic stimulation in volume-overload heart failure

scientific article published on 07 December 2012

Inducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury.

scientific article published on 19 March 2009

Inhibition of Senescence-Associated Genes Rb1 and Meis2 in Adult Cardiomyocytes Results in Cell Cycle Reentry and Cardiac Repair Post-Myocardial Infarction

scientific article published on 18 July 2019

Interactions between the regulatory subunit of type I protein kinase A and p90 ribosomal S6 kinase1 regulate cardiomyocyte apoptosis.

scientific article published on 04 December 2013

Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-κB

scientific article

KLF2 in Myeloid Lineage Cells Regulates the Innate Immune Response during Skeletal Muscle Injury and Regeneration

scientific article published on 08 July 2019

Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration

scientific article published on 16 February 2018

MYBPC3 truncation mutations enhance actomyosin contractile mechanics in human hypertrophic cardiomyopathy

scientific article published on 11 December 2018

MYBPC3's alternate ending: consequences and therapeutic implications of a highly prevalent 25 bp deletion mutation

scientific article published on 11 December 2013

MicroRNA-210-mediated proliferation, survival, and angiogenesis promote cardiac repair post myocardial infarction in rodents.

scientific article published on 25 September 2017

Molecular Screen Identifies Cardiac Myosin-Binding Protein-C as a Protein Kinase G-Iα Substrate

scientific article

Monoclonal Antibody-Based Immunotherapy and Its Role in the Development of Cardiac Toxicity

scientific article published on 30 December 2020

My Life, My Heart, and My(osin) Binding Protein-C

scientific article published on 01 March 2018

Myocardial infarction-induced N-terminal fragment of cardiac myosin-binding protein C (cMyBP-C) impairs myofilament function in human myocardium

scientific article

Myofilament Ca2+ desensitization mediates positive lusitropic effect of neuronal nitric oxide synthase in left ventricular myocytes from murine hypertensive heart.

scientific article published on 23 April 2013

Myofilaments: Movers and Rulers of the Sarcomere.

scientific article published on 16 March 2017

Myonuclear accretion is a determinant of exercise-induced remodeling in skeletal muscle

scientific article published on 23 April 2019

N-terminal fragment of cardiac myosin binding protein-C triggers pro-inflammatory responses in vitro.

scientific article published on 8 September 2016

Novel mitochondrial DNA mutations implicated in Noonan syndrome

scientific article published on 07 November 2006

Novel role for p90 ribosomal S6 kinase in the regulation of cardiac myofilament phosphorylation

scientific article

Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains

scientific article published on 08 December 2020

Orientation of myosin binding protein C in the cardiac muscle sarcomere determined by domain-specific immuno-EM.

scientific article published on 6 November 2014

Oxidative Stress in Dilated Cardiomyopathy Caused by MYBPC3 Mutation.

scientific article

PKC-betaII sensitizes cardiac myofilaments to Ca2+ by phosphorylating troponin I on threonine-144

scientific article published on 29 September 2006

Pathogenic properties of the N-terminal region of cardiac myosin binding protein-C in vitro ⬇️

scientific article published on April 17, 2012

Phosphoregulation of Cardiac Inotropy via Myosin Binding Protein-C During Increased Pacing Frequency or β1-Adrenergic Stimulation

scientific article

Phosphorylation and function of cardiac myosin binding protein-C in health and disease.

scientific article published on 03 December 2009

Phosphorylation of cMyBP-C affects contractile mechanisms in a site-specific manner

scientific article

Phosphorylation of cardiac myosin-binding protein-C contributes to calcium homeostasis

scientific article published on 18 June 2020

Probenecid Improves Cardiac Function in Patients With Heart Failure With Reduced Ejection Fraction In Vivo and Cardiomyocyte Calcium Sensitivity In Vitro.

scientific article published on 13 January 2018

Protein kinase C depresses cardiac myocyte power output and attenuates myofilament responses induced by protein kinase A

scientific article published on 22 April 2012

Protein kinase D increases maximal Ca2+-activated tension of cardiomyocyte contraction by phosphorylation of cMyBP-C-Ser315

scientific article

Recent Advances in the Molecular Genetics of Familial Hypertrophic Cardiomyopathy in South Asian Descendants

scientific article

Receptor-independent modulation of cAMP-dependent protein kinase and protein phosphatase signaling in cardiac myocytes by oxidizing agents

scientific article published on 31 August 2020

Release kinetics of circulating cardiac myosin binding protein-C following cardiac injury.

scientific article published on 13 December 2013

Roles for Cardiac MyBP-C in Maintaining Myofilament Lattice Rigidity and Prolonging Myosin Cross-Bridge Lifetime ⬇️

scientific article published on October 5, 2011

S-glutathiolation impairs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure.

scientific article published on 2 February 2016

Sarcomere mutation-specific expression patterns in human hypertrophic cardiomyopathy

scientific article

Sham surgery and inter-individual heterogeneity are major determinants of monocyte subset kinetics in a mouse model of myocardial infarction

scientific article

Skeletal MyBP-C isoforms tune the molecular contractility of divergent skeletal muscle systems

scientific article published on 07 October 2019

Skeletal myosin binding protein-C isoforms regulate thin filament activity in a Ca2+-dependent manner

scientific article published on 8 February 2018

Skeletal myosin binding protein-C: An increasingly important regulator of striated muscle physiology

scientific article published on 17 October 2018

Structural Insight into Unique Cardiac Myosin-binding Protein-C Motif: A PARTIALLY FOLDED DOMAIN

scientific article

Surviving the infarct: A profile of cardiac myosin binding protein-C pathogenicity, diagnostic utility, and proteomics in the ischemic myocardium.

scientific article

Targeted genome-wide enrichment of functional regions

scientific article

The Myofilament Field Revisited in the Age of Cellular and Molecular Biology

scientific article published in September 2017

The death of transcriptional chauvinism in the control and regulation of cardiac contractility.

scientific article

The naked mole-rat exhibits an unusual cardiac myofilament protein profile providing new insights into heart function of this naturally subterranean rodent.

scientific article published on 05 August 2017

The potential role of neddylation in pre- and postnatal cardiac remodeling

scientific article published on 05 July 2019

The rapid proliferation of solicited content online journals: a quest to disseminate knowledge?

scientific article published on 01 April 2019

Transmural heterogeneity of cellular level power output is reduced in human heart failure

scientific article

Unique single molecule binding of cardiac myosin binding protein-C to actin and phosphorylation-dependent inhibition of actomyosin motility requires 17 amino acids of the motif domain ⬇️

scientific article published on September 25, 2011

Usefulness of Released Cardiac Myosin Binding Protein-C as a Predictor of Cardiovascular Events.

scientific article published on 31 July 2017

List of works by Sakthivel Sadayappan

A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function

A hypertrophic cardiomyopathy-associated MYBPC3 mutation common in populations of South Asian descent causes contractile dysfunction

A sensitive and specific quantitation method for determination of serum cardiac myosin binding protein-C by electrochemiluminescence immunoassay.

Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury

Agonist activated PKCβII translocation and modulation of cardiac myocyte contractile function.

Alterations in Multi-Scale Cardiac Architecture in Association With Phosphorylation of Myosin Binding Protein-C.

Altered C10 domain in cardiac myosin binding protein-C results in hypertrophic cardiomyopathy

Analysis of cardiac myosin binding protein-C phosphorylation in human heart muscle

Application of an advanced maximum likelihood estimation restoration method for enhanced-resolution and contrast in second-harmonic generation microscopy

Assessing the multiscale architecture of muscular tissue with Q-space magnetic resonance imaging: Review.

Association of Cardiomyopathy With MYBPC3 D389V and MYBPC3Δ25bpIntronic Deletion in South Asian Descendants

Association of intronic DNA methylation and hydroxymethylation alterations in the epigenetic etiology of dilated cardiomyopathy

Basic Cardiovascular Sciences Scientific Sessions 2018

Cardiac Myosin Binding Protein-C Autoantibodies are Potential Early Indicators of Cardiac Dysfunction and Patient Outcome in Acute Coronary Syndrome

Cardiac Myosin Binding Protein-C: A Potential Early-Stage, Cardiac-Specific Biomarker of Ischemia-Reperfusion Injury ⬇️

Cardiac Myosin-binding Protein C and Troponin-I Phosphorylation Independently Modulate Myofilament Length-dependent Activation.

Cardiac inflammation in genetic dilated cardiomyopathy caused by MYBPC3 mutation

Cardiac isoform of alpha-2 macroglobulin--a new biomarker for myocardial infarcted diabetic patients.

Cardiac muscle organization revealed in 3-D by imaging whole-mount mouse hearts using two-photon fluorescence and confocal microscopy.

Cardiac myosin binding protein C phosphorylation affects cross-bridge cycle's elementary steps in a site-specific manner.

Cardiac myosin binding protein-C as a central target of cardiac sarcomere signaling: a special mini review series.

Cardiac myosin binding protein-C is a potential diagnostic biomarker for myocardial infarction.

Cardiac myosin binding protein-C phosphorylation in a {beta}-myosin heavy chain background

Cardiac myosin binding protein-C phosphorylation regulates the super-relaxed state of myosin

Cardiac myosin binding protein-C plays no regulatory role in skeletal muscle structure and function

Cardiac myosin binding protein-C: redefining its structure and function ⬇️

Cardiac myosin-binding protein-C phosphorylation and cardiac function

Cardiac transgenic and gene transfer strategies converge to support an important role for troponin I in regulating relaxation in cardiac myocytes.

Cardiovascular Early Careers: Past and Present.

Cardiovascular Leaders Are Made, not Born

Ceramide-mediated depression in cardiomyocyte contractility through PKC activation and modulation of myofilament protein phosphorylation

Contractile dysfunction in a mouse model expressing a heterozygous MYBPC3 mutation associated with hypertrophic cardiomyopathy

Contractile responses to endothelin-1 are regulated by PKC phosphorylation of cardiac myosin binding protein-C in rat ventricular myocytes

Control of in vivo left ventricular [correction] contraction/relaxation kinetics by myosin binding protein C: protein kinase A phosphorylation dependent and independent regulation

Dilated cardiomyopathy-mediated heart failure induces a unique skeletal muscle myopathy with inflammation

Distinct sarcomeric substrates are responsible for protein kinase D-mediated regulation of cardiac myofilament Ca2+ sensitivity and cross-bridge cycling ⬇️

Distribution and structure-function relationship of myosin heavy chain isoforms in the adult mouse heart

ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity

Effects of a myofilament calcium sensitizer on left ventricular systolic and diastolic function in rats with volume overload heart failure

Enhanced cardiac function in Gravin mutant mice involves alterations in the β-adrenergic receptor signaling cascade

Epigenetic modification: a regulatory mechanism in essential hypertension

Featured characteristics and pivotal roles of satellite cells in skeletal muscle regeneration

Finding the missing link: disulfide-containing proteins via a high-throughput proteomics approach.

GSK3β phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: short communication

Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice.

Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload

Hypertrophic cardiomyopathy clinical phenotype is independent of gene mutation and mutation dosage

Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin

In vivo and in vitro cardiac responses to beta-adrenergic stimulation in volume-overload heart failure

Inducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury.

Inhibition of Senescence-Associated Genes Rb1 and Meis2 in Adult Cardiomyocytes Results in Cell Cycle Reentry and Cardiac Repair Post-Myocardial Infarction

Interactions between the regulatory subunit of type I protein kinase A and p90 ribosomal S6 kinase1 regulate cardiomyocyte apoptosis.

Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-κB

KLF2 in Myeloid Lineage Cells Regulates the Innate Immune Response during Skeletal Muscle Injury and Regeneration

Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration

MYBPC3 truncation mutations enhance actomyosin contractile mechanics in human hypertrophic cardiomyopathy

MYBPC3's alternate ending: consequences and therapeutic implications of a highly prevalent 25 bp deletion mutation

MicroRNA-210-mediated proliferation, survival, and angiogenesis promote cardiac repair post myocardial infarction in rodents.

Molecular Screen Identifies Cardiac Myosin-Binding Protein-C as a Protein Kinase G-Iα Substrate

Monoclonal Antibody-Based Immunotherapy and Its Role in the Development of Cardiac Toxicity

My Life, My Heart, and My(osin) Binding Protein-C

Myocardial infarction-induced N-terminal fragment of cardiac myosin-binding protein C (cMyBP-C) impairs myofilament function in human myocardium

Myofilament Ca2+ desensitization mediates positive lusitropic effect of neuronal nitric oxide synthase in left ventricular myocytes from murine hypertensive heart.

Myofilaments: Movers and Rulers of the Sarcomere.

Myonuclear accretion is a determinant of exercise-induced remodeling in skeletal muscle

N-terminal fragment of cardiac myosin binding protein-C triggers pro-inflammatory responses in vitro.

Novel mitochondrial DNA mutations implicated in Noonan syndrome

Novel role for p90 ribosomal S6 kinase in the regulation of cardiac myofilament phosphorylation

Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains

Orientation of myosin binding protein C in the cardiac muscle sarcomere determined by domain-specific immuno-EM.

Oxidative Stress in Dilated Cardiomyopathy Caused by MYBPC3 Mutation.

PKC-betaII sensitizes cardiac myofilaments to Ca2+ by phosphorylating troponin I on threonine-144

Pathogenic properties of the N-terminal region of cardiac myosin binding protein-C in vitro ⬇️

Phosphoregulation of Cardiac Inotropy via Myosin Binding Protein-C During Increased Pacing Frequency or β1-Adrenergic Stimulation

Phosphorylation and function of cardiac myosin binding protein-C in health and disease.

Phosphorylation of cMyBP-C affects contractile mechanisms in a site-specific manner

Phosphorylation of cardiac myosin-binding protein-C contributes to calcium homeostasis

Probenecid Improves Cardiac Function in Patients With Heart Failure With Reduced Ejection Fraction In Vivo and Cardiomyocyte Calcium Sensitivity In Vitro.

Protein kinase C depresses cardiac myocyte power output and attenuates myofilament responses induced by protein kinase A