List of works - Tzong-Shyuan Lee

A nation-wide analysis of venous thromboembolism in 497,180 cancer patients with the development and validation of a risk-stratification scoring system.

scientific article published on 26 April 2012

AMP-activated protein kinase is involved in endothelial NO synthase activation in response to shear stress.

scientific article published on 6 April 2006

AMP-activated protein kinase mediates erythropoietin-induced activation of endothelial nitric oxide synthase

scientific article published on 01 August 2012

Activation of TRPV1 prevents OxLDL-induced lipid accumulation and TNF-α-induced inflammation in macrophages: role of liver X receptor α.

scientific article published on 26 June 2013

Activation of transient receptor potential vanilloid 1 decreases endothelial nitric oxide synthase phosphorylation at Thr497 by protein phosphatase 2B-dependent dephosphorylation of protein kinase C.

scientific article

Anti-atherogenic effect of berberine on LXRalpha-ABCA1-dependent cholesterol efflux in macrophages.

scientific article

Apocynin attenuates ventilator-induced lung injury in an isolated and perfused rat lung model.

scientific article

Asymmetric Dimethylarginine Limits the Efficacy of Simvastatin Activating Endothelial Nitric Oxide Synthase.

scientific article published on 18 April 2016

Asymmetric dimethylarginine predicts the risk of contrast-induced acute kidney injury in patients undergoing cardiac catheterization

scientific article published on 6 October 2016

Automated quantitative analysis of lipid accumulation and hydrolysis in living macrophages with label-free imaging.

scientific article published on 11 August 2013

Bromelain Confers Protection against the Non-Alcoholic Fatty Liver Disease in Male C57bl/6 Mice

scientific article published on 18 May 2020

CCN family member 1 deregulates cholesterol metabolism and aggravates atherosclerosis

scientific article published on 19 November 2018

Characterization of the transcriptional regulation of the regulator of G protein signaling 2 (RGS2) gene during 3T3-L1 preadipocyte differentiation.

scientific article published on October 2008

Colocalization of iron and ceroid in human atherosclerotic lesions

scientific article published in June 1998

Deficiency of Glycine N-Methyltransferase Aggravates Atherosclerosis in Apolipoprotein E-Null Mice ⬇️

scientific article published on July 18, 2012

Di-(2-ethylhexyl) phthalate accelerates atherosclerosis in apolipoprotein E-deficient mice.

scientific article published on 2 October 2014

Docosahexaenoic acid attenuates VCAM-1 expression and NF-κB activation in TNF-α-treated human aortic endothelial cells

scientific article published on 22 June 2010

EGb761 ameliorates the formation of foam cells by regulating the expression of SR-A and ABCA1: role of haem oxygenase-1.

scientific article published on 8 July 2010

Eicosapentaenoic acid attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling

scientific article

Endothelin-1 exacerbates lipid accumulation by increasing the protein degradation of the ATP-binding cassette transporter G1 in macrophages.

scientific article

Enhancing endothelial progenitor cell therapy for critical limb ischemia by extracorporeal shock wave* ⬇️

scientific article published on 01 January 2012

Erythropoietin suppresses the formation of macrophage foam cells: role of liver X receptor alpha

scientific article published on 12 April 2010

Exacerbation of wood smoke-induced acute lung injury by mechanical ventilation using moderately high tidal volume in mice

scientific article published on 22 September 2007

Excess Nitric Oxide Activates TRPV1-Ca(2+)-Calpain Signaling and Promotes PEST-dependent Degradation of Liver X Receptor α.

scientific article

Excess nitric oxide impairs LXR(α)-ABCA1-dependent cholesterol efflux in macrophage foam cells.

scientific article published in January 2014

Genetic Deletion of Soluble Epoxide Hydroxylase Causes Anxiety-Like Behaviors in Mice

scientific article published on 23 July 2018

Genetic deletion of soluble epoxide hydrolase attenuates inflammation and fibrosis in experimental obstructive nephropathy.

scientific article

Genetic deletion of soluble epoxide hydrolase delays the progression of Alzheimer's disease

scientific article published on 17 December 2019

Ginkgo biloba extract confers protection from cigarette smoke extract-induced apoptosis in human lung endothelial cells: Role of heme oxygenase-1.

scientific article published on 28 February 2009

Glucosamine attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling.

scientific article published on 28 January 2014

Glucosamine inhibits IL-1beta-mediated IL-8 production in prostate cancer cells by MAPK attenuation.

scientific article

Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K/Akt pathway in the liver

scientific article published on 04 October 2016

Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice

scientific article published on 01 March 2002

High expression of high-mobility group box 1 in the blood and lungs is associated with the development of chronic obstructive pulmonary disease in smokers.

scientific article published on 24 December 2013

Impaired Cd14 and Cd36 expression, bacterial clearance, and Toll-like receptor 4-Myd88 signaling in caveolin-1-deleted macrophages and mice.

scientific article published on January 2011

Implication of AMP-activated protein kinase in transient receptor potential vanilloid type 1-mediated activation of endothelial nitric oxide synthase

scientific article published on 01 January 2012

Induction of heme oxygenase-1 expression in murine macrophages is essential for the anti-inflammatory effect of low dose 15-deoxy-Delta 12,14-prostaglandin J2.

scientific article published on 17 March 2003

Inflammatory Effects of Menthol vs. Non-menthol Cigarette Smoke Extract on Human Lung Epithelial Cells: A Double-Hit on TRPM8 by Reactive Oxygen Species and Menthol.

scientific article

Intratracheal siRNA for the in vivo silencing of caspase-3: a novel therapy for acute lung injury?

scientific article published on 01 April 2010

Intravenous ferric chloride hexahydrate supplementation induced endothelial dysfunction and increased cardiovascular risk among hemodialysis patients

scientific article

Iron sucrose accelerates early atherogenesis by increasing superoxide production and upregulating adhesion molecules in CKD.

scientific article

Laminar flow activates peroxisome proliferator-activated receptor-gamma in vascular endothelial cells.

scientific article

Lung Epithelial TRPA1 Transduces the Extracellular ROS into Transcriptional Regulation of Lung Inflammation Induced by Cigarette Smoke: The Role of Influxed Ca²⁺.

scientific article

Modulation of microRNA Expression in Subjects with Metabolic Syndrome and Decrease of Cholesterol Efflux from Macrophages via microRNA-33-Mediated Attenuation of ATP-Binding Cassette Transporter A1 Expression by Statins

scientific article

Molecular mechanism of curcumin on the suppression of cholesterol accumulation in macrophage foam cells and atherosclerosis

scientific article published on 01 May 2012

N-terminal domain of soluble epoxide hydrolase negatively regulates the VEGF-mediated activation of endothelial nitric oxide synthase.

scientific article published on 8 November 2011

Niemann-Pick Type C2 Protein Mediates Hepatic Stellate Cells Activation by Regulating Free Cholesterol Accumulation

scientific article published on 13 July 2016

Novel effect of paeonol on the formation of foam cells: promotion of LXRα-ABCA1-dependent cholesterol efflux in macrophages.

scientific article published in January 2013

Oxidative stress enhances AP-1 and NF-κB-mediated regulation of β(2)-glycoprotein I gene expression in hepatoma cells.

scientific article published on November 2010

Paeonol attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling.

scientific article

Prevention of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice by Paeonol

scientific article published on 31 March 2017

Prior exercise training alleviates the lung inflammation induced by subsequent exposure to environmental cigarette smoke

scientific article published on 26 March 2012

Quercetin enhances ABCA1 expression and cholesterol efflux through a p38-dependent pathway in macrophages ⬇️

scientific article published on June 18, 2012

Ractopamine at legal residue dosage accelerates atherosclerosis by inducing endothelial dysfunction and promoting macrophage foam cell formation

scientific article published in 2022

Role of phosphatase activity of soluble epoxide hydrolase in regulating simvastatin-activated endothelial nitric oxide synthase

scientific article

Simvastatin induces heme oxygenase-1: a novel mechanism of vessel protection.

scientific article published on 30 August 2004

Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy

scientific article (publication date: 2015)

Statins activate AMP-activated protein kinase in vitro and in vivo

scientific article published on 20 November 2006

Stent implantation activates Akt in the vessel wall: role of mechanical stretch in vascular smooth muscle cells.

scientific article published on 11 September 2003

Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism

scientific article

The antiinflammatory effect of laminar flow: the role of PPARgamma, epoxyeicosatrienoic acids, and soluble epoxide hydrolase

scientific article

The duration of sustained convulsive seizures determines the pattern of hippocampal neurogenesis and the development of spontaneous epilepsy in rats.

scientific article published on 19 October 2011

The phosphatase activity of soluble epoxide hydrolase regulates ATP-binding cassette transporter-A1-dependent cholesterol efflux

scientific article published on 22 August 2019

Transient Receptor Potential Ankyrin 1 Channel Involved in Atherosclerosis and Macrophage-Foam Cell Formation

scientific article published on 25 May 2016

Transient receptor potential vanilloid type 1 is vital for (-)-epigallocatechin-3-gallate mediated activation of endothelial nitric oxide synthase.

scientific article published on 9 February 2015

Valsartan regulates the interaction of angiotensin II type 1 receptor and endothelial nitric oxide synthase via Src/PI3K/Akt signalling

scientific article published on 23 March 2009

Vascular endothelial growth factor activation of sterol regulatory element binding protein: a potential role in angiogenesis

scientific article

Wogonin promotes cholesterol efflux by increasing protein phosphatase 2B-dependent dephosphorylation at ATP-binding cassette transporter-A1 in macrophages

scientific article published on 28 December 2010

α-Lipoic acid ameliorates foam cell formation via liver X receptor α-dependent upregulation of ATP-binding cassette transporters A1 and G1

scientific article published on 27 October 2010

β Common Receptor Mediates Erythropoietin-Conferred Protection on OxLDL-Induced Lipid Accumulation and Inflammation in Macrophages.

scientific article published on 25 May 2015

β Common receptor integrates the erythropoietin signaling in activation of endothelial nitric oxide synthase

scientific article published on 01 December 2011

β₂-glycoprotein I inhibits VEGF-induced endothelial cell growth and migration via suppressing phosphorylation of VEGFR2, ERK1/2, and Akt.

scientific article published on 6 September 2012

List of works by Tzong-Shyuan Lee

A nation-wide analysis of venous thromboembolism in 497,180 cancer patients with the development and validation of a risk-stratification scoring system.

AMP-activated protein kinase is involved in endothelial NO synthase activation in response to shear stress.

AMP-activated protein kinase mediates erythropoietin-induced activation of endothelial nitric oxide synthase

Activation of TRPV1 prevents OxLDL-induced lipid accumulation and TNF-α-induced inflammation in macrophages: role of liver X receptor α.

Activation of transient receptor potential vanilloid 1 decreases endothelial nitric oxide synthase phosphorylation at Thr497 by protein phosphatase 2B-dependent dephosphorylation of protein kinase C.

Anti-atherogenic effect of berberine on LXRalpha-ABCA1-dependent cholesterol efflux in macrophages.

Apocynin attenuates ventilator-induced lung injury in an isolated and perfused rat lung model.

Asymmetric Dimethylarginine Limits the Efficacy of Simvastatin Activating Endothelial Nitric Oxide Synthase.

Asymmetric dimethylarginine predicts the risk of contrast-induced acute kidney injury in patients undergoing cardiac catheterization

Automated quantitative analysis of lipid accumulation and hydrolysis in living macrophages with label-free imaging.

Bromelain Confers Protection against the Non-Alcoholic Fatty Liver Disease in Male C57bl/6 Mice

CCN family member 1 deregulates cholesterol metabolism and aggravates atherosclerosis

Characterization of the transcriptional regulation of the regulator of G protein signaling 2 (RGS2) gene during 3T3-L1 preadipocyte differentiation.

Colocalization of iron and ceroid in human atherosclerotic lesions

Deficiency of Glycine N-Methyltransferase Aggravates Atherosclerosis in Apolipoprotein E-Null Mice ⬇️

Di-(2-ethylhexyl) phthalate accelerates atherosclerosis in apolipoprotein E-deficient mice.

Docosahexaenoic acid attenuates VCAM-1 expression and NF-κB activation in TNF-α-treated human aortic endothelial cells

EGb761 ameliorates the formation of foam cells by regulating the expression of SR-A and ABCA1: role of haem oxygenase-1.

Eicosapentaenoic acid attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling

Endothelin-1 exacerbates lipid accumulation by increasing the protein degradation of the ATP-binding cassette transporter G1 in macrophages.

Enhancing endothelial progenitor cell therapy for critical limb ischemia by extracorporeal shock wave* ⬇️

Erythropoietin suppresses the formation of macrophage foam cells: role of liver X receptor alpha

Exacerbation of wood smoke-induced acute lung injury by mechanical ventilation using moderately high tidal volume in mice

Excess Nitric Oxide Activates TRPV1-Ca(2+)-Calpain Signaling and Promotes PEST-dependent Degradation of Liver X Receptor α.

Excess nitric oxide impairs LXR(α)-ABCA1-dependent cholesterol efflux in macrophage foam cells.

Genetic Deletion of Soluble Epoxide Hydroxylase Causes Anxiety-Like Behaviors in Mice

Genetic deletion of soluble epoxide hydrolase attenuates inflammation and fibrosis in experimental obstructive nephropathy.

Genetic deletion of soluble epoxide hydrolase delays the progression of Alzheimer's disease

Ginkgo biloba extract confers protection from cigarette smoke extract-induced apoptosis in human lung endothelial cells: Role of heme oxygenase-1.

Glucosamine attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling.

Glucosamine inhibits IL-1beta-mediated IL-8 production in prostate cancer cells by MAPK attenuation.

Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K/Akt pathway in the liver

Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice

High expression of high-mobility group box 1 in the blood and lungs is associated with the development of chronic obstructive pulmonary disease in smokers.

Impaired Cd14 and Cd36 expression, bacterial clearance, and Toll-like receptor 4-Myd88 signaling in caveolin-1-deleted macrophages and mice.

Implication of AMP-activated protein kinase in transient receptor potential vanilloid type 1-mediated activation of endothelial nitric oxide synthase

Induction of heme oxygenase-1 expression in murine macrophages is essential for the anti-inflammatory effect of low dose 15-deoxy-Delta 12,14-prostaglandin J2.

Inflammatory Effects of Menthol vs. Non-menthol Cigarette Smoke Extract on Human Lung Epithelial Cells: A Double-Hit on TRPM8 by Reactive Oxygen Species and Menthol.

Intratracheal siRNA for the in vivo silencing of caspase-3: a novel therapy for acute lung injury?

Intravenous ferric chloride hexahydrate supplementation induced endothelial dysfunction and increased cardiovascular risk among hemodialysis patients

Iron sucrose accelerates early atherogenesis by increasing superoxide production and upregulating adhesion molecules in CKD.

Laminar flow activates peroxisome proliferator-activated receptor-gamma in vascular endothelial cells.

Lung Epithelial TRPA1 Transduces the Extracellular ROS into Transcriptional Regulation of Lung Inflammation Induced by Cigarette Smoke: The Role of Influxed Ca²⁺.

Modulation of microRNA Expression in Subjects with Metabolic Syndrome and Decrease of Cholesterol Efflux from Macrophages via microRNA-33-Mediated Attenuation of ATP-Binding Cassette Transporter A1 Expression by Statins

Molecular mechanism of curcumin on the suppression of cholesterol accumulation in macrophage foam cells and atherosclerosis

N-terminal domain of soluble epoxide hydrolase negatively regulates the VEGF-mediated activation of endothelial nitric oxide synthase.

Niemann-Pick Type C2 Protein Mediates Hepatic Stellate Cells Activation by Regulating Free Cholesterol Accumulation

Novel effect of paeonol on the formation of foam cells: promotion of LXRα-ABCA1-dependent cholesterol efflux in macrophages.

Oxidative stress enhances AP-1 and NF-κB-mediated regulation of β(2)-glycoprotein I gene expression in hepatoma cells.

Paeonol attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling.

Prevention of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice by Paeonol

Prior exercise training alleviates the lung inflammation induced by subsequent exposure to environmental cigarette smoke

Quercetin enhances ABCA1 expression and cholesterol efflux through a p38-dependent pathway in macrophages ⬇️

Ractopamine at legal residue dosage accelerates atherosclerosis by inducing endothelial dysfunction and promoting macrophage foam cell formation

Role of phosphatase activity of soluble epoxide hydrolase in regulating simvastatin-activated endothelial nitric oxide synthase

Simvastatin induces heme oxygenase-1: a novel mechanism of vessel protection.

Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy

Statins activate AMP-activated protein kinase in vitro and in vivo

Stent implantation activates Akt in the vessel wall: role of mechanical stretch in vascular smooth muscle cells.

Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism

The antiinflammatory effect of laminar flow: the role of PPARgamma, epoxyeicosatrienoic acids, and soluble epoxide hydrolase

The duration of sustained convulsive seizures determines the pattern of hippocampal neurogenesis and the development of spontaneous epilepsy in rats.

The phosphatase activity of soluble epoxide hydrolase regulates ATP-binding cassette transporter-A1-dependent cholesterol efflux

Transient Receptor Potential Ankyrin 1 Channel Involved in Atherosclerosis and Macrophage-Foam Cell Formation

Transient receptor potential vanilloid type 1 is vital for (-)-epigallocatechin-3-gallate mediated activation of endothelial nitric oxide synthase.

Valsartan regulates the interaction of angiotensin II type 1 receptor and endothelial nitric oxide synthase via Src/PI3K/Akt signalling

Vascular endothelial growth factor activation of sterol regulatory element binding protein: a potential role in angiogenesis

Wogonin promotes cholesterol efflux by increasing protein phosphatase 2B-dependent dephosphorylation at ATP-binding cassette transporter-A1 in macrophages

α-Lipoic acid ameliorates foam cell formation via liver X receptor α-dependent upregulation of ATP-binding cassette transporters A1 and G1

β Common Receptor Mediates Erythropoietin-Conferred Protection on OxLDL-Induced Lipid Accumulation and Inflammation in Macrophages.

β Common receptor integrates the erythropoietin signaling in activation of endothelial nitric oxide synthase

β₂-glycoprotein I inhibits VEGF-induced endothelial cell growth and migration via suppressing phosphorylation of VEGFR2, ERK1/2, and Akt.