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List of works by Sven Rottenberg

53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ

scientific article published in Nature

6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance

scientific article

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.

scientific article

BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance

scientific article

BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance.

scientific article published in December 2011

BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1

scientific article published on 25 July 2016

BRCA2-deficient sarcomatoid mammary tumors exhibit multidrug resistance.

scientific article published on 15 December 2014

Cancer cell death by programmed necrosis?

scientific article

Characterization of the bovine IkappaB kinases (IKK)alpha and IKKbeta, the regulatory subunit NEMO and their substrate IkappaBalpha.

scientific article published in October 2002

CopywriteR: DNA copy number detection from off-target sequence data

scientific article

Development of a Tumour Growth Inhibition Model to Elucidate the Effects of Ritonavir on Intratumoural Metabolism and Anti-tumour Effect of Docetaxel in a Mouse Model for Hereditary Breast Cancer

scientific article published on 24 November 2015

Drug resistance in the mouse cancer clinic

scientific article published on 14 February 2012

Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin

scientific article

EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.

scientific article published on 16 October 2017

EZN-2208 (PEG-SN38) overcomes ABCG2-mediated topotecan resistance in BRCA1-deficient mouse mammary tumors

scientific article (publication date: 2012)

Further evidence for BRCA1 communication with the inactive X chromosome.

scientific article published in March 2007

Genetic Dissection of Cancer Development, Therapy Response, and Resistance in Mouse Models of Breast Cancer

scientific article published on 4 November 2016

HELB Is a Feedback Inhibitor of DNA End Resection

scientific journal article

Haploid genetic screens identify genetic vulnerabilities to microtubule-targeting agents.

scientific article published on 24 April 2018

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

scientific article

Hijacking of host cell IKK signalosomes by the transforming parasite Theileria

scientific article published on November 2002

How do real tumors become resistant to cisplatin?

scientific article published on 17 March 2008

Identification and characterisation of a Theileria annulata proline-rich microtubule and SH3 domain-interacting protein (TaMISHIP) that forms a complex with CLASP1, EB1, and CD2AP at the schizont surface.

scientific article published on 3 April 2018

Identifying subgroup markers in heterogeneous populations

scientific article published on 22 September 2013

Impact of intertumoral heterogeneity on predicting chemotherapy response of BRCA1-deficient mammary tumors

scientific article

Increased levels of choline metabolites are an early marker of docetaxel treatment response in BRCA1-mutated mouse mammary tumors: an assessment by ex vivo proton magnetic resonance spectroscopy

scientific article

Intra-operative ex vivo photoacoustic nodal staging in a rat model using a clinical superparamagnetic iron oxide nanoparticle dispersion

scientific article published on 22 January 2013

Lack of ABCG2 shortens latency of BRCA1-deficient mammary tumors and this is not affected by genistein or resveratrol

scientific article published on 5 July 2012

Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors

scientific article

MEK inhibition as a strategy for targeting residual breast cancer cells with low DUSP4 expression

scientific article

Minimal residual disease in cancer therapy--Small things make all the difference

scientific article published on 14 August 2015

Modeling therapy resistance in genetically engineered mouse cancer models

scientific article published on 31 December 2007

Moderate Increase in Mdr1a/1b Expression Causes In vivo Resistance to Doxorubicin in a Mouse Model for Hereditary Breast Cancer

article

Monitoring of tumor response to Cisplatin using optical spectroscopy

scientific article

Multifaceted Impact of MicroRNA 493-5p on Genome-Stabilizing Pathways Induces Platinum and PARP Inhibitor Resistance in BRCA2-Mutated Carcinomas.

scientific article published in April 2018

Neoadjuvant olaparib targets hypoxia to improve radioresponse in a homologous recombination-proficient breast cancer model

scientific article published on 15 September 2017

New tools for old drugs: Functional genetic screens to optimize current chemotherapy.

scientific article published on 12 January 2018

Noninvasive functional imaging of P-glycoprotein-mediated doxorubicin resistance in a mouse model of hereditary breast cancer to predict response, and assign P-gp inhibitor sensitivity

scientific article published on 18 December 2008

Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells

scientific article

Proteomics of genetically engineered mouse mammary tumors identifies fatty acid metabolism members as potential predictive markers for cisplatin resistance

scientific article published on 8 February 2013

Proteomics of mouse BRCA1-deficient mammary tumors identifies DNA repair proteins with potential diagnostic and prognostic value in human breast cancer

scientific article

Publisher Correction: Truncated FGFR2 is a clinically actionable oncogene in multiple cancers

correction of a scholarly article

Questioning the value of 99mTc-HYNIC-annexin V based response monitoring after docetaxel treatment in a mouse model for hereditary breast cancer

scientific article published on 25 December 2010

REV7 counteracts DNA double-strand break resection and affects PARP inhibition

scientific article

Real-Time In Vivo Characterization of Primary Liver Tumors With Diffuse Optical Spectroscopy During Percutaneous Needle Interventions: Feasibility Study in Woodchucks.

scientific article published in July 2015

Replication fork stability confers chemoresistance in BRCA-deficient cells

scientific article

Ritonavir inhibits intratumoral docetaxel metabolism and enhances docetaxel antitumor activity in an immunocompetent mouse breast cancer model

scientific article published on 21 August 2015

Secretome proteomics reveals candidate non-invasive biomarkers of BRCA1 deficiency in breast cancer

scientific article published on 23 August 2016

Selected alkylating agents can overcome drug tolerance of G0-like tumor cells and eradicate BRCA1-deficient mammary tumors in mice

scientific article

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality

scientific article published on 01 June 2018

Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer

scholarly article

Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer.

scientific article published on 22 June 2015

Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan

scientific article

Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs

scientific article

The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity

scientific article published in Nature Communications

The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells.

scientific article published in May 2018

The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models

scientific article published on 22 August 2016

The rediscovery of platinum-based cancer therapy

scientific article published on 30 October 2020

The shieldin complex mediates 53BP1-dependent DNA repair

scientific article published in Nature

Theileria-induced leukocyte transformation

scientific article

Therapeutic options for triple-negative breast cancers with defective homologous recombination

scientific article published on 17 July 2009

Tumor-initiating cells are not enriched in cisplatin-surviving BRCA1;p53-deficient mammary tumor cells in vivo

scientific article

What makes tumors multidrug resistant?

scientific article published on 23 August 2007

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