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List of works by Giuseppina Di Stefano

A conjugate of doxorubicin with lactosaminated albumin enhances the drug concentrations in all the forms of rat hepatocellular carcinomas independently of their differentiation grade

scientific article published on 01 August 2006

A conjugate of lactosaminated poly-L-lysine with adenine arabinoside monophosphate, administered to mice by intramuscular route, accomplishes a selective delivery of the drug to the liver

scientific article published on 01 February 1994

A novel method for coupling doxorubicin to lactosaminated human albumin by an acid sensitive hydrazone bond: synthesis, characterization and preliminary biological properties of the conjugate.

scientific article published in December 2004

Adenine arabinoside monophosphate coupled to lactosaminated human albumin administered for 4 weeks in patients with chronic type B hepatitis decreased viremia without producing significant side effects

scientific article published on 01 April 1996

Albumin-drug conjugates in the treatment of hepatic disorders.

scientific article published on 29 April 2014

Alpha 2,6 sialylation of N-acetyllactosaminic sequences in human colorectal cancer cell lines. Relationship with non-adherent growth

scientific article published on 01 January 1991

Altered glycosylation profile of purified plasma ACT from Alzheimer's disease

scientific article published on 16 December 2010

Binding of the doxorubicin-lactosaminated human albumin conjugate to HCC cells is mediated by the drug moieties

scientific article published on 07 July 2008

Coupling of antiviral nucleoside analogs to lactosaminated human albumin by using the imidazolides of their phosphoric esters

scientific article published on 01 August 1993

Coupling of lactose molecules to the carrier protein hinders the spleen and bone marrow uptake of doxorubicin conjugated with human albumin

scientific article published on 19 December 2006

Coupling to lactosaminated poly-L-lysine reduces the toxic effects of ribavirin on red blood cells.

scientific article published in December 1998

Doxorubicin coupled to lactosaminated albumin inhibits the growth of hepatocellular carcinomas induced in rats by diethylnitrosamine.

scientific article published in October 2005

Doxorubicin coupled to lactosaminated albumin: Effects on rats with liver fibrosis and cirrhosis

scientific article published on 03 April 2006

Doxorubicin coupled to lactosaminated albumin: enhanced drug levels in rat hepatocarcinomas

scientific article published on 20 December 2005

Doxorubicin coupled to lactosaminated human albumin remains confined within mouse liver cells after the intracellular release from the carrier.

scientific article published in June 2003

Doxorubicin coupled to lactosaminated human albumin: a hepatocellular carcinoma targeted drug.

scientific article published on 11 September 2008

Effect of sorafenib on the energy metabolism of hepatocellular carcinoma cells

scientific article published on 10 September 2011

Elevated plasma levels of alpha-1-anti-chymotrypsin in age-related cognitive decline and Alzheimer's disease: a potential therapeutic target.

scientific article published in January 2008

Enhanced liver blood concentrations of adenine arabinoside accomplished by lactosaminated poly-L-lysine coupling: implications for regional chemotherapy of hepatic micrometastases

scientific article published on 01 February 2000

Enhanced uptake of lactosaminated human albumin by rat hepatocarcinomas: implications for an improved chemotherapy of primary liver tumors.

scientific article published in August 2005

Floxuridine coupling with lactosaminated human albumin to increase drug efficacy on liver micrometastases.

scientific article

Galloflavin (CAS 568-80-9): a novel inhibitor of lactate dehydrogenase.

scientific article

Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells ⬇️

scientific article published on December 10, 2012

Galloflavin suppresses lactate dehydrogenase activity and causes MYC downregulation in Burkitt lymphoma cells through NAD/NADH-dependent inhibition of sirtuin-1.

scientific article published on September 2013

Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways ⬇️

scientific article published on August 30, 2012

Hepatotropic conjugate of adenine arabinoside monophosphate with lactosaminated poly-L-lysine. Synthesis of the carrier and pharmacological properties of the conjugate

scientific article published on 01 February 1997

Identification of N-acylhydrazone derivatives as novel lactate dehydrogenase A inhibitors.

scientific article

Impairment of aerobic glycolysis by inhibitors of lactic dehydrogenase hinders the growth of human hepatocellular carcinoma cell lines.

scientific article published on 10 August 2010

Increased CMP-NeuAc:Gal beta 1,4GlcNAc-R alpha 2,6 sialyltransferase activity in human colorectal cancer tissues

scientific article published on 01 September 1989

Inhibition of [3H]thymidine incorporation into DNA of rat regenerating liver by 2',2'-difluorodeoxycytidine coupled to lactosaminated poly-L-lysine.

scientific article published on April 1999

Inhibition of hepatitis B virus replication by adenine arabinoside monophosphate coupled to lactosaminated albumin. Efficacy and minimal active dose.

scientific article

Inhibition of lactate dehydrogenase activity as an approach to cancer therapy

scientific article

Inhibition of lactic dehydrogenase as a way to increase the anti-proliferative effect of multi-targeted kinase inhibitors.

scientific article published on 17 December 2010

LDH inhibition impacts on heat shock response and induces senescence of hepatocellular carcinoma cells

scientific article published on 10 May 2017

Lactate dehydrogenase inhibition: exploring possible applications beyond cancer treatment

scientific article published on 7 April 2016

Lactate dehydrogenase inhibitors can reverse inflammation induced changes in colon cancer cells

scientific article

Lactate dehydrogenase inhibitors sensitize lymphoma cells to cisplatin without enhancing the drug effects on immortalized normal lymphocytes

scientific article published on 28 April 2015

Lactosaminated human albumin, a hepatotropic carrier of drugs.

scientific article published on 18 April 2010

Liver targeting of antiviral nucleoside analogues through the asialoglycoprotein receptor.

scientific article published on January 1997

NAD metabolism and functions: a common therapeutic target for neoplastic, metabolic and neurodegenerative diseases

scientific article published on January 2013

Organ distribution of a conjugate of adenine arabinoside monophosphate with lactosaminated albumin in the rat

scientific article published on 01 May 1994

Rad51/BRCA2 disruptors inhibit homologous recombination and synergize with olaparib in pancreatic cancer cells

scientific article published on 10 January 2019

Synthesis and physicochemical characteristics of a liver-targeted conjugate of fluorodeoxyuridine monophosphate with lactosaminated human albumin.

scientific article published in January 2003

Synthesis of natural urolithin M6, a galloflavin mimetic, as a potential inhibitor of lactate dehydrogenase A.

scientific article published on 9 November 2016

Synthetic Lethality Triggered by Combining Olaparib with BRCA2-Rad51 Disruptors

scientific article published on 25 August 2017

The activation of lactate dehydrogenase induced by mTOR drives neoplastic change in breast epithelial cells

scientific article published in PLoS ONE

The pathogenesis of vacuoles produced in rat and mouse liver cells by a conjugate of adenine arabinoside monophosphate with lactosaminated albumin

scientific article published on 01 July 1992

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