List of works - Pavel K Mykhailiuk

"Reported, but still unknown." A closer look into 3,4-bis- and 3,4,5-tris(trifluoromethyl)pyrazoles

scientific article published on 21 December 2011

(Chlorosulfonyl)benzenesulfonyl fluorides - versatile building blocks for combinatorial chemistry. Design, synthesis and evaluation of a covalent inhibitor library

article

1-Substituted 2-Azaspiro[3.3]heptanes: Overlooked Motifs for Drug Discovery

scientific article published on 19 June 2017

2,2,2-Trifluorodiazoethane (CF3CHN2): A Long Journey since 1943

scientific article published on 17 September 2020

2,2,2-Trifluoroethyl Chlorooxoacetate--Universal Reagent for One-Pot Parallel Synthesis of N(1)-Aryl-N(2)-alkyl-Substituted Oxamides.

scientific article published on September 2015

3-Benzyl-3-azabicyclo[3.1.1]heptan-6-one: a promising building block for medicinal chemistry.

scientific article published on October 2010

A Convenient Route to Trifluoromethyl-Substituted Cyclopropane Derivatives

A Radical Approach to Anionic Chemistry: Synthesis of Ketones, Alcohols, and Amines

scientific article published on 16 April 2019

A one-pot parallel reductive amination of aldehydes with heteroaromatic amines

scientific article

A19F NMR Label to Substitute Polar Amino Acids in Peptides: A CF3-Substituted Analogue of Serine and Threonine

scientific article published on 12 December 2012

Approach to the library of fused pyridine-4-carboxylic acids by Combes-type reaction of acyl pyruvates and electron-rich amino heterocycles.

scientific article

Bicyclic Piperidines via [2 + 2] Photocycloaddition

scientific article published on 19 November 2020

Bis(2,2,2-trifluoroethyl) carbonate as a condensing agent in one-pot parallel synthesis of unsymmetrical aliphatic ureas.

scientific article

Carbonyl complexes of copper(i) stabilized by bridging fluorinated pyrazolates and halide ions

scientific article published on 01 May 2019

Conformational Plasticity of the Cell-Penetrating Peptide SAP As Revealed by Solid-State 19F-NMR and Circular Dichroism Spectroscopies.

scientific article published on 13 June 2017

Controlling biological activity with light: diarylethene-containing cyclic peptidomimetics

scientific article

Convenient Access to Conformationally Rigid Sultams

scientific article published on 11 October 2019

Copper-Catalyzed O-Difluoromethylation of Functionalized Aliphatic Alcohols: Access to Complex Organic Molecules with an OCF2H Group

scientific article published on 6 May 2016

Deoxofluorination of (Hetero)aromatic Acids

scientific article published on 27 January 2020

Deoxofluorination of Aliphatic Carboxylic Acids: A Route to Trifluoromethyl-Substituted Derivatives

scientific article published on 26 November 2019

Design and synthesis of novel 19F-amino acid: a promising 19F NMR label for peptide studies

scientific article published on 29 December 2014

Design, Synthesis, and Application of a Trifluoromethylated Phenylalanine Analogue as a Label to Study Peptides by Solid-State19F NMR Spectroscopy

scientific article published on 07 May 2013

Design, Synthesis, and Application of an Optimized Monofluorinated Aliphatic Label for Peptide Studies by Solid-State (19) F NMR Spectroscopy

scientific article published on 5 October 2016

Design, synthesis, and characterization of SO2-containing azabicyclo[3.n.1]alkanes: promising building blocks for drug discovery

scientific article published on 31 March 2015

Diazoacetonitrile (N2 CHCN): A Long Forgotten but Valuable Reagent for Organic Synthesis

scientific article published on 15 October 2019

Difluoro-Substituted Bicyclo[1.1.1]pentanes for Medicinal Chemistry: Design, Synthesis, and Characterization

scientific article published on 07 October 2019

Difluorodiazoethane (CF 2 HCHN 2 ): A New Reagent for the Introduction of the Difluoromethyl Group

scientific article published on 22 February 2019

Expanding Synthesizable Space of Disubstituted 1,2,4-Oxadiazoles

scientific article

Fluorinated Pyrazoles: From Synthesis to Applications

scientific article published on 31 December 2020

Generation of C(2)F(5)CHN(2) in situ and its first reaction: [3+2] cycloaddition with alkenes

scientific article published on 02 April 2014

Hindered dialkyl ether synthesis with electrogenerated carbocations

scientific article published on 09 September 2019

In Situ generation of difluoromethyl diazomethane for [3+2] cycloadditions with alkynes

scientific article published on 20 March 2015

Incorporation of cis- and trans-4,5-difluoromethanoprolines into polypeptides

scientific article published on 28 September 2012

Low net heat of adsorption of ethylene achieved by major solid-state structural rearrangement of a discrete copper complex

scientific article published on 15 November 2018

One-Pot Parallel Synthesis of Alkyl Sulfides, Sulfoxides, and Sulfones.

scientific article published on 13 May 2015

Orientation and Location of the Cyclotide Kalata B1 in Lipid Bilayers Revealed by Solid-State NMR.

scientific article

Peptidyl-Prolyl Model Study: How Does the Electronic Effect Influence the Amide Bond Conformation?

scientific article published on 7 June 2017

Photochemical Synthesis of 2-Azabicyclo[3.2.0]heptanes: Advanced Building Blocks for Drug Discovery. Synthesis of 2,3-Ethanoproline

scientific article published on 3 January 2018

Photochemical Synthesis of 3-Azabicyclo[3.2.0]heptanes: Advanced Building Blocks for Drug Discovery.

scientific article published on 16 August 2017

Photochemical in flow synthesis of 2,4-methanopyrrolidines: pyrrolidine analogues with improved water solubility and reduced lipophilicity

scientific article published on 06 November 2018

Photosensitization enables Pauson-Khand–type reactions with nitrenes

scientific article published on 01 February 2024

Preparation of 5-Fluoropyrazoles from Pyrazoles and N-Fluorobenzenesulfonimide (NFSI)

scientific article published on 07 March 2018

Quaternary Centers by Nickel-Catalyzed Cross-Coupling of Tertiary Carboxylic Acids and (Hetero)Aryl Zinc Reagents

scientific article published on 30 January 2019

Saturated Heterocyclic Aminosulfonyl Fluorides: New Scaffolds for Protecting-Group-Free Synthesis of Sulfonamides

scientific article published on 29 May 2018

Saturated bioisosteres of benzene: where to go next?

scientific article published on 01 March 2019

Selective 19 F-Labeling of Functionalized Carboxylic Acids with Difluoromethyl Diazomethane (CF2 HCHN2 ).

scientific article published on 28 July 2017

Silver(I) and Copper(I) Adducts of a Tris(pyrazolyl)borate Decorated with Nine Trifluoromethyl Groups ⬇️

scientific article published on January 31, 2013

Stereochemical effects on the aggregation and biological properties of the fibril-forming peptide [KIGAKI]3 in membranes

scientific article published on 7 May 2013

Structure analysis and conformational transitions of the cell penetrating peptide transportan 10 in the membrane-bound state

scientific article

Sulfonyl fluorides as alternative to sulfonyl chlorides in parallel synthesis of aliphatic sulfonamides

scientific article published on 17 March 2014

Synthesis of Multifunctional Spirocyclic Azetidines and Their Application in Drug Discovery

scientific article published on 16 January 2018

Synthesis of Spirocyclic Pyrrolidines: Advanced Building Blocks for Drug Discovery.

scientific article published on 11 August 2017

Synthesis of a Conformationally Rigid Analogue of 2-Aminoadipic Acid Containing an 8-Azabicyclo[3.2.1]octane Skeleton

Synthesis of functionalized difluorocyclopropanes: unique building blocks for drug discovery

scientific article

Synthesis of trifluoromethyl-substituted proline analogues as 19F NMR labels for peptides in the polyproline II conformation

scientific article published in January 2008

Three-component synthesis of C2F5-substituted pyrazoles from C2F5CH2NH2·HCl, NaNO2 and electron-deficient alkynes

scientific article

Three-component synthesis of fluorinated pyrazoles from fluoroalkylamines, NaNO2 and electron-deficient alkynes.

scientific article

Unexpected Reactivity of Trifluoromethyl Diazomethane (CF3CHN2): Electrophilicity of the Terminal N-Atom

scientific article

Water-Soluble Non-Classical Benzene Mimetics

scientific article published on 15 February 2020

[2+2]-Photocycloaddition of N-Benzylmaleimide to Alkenes As an Approach to Functional 3-Azabicyclo[3.2.0]heptanes

scientific article published on 12 March 2018

γ-(S)-Trifluoromethyl proline: evaluation as a structural substitute of proline for solid state (19)F-NMR peptide studies.

scientific article

List of works by Pavel K Mykhailiuk

"Reported, but still unknown." A closer look into 3,4-bis- and 3,4,5-tris(trifluoromethyl)pyrazoles

(Chlorosulfonyl)benzenesulfonyl fluorides - versatile building blocks for combinatorial chemistry. Design, synthesis and evaluation of a covalent inhibitor library

1-Substituted 2-Azaspiro[3.3]heptanes: Overlooked Motifs for Drug Discovery

2,2,2-Trifluorodiazoethane (CF3CHN2): A Long Journey since 1943

2,2,2-Trifluoroethyl Chlorooxoacetate--Universal Reagent for One-Pot Parallel Synthesis of N(1)-Aryl-N(2)-alkyl-Substituted Oxamides.

3-Benzyl-3-azabicyclo[3.1.1]heptan-6-one: a promising building block for medicinal chemistry.

A Convenient Route to Trifluoromethyl-Substituted Cyclopropane Derivatives

A Radical Approach to Anionic Chemistry: Synthesis of Ketones, Alcohols, and Amines

A one-pot parallel reductive amination of aldehydes with heteroaromatic amines

A19F NMR Label to Substitute Polar Amino Acids in Peptides: A CF3-Substituted Analogue of Serine and Threonine

Approach to the library of fused pyridine-4-carboxylic acids by Combes-type reaction of acyl pyruvates and electron-rich amino heterocycles.

Bicyclic Piperidines via [2 + 2] Photocycloaddition

Bis(2,2,2-trifluoroethyl) carbonate as a condensing agent in one-pot parallel synthesis of unsymmetrical aliphatic ureas.

Carbonyl complexes of copper(i) stabilized by bridging fluorinated pyrazolates and halide ions

Conformational Plasticity of the Cell-Penetrating Peptide SAP As Revealed by Solid-State 19F-NMR and Circular Dichroism Spectroscopies.

Controlling biological activity with light: diarylethene-containing cyclic peptidomimetics

Convenient Access to Conformationally Rigid Sultams

Copper-Catalyzed O-Difluoromethylation of Functionalized Aliphatic Alcohols: Access to Complex Organic Molecules with an OCF2H Group

Deoxofluorination of (Hetero)aromatic Acids

Deoxofluorination of Aliphatic Carboxylic Acids: A Route to Trifluoromethyl-Substituted Derivatives

Design and synthesis of novel 19F-amino acid: a promising 19F NMR label for peptide studies

Design, Synthesis, and Application of a Trifluoromethylated Phenylalanine Analogue as a Label to Study Peptides by Solid-State19F NMR Spectroscopy

Design, Synthesis, and Application of an Optimized Monofluorinated Aliphatic Label for Peptide Studies by Solid-State (19) F NMR Spectroscopy

Design, synthesis, and characterization of SO2-containing azabicyclo[3.n.1]alkanes: promising building blocks for drug discovery

Diazoacetonitrile (N2 CHCN): A Long Forgotten but Valuable Reagent for Organic Synthesis

Difluoro-Substituted Bicyclo[1.1.1]pentanes for Medicinal Chemistry: Design, Synthesis, and Characterization

Difluorodiazoethane (CF 2 HCHN 2 ): A New Reagent for the Introduction of the Difluoromethyl Group

Expanding Synthesizable Space of Disubstituted 1,2,4-Oxadiazoles

Fluorinated Pyrazoles: From Synthesis to Applications

Generation of C(2)F(5)CHN(2) in situ and its first reaction: [3+2] cycloaddition with alkenes

Hindered dialkyl ether synthesis with electrogenerated carbocations

In Situ generation of difluoromethyl diazomethane for [3+2] cycloadditions with alkynes

Incorporation of cis- and trans-4,5-difluoromethanoprolines into polypeptides

Low net heat of adsorption of ethylene achieved by major solid-state structural rearrangement of a discrete copper complex

One-Pot Parallel Synthesis of Alkyl Sulfides, Sulfoxides, and Sulfones.

Orientation and Location of the Cyclotide Kalata B1 in Lipid Bilayers Revealed by Solid-State NMR.

Peptidyl-Prolyl Model Study: How Does the Electronic Effect Influence the Amide Bond Conformation?

Photochemical Synthesis of 2-Azabicyclo[3.2.0]heptanes: Advanced Building Blocks for Drug Discovery. Synthesis of 2,3-Ethanoproline

Photochemical Synthesis of 3-Azabicyclo[3.2.0]heptanes: Advanced Building Blocks for Drug Discovery.

Photochemical in flow synthesis of 2,4-methanopyrrolidines: pyrrolidine analogues with improved water solubility and reduced lipophilicity

Photosensitization enables Pauson-Khand–type reactions with nitrenes

Preparation of 5-Fluoropyrazoles from Pyrazoles and N-Fluorobenzenesulfonimide (NFSI)

Quaternary Centers by Nickel-Catalyzed Cross-Coupling of Tertiary Carboxylic Acids and (Hetero)Aryl Zinc Reagents

Saturated Heterocyclic Aminosulfonyl Fluorides: New Scaffolds for Protecting-Group-Free Synthesis of Sulfonamides

Saturated bioisosteres of benzene: where to go next?

Selective 19 F-Labeling of Functionalized Carboxylic Acids with Difluoromethyl Diazomethane (CF2 HCHN2 ).

Silver(I) and Copper(I) Adducts of a Tris(pyrazolyl)borate Decorated with Nine Trifluoromethyl Groups ⬇️

Stereochemical effects on the aggregation and biological properties of the fibril-forming peptide [KIGAKI]3 in membranes

Structure analysis and conformational transitions of the cell penetrating peptide transportan 10 in the membrane-bound state

Sulfonyl fluorides as alternative to sulfonyl chlorides in parallel synthesis of aliphatic sulfonamides

Synthesis of Multifunctional Spirocyclic Azetidines and Their Application in Drug Discovery

Synthesis of Spirocyclic Pyrrolidines: Advanced Building Blocks for Drug Discovery.

Synthesis of a Conformationally Rigid Analogue of 2-Aminoadipic Acid Containing an 8-Azabicyclo[3.2.1]octane Skeleton

Synthesis of functionalized difluorocyclopropanes: unique building blocks for drug discovery

Synthesis of trifluoromethyl-substituted proline analogues as 19F NMR labels for peptides in the polyproline II conformation

Three-component synthesis of C2F5-substituted pyrazoles from C2F5CH2NH2·HCl, NaNO2 and electron-deficient alkynes

Three-component synthesis of fluorinated pyrazoles from fluoroalkylamines, NaNO2 and electron-deficient alkynes.

Unexpected Reactivity of Trifluoromethyl Diazomethane (CF3CHN2): Electrophilicity of the Terminal N-Atom

Water-Soluble Non-Classical Benzene Mimetics

[2+2]-Photocycloaddition of N-Benzylmaleimide to Alkenes As an Approach to Functional 3-Azabicyclo[3.2.0]heptanes

γ-(S)-Trifluoromethyl proline: evaluation as a structural substitute of proline for solid state (19)F-NMR peptide studies.