List of works - Giulio Poli

1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors

scientific article published on 04 February 2020

A Virtual Screening Study for Lactate Dehydrogenase 5 Inhibitors by Using a Pharmacophore-based Approach.

scientific article

An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present)

scientific article published on 21 October 2020

Anticancer Activity of Euplotin C, Isolated from the Marine Ciliate Euplotes crassus, Against Human Melanoma Cells.

scientific article published on 16 May 2018

Application of MM-PBSA Methods in Virtual Screening

scientific article published on 23 April 2020

Application of a FLAP-consensus docking mixed strategy for the identification of new fatty acid amide hydrolase inhibitors.

scientific article published on 12 March 2015

Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors.

scientific article

Computational approaches for the identification and optimization of Src family kinases inhibitors

scientific article published on January 2014

Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors

scientific article published on 01 December 2019

Conformational Sampling of Small Molecules With iCon: Performance Assessment in Comparison With OMEGA.

scientific article

Continued exploration of 1,2,4-oxadiazole periphery for carbonic anhydrase-targeting primary arene sulfonamides: Discovery of subnanomolar inhibitors of membrane-bound hCA IX isoform that selectively kill cancer cells in hypoxic environment

scientific article published on 21 December 2018

Design, Synthesis, Docking Studies and Monoamine Oxidase Inhibition of a Small Library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazoles

scientific article published on 29 January 2019

Development of a Fingerprint-Based Scoring Function for the Prediction of the Binding Mode of Carbonic Anhydrase II Inhibitors.

scientific article published on 23 June 2018

Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors.

scientific article

Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents

scientific article published on 18 June 2018

Discovery of Monoacylglycerol Lipase (MAGL) Inhibitors Based on a Pharmacophore-Guided Virtual Screening Study

scientific article published on 26 December 2020

Discovery of a new ATP-citrate lyase (ACLY) inhibitor identified by a pharmacophore-based virtual screening study

scientific article published on 25 May 2020

Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors

scientific article published on 16 August 2018

Drug Affinity Responsive Target Stability (DARTS) Identifies Laurifolioside as a New Clathrin Heavy Chain Modulator

scientific article published on 5 October 2016

Extensive Reliability Evaluation of Docking-Based Target-Fishing Strategies ⬇️

scientific article published on 27 February 2019

Extensive consensus docking evaluation for ligand pose prediction and virtual screening studies

scientific article

First-of-its-kind STARD3 Inhibitor: In Silico Identification and Biological Evaluation as Anticancer Agent

scientific article published on 20 February 2019

Identification of a new STAT3 dimerization inhibitor through a pharmacophore-based virtual screening approach

scientific article published on 24 August 2015

Identification of new Fyn kinase inhibitors using a FLAP-based approach.

scientific article

Identification of the putative binding pocket of valerenic acid on GABAA receptors using docking studies and site-directed mutagenesis.

scientific article published on 16 September 2015

Largazole Analogues as Histone Deacetylase Inhibitors and Anticancer Agents: An Overview of Structure-Activity Relationships.

scientific article

N-aryl-N'-ureido-O-sulfamates: Potent and selective inhibitors of the human Carbonic Anhydrase VII isoform with neuropathic pain relieving properties

scientific article published on 06 June 2019

New Chromane-Based Derivatives as Inhibitors of Salicylate Synthase (MbtI): Preliminary Biological Evaluation and Molecular Modeling Studies

scientific article published on 21 June 2018

New diterpenes from Salvia pseudorosmarinus and their activity as inhibitors of monoacylglycerol lipase (MAGL)

scientific article published on 18 September 2018

New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents

scientific article published on 01 December 2019

Novel 8-Substituted Coumarins That Selectively Inhibit Human Carbonic Anhydrase IX and XII ⬇️

scientific article published on 10 March 2019

Novel broad spectrum virucidal molecules against enveloped viruses

scientific article published in PLoS ONE

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor

scientific article published on 11 February 2019

Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system

scientific article published on 14 May 2018

Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines

scientific article published on 15 February 2019

Receptor-based virtual screening evaluation for the identification of estrogen receptorβligands

scientific article published on 29 September 2014

Reliability analysis and optimization of the consensus docking approach for the development of virtual screening studies.

scientific article published on 17 June 2016

Rhodanine derivatives as potent anti-HIV and anti-HSV microbicides.

scientific article

Synthesis and Biological Evaluation of New Glycoconjugated LDH Inhibitors as Anticancer Agents

scientific article published on 28 September 2019

Synthesis and structure activity relationship investigation of triazolo[1,5-a]pyrimidines as CB2 cannabinoid receptor inverse agonists

scientific article published on 16 February 2016

The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel

scientific article published on 19 February 2019

Three-Dimensional Analysis of the Interactions between hLDH5 and Its Inhibitors.

scientific article published on 13 December 2017

Virtual screening identifies a PIN1 inhibitor with possible antiovarian cancer effects

scientific article published on 29 January 2019

List of works by Giulio Poli

1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors

A Virtual Screening Study for Lactate Dehydrogenase 5 Inhibitors by Using a Pharmacophore-based Approach.

An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present)

Anticancer Activity of Euplotin C, Isolated from the Marine Ciliate Euplotes crassus, Against Human Melanoma Cells.

Application of MM-PBSA Methods in Virtual Screening

Application of a FLAP-consensus docking mixed strategy for the identification of new fatty acid amide hydrolase inhibitors.

Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors.

Computational approaches for the identification and optimization of Src family kinases inhibitors

Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors

Conformational Sampling of Small Molecules With iCon: Performance Assessment in Comparison With OMEGA.

Continued exploration of 1,2,4-oxadiazole periphery for carbonic anhydrase-targeting primary arene sulfonamides: Discovery of subnanomolar inhibitors of membrane-bound hCA IX isoform that selectively kill cancer cells in hypoxic environment

Design, Synthesis, Docking Studies and Monoamine Oxidase Inhibition of a Small Library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazoles

Development of a Fingerprint-Based Scoring Function for the Prediction of the Binding Mode of Carbonic Anhydrase II Inhibitors.

Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors.

Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents

Discovery of Monoacylglycerol Lipase (MAGL) Inhibitors Based on a Pharmacophore-Guided Virtual Screening Study

Discovery of a new ATP-citrate lyase (ACLY) inhibitor identified by a pharmacophore-based virtual screening study

Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors

Drug Affinity Responsive Target Stability (DARTS) Identifies Laurifolioside as a New Clathrin Heavy Chain Modulator

Extensive Reliability Evaluation of Docking-Based Target-Fishing Strategies ⬇️

Extensive consensus docking evaluation for ligand pose prediction and virtual screening studies

First-of-its-kind STARD3 Inhibitor: In Silico Identification and Biological Evaluation as Anticancer Agent

Identification of a new STAT3 dimerization inhibitor through a pharmacophore-based virtual screening approach

Identification of new Fyn kinase inhibitors using a FLAP-based approach.

Identification of the putative binding pocket of valerenic acid on GABAA receptors using docking studies and site-directed mutagenesis.

Largazole Analogues as Histone Deacetylase Inhibitors and Anticancer Agents: An Overview of Structure-Activity Relationships.

N-aryl-N'-ureido-O-sulfamates: Potent and selective inhibitors of the human Carbonic Anhydrase VII isoform with neuropathic pain relieving properties

New Chromane-Based Derivatives as Inhibitors of Salicylate Synthase (MbtI): Preliminary Biological Evaluation and Molecular Modeling Studies

New diterpenes from Salvia pseudorosmarinus and their activity as inhibitors of monoacylglycerol lipase (MAGL)

New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents

Novel 8-Substituted Coumarins That Selectively Inhibit Human Carbonic Anhydrase IX and XII ⬇️

Novel broad spectrum virucidal molecules against enveloped viruses

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor

Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system

Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines

Receptor-based virtual screening evaluation for the identification of estrogen receptorβligands

Reliability analysis and optimization of the consensus docking approach for the development of virtual screening studies.

Rhodanine derivatives as potent anti-HIV and anti-HSV microbicides.

Synthesis and Biological Evaluation of New Glycoconjugated LDH Inhibitors as Anticancer Agents

Synthesis and structure activity relationship investigation of triazolo[1,5-a]pyrimidines as CB2 cannabinoid receptor inverse agonists

The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel

Three-Dimensional Analysis of the Interactions between hLDH5 and Its Inhibitors.

Virtual screening identifies a PIN1 inhibitor with possible antiovarian cancer effects