List of works - Taku Yoshiya

"O-acyl isopeptide method" for peptide synthesis: synthesis of forty kinds of "O-acyl isodipeptide unit" Boc-Ser/Thr(Fmoc-Xaa)-OH

scientific article published on 25 April 2007

'Click peptide': a novel 'O-acyl isopeptide method' for peptide synthesis and chemical biology-oriented synthesis of amyloid beta peptide analogues

scientific article published on 01 December 2006

'O-Acyl isopeptide method' for peptide synthesis: Solvent effects in the synthesis of Abeta1-42 isopeptide using 'O-acyl isodipeptide unit'

scientific article published on 01 December 2007

1,2,4-Triazole-aided native chemical ligation between peptide-N-acyl-N'-methyl-benzimidazolinone and cysteinyl peptide

scientific article published on 01 November 2017

A GGCT fluorogenic probe: design, synthesis and application to cancer-related cells.

scientific article

A Novel Prodrug of a γ-Glutamylcyclotransferase Inhibitor Suppresses Cancer Cell Proliferation in vitro and Inhibits Tumor Growth in a Xenograft Mouse Model of Prostate Cancer.

scientific article published on 9 January 2018

A fluorogenic probe for γ-glutamyl cyclotransferase: application of an enzyme-triggered O-to-N acyl migration-type reaction

scientific article published on 24 September 2013

A trimethyllysine-containing trityl tag for solubilizing hydrophobic peptides

scientific article published on 29 November 2019

B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction

scientific article published on 26 February 2020

Click Peptide concept: o-acyl isopeptide of islet amyloid polypeptide as a nonaggregative precursor molecule.

scientific article published on 28 April 2011

Design of fluorogenic probes and fluorescent-tagged inhibitors for γ-glutamyl cyclotransferase.

scientific article published on 15 February 2017

Development of O-acyl isopeptide method.

scientific article published on January 2007

Development of Trityl Group Anchored Solubilizing Tags for Peptide and Protein Synthesis

scientific article published on 27 May 2019

Development of a sufficiently reactive thioalkylester involving the side-chain thiol of cysteine applicable for kinetically controlled ligation

scientific article published on 01 November 2016

Easy-to-Attach/Detach Solubilizing Tag-Aided Chemical Synthesis of an Aggregative Capsid Protein.

scientific article published on 6 January 2018

Epimerization-Free Preparation of C-Terminal Cys Peptide Acid by Fmoc SPPS Using Pseudoproline-Type Protecting Group

scientific article published on 31 October 2019

Epimerization-free synthesis of cyclic peptide by use of the O-acyl isopeptide method

scientific article published on 01 August 2010

HAP-01, the first chromogenic substrate for Aspergillus oryzae acid protease

scientific article published on 01 January 2019

Imidazole-Aided Native Chemical Ligation: Imidazole as a One-Pot Desulfurization-Amenable Non-Thiol-Type Alternative to 4-Mercaptophenylacetic Acid.

scientific article published on 5 October 2016

Isopeptide method: development of S-acyl isopeptide method for the synthesis of difficult sequence-containing peptides.

scientific article published in November 2008

Mechanisms of Tumor Growth Inhibition by Depletion of γ-Glutamylcyclotransferase (GGCT): A Novel Molecular Target for Anticancer Therapy

scientific article published on 14 July 2018

Non-pretreated O-acyl isopeptide of amyloid β peptide 1-42 is monomeric with a random coil structure but starts to aggregate in a concentration-dependent manner.

scientific article

O-acyl isopeptide method: development of an O-acyl isodipeptide unit for Boc SPPS and its application to the synthesis of Aβ1-42 isopeptide.

scientific article

Peptide self-cleavage at a canaline residue: application to a solubilizing tag system for native chemical ligation

scientific article published on 01 August 2018

Racemization-free segment condensation based on the O-acyl isopeptide method: toward a chemical protein synthesis on solid support.

scientific article published in January 2009

Ring-closing metathesis of unprotected peptides in water

scientific article published on 01 December 2018

S-acyl isopeptide method: use of allyl-type protective group for improved preparation of thioester-containing S-acyl isopeptides by Fmoc-based SPPS

scientific article published on 01 January 2011

Solubilizing Trityl-Type Tag To Synthesize Asx/Glx-Containing Peptides

scientific article published on 18 April 2019

Synthesis and conformation of an analog of the helix-loop-helix domain of the Id1 protein containing the O-acyl iso-prolyl-seryl switch motif.

scientific article published in June 2010

Synthesis of cysteine-rich peptides by native chemical ligation without use of exogenous thiols

scientific article published on 19 March 2015

The versatile use of solubilizing trityl tags for difficult peptide/protein synthesis

scientific article published on 01 January 2019

List of works by Taku Yoshiya

"O-acyl isopeptide method" for peptide synthesis: synthesis of forty kinds of "O-acyl isodipeptide unit" Boc-Ser/Thr(Fmoc-Xaa)-OH

'Click peptide': a novel 'O-acyl isopeptide method' for peptide synthesis and chemical biology-oriented synthesis of amyloid beta peptide analogues

'O-Acyl isopeptide method' for peptide synthesis: Solvent effects in the synthesis of Abeta1-42 isopeptide using 'O-acyl isodipeptide unit'

1,2,4-Triazole-aided native chemical ligation between peptide-N-acyl-N'-methyl-benzimidazolinone and cysteinyl peptide

A GGCT fluorogenic probe: design, synthesis and application to cancer-related cells.

A Novel Prodrug of a γ-Glutamylcyclotransferase Inhibitor Suppresses Cancer Cell Proliferation in vitro and Inhibits Tumor Growth in a Xenograft Mouse Model of Prostate Cancer.

A fluorogenic probe for γ-glutamyl cyclotransferase: application of an enzyme-triggered O-to-N acyl migration-type reaction

A trimethyllysine-containing trityl tag for solubilizing hydrophobic peptides

B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction

Click Peptide concept: o-acyl isopeptide of islet amyloid polypeptide as a nonaggregative precursor molecule.

Design of fluorogenic probes and fluorescent-tagged inhibitors for γ-glutamyl cyclotransferase.

Development of O-acyl isopeptide method.

Development of Trityl Group Anchored Solubilizing Tags for Peptide and Protein Synthesis

Development of a sufficiently reactive thioalkylester involving the side-chain thiol of cysteine applicable for kinetically controlled ligation

Easy-to-Attach/Detach Solubilizing Tag-Aided Chemical Synthesis of an Aggregative Capsid Protein.

Epimerization-Free Preparation of C-Terminal Cys Peptide Acid by Fmoc SPPS Using Pseudoproline-Type Protecting Group

Epimerization-free synthesis of cyclic peptide by use of the O-acyl isopeptide method

HAP-01, the first chromogenic substrate for Aspergillus oryzae acid protease

Imidazole-Aided Native Chemical Ligation: Imidazole as a One-Pot Desulfurization-Amenable Non-Thiol-Type Alternative to 4-Mercaptophenylacetic Acid.

Isopeptide method: development of S-acyl isopeptide method for the synthesis of difficult sequence-containing peptides.

Mechanisms of Tumor Growth Inhibition by Depletion of γ-Glutamylcyclotransferase (GGCT): A Novel Molecular Target for Anticancer Therapy

Non-pretreated O-acyl isopeptide of amyloid β peptide 1-42 is monomeric with a random coil structure but starts to aggregate in a concentration-dependent manner.

O-acyl isopeptide method: development of an O-acyl isodipeptide unit for Boc SPPS and its application to the synthesis of Aβ1-42 isopeptide.

Peptide self-cleavage at a canaline residue: application to a solubilizing tag system for native chemical ligation

Racemization-free segment condensation based on the O-acyl isopeptide method: toward a chemical protein synthesis on solid support.

Ring-closing metathesis of unprotected peptides in water

S-acyl isopeptide method: use of allyl-type protective group for improved preparation of thioester-containing S-acyl isopeptides by Fmoc-based SPPS

Solubilizing Trityl-Type Tag To Synthesize Asx/Glx-Containing Peptides

Synthesis and conformation of an analog of the helix-loop-helix domain of the Id1 protein containing the O-acyl iso-prolyl-seryl switch motif.

Synthesis of cysteine-rich peptides by native chemical ligation without use of exogenous thiols

The versatile use of solubilizing trityl tags for difficult peptide/protein synthesis