List of works by Olivier Hyrien

Bi-directional replication and random termination.

scientific article

Broadening of DNA replication origin usage during metazoan cell differentiation

scientific article published on 16 June 2006

Cdc45 is a critical effector of myc-dependent DNA replication stress.

scientific article published on 02 May 2013

Control of replication origin density and firing time in Xenopus egg extracts: role of a caffeine-sensitive, ATR-dependent checkpoint.

scientific article

DNA replication timing is deterministic at the level of chromosomal domains but stochastic at the level of replicons in Xenopus egg extracts.

scientific article published on 2 September 2008

DNA topoisomerase IIα controls replication origin cluster licensing and firing time in Xenopus egg extracts

scientific article published on 11 June 2013

Deciphering DNA replication dynamics in eukaryotic cell populations in relation with their averaged chromatin conformations.

scientific article published on 03 March 2016

Developmental and cancer-associated plasticity of DNA replication preferentially targets GC-poor, lowly expressed and late-replicating regions

scientific article published on 01 November 2018

Developmental and cancer-associated plasticity of DNA replication preferentially targets GC-poor, lowly expressed and late-replicating regions

Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse.

scientific article

Evidence for sequential and increasing activation of replication origins along replication timing gradients in the human genome

scientific article

From simple bacterial and archaeal replicons to replication N/U-domains.

scientific article published on 03 October 2013

Genome-wide mapping of individual replication fork velocities using nanopore sequencing

scientific article published on 08 June 2022

Hemicatenanes form upon inhibition of DNA replication

scientific article

How MCM loading and spreading specify eukaryotic DNA replication initiation sites

scientific article

Mathematical modelling of eukaryotic DNA replication.

scientific article

Mechanisms and consequences of replication fork arrest.

scientific article

Mechanisms ensuring rapid and complete DNA replication despite random initiation in Xenopus early embryos

scientific article published on 01 February 2000

Multiscale analysis of genome-wide replication timing profiles using a wavelet-based signal-processing algorithm.

scientific article published on 13 December 2012

Paradoxes of eukaryotic DNA replication: MCM proteins and the random completion problem.

scientific article

Peaks cloaked in the mist: the landscape of mammalian replication origins

scientific article

Plasmid replication in Xenopus eggs and egg extracts: a 2D gel electrophoretic analysis ⬇️

scientific article published on April 11, 1992

Proliferating human cells hypomorphic for origin recognition complex 2 and pre-replicative complex formation have a defect in p53 activation and Cdk2 kinase activation.

scientific article published on 10 January 2006

Replication fork polarity gradients revealed by megabase-sized U-shaped replication timing domains in human cell lines

scientific article

Replication landscape of the human genome

scientific article published on 11 January 2016

Replication of the Chicken β-Globin Locus: Early-Firing Origins at the 5′ HS4 Insulator and the ρ- and βA-Globin Genes Show Opposite Epigenetic Modifications ⬇️

scientific article published on May 1, 2003

Replication-fork stalling and processing at a single psoralen interstrand crosslink in Xenopus egg extracts

scientific article

Single-molecule, antibody-free fluorescent visualisation of replication tracts along barcoded DNA molecules.

scientific article published on 20 May 2016

Site-specific and temporally controlled initiation of DNA replication in a human cell-free system

scientific article published on May 2002

The eukaryotic bell-shaped temporal rate of DNA replication origin firing emanates from a balance between origin activation and passivation.

scientific article published in June 2018

Topoisomerase II can unlink replicating DNA by precatenane removal

scientific article

Topoisomerase II-DNA complexes trapped by ICRF-193 perturb chromatin structure.

scientific article published on August 2005

Topological analysis of plasmid DNA replication intermediates using two-dimensional agarose gels.

scientific article published in January 2009

Transition in specification of embryonic metazoan DNA replication origins

scientific article

Universal temporal profile of replication origin activation in eukaryotes

scientific article

Use of DNA combing to study DNA replication in Xenopus and human cell-free systems

scientific article

Visualization of bidirectional initiation of chromosomal DNA replication in a human cell free system

scientific article

Y RNA functions at the initiation step of mammalian chromosomal DNA replication

scientific article published on August 2009

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