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List of works by Bernard Ducommun

3D imaging of the response to CDC25 inhibition in multicellular spheroids.

scientific article

3D print customized sample holders for live light sheet microscopy

scientific article published on 18 June 2015

5-Substituted [1]pyrindine derivatives with antiproliferative activity.

scientific article

A caspase-dependent cleavage of CDC25A generates an active fragment activating cyclin-dependent kinase 2 during apoptosis.

scientific article

A checkpoint-oriented cell cycle simulation model

scientific article published on 04 April 2019

A new mitotic-cell specific monoclonal antibody

scientific article published on 07 November 2007

A novel synthetic inhibitor of CDC25 phosphatases: BN82002.

scientific article published on May 2004

A screen for deubiquitinating enzymes involved in the G₂/M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stability.

scientific article

A versatile microtiter assay for the universal cdc2 cell cycle regulator.

scientific article published on May 1990

A versatile sample holder for single plane illumination microscopy.

scientific article published on 20 May 2013

Are Tumor Cell Lineages Solely Shaped by Mechanical Forces?

scientific article published on 29 August 2017

Asymmetric localization of the CDC25B phosphatase to the mother centrosome during interphase.

scientific article

CDC25 phosphatases in cancer cells: key players? Good targets?

scientific article published on July 2007

CDC25B associates with a centrin 2-containing complex and is involved in maintaining centrosome integrity.

scientific article

CDC25B overexpression stabilises centrin 2 and promotes the formation of excess centriolar foci

scientific article

CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis

scientific article

CDC25B phosphorylation by Aurora-A occurs at the G2/M transition and is inhibited by DNA damage.

scientific article

CDC25B phosphorylation by p38 and MK-2

scientific article published on 01 August 2006

Cdc25B is negatively regulated by p53 through Sp1 and NF-Y transcription factors.

scientific article published on 17 January 2011

Cell adhesion regulates CDC25A expression and proliferation in acute myeloid leukemia

scientific article published on 01 July 2006

Cell cycle control by the CDC25 phosphatases

scientific journal article

Cell cycle regulation of p34cdc2 kinase activity in Physarum polycephalum

scientific article published on 01 August 1990

Cell-Cell Adhesion and Cytoskeleton Tension Oppose Each Other in Regulating Tumor Cell Aggregation

scientific article published on 08 April 2015

Characterisation of human cdc2 lysine 33 mutations expressed in the fission yeast Schizosaccharomyces pombe

scientific article published on 01 February 1996

Characterization of an active GST-human Cdc2 fusion protein kinase expressed in the fission yeast Schizosaccharomyces pombe: a new approach to the study of cell cycle control proteins

scientific article published on 01 December 1994

Characterization of the antiproliferative activity of Xylopia aethiopica

scientific article published on 12 March 2012

Characterization of the physical properties of tumor-derived spheroids reveals critical insights for pre-clinical studies

scientific article published on 29 April 2019

Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells

scientific article published on 20 May 2016

Constitutive activation of the DNA damage signaling pathway in acute myeloid leukemia with complex karyotype: potential importance for checkpoint targeting therapy.

scientific article published on 20 October 2009

Cyclin E-cdk2 phosphorylation promotes late G1-phase degradation of MyoD in muscle cells

scientific article published on 01 August 2000

Deep and clear optical imaging of thick inhomogeneous samples

scientific article (publication date: 2012)

Design, synthesis, and biological evaluation of novel naphthoquinone derivatives with CDC25 phosphatase inhibitory activity.

scientific article

Development of novel thiazolopyrimidines as CDC25B phosphatase inhibitors

scientific article

Direct activation of cdc2 with phosphatase: identification of p13suc1-sensitive and insensitive steps

scientific article published on 01 June 1990

Distinct Chk2 activation pathways are triggered by genistein and DNA-damaging agents in human melanoma cells

scientific article published on 01 May 2000

Distinct nuclear and spindle pole body populations of cyclin–cdc2 in fission yeast

scientific article published in Nature

Distinct pools of proliferating cell nuclear antigen associated to DNA replication sites interact with the p125 subunit of DNA polymerase delta or DNA ligase I.

scientific article published on February 2004

Doxorubicin promotes transcriptional upregulation of Cdc25B in cancer cells by releasing Sp1 from the promoter.

scientific article

Effect of phenylarsine oxide on the fission yeast Schizosaccharomyces pombe cell cycle

scientific article published on 01 January 1995

Effects of TGF-beta 1 (transforming growth factor-beta 1) on the cell cycle regulation of human breast adenocarcinoma (MCF-7) cells.

scientific article published on April 1995

Effects of phleomycin-induced DNA damage on the fission yeast Schizosaccharomyces pombe cell cycle

scientific article published on 01 March 1995

Escherichia coli cytolethal distending toxin blocks the HeLa cell cycle at the G2/M transition by preventing cdc2 protein kinase dephosphorylation and activation ⬇️

scientific article published on December 1, 1997

Etoposide and adriamycin but not genistein can activate the checkpoint kinase Chk2 independently of ATM/ATR.

scientific article

Evaluation by quantitative image analysis of anticancer drug activity on multicellular spheroids grown in 3D matrices

scientific article

Evaluation of Polo-like Kinase 1 inhibition on the G2/M checkpoint in Acute Myelocytic Leukaemia.

scientific article published on 19 June 2008

Evaluation of checkpoint kinase targeting therapy in acute myeloid leukemia with complex karyotype

scientific article

Evidence for a mammalian Nim1-like kinase pathway acting at the G0-1/S transition

scientific article published on 01 July 1997

Evolutionary conservation of a novel splice variant of the Cds1/CHK2 checkpoint kinase restricted to its regulatory domain.

scientific article published on 6 October 2004

Fission yeast Msp1 is a mitochondrial dynamin-related protein

scientific article published on 01 November 1999

Fission yeast cdc25 is a cell-cycle regulated protein.

scientific article

G2/M checkpoint stringency is a key parameter in the sensitivity of AML cells to genotoxic stress.

scientific article published on 21 January 2008

Gap junctions contribute to anchorage-independent clustering of breast cancer cells.

scientific article published on 27 February 2018

Genotoxic-activated G2-M checkpoint exit is dependent on CDC25B phosphatase expression

scientific article published on 01 June 2006

High-resolution in-depth imaging of optically cleared thick samples using an adaptive SPIM

scientific article

Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A.

scientific article published on November 1998

Human CDC25B and CDC25C differ by their ability to restore a functional checkpoint response after gene replacement in fission yeast.

scientific article published in July 2002

Identification of N-Terminally Truncated Stable Nuclear Isoforms of CDC25B That Are Specifically Involved in G2/M Checkpoint Recovery ⬇️

scientific article published on March 1, 2011

Identification of a fission yeast dynamin-related protein involved in mitochondrial DNA maintenance.

scientific article published in October 1998

Identification of an unexpected link between the Shh pathway and a G2/M regulator, the phosphatase CDC25B

scientific article published on 29 March 2006

Identification of binding domains on the p21Cip1 cyclin-dependent kinase inhibitor

scientific article published on 01 June 1995

Impact of physical confinement on nuclei geometry and cell division dynamics in 3D spheroids.

scientific article

Inhibition of human tumor cell growth in vivo by an orally bioavailable inhibitor of CDC25 phosphatases.

scientific article published in September 2005

Inhibitors of the CDC25 phosphatases

scientific article published on January 1, 2003

Interaction between the fission yeast nim1/cdr1 protein kinase and a dynamin-related protein

scientific article published on 01 January 1999

Interaction of p21(CDKN1A) with PCNA regulates the histone acetyltransferase activity of p300 in nucleotide excision repair

scientific article published on 7 February 2008

Interaction studies between the p21Cip1/Waf1 cyclin-dependent kinase inhibitor and proliferating cell nuclear antigen (PCNA) by surface plasmon resonance

scientific article published on 01 August 1996

Interaction with cyclin-dependent kinases and PCNA modulates proteasome-dependent degradation of p21

scientific article published on 01 November 1998

Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2/M arrest after DNA damage.

scientific article

Linking PCNA-dependent replication and ATR by human Claspin

scientific article published on 25 January 2007

Live cell division dynamics monitoring in 3D large spheroid tumor models using light sheet microscopy

scientific article

Measure and characterization of the forces exerted by growing multicellular spheroids using microdevice arrays

scientific article published on 23 May 2019

Mechanical stress impairs mitosis progression in multi-cellular tumor spheroids

scientific article

Mechanism of inhibition of proliferating cell nuclear antigen-dependent DNA synthesis by the cyclin-dependent kinase inhibitor p21.

scientific article

Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1

scientific article published on 22 June 2009

Microdevice arrays of high aspect ratio poly(dimethylsiloxane) pillars for the investigation of multicellular tumour spheroid mechanical properties

scientific article published on July 2014

Microtubule cytoskeleton and morphogenesis in the amoebae of the myxomycete Physarum polycephalum.

scientific article published on January 1988

Mitotic phosphorylation of Cdc25B Ser321 disrupts 14-3-3 binding to the high affinity Ser323 site

scientific article

Monitoring the Activation of the DNA Damage Response Pathway in a 3D Spheroid Model

scientific article

Multicellular tumor spheroid model to evaluate spatio-temporal dynamics effect of chemotherapeutics: application to the gemcitabine/CHK1 inhibitor combination in pancreatic cancer ⬇️

scientific article published on January 13, 2012

Multicellular tumor spheroid models to explore cell cycle checkpoints in 3D. ⬇️

scientific article

Mutations at sites involved in Suc1 binding inactivate Cdc2.

scientific article published on December 1991

NanoLC-MS/MS analysis provides new insights into the phosphorylation pattern of Cdc25B in vivo: full overlap with sites of phosphorylation by Chk1 and Cdk1/cycB kinases in vitro.

scientific article published on February 2008

Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties.

scientific article

Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy

scientific article (publication date: October 2000)

OPA1 functions in mitochondria and dysfunctions in optic nerve.

scientific article published on 21 April 2009

Oxygen Partial Pressure Is a Rate-Limiting Parameter for Cell Proliferation in 3D Spheroids Grown in Physioxic Culture Condition

scientific article

PKB/Akt phosphorylates the CDC25B phosphatase and regulates its intracellular localisation.

scientific article published on November 2003

Pharmacologic inhibition of CDC25 phosphatases impairs interphase microtubule dynamics and mitotic spindle assembly

scientific article published on 01 January 2007

Pharmacological inhibition of aurora-A but not aurora-B impairs interphase microtubule dynamics

scientific article

Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition.

scientific article

Phosphorylation of Human CDC25B Phosphatase by CDK1-Cyclin A Triggers Its Proteasome-dependent Degradation ⬇️

scientific article published on December 26, 1997

Phosphorylation of the myristoylated protein kinase C substrate MARCKS by the cyclin E-cyclin-dependent kinase 2 complex in vitro.

scientific article published on June 1999

Protein kinase CK2 regulates CDC25B phosphatase activity

scientific article (publication date: 16 January 2003)

Regulation of CDC25B phosphatases subcellular localization

scientific article published on 01 April 2000

Regulation of tubulin synthesis during the cell cycle in the synchronous plasmodia of Physarum polycephalum

scientific article published on 01 October 1990

Reversible growth arrest of 3D tumor spheroids stored in oxygen absorber-induced anoxia.

scientific article published on 21 November 2017

Role of CDC25 phosphatases in the control of proliferation

scientific article published on 01 April 2000

Role of the fission yeast nim 1 protein kinase in the cell cycle response to nutritional signals.

scientific article published in March 1997

Short and long time effects of low temperature Plasma Activated Media on 3D multicellular tumor spheroids.

scientific article published on 22 February 2016

Structure Tensor Based Analysis of Cells and Nuclei Organization in Tissues.

scientific article published on 19 August 2015

Study of the cytolethal distending toxin (CDT)-activated cell cycle checkpoint. Involvement of the CHK2 kinase.

scientific article

Study of the cytolethal distending toxin-induced cell cycle arrest in HeLa cells: involvement of the CDC25 phosphatase

scientific article published on 01 May 2000

Study of the docking-dependent PLK1 phosphorylation of the CDC25B phosphatase.

scientific article published on 27 May 2011

Subcellular localisation of human wee1 kinase is regulated during the cell cycle.

scientific article

Synthesis and biological evaluation of novel heterocyclic quinones as inhibitors of the dual specificity protein phosphatase CDC25C.

scientific article published on 10 October 2005

The "starter" and "gas pedal" of mitosis reside at the centrosome. Commentary on "characterization of centrosomal localization and dynamics of CDC25C phosphatase in mitosis" by Bonnet et al

scientific article published on 01 July 2008

The CDC25B phosphatase shortens the G2 phase of neural progenitors and promotes efficient neuron production ⬇️

scientific article published on February 8, 2012

The bacterial cytolethal distending toxin (CDT) triggers a G2 cell cycle checkpoint in mammalian cells without preliminary induction of DNA strand breaks.

scientific article

The cell cycle regulator CDC25A is a target for JAK2V617F oncogene.

scientific article published on 7 November 2011

The fission yeast Nim1/Cdr1 kinase: a link between nutritional state and cell cycle control.

scientific article published on January 1995

The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space

scientific article (publication date: 17 July 2002)

The polo-like kinase 1 regulates CDC25B-dependent mitosis entry

scientific article published on 02 January 2009

Use of CDC2 from etoposide-treated cells as substrate to assay CDC25 phosphatase activity

scientific article published on 01 March 1999

Use of the two-hybrid system to identify protein-protein interaction temperature-sensitive mutants: application to the CDK2/p21Cip1 interaction ⬇️

scientific article published on September 15, 1997

Variation of tubulin half-life during the cell cycle in the synchronous plasmodia of Physarum polycephalum

scientific article published on 01 October 1989

What similarity between human and fission yeast proteins is required for orthology?

scientific article published on 01 September 2002

[Bacterial cyclostatin, or how do bacteria manipulate the eukaryotic cell cycle]

scientific article published on 01 November 2003

[The cell cycle and its regulation]

scientific article published on 01 January 2000

cdc2 phosphorylation is required for its interaction with cyclin.

scientific article

cdc2 protein kinase: interactions with cyclins and suc1

scientific article published on 01 January 1991

p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells

scientific article published on 01 January 1998

p21CDKN1A does not interfere with loading of PCNA at DNA replication sites, but inhibits subsequent binding of DNA polymerase delta at the G1/S phase transition

scientific article published on 01 November 2003

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