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List of works by Muriel Laffargue

17Beta-estradiol promotes TLR4-triggered proinflammatory mediator production through direct estrogen receptor alpha signaling in macrophages in vivo.

scientific article published on 16 June 2010

A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor.

scientific article

A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid.

scientific article published on 26 March 2002

An epidermal growth factor receptor/Gab1 signaling pathway is required for activation of phosphoinositide 3-kinase by lysophosphatidic acid.

scientific article

Anti-inflammatory and antiatherogenic effects of the NLRP3 inflammasome inhibitor arglabin in ApoE2.Ki mice fed a high-fat diet

scientific article

Chronic estradiol administration in vivo promotes the proinflammatory response of macrophages to TLR4 activation: involvement of the phosphatidylinositol 3-kinase pathway.

scientific article published in June 2008

Chronic pharmacological activation of P2Y13 receptor in mice decreases HDL-cholesterol level by increasing hepatic HDL uptake and bile acid secretion

scientific article published on 20 December 2012

Elastic fibers and elastin receptor complex: Neuraminidase-1 takes the center stage

scientific article published on 18 June 2019

Elastin fragmentation and atherosclerosis progression: the elastokine concept.

scientific article published on 02 April 2013

Elastin-derived peptides potentiate atherosclerosis through the immune Neu1-PI3Kγ pathway.

scientific article

Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes

scientific article published on 11 February 2008

Increased atherosclerosis in P2Y13/apolipoprotein E double-knockout mice: contribution of P2Y13 to reverse cholesterol transport

scientific article published on 13 March 2015

Integrin-Dependent Tyrosine Phoshorylation and Cytoskeletal Translocation of Tec in Thrombin-Activated Platelets ⬇️

scientific article published on September 8, 1997

Lack of P2Y13 in mice fed a high cholesterol diet results in decreased hepatic cholesterol content, biliary lipid secretion and reverse cholesterol transport

scientific article

Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.

scientific article published on 28 February 2002

Matrix ageing and vascular impacts: focus on elastin fragmentation.

scientific article published on 22 March 2016

PI3K and Calcium Signaling in Cardiovascular Disease

scientific article

PI3K signaling in arterial diseases: Non redundant functions of the PI3K isoforms

scientific article published on 26 July 2015

PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling

scientific article published on 23 June 2015

PI3Kβ Plays a Key Role in Apolipoprotein A-I-Induced Endothelial Cell Proliferation Through Activation of the Ecto-F1-ATPase/P2Y1 Receptors

scientific article published on 05 June 2017

PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control

scientific article (publication date: 2013)

Phosphoinositide 3-kinase and integrin signalling are involved in activation of Bruton tyrosine kinase in thrombin-stimulated platelets

scientific article published on 22 January 1999

Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function

scientific article published in March 2002

Phosphoinositide 3-kinases and their role in inflammation: potential clinical targets in atherosclerosis?

scientific article published on May 2009

Resistance to thromboembolism in PI3Kgamma-deficient mice.

scientific article published on 9 July 2001

Response to Letter Regarding Article, "Anti-inflammatory and Antiatherogenic Effects of the Inflammasome NLRP3 Inhibitor Arglabin in ApoE2.Ki Mice Fed a High-Fat Diet".

scientific article published in November 2015

Role of the ubiquitin-proteasome system in the regulation of P2Y13 receptor expression: impact on hepatic HDL uptake

scientific article published on 13 September 2013

Selective activation of nuclear phospholipase D-1 by g protein-coupled receptor agonists in vascular smooth muscle cells

scientific article published on 15 June 2006

Serum IF1 concentration is independently associated to HDL levels and to coronary heart disease: the GENES study.

scientific article published on 21 June 2013

Small GTPases orchestrate cell-cell communication during collective cell movement.

scientific article published on 5 October 2017

Smooth muscle cells-derived CXCL10 prevents endothelial healing through PI3Kγ-dependent T cells response

scientific article published on 01 February 2020

Sonic hedgehog mediates a novel pathway of PDGF-BB-dependent vessel maturation

scientific article

Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response.

scientific article

The Activation Function-1 of Estrogen Receptor Alpha Prevents Arterial Neointima Development Through a Direct Effect on Smooth Muscle Cells.

scientific article

The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells

scientific article (publication date: 27 July 2001)

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