List of works - Antonio Zaza

A Brugada syndrome mutation (p.S216L) and its modulation by p.H558R polymorphism: standard and dynamic characterization.

scientific article published on 24 June 2011

A variant in the carboxyl-terminus of connexin 40 alters GAP junctions and increases risk for tetralogy of Fallot

scientific article

Action Potential Prolongation, β-Adrenergic Stimulation, and Angiotensin II as Co-factors in Sarcoplasmic Reticulum Instability

Action potential contour contributes to species differences in repolarization response to β-adrenergic stimulation.

scientific article published on 17 October 2017

Altered functional differentiation of mesoangioblasts in a genetic myopathy

scientific article published on 7 February 2013

Arrhythmias and Heart Rate: Mechanisms and Significance of a Relationship

Autonomic indexes based on the analysis of heart rate variability: a view from the sinus node

scientific article published on 01 June 2001

Baroreflex sensitivity and its evolution during the first year after myocardial infarction

scientific article published on 01 September 1988

CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation

scientific article published in Nature

CVT-510 (CV Therapeutics).

scientific article

Caffeine-induced Ca(2+) signaling as an index of cardiac progenitor cells differentiation.

scientific article published on 23 July 2010

Calcium store stability as an antiarrhythmic endpoint

scientific article

Calmodulinopathy: A Novel, Life-Threatening Clinical Entity Affecting the Young

scientific article published on 06 December 2018

Calmodulinopathy: Functional Effects of CALM Mutations and Their Relationship With Clinical Phenotypes

scientific article published on 11 December 2018

Cardiac precursors in human bone marrow and cord blood: in vitro cell cardiogenesis.

scientific article published in May 2004

Case of polymorphic ventricular tachycardia after stroke necessitating defibrillation

scientific article published on 01 January 2008

Case of the month by the EHRA Education committee: exercise-related arrhythmias

scientific article published on 01 February 2008

Celecoxib blocks cardiac Kv1.5, Kv4.3 and Kv7.1 (KCNQ1) channels: effects on cardiac action potentials

scientific article published on 18 September 2010

Characterization of the non-linear rate-dependency of QT interval in humans.

scientific article published in April 2003

Combination of miRNA499 and miRNA133 exerts a synergic effect on cardiac differentiation.

scientific article published on April 2015

Combined action potential- and dynamic-clamp for accurate computational modelling of the cardiac IKr current

scientific article published on 18 November 2014

Computational cardiac electrophysiology is moving towards translation medicine

scientific article published on 01 May 2014

Computational cardiac electrophysiology is ready for prime time

scientific article published on 01 March 2014

Control of the cardiac action potential: The role of repolarization dynamics.

scientific article published on 07 August 2009

Deranged sodium to sudden death.

scientific article published on March 2015

Determinants of beat-to-beat variability of repolarization duration in the canine ventricular myocyte: a computational analysis

scientific article (publication date: 2013)

Different effects of antiarrhythmic drugs on the rate-dependency of QT interval: a study with amiodarone and flecainide

scientific article published in November 2007

Diverse toxicity associated with cardiac Na+/K+ pump inhibition: evaluation of electrophysiological mechanisms.

scientific article published on 20 February 2003

Efficacy of diltiazem in two experimental feline models of sudden cardiac death

scientific article published on 01 September 1986

Electrophysiology meets geometry

scientific article published on 23 December 2015

Elucidating arrhythmogenic mechanisms of long-QT syndrome CALM1-F142L mutation in patient-specific induced pluripotent stem cell-derived cardiomyocytes.

scientific article published on 2 February 2017

IKr Impact on Repolarization and Its Variability Assessed by Dynamic Clamp

scientific article published on 23 June 2015

Induced pluripotent stem cells: progress towards a biomedical application

scientific article published on 01 October 2011

Interstitial pressure and lung oedema in chronic hypoxia

scientific article published on 06 August 2010

Intracellular calcium does not directly modulate cardiac pacemaker (if) channels

scientific article published on 01 December 1991

Ionic currents during sustained pacemaker activity in rabbit sino-atrial myocytes

scientific article published on 01 December 1997

Lack of correlation between occlusion and reperfusion arrhythmias in the cat

scientific article published in May 1985

Late sodium current (INaL) in pancreatic β-cells.

scientific article published on 20 September 2014

Late sodium current and intracellular ionic homeostasis in acute ischemia

scientific article

Lidocaine inhibition of the hyperpolarization-activated current (I(f)) in sinoatrial myocytes.

scientific article published in September 1999

MTMR4 SNVs modulate ion channel degradation and clinical severity in congenital long QT syndrome: insights in the mechanism of action of protective modifier genes

scientific article published on 16 March 2020

Marine n-3 PUFAs modulate IKs gating, channel expression, and location in membrane microdomains.

scientific article

Mechanism of reverse rate-dependent action of cardioactive agents.

scientific article

Mechanisms of beta-adrenergic modulation of I(Ks) in the guinea-pig ventricle: insights from experimental and model-based analysis

scientific article published on May 2009

Modulation of sarcoplasmic reticulum function by Na+/K+ pump inhibitors with different toxicity: digoxin and PST2744 [(E,Z)-3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochloride].

scientific article published on 2 December 2004

Modulation of sarcoplasmic reticulum function by PST2744 [istaroxime; (E,Z)-3-((2-aminoethoxy)imino) androstane-6,17-dione hydrochloride)] in a pressure-overload heart failure model

scientific article published on 6 June 2008

Modulation of sympathetic activity and heart rate variability by ivabradine.

scientific article

Modulation of the electrical restitution of canine Purkinje fibers by local anesthetic drugs: a study with flecainide and propafenone.

scientific article published in November 1994

NOS1AP polymorphisms reduce NOS1 activity and interact with prolonged repolarization in arrhythmogenesis

scientific article published on 15 February 2020

Opportunities and challenges of current electrophysiology research: a plea to establish 'translational electrophysiology' curricula

scientific article published on 17 February 2015

Pathophysiology and pharmacology of the cardiac "late sodium current.".

scientific article published on July 2008

Peptidomimetic Targeting of Cavβ2 Overcomes Dysregulation of the L-Type Calcium Channel Density and Recovers Cardiac Function.

scientific article published on 2 August 2016

Pharmacological profile of the novel inotropic agent (E,Z)-3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochloride (PST2744).

scientific article published in November 2002

Ranolazine ameliorates postresuscitation electrical instability and myocardial dysfunction and improves survival with good neurologic recovery in a rat model of cardiac arrest.

scientific article

Ranolazine prevents INaL enhancement and blunts myocardial remodelling in a model of pulmonary hypertension

scientific article published on 18 August 2014

Rate dependency of beta-adrenergic modulation of repolarizing currents in the guinea-pig ventricle.

scientific article published on 16 February 2006

Reverse rate dependency is an intrinsic property of canine cardiac preparations.

scientific article published on 25 June 2009

Reverse rate-dependent changes are determined by baseline action potential duration in mammalian and human ventricular preparations.

scientific article published on 3 February 2010

Role and mechanism of subcellular Ca2+ distribution in the action of two inotropic agents with different toxicity

scientific article published on 23 February 2011

Role of the Autonomic Nervous System in the Genesis of Early Ischemic Arrhythmias

scientific article published in 1985

Role of the β3-adrenergic receptor subtype in catecholamine-induced myocardial remodeling.

scientific article

Selective cardiodepressant activity of fluodipine, a fluorenone-1,4-dihydropyridine derivative.

scientific article

Self-augmentation of the lengthening of repolarization is related to the shape of the cardiac action potential: implications for reverse rate dependency

scientific article published on 18 February 2008

Serum potassium and arrhythmias.

scientific article published on 31 January 2009

Sodium current block caused by group IIb cations in calf Purkinje fibres and in guinea-pig ventricular myocytes

scientific article published on 01 October 1990

Special issue on biopacemaking: clinically attractive, scientifically a challenge.

scientific article published on 6 February 2007

Straightforward synthesis of novel Akt inhibitors based on a glucose scaffold

scientific article published on 16 December 2009

Sulfonylureas blockade of neural and cardiac HERG channels

scientific article published on 01 November 1998

The effect of antiarrhythmic drugs on life-threatening arrhythmias induced by the interaction between acute myocardial ischemia and sympathetic hyperactivity.

scientific article published in May 1985

The late Na+ current--origin and pathophysiological relevance

scientific article

The late sodium current: pathophysiology and pharmacology of a new therapeutic target

scientific article published on 01 October 2011

The role of the autonomic system in rate-dependent repolarization changes.

scientific article published on 25 May 2010

Theoretical investigation of action potential duration dependence on extracellular Ca2+ in human cardiomyocytes

scientific article published on 11 December 2008

miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors

scientific journal article

List of works by Antonio Zaza

A Brugada syndrome mutation (p.S216L) and its modulation by p.H558R polymorphism: standard and dynamic characterization.

A variant in the carboxyl-terminus of connexin 40 alters GAP junctions and increases risk for tetralogy of Fallot

Action Potential Prolongation, β-Adrenergic Stimulation, and Angiotensin II as Co-factors in Sarcoplasmic Reticulum Instability

Action potential contour contributes to species differences in repolarization response to β-adrenergic stimulation.

Altered functional differentiation of mesoangioblasts in a genetic myopathy

Arrhythmias and Heart Rate: Mechanisms and Significance of a Relationship

Autonomic indexes based on the analysis of heart rate variability: a view from the sinus node

Baroreflex sensitivity and its evolution during the first year after myocardial infarction

CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation

CVT-510 (CV Therapeutics).

Caffeine-induced Ca(2+) signaling as an index of cardiac progenitor cells differentiation.

Calcium store stability as an antiarrhythmic endpoint

Calmodulinopathy: A Novel, Life-Threatening Clinical Entity Affecting the Young

Calmodulinopathy: Functional Effects of CALM Mutations and Their Relationship With Clinical Phenotypes

Cardiac precursors in human bone marrow and cord blood: in vitro cell cardiogenesis.

Case of polymorphic ventricular tachycardia after stroke necessitating defibrillation

Case of the month by the EHRA Education committee: exercise-related arrhythmias

Celecoxib blocks cardiac Kv1.5, Kv4.3 and Kv7.1 (KCNQ1) channels: effects on cardiac action potentials

Characterization of the non-linear rate-dependency of QT interval in humans.

Combination of miRNA499 and miRNA133 exerts a synergic effect on cardiac differentiation.

Combined action potential- and dynamic-clamp for accurate computational modelling of the cardiac IKr current

Computational cardiac electrophysiology is moving towards translation medicine

Computational cardiac electrophysiology is ready for prime time

Control of the cardiac action potential: The role of repolarization dynamics.

Deranged sodium to sudden death.

Determinants of beat-to-beat variability of repolarization duration in the canine ventricular myocyte: a computational analysis

Different effects of antiarrhythmic drugs on the rate-dependency of QT interval: a study with amiodarone and flecainide

Diverse toxicity associated with cardiac Na+/K+ pump inhibition: evaluation of electrophysiological mechanisms.

Efficacy of diltiazem in two experimental feline models of sudden cardiac death

Electrophysiology meets geometry

Elucidating arrhythmogenic mechanisms of long-QT syndrome CALM1-F142L mutation in patient-specific induced pluripotent stem cell-derived cardiomyocytes.

IKr Impact on Repolarization and Its Variability Assessed by Dynamic Clamp

Induced pluripotent stem cells: progress towards a biomedical application

Interstitial pressure and lung oedema in chronic hypoxia

Intracellular calcium does not directly modulate cardiac pacemaker (if) channels

Ionic currents during sustained pacemaker activity in rabbit sino-atrial myocytes

Lack of correlation between occlusion and reperfusion arrhythmias in the cat

Late sodium current (INaL) in pancreatic β-cells.

Late sodium current and intracellular ionic homeostasis in acute ischemia

Lidocaine inhibition of the hyperpolarization-activated current (I(f)) in sinoatrial myocytes.

MTMR4 SNVs modulate ion channel degradation and clinical severity in congenital long QT syndrome: insights in the mechanism of action of protective modifier genes

Marine n-3 PUFAs modulate IKs gating, channel expression, and location in membrane microdomains.

Mechanism of reverse rate-dependent action of cardioactive agents.

Mechanisms of beta-adrenergic modulation of I(Ks) in the guinea-pig ventricle: insights from experimental and model-based analysis

Modulation of sarcoplasmic reticulum function by Na+/K+ pump inhibitors with different toxicity: digoxin and PST2744 [(E,Z)-3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochloride].

Modulation of sarcoplasmic reticulum function by PST2744 [istaroxime; (E,Z)-3-((2-aminoethoxy)imino) androstane-6,17-dione hydrochloride)] in a pressure-overload heart failure model

Modulation of sympathetic activity and heart rate variability by ivabradine.

Modulation of the electrical restitution of canine Purkinje fibers by local anesthetic drugs: a study with flecainide and propafenone.

NOS1AP polymorphisms reduce NOS1 activity and interact with prolonged repolarization in arrhythmogenesis

Opportunities and challenges of current electrophysiology research: a plea to establish 'translational electrophysiology' curricula

Pathophysiology and pharmacology of the cardiac "late sodium current.".

Peptidomimetic Targeting of Cavβ2 Overcomes Dysregulation of the L-Type Calcium Channel Density and Recovers Cardiac Function.

Pharmacological profile of the novel inotropic agent (E,Z)-3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochloride (PST2744).

Ranolazine ameliorates postresuscitation electrical instability and myocardial dysfunction and improves survival with good neurologic recovery in a rat model of cardiac arrest.

Ranolazine prevents INaL enhancement and blunts myocardial remodelling in a model of pulmonary hypertension

Rate dependency of beta-adrenergic modulation of repolarizing currents in the guinea-pig ventricle.

Reverse rate dependency is an intrinsic property of canine cardiac preparations.

Reverse rate-dependent changes are determined by baseline action potential duration in mammalian and human ventricular preparations.

Role and mechanism of subcellular Ca2+ distribution in the action of two inotropic agents with different toxicity

Role of the Autonomic Nervous System in the Genesis of Early Ischemic Arrhythmias

Role of the β3-adrenergic receptor subtype in catecholamine-induced myocardial remodeling.

Selective cardiodepressant activity of fluodipine, a fluorenone-1,4-dihydropyridine derivative.

Self-augmentation of the lengthening of repolarization is related to the shape of the cardiac action potential: implications for reverse rate dependency

Serum potassium and arrhythmias.

Sodium current block caused by group IIb cations in calf Purkinje fibres and in guinea-pig ventricular myocytes

Special issue on biopacemaking: clinically attractive, scientifically a challenge.

Straightforward synthesis of novel Akt inhibitors based on a glucose scaffold

Sulfonylureas blockade of neural and cardiac HERG channels

The effect of antiarrhythmic drugs on life-threatening arrhythmias induced by the interaction between acute myocardial ischemia and sympathetic hyperactivity.

The late Na+ current--origin and pathophysiological relevance

The late sodium current: pathophysiology and pharmacology of a new therapeutic target

The role of the autonomic system in rate-dependent repolarization changes.

Theoretical investigation of action potential duration dependence on extracellular Ca2+ in human cardiomyocytes

miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors