List of works by Leocadio Rodríguez-Mañas

A Multicomponent Exercise Intervention that Reverses Frailty and Improves Cognition, Emotion, and Social Networking in the Community-Dwelling Frail Elderly: A Randomized Clinical Trial.

scientific article published on 03 March 2016

A New Frailty Score for Experimental Animals Based on the Clinical Phenotype: Inactivity as a Model of Frailty

scientific article published on 19 January 2017

A call for action in diabetes care for older people.

scientific article published in July 2011

A new operational definition of frailty: the Frailty Trait Scale.

scientific article

A step forward in the right direction

scientific article published on 01 May 2014

ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

scientific article

Adipose tissue compartments, muscle mass, muscle fat infiltration, and coronary calcium in institutionalized frail nonagenarians.

scientific article published on 16 December 2014

Aeroaging - A New Collaboration between Life Sciences Experts and Aerospace Engineers.

scientific article published in January 2017

Age and gender, two key factors in the associations between physical activity and strength during the ageing process

scientific article published on 25 March 2014

Age, frailty, disability, institutionalization, multimorbidity or comorbidity. Which are the main targets in older adults?

scientific article published on 01 January 2014

Age-related differences in the effects of α and γ peroxisome proliferator-activated receptor subtype agonists on endothelial vasodilation in human microvessels

scientific article published on 07 July 2012

Amadori adducts activate nuclear factor-kappaB-related proinflammatory genes in cultured human peritoneal mesothelial cells

scientific article published on September 2005

Amylin and hypertension: association of an amylin -G132A gene mutation and hypertension in humans and amylin-induced endothelium dysfunction in rats.

scientific article published on 9 January 2007

Amylin effect in extrapancreatic tissues participating in glucose homeostasis, in normal, insulin-resistant and type 2 diabetic state

scientific article published on 16 September 2011

An evaluation of the effectiveness of a multi-modal intervention in frail and pre-frail older people with type 2 diabetes--the MID-Frail study: study protocol for a randomised controlled trial

scientific article published on 24 January 2014

Angiotensin II mediates cell hypertrophy in vascular smooth muscle cultures from hypertensive Ren-2 transgenic rats by an amiloride- and furosemide-sensitive mechanism.

scientific article published on November 1997

Assessment of Muscle Function and Physical Performance in Daily Clinical Practice : A position paper endorsed by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)

scientific article published on 10 April 2019

Association between endothelial dysfunction and frailty: the Toledo Study for Healthy Aging.

scientific article published on February 2014

Association of regional muscle strength with mortality and hospitalisation in older people.

scientific article published on 11 July 2015

Associations between frailty and serum N-terminal propeptide of type I procollagen and 25-hydroxyvitamin D in older Spanish women: The Toledo Study for Healthy Aging

scientific article published on 30 May 2015

Asymmetric dimethylarginine (ADMA) elevation and arginase up-regulation contribute to endothelial dysfunction related to insulin resistance in rats and morbidly obese humans.

scientific article published on 4 March 2016

Automatic and Real-Time Computation of the 30-Seconds Chair-Stand Test without Professional Supervision for Community-Dwelling Older Adults

scientific article published on 14 October 2020

Automatic evaluation of the 30-s chair stand test using inertial/magnetic-based technology in an older prefrail population.

scientific article published in July 2013

Building Bridges for Innovation in Ageing: Synergies between Action Groups of the EIP on AHA.

scientific article published on January 2017

Centenarians, but not octogenarians, up-regulate the expression of microRNAs

scientific article published on 11 December 2012

Cognitive Performance across 3 Frailty Phenotypes: Toledo Study for Healthy Aging

scientific article published on 13 June 2017

Complete blockade of the vasorelaxant effects of angiotensin-(1-7) and bradykinin in murine microvessels by antagonists of the receptor Mas.

scientific article

Correction of glycosylated oxyhemoglobin-induced impairment of endothelium-dependent vasodilatation by gliclazide

scientific article published on 01 July 2000

Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162].

scientific article published on 26 October 2017

Costs of Malnutrition in Institutionalized and Community-Dwelling Older Adults: A Systematic Review.

scientific article published in January 2016

Degree of cognitive impairment and mortality: a 17-year follow-up in a community study

scientific article published on 6 June 2014

Determinants of Frailty and Longevity: Are They the Same Ones?

scientific article

Diabetes and Frailty: Two Converging Conditions?

scientific article published on 09 December 2015

Diabetes and ageing-induced vascular inflammation

scientific article published on 05 October 2015

Diabetes and risk of frailty and its potential mechanisms: a prospective cohort study of older adults.

scientific article published on 16 May 2015

Diabetes in older people: new insights and remaining challenges.

scientific article

Diabetes mellitus as a risk factor for functional and cognitive decline in very old people: the Octabaix study

scientific article published on 27 September 2014

Diabetes mellitus in older people: position statement on behalf of the International Association of Gerontology and Geriatrics (IAGG), the European Diabetes Working Party for Older People (EDWPOP), and the International Task Force of Experts in Diab

scientific article published on July 2012

Differential effect of amylin on endothelial-dependent vasodilation in mesenteric arteries from control and insulin resistant rats

scientific article

Disfunción endotelial asociada al envejecimiento vascular humano

Early and intermediate Amadori glycosylation adducts, oxidative stress, and endothelial dysfunction in the streptozotocin-induced diabetic rats vasculature

scientific article published on 12 March 2003

Effect of glycaemic control on the vascular nitric oxide system in patients with type 1 diabetes

scientific article published in June 2003

Effectiveness of acute geriatric units on functional decline, living at home, and case fatality among older patients admitted to hospital for acute medical disorders: meta-analysis

scientific article

Effects of captopril, losartan, and nifedipine on cell hypertrophy of cultured vascular smooth muscle from hypertensive Ren-2 transgenic rats

scientific article

Effects of different doses of high-speed resistance training on physical performance and quality of life in older women: a randomized controlled trial

scientific article published on 13 December 2016

Effects of different exercise interventions on risk of falls, gait ability, and balance in physically frail older adults: a systematic review

scientific article published on April 2013

Efficiency of acute geriatric units: a meta-analysis of controlled studies

scientific article

Endocrinology of Aging From a Muscle Function Point of View: Results From the Toledo Study for Healthy Aging

scientific article published on 21 October 2016

Endothelial Stimulation of Sodium Pump in Cultured Vascular Smooth Muscle

scientific article published on 01 July 1995

Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation

scientific article published on 26 February 2009

Endothelial dysfunction through genetic deletion or inhibition of the G protein-coupled receptor Mas: a new target to improve endothelial function

scientific article published in December 2007

Endothelial modulation of the ouabain-induced contraction in human placental vessels

scientific article published on 01 October 1992

Engaging clinicians and patients to assess and improve frailty measurement in adults with end stage renal disease.

scientific article published on 12 January 2018

Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5).

scientific article published on 20 February 2017

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).

scientific article published on 18 May 2017

Evidence for Sodium Azide as an Artifact Mediating the Modulation of Inducible Nitric Oxide Synthase by C-Reactive Protein

scientific article published on 01 March 2005

Exercise training as a drug to treat age associated frailty

scientific article published on 25 March 2016

Exercise: the lifelong supplement for healthy ageing and slowing down the onset of frailty.

scientific article published on 13 February 2016

Exome sequencing of three cases of familial exceptional longevity.

scientific article

Extracellular PBEF/NAMPT/visfatin activates pro-inflammatory signalling in human vascular smooth muscle cells through nicotinamide phosphoribosyltransferase activity

scientific article

FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR/HIF-1α activation.

scientific article

Frailty Is Associated With Lower Expression of Genes Involved in Cellular Response to Stress: Results From the Toledo Study for Healthy Aging.

scientific article

Frailty and sarcopenia - newly emerging and high impact complications of diabetes

scientific article published on 12 May 2017

Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults.

scientific article published on 28 June 2016

Frailty as a Major Factor in the Increased Risk of Death and Disability in Older People With Diabetes.

scientific article published on 2 September 2016

Frailty assessment based on trunk kinematic parameters during walking

scientific article published on 24 May 2015

Frailty in the clinical scenario

scientific article published on 06 November 2014

Frailty is associated with objectively assessed sedentary behaviour patterns in older adults: Evidence from the Toledo Study for Healthy Aging (TSHA).

scientific article published on 11 September 2017

Frailty, sarcopenia and diabetes.

scientific article published on 20 November 2014

Frailty, what are we talking about? Implications for the daily clinical practice

scientific article published on 5 June 2017

Frailty: An Emerging Public Health Priority.

scientific article published on 21 January 2016

Frailty: the quest for new domains, clinical definitions and subtypes. Is this justified on new evidence emerging?

scientific article published on 01 January 2014

Function But Not Multimorbidity at The Cornerstone of Geriatric Medicine

scientific article published on 22 August 2017

Gait Velocity and Chair Sit-Stand-Sit Performance Improves Current Frailty-Status Identification

scientific article published on 27 April 2017

Global Performance of Executive Function Is Predictor of Risk of Frailty and Disability in Older Adults

scientific article published in January 2017

Glycosylated human oxyhaemoglobin activates nuclear factor-kappaB and activator protein-1 in cultured human aortic smooth muscle.

scientific article published on 22 September 2003

High Serum Retinol as a Relevant Contributor to Low Bone Mineral Density in Postmenopausal Osteoporotic Women

scientific article published on 2 January 2018

High glucose induces cell death of cultured human aortic smooth muscle cells through the formation of hydrogen peroxide

scientific article

Higher levels of endogenous estradiol are associated with frailty in postmenopausal women from the toledo study for healthy aging.

scientific article published on 7 June 2012

Human exceptional longevity: transcriptome from centenarians is distinct from septuagenarians and reveals a role of Bcl-xL in successful aging

scientific article published on 28 October 2016

Hyperphosphatemia induces senescence in human endothelial cells by increasing endothelin-1 production.

scientific article

Hypoglycemia in older patients with diabetes

scientific article published on 7 May 2012

Hypoglycemia in older people - a less well recognized risk factor for frailty

scientific article

Impairment of Endothelium-Dependent Relaxation by Increasing Percentages of Glycosylated Human Hemoglobin

scientific article published on 01 October 1996

Impairment of endothelial relaxations by glycosylated human oxyhemoglobin depends on the oxidative state of the heme group

scientific article published on 01 April 1999

Impairment of nitric oxide-mediated relaxations in anaesthetized autoperfused streptozotocin-induced diabetic rats.

scientific article published in November 1998

Improving drug prescription in elderly diabetic patients

scientific article published on 19 March 2016

In Search of 'Omics'-Based Biomarkers to Predict Risk of Frailty and Its Consequences in Older Individuals: The FRAILOMIC Initiative.

scientific article published on 23 July 2015

Inflammation determines the pro-adhesive properties of high extracellular d-glucose in human endothelial cells in vitro and rat microvessels in vivo

scientific article

Integrated Care Program for Older Adults: Analysis and Improvement.

scientific article published in January 2017

Interference of glycosylated human hemoglobin with endothelium-dependent responses

scientific article published on 01 November 1993

Is It Ethical Not to Prescribe Physical Activity for the Elderly Frail?

scientific article published on 28 July 2016

Is quality of life different between diabetic and non-diabetic people? The importance of cardiovascular risks

scientific article published on 14 December 2017

Laboratory biomarkers and frailty: presentation of the FRAILOMIC initiative

scientific article published on 14 March 2015

Management of Cancer in the Older Age Person: An Approach to Complex Medical Decisions.

scientific article published on 20 February 2017

Mechanisms involved in the aging-induced vascular dysfunction

scientific article

Methodological aspects of integrated care pathways

scientific article published on 7 March 2017

Mild cognitive impairment diagnosed with the new DSM-5 criteria: prevalence and associations with non-cognitive psychopathology

scientific article published on 4 June 2014

Multicomponent exercises including muscle power training enhance muscle mass, power output, and functional outcomes in institutionalized frail nonagenarians.

scientific article

Nifedipine, losartan and captopril effects on hyperplasia of vascular smooth muscle from Ren-2 transgenic rats

scientific article published on 01 April 1997

Noncoronary Vascular Calcification, Bone Mineral Density, and Muscle Mass in Institutionalized Frail Nonagenarians

scientific article published on 24 March 2017

Nonlinear relationship between waist to hip ratio, weight and strength in elders: is gender the key?

scientific article published on 13 May 2015

Obesity, fat distribution, and risk of frailty in two population-based cohorts of older adults in Spain

scientific article published on 13 February 2015

Operational Definition of Active and Healthy Ageing (AHA): A Conceptual Framework.

scientific article published in January 2015

Outcome of older critically ill patients: a matched cohort study

scientific article published on 01 January 2006

Oxidative stress and vascular inflammation in aging.

scientific article published on 10 July 2013

Oxidative stress is related to frailty, not to age or sex, in a geriatric population: lipid and protein oxidation as biomarkers of frailty

scientific article published on 24 June 2014

Pathways responsible for apoptosis resulting from amadori-induced oxidative and nitrosative stress in human mesothelial cells

scientific article

Performance of the European Working Group on Sarcopenia in Older People algorithm in screening older adults for muscle mass assessment.

scientific article published on 23 December 2014

Pharmaceutical interventions for frailty and sarcopenia

scientific article published on January 2014

Physical activity trajectories, mortality, hospitalization, and disability in the Toledo Study of Healthy Aging

scientific article published on 12 March 2020

Positive effects of resistance training in frail elderly patients with dementia after long-term physical restraint.

scientific article

Preserved endothelial function in human obesity in the absence of insulin resistance

scientific article

Prevention of endothelial dysfunction in streptozotocin-induced diabetic rats by gliclazide treatment

scientific article published on 01 July 2000

Pro-inflammatory effects of early non-enzymatic glycated proteins in human mesothelial cells vary with cell donor's age.

scientific article published on 30 October 2006

Promoting access to innovation for frail old persons. IAGG (International Association of Gerontology and Geriatrics), WHO (World Health Organization) and SFGG (Société Française de Gériatrie et de Gérontologie) Workshop--Athens January 20-21, 2012.

scientific article published in January 2013

Quality of life in sarcopenia and frailty

scientific article published on 05 July 2013

Reallocating Accelerometer-Assessed Sedentary Time to Light or Moderate- to Vigorous-Intensity Physical Activity Reduces Frailty Levels in Older Adults: An Isotemporal Substitution Approach in the TSHA Study.

scientific article published on 18 December 2017

Relationship Between Sarcopenia and Frailty in the Toledo Study of Healthy Aging: A Population Based Cross-Sectional Study.

scientific article published on 24 October 2017

Reply: To PMID 24893954.

scientific article published on 20 February 2015

Role of oestrogens on oxidative stress and inflammation in ageing.

scientific article published in December 2013

STOPPFrail: a misleading name for a potentially useful tool

scientific article published in September 2017

Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

scientific article

Searching for an operational definition of frailty: a Delphi method based consensus statement: the frailty operative definition-consensus conference project

scientific article published on 16 April 2012

Serum uric acid concentrations and risk of frailty in older adults.

scientific article published on 6 July 2016

Should we use gait speed in COPD, FEV1in frailty and dyspnoea in both?

scientific article published on 31 July 2016

Skeletal Muscle Regulates Metabolism via Interorgan Crosstalk: Roles in Health and Disease

scientific article

Standardizing in vitro diagnostics tasks in clinical trials: a call for action

scientific article

Thapsigargin Induces Apoptosis in Cultured Human Aortic Smooth Muscle Cells

scientific article published on 01 November 2000

The "Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies" (SPRINTT) randomized controlled trial: design and methods.

scientific article published on 31 January 2017

The Standardization of Frailty Phenotype Criteria Improves Its Predictive Ability: The Toledo Study for Healthy Aging

scientific article

The Third Transition: The Clinical Evolution Oriented to the Contemporary Older Patient

scientific article published on 22 November 2016

The deleterious effect of high concentrations of D-glucose requires pro-inflammatory preconditioning

scientific article

The frailty syndrome in the public health agenda.

scientific article published on 29 April 2014

The problems in interpreting qualitative studies: presentation of a case and an editorial

scientific article published on 14 March 2013

The relevance of biomaterials to the prevention and treatment of osteoporosis.

scientific article published on 10 January 2014

The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) randomized controlled trial: Case finding, screening and characteristics of eligible participants

scientific article published on 24 September 2018

Thromboprophylaxis with the low-molecular-weight heparin bemiparin sodium in elderly medical patients in usual clinical practice: the ANCIANOS study

scientific article

Treatment of type 2 diabetes mellitus in elderly patients.

scientific article published on 21 January 2018

Type 2 diabetes mellitus in the elderly, new evidence to apply the knowledge in daily clinical practice

scientific article published on 16 January 2013

Un ejemplo de cooperación para la implementación de programas relacionados con el desarrollo de ejercicio en ancianos frágiles: programa europeo Erasmus + «Vivifrail»

scientific article published on 04 May 2016

Usefulness of 2 questions about age and year of birth in the case-finding of dementia

scientific article

What is new in exercise regimes for frail older people — How does the Erasmus Vivifrail Project take us forward?

scientific article published on 01 January 2016

Xanthine oxidase-derived extracellular superoxide anions stimulate activator protein 1 activity and hypertrophy in human vascular smooth muscle via c-Jun N-terminal kinase and p38 mitogen-activated protein kinases

article published in 2007

[Cardiovascular risk factors in the elderly: 2007]

scientific article published on 01 May 2008

[Diabetes, depression and dementia. Three interrelated «d's» in the elderly]

scientific article published on 25 February 2015

[Differential characteristics of type 2 diabetes in the elderly. Role of dipeptidyl peptidase 4 inhibitors]

scientific article published on 12 June 2015

[Effectiveness of reevaluation of admission of patients with poor functional status]

scientific article published on 30 December 2009

[Elderly patients with diabetes mellitus and frailty. Association always present?]

scientific article published on 01 August 2014

[Frailty: a phenotype under review]

scientific article published on 26 October 2011

[Functional impairment as an expression of an uncommon disease in the elderly]

scientific article published on 23 September 2011

[RETICEF: an opportunity to stimulate Spanish research on ageing and frailty]

scientific article published on 01 March 2008

[Role of SGLT2 inhibitors in elderly diabetic patients; we should avoid ageism]

scientific article published on 18 July 2016

[Self-measurement of blood pressure. Consensus Paper Spain 2007]

scientific article published on 01 April 2007

[Strategies for effective control of arterial hypertension in Spain. Consensus document]

scientific article published on 01 November 2006

[Sublinical cardiovascular disease and frailty]

scientific article published on 14 April 2010

[The World Health Organization report on ageing and health: A gift for the geriatrics community]

scientific article published on 19 February 2016

[Treatment of type 2 diabetes in the elderly].

scientific article

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